Consequently RNA interference was observed is eukaryotic organisms including fungi, Arabidopsis,C. elegans, trypanosomes, hydra, planaria, Drosophila, zabrafish, and mouse.

到目前为止在真菌、拟南芥、线虫、锥虫、水螅、涡虫、果蝇、斑马鱼、小鼠等真核生物中都发现存在这一基因沉默机制。