A drug's effectiveness stems from its ability to manipulate these synaptic transmissions at different phases of the process.

药物的有效性源于它在过程的不同阶段操纵这些突触传递的能力。

So, NMDA receptors belong to the family of ionotropic glutamate receptors, which mediate most of the excitatory synaptic transmission in the brain.

因此，NMDA受体属于离子型谷氨酸受体家族，它介导大脑中大部分的兴奋性突触传递。

The initial action potential accounts for 1 to 5 milliseconds and synaptic transmissions only take 0.1 to 0.5 milliseconds, so the bulk of that time is spent within the axons.

产生最初的运动电位占用了 1 到 5 毫秒，突触传播仅需 1 至 5 毫秒，所以大块时间用在了神经轴突上。

Now, as you may know, the binding of glutamate to the NMDA receptor results in an influx of extracellular calcium, which controls membrane excitability and synaptic transmission.

现在，如你所知，谷氨酸与NMDA受体的结合导致内流细胞外钙，控制膜的兴奋性和突触传递。