When gonadotropin-releasing hormone reach the pituitary gland, it stimulates cells in the anterior pituitary, called gonadotrophs, to release gonadotropin hormones: luteinizing hormone and follicle-stimulating hormone which then enter the blood.

当GnRH到达垂体时，可刺激垂体前叶的促性腺激素细胞，释放促性腺激素黄体生成素（LH）和促卵泡生成激素（FSH），两者随后进入血液。