Resulting from the increased breakdown of most types of tissue, the individual presents with muscle wasting and thin extremities, skin thinning, easy bruising and abdominal striae or lines as well as fractures due to osteoporosis or brittle bones.

大多数组织分解导致患者出现肌肉萎缩和四肢瘦弱、皮肤变薄、易出现瘀伤和腹部出现皮纹，以及由骨质疏松或骨骼脆弱引起的骨折。