They noted that uncontrolled activation of the smoothened protein was associated with a human syndrome.

他们指出，smoothened蛋白质不受控制的激活和一种人类综合症相关。

So even though the hedgehog protein is still doing its job of keeping the way clear for smoothened, cyclopamine blocks smoothened from passing along its chemical message.

因此，虽然刺猬蛋白仍在工作，帮助smoothened保持通路顺畅，环杷明阻挡了smoothened通过化学信息传递。

That locks smoothened up so that it's unable to send the signals needed to mold the brain into two hemispheres, and form fingers or separate eyes.

它锁住了smoothened，因此让其无法传递信号让大脑形成两个半球并形成手指和分开的眼睛。

That inhibits, or holds, patched back, allowing another protein called smoothened to freely signal the cells, telling them where to go and what kind of tissues to become.

那会抑制，或者阻止补丁，让另一种叫smoothened的蛋白来自由标记细胞，告诉细胞要去往那里，要成为哪一种组织。