| 单词 | multiple myeloma |
| 例句 | Mr. Polito had been treated for multiple myeloma, a form of blood cancer, for several years but continued to act until shortly before his death. Jon Polito, character actor in ‘Homicide,’ Coen brothers films, dies at 65 2016-09-02T04:00:00Z That same year, Bissell told me, after several scary bouts with pneumonia, he was diagnosed with multiple myeloma, a cancer that attacks plasma cells. The 18-Year Wait for New Wrens Music Is Over. Sort Of. 2021-09-20T04:00:00Z The cause was multiple myeloma, his wife, Catherine Mauger Williams, said. C. K. Williams, Poet Who Tackled Moral Issues, Dies at 78 2015-09-20T04:00:00Z The cause was complications of multiple myeloma, his son, Jerome, said. Jerome Tuccille, Libertarian Author and Trump Biographer, Dies at 79 2017-02-24T05:00:00Z Ray also plans to continue efforts to raise awareness for multiple myeloma. Lisa Ray -- cancer-free and ready to re-embrace India 2010-04-22T00:07:00Z Guru suffered from multiple myeloma for over a year. Guru cannot have written 'deathbed' statement, say family 2010-04-22T09:03:00Z The cause was complications of multiple myeloma, said Charlotte Blake Alston, his sister. John Blake Jr., Versatile Jazz Violinist, Dies at 67 2014-08-19T04:00:00Z The multiple myeloma cancer diagnosis he recently received is dire. A Debut Novel Where Small Moments Add Up to Something Big 2021-11-16T05:00:00Z I am a caregiver for my husband who was diagnosed with multiple myeloma. How Can I Tell My Mother-in-Law to Buzz Off? 2021-06-24T04:00:00Z After poring through charts to diagnose a patient with multiple myeloma, a blood cancer masquerading as schizophrenia, she writes that it is proof that being rushed in medicine is not only wasteful but dangerous. A Doctor Argues That Her Profession Needs to Slow Down, Stat 2018-01-26T05:00:00Z Chris Wedes, better known as TV clown J. P. Patches, died Sunday morning after a long battle with multiple myeloma, a form of blood cancer. Obituary: "J.P. Patches," Seattle's beloved TV clown 2012-07-23T01:42:03Z Along the way, they lost Gates to complications from multiple myeloma and Ciccone to a heart attack. Musicians Hall of Fame to honor group with New Jersey roots 2019-10-16T04:00:00Z Mr. Vines has multiple myeloma but hasn’t slowed down. Guitar Making as a Life’s Work 2023-05-29T04:00:00Z He was diagnosed in 2013 with multiple myeloma, an incurable blood cancer that affects the bone marrow, and this has led to painful back surgery. Retiring Brokaw: Journalists should get out of power centers 2021-01-28T05:00:00Z My father lived 12 years after his transplant, most of it in reasonably good health, until the very end when he developed multiple myeloma. In health care access, doctor privilege is real. This is how it works 2020-04-11T04:00:00Z A son from his first marriage, Daniel, was killed by a drunken driver in 1968; another, David, the longtime principal clarinetist of the San Francisco Symphony, died from complications of multiple myeloma in 2005. Leon Breeden, Jazz Educator, Dies at 88 2010-08-14T04:45:00Z Edmund L. Epstein William Golding’s “Lord of the Flies” in paperback The cause was complications of multiple myeloma, his daughter Dr. Lucy Hutner said. Edmund Epstein Dies at 80; Gave ?Lord of the Flies? Wings 2012-04-07T21:31:02Z The cause of her death, in a hospital, was multiple myeloma, said Diana Finney, her sister and only immediate survivor. Shirley Jo Finney, 74, Dies; Addressed the Black Experience Onstage 2023-11-13T05:00:00Z Maria Cuomo Cole, a close friend, said the cause of his death, in a hospice, was complications of multiple myeloma. Rock Brynner, Son of Hollywood Royalty Who Cut His Own Path, Dies at 76 2023-10-25T04:00:00Z The network says Brokaw was diagnosed in August with multiple myeloma, a cancer affecting blood cells in the bone marrow. NBC's Tom Brokaw diagnosed with cancer 2014-02-12T00:36:12Z Gregory Evans, a longtime friend, said the cause was multiple myeloma. Dagny Corcoran, Bookseller and Fixture of the L.A. Art Scene, Dies at 77 2022-11-20T05:00:00Z First, in a Sunday New York Times essay, veteran journalist Tom Brokaw wrote eloquently about how he’s been living with his multiple myeloma the past three years. Thank you, Ben Stiller: The actor’s essay on cancer rings true with humility, honesty and heart 2016-10-05T04:00:00Z Over the years I’d been a bit puzzled about Ms. Ferraro, who was 75 when she died on March 26 of complications of the cancer that invaded her, multiple myeloma. Cultural Studies: Why Gerry Ferraro Mattered 2011-04-01T23:37:02Z Kent Damon is fighting multiple myeloma, an incurable form of cancer. Krasinski says life is weird after 'The Office' 2013-06-06T17:31:05Z Errors in these processes can give rise to acquired diseases including cancers, such as leukemia, lymphoma, and multiple myeloma, and those, such as sickle cell anemia, present from birth. Researchers chart the contents of human bone marrow 2023-11-14T05:00:00Z He faced questions about his health, as he has been in treatment for multiple myeloma, a form of blood cancer, since August. US House Republicans speaker fight: Who's in, who's out? 2023-10-13T04:00:00Z But Scalise also faces new health concerns as he undergoes treatment for multiple myeloma, a form of blood cancer, which some Jordan supporters cited as a reason not to vote for him. Republican Scalise struggles for votes after winning US House speaker nomination 2023-10-12T04:00:00Z Scalise announced in August he was in treatment for multiple myeloma, a form of blood cancer. Republican Steve Scalise on path to US House speaker in turbulent time 2023-10-11T04:00:00Z He may face questions from the caucus about his health, as he has been in treatment for multiple myeloma, a form of blood cancer, since August. US House Republicans eye Scalise, Jordan for possible next speaker 2023-10-11T04:00:00Z In August, the Louisiana lawmaker announced he was seeking treatment for multiple myeloma, a form of blood cancer. US House's Scalise, Jordan locked in two-way speaker race, for now 2023-10-07T04:00:00Z Mr. Scalise, Louisiana Republican, who appeared on Fox News Friday, was diagnosed with multiple myeloma in late August— a blood cancer that develops in plasma cells in the bone marrow. Rep. Scalise says cancer treatment going ‘phenomenally’ well 2023-10-06T04:00:00Z The Louisiana lawmaker may face questions from the caucus about his health, as he announced in August that he was in treatment for multiple myeloma, a form of blood cancer. Who could succeed Republican Kevin McCarthy as speaker of the US House? 2023-10-04T04:00:00Z He is dealing with multiple myeloma, a form of blood cancer, and undergoing chemotherapy treatment. Who might replace McCarthy as House speaker? What are Republicans already demanding for their vote? 2023-10-05T04:00:00Z Mr. Scalise is undergoing treatment for multiple myeloma, a blood cancer that he said was detected early and is responding well to treatment. Jim Jordan shakes up race for House speaker 2023-10-04T04:00:00Z More recently, he was diagnosed in late August with multiple myeloma, a blood cancer that develops in plasma cells in the bone marrow. Scalise building backing to become next speaker 2023-10-04T04:00:00Z He announced in August that he has a blood cancer known as multiple myeloma and was undergoing treatment. Here are the Republicans in the mix to replace Kevin McCarthy 2023-10-03T04:00:00Z Patients with multiple myeloma, a blood cancer of plasma cells in the bone marrow, who also have diabetes have a reduced overall survival when compared to those without diabetes. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z Mr. Scalise, Louisiana Republican, was diagnosed with multiple myeloma, a type of blood cancer, in late August. Scalise says cancer has ‘dropped dramatically’ after month of treatment 2023-09-27T04:00:00Z Locke and colleagues designed a dendritic cell vaccine targeting a protein called survivin and tested this vaccine in a phase I clinical trial involving 13 patients with multiple myeloma. A dendritic cell vaccine was safe and induced immune responses in patients with multiple myeloma 2023-09-22T04:00:00Z They also demonstrate that these CAR-T cells -- which are engineered to target specific markers on cancer cells -- show enhanced anti-tumor activity in mouse models of melanoma, leukemia and multiple myeloma. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z To investigate the role of reductive carboxylation, the scientists inhibited this mechanism in CAR-T cells in mouse models of leukemia and multiple myeloma, two blood cancers. Strengthening artificial immune cells to fight cancer 2023-09-20T04:00:00Z "We knew from prior studies that patients with multiple myeloma and diabetes have lower survival rates," explained Urvi Shah, MD, a multiple myeloma specialist at Memorial Sloan Kettering Cancer Center. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z Mr. Scalise, Louisiana Republican, has been undergoing chemotherapy treatments since being diagnosed with multiple myeloma, a type of blood cancer. Scalise returns to the Hill for first time since cancer diagnosis 2023-09-14T04:00:00Z Capitol on Thursday for the first time since being diagnosed with a blood cancer known as multiple myeloma and told reporters his chemotherapy treatment is underway. No. 2 House Republican Steve Scalise returns to the Capitol after his blood cancer diagnosis 2023-09-14T04:00:00Z And in the House, Rep. Steve Scalise, the No. 2 Republican, disclosed last week that he has been diagnosed with a form of blood cancer known as multiple myeloma and is undergoing treatment. Congress returns to try to stave off a government shutdown while GOP weighs impeachment inquiry 2023-09-04T04:00:00Z The White House says President Biden has called House Majority Leader Steve Scalise to express his best wishes for a swift recovery as the Louisiana Republican battles multiple myeloma, a type of blood cancer. Biden wishes GOP leader Steve Scalise a speedy recovery from cancer 2023-08-30T04:00:00Z Younger patients may tolerate multiple myeloma treatments better than older individuals, and these differences could explain some of the racial differences investigators observed in survival outcomes. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z House Majority Leader Steve Scalise, the number two Republican in the House, announced on Tuesday that he has been diagnosed with multiple myeloma, a type of blood cancer. Majority Leader Scalise diagnosed with cancer, promises to continue working 2023-08-29T04:00:00Z He said the diagnosis was made quickly and his wife and he decided they wanted to be “very aggressive” in treating the multiple myeloma. No. 2 House Republican Steve Scalise returns to the Capitol after his blood cancer diagnosis 2023-09-14T04:00:00Z Blood tests showed some irregularities and after additional screening, he said he was diagnosed with multiple myeloma. No. 2 House Republican Steve Scalise diagnosed with blood cancer, undergoing treatment 2023-08-29T04:00:00Z He tweeted again on Monday about a treatment for multiple myeloma, an aggressive blood cancer. NOT REAL NEWS: A look at what didn’t happen this week 2023-08-18T04:00:00Z When investigating the mechanisms behind these findings, Dr. Shah and colleagues observed that in genetically engineered mouse models, multiple myeloma tumors grew more rapidly in non-obese diabetic mice than in non-diabetic controls. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z Just two days later, Ingalls died, at 78, of multiple myeloma. Reviving a novelist of monsters and men: Why Rachel Ingalls matters now 2023-07-12T04:00:00Z Kevin Wright, who has multiple myeloma, unknowingly built his home directly over the chemical pit near Santa Barbara in 1985, according to his lawsuit. California jury returns $63M verdict after finding Chevron covered up toxic pit before selling land 2023-06-08T04:00:00Z Mr. French’s death from multiple myeloma, at a hospital in London, was confirmed by his wife, Meru Gokhale, a former publisher at Penguin Random House India. Patrick French, renowned biographer of V.S. Naipaul, dies at 56 2023-03-23T04:00:00Z She was a vocal advocate for stem-cell research, which she argued held the promise of improved therapies for diseases including multiple myeloma, a blood cancer for which she was treated. Marilyn Goldwater, Maryland delegate and health care champion, dies at 95 2023-03-13T04:00:00Z "In my own practice, I work with many patients with both multiple myeloma and diabetes. And usually treating multiple myeloma involves many rounds of chemotherapy," said Dr. Shah. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z They later said he also needed access to the drug daratumumab, which is used to treat multiple myeloma. Pervez Musharraf, Pakistan martial ruler in 9/11 wars, dies 2023-02-04T05:00:00Z She was diagnosed in 2018 with multiple myeloma, which is an incurable disease. NI health: Seriously ill woman urges more resources for health system 2023-02-03T05:00:00Z Just 16 months prior, the Kirkland resident was undergoing a stem cell transplant after seven months of induction chemotherapy to treat multiple myeloma. Cancer survivors summit Mount St. Helens as a team, raising nearly $50K 2022-10-06T04:00:00Z For about 10 years, oncologists have used CAR T-cell therapy in clinical trials for patients with blood cancers — including BeHanna, who has diffuse large B-cell lymphoma, and others with lymphoblastic leukemia and multiple myeloma. Rural Americans have difficulty accessing a promising cancer treatment 2022-08-26T04:00:00Z A retired Washington, D.C., public relations man, he learned in 2010 that he had multiple myeloma, an incurable blood cancer. Democrats’ Long-Sought Plan for Lowering Drug Costs Is at Hand 2022-08-05T04:00:00Z Holland was first diagnosed with multiple myeloma in September 2019 but managed to coach through the season and help the Niners reach the Super Bowl. Return of beloved 49ers LB coach highlights training camp 2022-08-03T04:00:00Z Cohen, who worked on the implementation of the Affordable Care Act in the Obama administration, was diagnosed with multiple myeloma in 2020. Deal on Capitol Hill could ease seniors’ health costs 2022-07-28T04:00:00Z And even when they do have access to the latest medicines, these treatments, such as those for multiple myeloma, may not work as well in ethnic minority groups, especially in older patients. We Must End Ageism in Cancer Clinical Trials 2022-06-14T04:00:00Z At almost the same time, Macdonald’s monthly visit to the hospital revealed that the original cancer, multiple myeloma, had metastasized into myelodysplastic syndrome, which can often lead to acute leukemia. Norm Macdonald had one last secret 2022-05-29T04:00:00Z For Waleed and Mohammed Hamza, Monday’s trip to Amman, Jordan — unfathomable just months ago — could mean the difference between life and death for their mother, Lutfiya, who has multiple myeloma, a form of cancer. Yemen’s Sanaa airport reopens, a lifeline for the sick and stranded 2022-05-16T04:00:00Z Robin was diagnosed with multiple myeloma, a cancer that affects bone marrow, in 2019. ‘Truly a dream come true:’ Jahan Dotson savors moment, relishes opportunity 2022-04-29T04:00:00Z Six years ago, Ms. Solod began treatment for lung cancer, then multiple myeloma. How Loneliness Is Damaging Our Health 2022-04-20T04:00:00Z The actor and singer who played the Fix-it Shop owner on PBS’ “Sesame Street,” died Thursday in his New York home at 81 after a yearlong battle with multiple myeloma — a type of blood cancer. Emilio Delgado's character Luis made Latino kids feel 'seen, accepted, and sunny' 2022-03-11T05:00:00Z His wife, Carol Delgado, confirmed he had died from the blood cancer multiple myeloma, which he had been battling since 2020, at their home in New York. Sesame Street star Emilio Delgado dies aged 81 2022-03-11T05:00:00Z He has multiple myeloma, a sometimes deadly blood cancer, and the four drugs keeping him alive retail for about $935,000 per year. Mark Cuban’s new pharmacy business and the future of drug pricing 2022-03-05T05:00:00Z Meschery, who has multiple myeloma, said he had two weeks left of treatment. Wilt Chamberlain’s 100-Point Game Changed the N.B.A. 2022-03-02T05:00:00Z Trichloroethylene, also known as the miracle degreaser TCE, for example, is now a known human carcinogen, and epidemiological studies indicate a link between TCE and blood cancers like non-Hodgkin lymphoma and multiple myeloma. What Lies Beneath: Key findings of AP’s investigation 2022-02-22T05:00:00Z Last year, a CAR-T cell therapy was approved for multiple myeloma, the most common malignancy of the bone marrow in adults. Doctors: Long-lasting cell treatment cured leukemia patients 2022-02-02T05:00:00Z He had been vaccinated but suffered from multiple myeloma, a blood cancer that attacks infection-fighting white blood cells and is often treated with drugs that suppress the immune system even further. How Immunocompromised People without Strong Vaccine Protection Are Coping with COVID 2022-01-24T05:00:00Z He had been vaccinated, after all, and was under the best of care at the Walter Reed National Military Medical Center, and still he succumbed, his 84-year-old immune system compromised by multiple myeloma. Deaths in 2021: Headline names against the backdrop of pandemic 2021-12-30T05:00:00Z He also had multiple myeloma, a blood cancer. Chun Doo-hwan, brutal South Korean dictator, dies at 90 2021-11-23T05:00:00Z Chun, who was diagnosed earlier this year with multiple myeloma, collapsed in his Seoul home early Tuesday, according to his former spokesman. Chun Doo-hwan, ex-military dictator who brutally cracked down on democratic uprisings in South Korea, dies 2021-11-23T05:00:00Z Chun had multiple myeloma, a blood cancer which was in remission, and his health had deteriorated recently. Former South Korean military dictator Chun Doo-hwan dies at 90 2021-11-23T05:00:00Z Nearly 35,000 people in the U.S. are diagnosed with multiple myeloma every year. How Immunocompromised People without Strong Vaccine Protection Are Coping with COVID 2022-01-24T05:00:00Z Battling multiple myeloma, Mitchell says one of his cancer drugs alone costs him $15,000 a year through Medicare. Real Medicare drug savings in Dems’ bill — but not overnight 2021-11-10T05:00:00Z He had been vaccinated but suffered from multiple myeloma—a blood cancer that attacks infection-fighting white blood cells and is often treated with drugs that suppress the immune system even further. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z There’s a drug called Revlimid that treats the blood cancer multiple myeloma. Democrats Choosing Less Risky Path on Drug Prices 2021-11-06T04:00:00Z Powell, who was fully vaccinated, had Parkinson’s disease and multiple myeloma, a form of blood cancer that impairs the body’s ability to fight infection. Colin Powell remembered for leadership, integrity and a love of ABBA and Marley at funeral 2021-11-05T04:00:00Z Diana M. Chavez of Los Angeles was diagnosed with multiple myeloma in 2020. How Immunocompromised People without Strong Vaccine Protection Are Coping with COVID 2022-01-24T05:00:00Z "He said 'you have multiple myeloma' and I told him I had never heard of it and that he had the wrong person." 'I kept falling asleep in board meetings and then found out I had cancer' 2021-11-05T04:00:00Z Nearly 35,000 Americans are diagnosed with multiple myeloma every year. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z He had been vaccinated against the coronavirus, but his family said his immune system had been compromised by multiple myeloma, a blood cancer for which he had been undergoing treatment. Son and colleagues to eulogize soldier-diplomat Colin Powell 2021-11-04T04:00:00Z Then, after she received a diagnosis of smoldering multiple myeloma, she began to see firsthand what it meant to depend on a costly drug. This May Be Democrats’ Best Chance to Lower Drug Prices 2021-10-27T04:00:00Z He is now studying the effect of additional vaccine doses in multiple myeloma patients, and the results, he says, are “shockingly promising.” How Immunocompromised People without Strong Vaccine Protection Are Coping with COVID 2022-01-24T05:00:00Z The former secretary of state, who was 84, had also been undergoing treatment for multiple myeloma. Perspective | You’re not ‘fully vaccinated.’ You never will be. 2021-10-21T04:00:00Z Diana M. Chavez of Los Angeles, who asked that her married name be used to maintain her privacy, was diagnosed with multiple myeloma last year. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z A spokesperson said his immune system had been compromised by multiple myeloma, for which he had been undergoing treatment. This week’s passages 2021-10-22T04:00:00Z Patients and clinicians dealing with multiple myeloma feel this tension, too. This May Be Democrats’ Best Chance to Lower Drug Prices 2021-10-27T04:00:00Z The former deep sea diver, who turned to farming after retiring as a marine operations manager, was diagnosed with multiple myeloma, a form of blood cancer last April. Farmer crushed to death by Aga cooker, inquest hears 2021-10-21T04:00:00Z In July, a study of vaccinated people with multiple myeloma found that only 45 percent had immune responses that would be “adequate” to protect them against covid. Perspective | You’re not ‘fully vaccinated.’ You never will be. 2021-10-21T04:00:00Z Berenson says he and his colleagues have a paper coming out in a few weeks on the effect of additional vaccine doses in multiple myeloma patients. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z He had been vaccinated, but his family said his immune system had been compromised by multiple myeloma, a blood cancer for which he had been undergoing treatment. Memorial service in honor of Colin Powell set for Nov. 5 2021-10-21T04:00:00Z In addition to his advanced age, Powell suffered from multiple myeloma, a form of blood cancer that researchers have determined makes the vaccines less effective. Vaccine skeptics seize on Colin Powell’s death 2021-10-19T04:00:00Z A spokeswoman said his immune system had been compromised by multiple myeloma, for which he had been undergoing treatment. Colin Powell, Who Shaped U.S. National Security, Dies at 84 2021-10-18T04:00:00Z Albert Ko, an infectious-disease physician at the Yale Schools of Public Health and Medicine, said Monday that multiple myeloma takes over the bone marrow and impairs the ability to block infections generally. Colin Powell had been treated for a cancer that severely impairs the immune system, lowering coronavirus vaccine effectiveness 2021-10-18T04:00:00Z She said Gen. Powell, who was fully vaccinated, had Parkinson’s disease and multiple myeloma, a form of blood cancer that impairs the body’s ability to fight infection. Colin L. Powell, former secretary of state and military leader, dies at 84 2021-10-18T04:00:00Z Powell, 84, had been treated over the past few years for multiple myeloma, a blood cancer that impairs the body’s ability to fight infections — and to respond well to vaccines. Powell’s age and cancer bout left him vulnerable to COVID 2021-10-18T04:00:00Z A recent study in Nature showed that, for those with multiple myeloma, less than half of patients developed what researchers termed “an adequate response” to the Pfizer-BioNTech and Moderna vaccines. Vaccine skeptics seize on Colin Powell’s death 2021-10-19T04:00:00Z Powell suffered from multiple myeloma, a blood cancer that affects the body's ability to fight infections, according to NBC News. Colin Powell, former general and secretary of state, dies at 85 from COVID complications 2021-10-18T04:00:00Z Another study that focused specifically on 103 multiple myeloma patients showed that 45 percent developed an adequate antibody response to vaccination, and 22 percent had a partial response to the two companies’ mRNA vaccines. Colin Powell had been treated for a cancer that severely impairs the immune system, lowering coronavirus vaccine effectiveness 2021-10-18T04:00:00Z Van Oldenborgh continued his work after being diagnosed eight years ago with Kahler’s disease, or multiple myeloma, a type of blood cancer. Dutch climate scientist Geert Jan van Oldenborgh dies at 59 2021-10-14T04:00:00Z Several studies have found as few as 45% of people with multiple myeloma may develop protective levels of coronavirus-fighting antibodies after getting the vaccine. Powell’s age and cancer bout left him vulnerable to COVID 2021-10-18T04:00:00Z After losing her husband in September 2020 to multiple myeloma, a type of bone marrow cancer, she said although her whole family, friends and neighbours were there for her "it wasn't enough". Northampton widow walking 1,000 miles in memory of husband 2021-10-10T04:00:00Z But Callagan, 72, has a condition called multiple myeloma, a blood cancer of the bone marrow. Oregon hospitals overwhelmed by COVID postpone care for cancer patients, ‘hope they come back’ 2021-09-21T04:00:00Z But that research, also conducted by the Leukemia & Lymphoma Society, looked at just 49 people who had blood cancers such as multiple myeloma and chronic lymphocytic leukemia. Colin Powell had been treated for a cancer that severely impairs the immune system, lowering coronavirus vaccine effectiveness 2021-10-18T04:00:00Z Holland said he has undergone several rounds of remission and relapse since being originally diagnosed with multiple myeloma in September 2019. 49ers QB Trey Lance to miss 1 week with injured finger 2021-08-30T04:00:00Z Mr. Rumsfeld died on June 29, at 88, of complications related to multiple myeloma. Donald Rumsfeld, Architect of War in Afghanistan, Is Laid to Rest 2021-08-24T04:00:00Z The FDA action “is the right thing to do,” said Mounzer E. Agha, a hematologist at the University of Pittsburgh Medical Center who treats patients with multiple myeloma, lymphoma and other blood cancers. FDA authorizes extra vaccine doses for immunocompromised patients to bolster protection against the coronavirus 2021-08-12T04:00:00Z That was a relief; the prognosis for patients with cardiac amyloidosis from multiple myeloma is poor. He Was Coughing Up Blood. But His Lungs Looked O.K. 2021-07-28T04:00:00Z Samir Parekh, a hematologist and oncologist at the Icahn School of Medicine at Mount Sinai, said both multiple myeloma and the most common treatments for the disease kill the body’s antibody producing B cells. Colin Powell had been treated for a cancer that severely impairs the immune system, lowering coronavirus vaccine effectiveness 2021-10-18T04:00:00Z Before the memorable 2012-2013 season, Moore’s mother was diagnosed with multiple myeloma, a form of cancer. A former college basketball star was waiting for his big chance. Then came the accident. 2021-07-15T04:00:00Z Houston third base coach Gary Pettis is set to rejoin the team on Tuesday after being on leave since being diagnosed with multiple myeloma in Sept. 2020. Hays homers to help Orioles to 5-2 win to sweep Astros 2021-07-01T04:00:00Z The cause was complications from multiple myeloma and oral cancer, said his wife, Dr. Vivian Chen. Charles ‘Chuck’ Lewis, stalwart Washington journalist, dies at 80 2021-03-22T04:00:00Z She is undergoing chemotherapy for multiple myeloma, a cancer of the plasma cells in her bone marrow. Beer Here, Bouquets Next Door: How a Bar Defied the Pandemic 2021-03-16T04:00:00Z However, this joyous step into the relaxing years of their lives was marred by the discovery of a type of cancer called multiple myeloma in Youngblood in 2018. Teacher donates stem cells to brother battling rare cancer 2021-03-13T05:00:00Z Her husband, Alfred Branch, 88, died from multiple myeloma, a cancer of plasma cells, a few days earlier. Grit, gratitude evident in lives of Mississippi residents 2020-11-28T05:00:00Z Bonds was diagnosed with multiple myeloma in the spring of 2018 and went into remission after treatment. St. Francis football coach and former UCLA quarterback Jim Bonds has died at 51 2020-10-28T04:00:00Z After medical tests, he was diagnosed with multiple myeloma, a blood cancer that disproportionately affects African Americans. Why a top Pentagon civilian just lost his job 2020-10-24T04:00:00Z Genmab, which specialises in the development of antibody therapeutics for cancer treatment, currently receives royalties from Janssen, a Johnson & Johnson company, for sales of its blockbuster Darzalex drug for treatment of multiple myeloma. Genmab shares drop on legal battle with J&J over cancer drug 2020-09-23T04:00:00Z For five seasons, Trosclair had endured fatigue and other effects of multiple myeloma, a treatable but incurable blood cancer, missing only a single game. The Pandemic Is Chasing Aging Coaches From the Field 2020-09-18T04:00:00Z In 2017, he was diagnosed with multiple myeloma, a blood cancer. Lou Brock, Cardinals great and MLB Hall of Famer, dies at 81 2020-09-06T04:00:00Z He was hospitalized in the summer of 2019 after falling off his boat, and doctors diagnosed him with multiple myeloma, a form of cancer. Howard Croft, longtime D.C. activist and social justice crusader, dies of covid-19 2020-08-18T04:00:00Z Unfortunately, Endres’ wife was diagnosed in June with multiple myeloma, a form of blood cancer. Column: Customer service doesn't have to be this awful 2020-08-11T04:00:00Z Obesity is a well-known risk factor for multiple myeloma and other cancers. Cancer researchers in Maine awarded grant of $1.9 million 2020-07-05T04:00:00Z The athletic director of an area high school also retired with multiple myeloma. The Pandemic Is Chasing Aging Coaches From the Field 2020-09-18T04:00:00Z About 1,500 cases are diagnosed annually in the United States, compared to about 32,000 cases of multiple myeloma. His anemia was followed by searing foot pain. Seventeen years later, in precarious shape, a stellar athlete learned what was wrong. 2020-06-26T04:00:00Z For patients like Douglas Winger, a multiple myeloma patient at Hopkins, that means hours-long chemotherapy treatments without his wife. Having cancer is hard. It’s more terrifying during the pandemic. 2020-06-27T04:00:00Z For patients like Douglas Winger, a multiple myeloma patient at Hopkins, that means hourslong chemotherapy treatments without his wife. Baltimore residents deal with cancer diagnoses amid pandemic 2020-06-21T04:00:00Z The progression of multiple myeloma, a bone-marrow cancer typically affecting people over the age of 60, varies greatly from one person to the next. Research round-up: extracellular RNA 2020-06-16T04:00:00Z The diagnosis was multiple myeloma, which begins in the bone marrow and limits the body’s ability to fight off infections, weakens bones, reduces kidney function and lowers a person’s red blood cell count. The Pandemic Is Chasing Aging Coaches From the Field 2020-09-18T04:00:00Z In 1997, doctors began to test the drug against multiple myeloma, a cancer affecting white blood cells. Computer algorithms find tumors’ molecular weak spots 2020-06-11T04:00:00Z Bristol Myers Squibb said Wednesday that it planned to resubmit its application for an experimental multiple myeloma therapy by the end of July after the U.S. U.S. wholesale prices slide record 1.3% for April, threatening deflation 2020-05-13T04:00:00Z His case was complicated by multiple myeloma, a cancer of the bone marrow. Gerald Slater, a public television pioneer, dies at 86 of coronavirus 2020-05-06T04:00:00Z The team plans to test a larger group of people with multiple myeloma to see if these circulating RNAs prove useful as biomarkers in a broader population. Research round-up: extracellular RNA 2020-06-16T04:00:00Z For a decade, he’s been grappling with multiple myeloma, a form of blood cancer. Column: Here's why a COVID-19 vaccine could end up costing you a small fortune 2020-04-21T04:00:00Z In multiple myeloma, those transcription factors, IKZF1 and IKZF3, act as linchpins in the genetic network that allows the cancer to thrive. Computer algorithms find tumors’ molecular weak spots 2020-06-11T04:00:00Z In the past, her tests suggested that she was prone to a blood cancer, multiple myeloma. The Pandemic’s Hidden Victims: Sick or Dying, but Not From the Virus 2020-04-20T04:00:00Z Now it’s used to treat leprosy and multiple myeloma, and was considered as a treatment for lung injury caused by the H1N1 flu virus when it first appeared in humans in 2009. Malaria drugs aren't the only ones on the shelf that might help coronavirus patients 2020-04-03T04:00:00Z Like many patients with multiple myeloma nationwide, his transplant is being delayed. Some cancer patients face delayed surgeries and scaled-back treatments as the coronavirus advances 2020-03-24T04:00:00Z The 60-year-old, who spent decades as a medical transcriptionist, had to stop working because of spinal stenosis and multiple myeloma, a form of bone and blood cancer. ‘If coronavirus doesn’t get us, starvation will’: A growing number of Americans say they can’t afford to stock up on groceries 2020-03-20T04:00:00Z Lisa Hamilton, 55, a teacher’s aide from Shaker Heights, Ohio, said she voted Sunday because she is in remission after battling multiple myeloma and was worried about her vulnerability to the coronavirus. Intensifying coronavirus fears rattle voters and elections officials in advance of Tuesday primaries 2020-03-15T04:00:00Z Once again, he required chemotherapy to try to bring the disease, multiple myeloma, under control. The Pandemic’s Hidden Victims: Sick or Dying, but Not From the Virus 2020-04-20T04:00:00Z During the fourth quarter, the European Commission approved Spravato, a nasal spray for treating depression, and cancer blockbuster Darzalex, for treating the bone cancer multiple myeloma in combination with other medicines. Johnson & Johnson posts higher sales, big 4Q profit jump 2020-01-22T05:00:00Z Arent disclosed last May she was being treated for multiple myeloma, a form of cancer affecting plasma cells. Long-serving Democrat plans to retire from Utah Legislature 2020-01-16T05:00:00Z The seven cancers are breast, colon, endometrial, kidney, liver, multiple myeloma and non-Hodgkin lymphoma. The Big Number: Why your risks for 7 types of cancer could be reduced with physical activity 2020-01-10T05:00:00Z Lewis has passed away after a lengthy battle with multiple myeloma, a form of bone marrow cancer. J.L. Lewis, two-time PGA Tour winner, dies from multiple myeloma at age 59 - Golf Digest 2020-01-02T05:00:00Z Even after being diagnosed with multiple myeloma last year, she completed another book, “Innocent Witnesses: World War II Viewed by Children,” and started a personal account of mortality, co-written with her husband. Marilyn Yalom, who wrote histories of the wife, the female breast and the chess queen, dies at 87 2019-11-26T05:00:00Z In clinic, I met a man with multiple myeloma six months after a CAR-T trial that supposedly cured him. Behind the Scenes of a Radical New Cancer Cure 2019-11-09T05:00:00Z A company spokesman said the cause was complications of multiple myeloma. David Jones, Health Care Entrepreneur Behind Humana, Is Dead at 88 2019-09-20T04:00:00Z Best known for his role as Dr. Hoover on “The Fresh Prince of Bel Air,” Wesley's family on Sunday confirmed to Variety that he died due to complications from a long battle with multiple myeloma. 'Fresh Prince of Bel Air' actor John Wesley dead at 72 2019-09-09T04:00:00Z Biotechnology company IDP Pharma is developing a type of protein inhibitor to treat multiple myeloma and small-cell lung cancer. A Special Class of Proteins Are Promising Targets for Drugs for Cancer and Alzehimer's 2019-07-02T04:00:00Z Another study released Sunday identified socioeconomic factors that are associated with multiple myeloma, a serious blood cancer. ACA linked to reduced racial disparities, earlier diagnosis and treatment in cancer care 2019-06-02T04:00:00Z The Olympian was diagnosed with Stage 4 multiple myeloma in 2005. Olympic gold medalist, ex-NFL wide receiver Johnny ‘Lam’ Jones dead at 60 2019-03-15T04:00:00Z This condition precedes a type of blood cancer, multiple myeloma, that your drug Darzalex treats. Johnson & Johnson research head aims to block, cure disease 2019-03-03T05:00:00Z A friend was recently diagnosed with multiple myeloma, a cancer of a type of white blood cell called plasma cells. Can a Doctor Refuse to Treat a Patient Who Takes Cannabis? 2019-02-05T05:00:00Z FC Dallas said he died Friday at his home in Fort Lauderdale, Florida, from multiple myeloma. Former US defender Fernando Clavijo dies at 63 2019-02-09T05:00:00Z The six obesity-related cancers cited in the analysis are colorectal, endometrial, gallbladder, pancreatic, kidney and multiple myeloma. Editorials from around New England 2019-02-08T05:00:00Z He talked of his fervent desire to find a cure for multiple myeloma – too late for him, he realized, but for others. Mel Stottlemyre was a great pitcher and coach, and a firm believer in doing the right thing 2019-01-14T05:00:00Z He worked despite being diagnosed with multiple myeloma in 2000 and underwent multiple treatments, which sent the cancer into remission. Former Yankees pitcher, coach Stottlemyre dies at 77 2019-01-14T05:00:00Z The Hazelton, Mo., native was diagnosed with multiple myeloma in the spring of 1999 and underwent experimental treatment for the disease, including stem cell transplant and chemotherapy, according to the New York Daily News. Mel Stottlemyre, former New York Yankees great, dies after long battle with cancer 2019-01-14T05:00:00Z Summit, N.J.-based Celgene leads in the sale of treatments for multiple myeloma. Bristol-Myers Squibb to Acquire Celgene for About $74 Billion 2019-01-03T05:00:00Z A post-mortem revealed that he was most likely suffering from multiple myeloma, a type of blood cancer known to cause excruciating pain. The mystery dead man found with only one clue 2019-01-03T05:00:00Z But other researchers are exploring the same approach in different cancers, including multiple myeloma. How Can We Unleash the Immune System? 2018-11-20T05:00:00Z Then it happened again in 2017 when her dad was diagnosed with multiple myeloma and needed a lifesaving stem cell transplant. Battle-tested: Soldier, single mom battles history of cancer 2018-10-28T04:00:00Z The cause was multiple myeloma, a blood cancer. Will Vinton, filmmaker and animator who created the California Raisins, dies at 70 2018-10-05T04:00:00Z Will Vinton died Thursday at the age of 70 following a lengthy battle with multiple myeloma. Will Vinton, who animated California Raisins, dies at 70 2018-10-05T04:00:00Z In recent years, he moderated an international online support group for those with multiple myeloma. Notable deaths in the Washington area 2018-09-01T04:00:00Z Q. How does one typically die from cancer of the bone marrow, such as leukemia or multiple myeloma? How Do You Die From Leukemia? 2018-08-17T04:00:00Z One of the curative therapies is for triple negative breast cancer and the other for multiple myeloma. Recent editorials published in Indiana newspapers 2018-08-08T04:00:00Z The cause was multiple myeloma, said his wife, Sita Graham Vasan. Michael A. Sheehan, counterterrorism expert who warned of bin Laden, dies at 63 2018-08-01T04:00:00Z Other experimental trials, involving cancers such as multiple myeloma and melanoma, show encouraging results. With new genes and an electric shock, scientists turn immune cells against cancer 2018-07-11T04:00:00Z He retired in 1994 and had struggled in recent years with multiple myeloma and malignant melanoma, according to an obituary published by Hill & Wood Funeral Service in Charlottesville. Milton Edgerton, trailblazing plastic surgeon for children and transgender patients, dies at 96 2018-07-16T04:00:00Z A. People diagnosed with leukemia and multiple myeloma, both cancers originating in the bone marrow, are living much longer than they did just a few decades ago. How Do You Die From Leukemia? 2018-08-17T04:00:00Z The company expects to submit for U.S. regulatory review another of its cancer candidates, isatuximab, to treat multiple myeloma later this year or in early 2019. Latecomer Sanofi looks to catch next wave of cancer therapies 2018-06-20T04:00:00Z His third and most recent cancer bout started late last year when he was diagnosed with multiple myeloma, which caused small tumors on his spine and two large tumors in both hips. Napoleonville tennis coach refuses to let cancer win 2018-05-13T04:00:00Z In 2008, he was diagnosed with multiple myeloma and given three to five years to live. EXCHANGE: Exercise builds strength in those with Parkinson’s 2018-04-28T04:00:00Z The latest, also published Thursday in JAMA, focuses on multiple myeloma, a cancer of the blood, specifically affecting plasma cells, integral to the functioning of the immune system. Cancer burden among 9/11 firefighters and first responders larger than previously thought: Study 2018-04-26T04:00:00Z As cancerous leukemia or multiple myeloma cells grow unchecked, they fill precious bone marrow space and cause the normal cells there to die. How Do You Die From Leukemia? 2018-08-17T04:00:00Z “We would like to thank all the doctors, hospital staff, relatives, friends and fans for the overwhelming support given to Paul and our family while he heroically battled multiple myeloma,” he added. Wa Wa Nee lead singer Paul Gray dies of cancer at age 54 2018-04-24T04:00:00Z Phillip Christian Smith, a 48-year-old actor and playwright, took part in the Sinai trial when he was hospitalized in September for multiple myeloma, a cancer of the blood. The Benefits of Bright Light for Hospital Patients 2018-04-14T04:00:00Z The cause was multiple myeloma, a form of cancer, said a daughter, Cheryl Sanders. Washington-area obituaries of note 2018-04-10T04:00:00Z So far, however, the foundation has expanded only into targeted treatments for multiple myeloma and a few types of solid tumour. Bringing down the cost of cancer treatment 2018-03-06T05:00:00Z Similarly, for multiple myeloma, a British study of over 3,100 patients treated from 1980 to 2002 found that 10 percent died within 60 days of starting therapy. How Do You Die From Leukemia? 2018-08-17T04:00:00Z They also “release carcinogenic gases that may cause acute myeloid Leukemia and possibly acute lymphocytic leukemia, chronic lymphocytic leukemia, multiple myeloma, and non-Hodgkin’s lymphoma,” as explained in the bill’s list of horribles. Colorado Editorial Roundup 2018-01-24T05:00:00Z Chinese CAR-T cell trial impresses on the global stage, showing excellent results for relapsed or refractory multiple myeloma. Biotech booms in China 2018-01-16T05:00:00Z Celgene, based in Summit, N.J., is one of the biggest U.S. biotech companies, specializing in a form of cancer known as multiple myeloma. Celgene Nears Deal to Buy Impact Biomedicines for as Much as $7 Billion 2018-01-07T05:00:00Z Kent Damon died on Dec. 14 after complications from multiple myeloma, a rare blood disease that affects the bone marrow, the actor’s rep Jennifer Allen confirmed to the Associated Press on Saturday. Los Angeles Times 2017-12-26T05:00:00Z She said Saturday he died of complications from multiple myeloma, a rare blood disease that affects bone marrow. Matt Damon’s father dies of cancer at 74; had blood disease 2017-12-23T05:00:00Z Bluebird and Celgene reported positive results from an early clinical trial of a multiple myeloma treatment. Apple and Chesapeake Energy rise; Spark Therapeutics sinks 2017-12-11T05:00:00Z Daniel Swift, a lawyer who worked in Mr. Bassiouni’s legal practice, said the cause was complications from multiple myeloma, a cancer that forms in plasma cells. M. Cherif Bassiouni, ‘father of international criminal law,’ dies at 79 2017-09-26T04:00:00Z But the one-time, customized treatment is also being tested for a range of diseases from non-Hodgkin lymphoma and multiple myeloma to solid tumors. FDA clears first gene-altering therapy — ‘a living drug’ — for childhood leukemia 2017-08-30T04:00:00Z The Novartis drug has the potential to be one of the most expensive drugs ever sold, said David Mitchell, the patients group’s president, who has been treated for multiple myeloma, a blood cancer, since 2010. "Breakthrough" Leukemia Drug Portends "Quantum Leap" In Cost 2017-08-24T04:00:00Z Don is undergoing treatment for multiple myeloma, which affects plasma cells in the bone and is sometimes called bone marrow cancer. Salem couple finds room in hearts for 72 exchange students 2017-08-13T04:00:00Z Don Baylor, who died of multiple myeloma at age 68 on Aug. 7, played 19 seasons and finished his career by appearing in three World Series for three different teams. Braves’ Freddie Freeman Sets a Moving Example 2017-08-12T04:00:00Z Baylor, 68, died after a lengthy bout with multiple myeloma, the family announced Monday. Angels players express respect and affection for Don Baylor, who died Monday at 68 2017-08-07T04:00:00Z Baylor, who played 19 seasons in his major league career and was the 1979 American League MVP, died at a hospital in his native Austin, Texas, after a 14-year struggle with multiple myeloma. Former AL MVP Don Baylor dies of cancer at age 68 2017-08-07T04:00:00Z Brock said that a doctor’s diagnosis that he was free of multiple myeloma was “the greatest news ever.” Caeleb Dressel’s Evening Produces 3 Gold Medals 2017-07-29T04:00:00Z Novartis is studying several other types of T-cells, with different genetic tweaks, to treat chronic lymphocytic leukemia, multiple myeloma as well as glioblastoma. A Rush to Develop ‘Utterly Transformative’ Gene Therapies Against Cancer 2017-07-23T04:00:00Z Meanwhile, other minor acquisitions and approval of the company’s surging multiple myeloma drug to treat additional patients should also add to future revenue. Johnson & Johnson tops 2Q profit forecasts 2017-07-18T04:00:00Z But the approach also is being tested for a range of diseases from non-Hodgkin lymphoma and multiple myeloma to solid tumors. Novel cancer treatment wins endorsement of FDA advisers 2017-07-12T04:00:00Z Baylor, who played 19 seasons in his major league career and was the 1979 American League MVP, died at a hospital in his native Austin, Texas, after a 14-year struggle with multiple myeloma. Former AL MVP Don Baylor dies of cancer at age 68 2017-08-07T04:00:00Z Novartis is now poised to be the first, and it is working on similar types of treatments for another type of leukemia, as well as multiple myeloma and an aggressive brain tumor. F.D.A. Panel Recommends Approval for Gene-Altering Leukemia Treatment 2017-07-12T04:00:00Z He had been fighting multiple myeloma, a form of cancer. The week’s passages 2017-03-17T04:00:00Z A friend, Scott Cawelti, told the Associated Press that the cause was multiple myeloma, a form of cancer. Robert James Waller, author of best-selling ‘Bridges of Madison County,’ dies at 77 2017-03-10T05:00:00Z Ivan died in 2015 of multiple myeloma after battling it for years — he had kept it a secret from all but his closest friends. Closing the book on 34 years in The Seattle Times newsroom 2017-02-02T05:00:00Z She’s a beneficiary of accelerated approval of a drug for multiple myeloma. The head of the FDA defends the importance of drug effectiveness 2016-12-29T05:00:00Z “I’m scared to death,” said Mr. Drapeau, who has multiple myeloma, a type of blood cancer, and takes a drug that costs more than $10,000 a month. A Battle to Change Medicare Is Brewing, Whether Trump Wants It or Not 2016-11-24T05:00:00Z When you’re working in multiple myeloma, nobody’s ever heard of it, and it takes you half an hour to explain it. Kathy Giusti: Sharing Life Lessons From a Death Sentence 2016-10-07T04:00:00Z He was 92 and had been suffering from multiple myeloma. Richard Cooley Overcame Loss of Arm to Excel in Business and Sports 2016-09-30T04:00:00Z The list also includes a form of brain cancer known as meningioma, as well as a type of blood cancer called multiple myeloma. Excess Weight Tied to Higher Risk for Many Cancers, Experts Say 2016-08-24T04:00:00Z Its main growth driver is its Revlimid drug, which is delivering increasing revenue due to a growing number of multiple myeloma diagnoses, longer treatment time frames and pricing power. The Motley Fool: Useful tips on investing 2016-07-30T04:00:00Z And less than six months after this conversation, my mom herself will be dead from a blood cancer called multiple myeloma. A family tree entwined by cancer 2016-07-25T04:00:00Z For example, the rates of certain cancers are declining, but others, such as lymphoma and multiple myeloma, are increasing. A Medical Mystery of the Best Kind: Major Diseases Are in Decline 2016-07-08T04:00:00Z The study will be funded by the Parker Institute for Cancer Immunotherapy and affect patients with multiple myeloma, melanoma, and sarcoma. Federal panel approves CRISPR gene-editing study for cancer patients 2016-06-22T04:00:00Z The university announced in a statement Tuesday that Battle will undergo a stem cell transplant for multiple myeloma at Emory University. Alabama: AD Bill Battle to undergo cancer treatments 2016-06-21T04:00:00Z The dreaded diagnosis of multiple myeloma — a cancer of the blood marrow — haunts Mel Sr. to this day. Mel Stottlemyre on Father’s Day: Courage, tragedy and an unbreakable family bond 2016-06-17T04:00:00Z In a test case, researchers worked with Janssen Pharmaceuticals to determine how to distribute limited supplies of daratumumab, an experimental drug intended to treat multiple myeloma. Fairer way to distribute last-ditch drugs gets real-world trial 2016-06-06T04:00:00Z For more on multiple myeloma, visit the American Cancer Society. Superior Results for Myeloma Drug That's Added Earlier in Treatment 2016-06-06T04:00:00Z The new study of J&J’s Darzalex included nearly 500 patients whose multiple myeloma had worsened despite at least one prior treatment with other drugs. Combination Drug Therapies for Cancer Show Promise at Higher Potential Cost 2016-06-05T04:00:00Z For example, an experimental treatment for multiple myeloma, ricolinostat, was created as a result of research at the Dana-Farber Cancer Institute in Boston, and the Broad Institute of MIT and Harvard in Cambridge, Massachusetts. Technology transfer: The leap to industry : Nature : Nature Publishing Group 2016-05-03T04:00:00Z I’m a black woman in my 60s, and I’m currently battling multiple myeloma. Here's why I'm suing the New York Times for discrimination | Marjorie Walker 2016-04-29T04:00:00Z Bard, 54, started driving for Uber in November, after his wife was diagnosed with multiple myeloma, a cancer of the plasma cells. Uber drivers have mixed reactions to $100 million settlement 2016-04-22T04:00:00Z Sean Merriam, who participated in the Mount Sinai clinical trial, says he felt tired and drained from his treatment for multiple myeloma. A Simple Tool to Ease Cancer’s Side Effects 2016-04-11T04:00:00Z A few months later in Europe, Sninsky was diagnosed with multiple myeloma, a cancer formed by malignant plasma cells. Cyclist returns to Thibodaux with message of hope 2016-04-02T04:00:00Z The drug is now in phase II trials for multiple myeloma. Technology transfer: The leap to industry : Nature : Nature Publishing Group 2016-05-03T04:00:00Z About 27 percent to 30 percent of another drug, bortezomib, which treats multiple myeloma, is projected to be wasted, resulting in excess spending of $309 million. Study: $3 Billion in Cancer Drugs Thrown Away 2016-03-01T05:00:00Z In an email to the college community Wednesday, Carney says that she’s started drug therapy for multiple myeloma, a type of blood cancer. Outgoing St. Bonaventure president reveals cancer diagnosis 2016-02-25T05:00:00Z Journalist Tom Brokaw revealed his battle with multiple myeloma in May in his book “A Lucky Life Interrupted.” New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z Forty-eight years later, Sninsky pedaled through the city again to raise awareness about multiple myeloma cancer and encourage those battling cancer. Cyclist returns to Thibodaux with message of hope 2016-04-02T04:00:00Z Empliciti directs the immune system to kill multiple myeloma cells, the FDA explained Monday in a news release. Empliciti Approved for Multiple Myeloma 2015-11-30T05:00:00Z Ninlaro, from a class of drugs called proteasome inhibitors, is designed to block enzymes that spur the growth and survival of multiple myeloma cells, the FDA said Friday in a news release. Ninlaro Approved for Multiple Myeloma 2015-11-20T05:00:00Z Darzalex, known chemically as daratumumab, helps immune system cells attack malignant multiple myeloma cells by binding to a protein on their surface. Johnson & Johnson drug for patients failing other multiple myeloma meds wins accelerated OK 2015-11-16T05:00:00Z Those treatments changed the landscape for multiple myeloma when they were approved in the mid-2000s. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z Wells was diagnosed with multiple myeloma in late September, and as a result Three Dog Night cancelled a string of October concerts. Cory Wells obituary 2015-10-25T04:00:00Z Food and Drug Administration to treat the blood cancer multiple myeloma. Empliciti Approved for Multiple Myeloma 2015-11-30T05:00:00Z Researchers at the Mayo Clinic and Duke University have been using genetically engineered versions of the measles virus and poliovirus to treat multiple myeloma and brain cancer, respectively. Immunotherapy’s Promise Against Cancer 2015-10-06T04:00:00Z Darzalex is the first biologic drug and first monoclonal antibody — a genetically engineered drug designed to target diseased tissue and spare healthy cells — approved for multiple myeloma. Johnson & Johnson drug for patients failing other multiple myeloma meds wins accelerated OK 2015-11-16T05:00:00Z There are 10 multiple myeloma treatments on the market, including three that won Food and Drug Administration approval during a remarkable 15-day span in November. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z It took a diagnosis of multiple myeloma, a bone marrow cancer, for Thomas Ditmar to rethink his approach to work. America’s national vacation problem - BBC News 2015-09-06T04:00:00Z Empliciti was evaluated in clinical studies involving more than 640 people whose multiple myeloma returned or didn't respond to prior treatment. Empliciti Approved for Multiple Myeloma 2015-11-30T05:00:00Z It is the only published case of cancer in ancient Iceland to date, and one of only a handful of archaeological cases of multiple myeloma worldwide. Archaeologists Find Viking Families Among Skeletons in Northern Iceland 2015-08-10T04:00:00Z In 2006, thalidomide was cleared for use with the medicine dexamethasone for certain cases of multiple myeloma, a cancer of the bone marrow. Frances Oldham Kelsey, heroine of thalidomide tragedy, dies at 101 2015-08-07T04:00:00Z By comparison, prospects for patients diagnosed with multiple myeloma just over a decade ago were grim. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z Three blood cancers – leukemia, lymphoma and multiple myeloma – were next, followed by kidney disease, birth defects, preterm births, congestive heart failure, stroke, respiratory failure, medical or surgical complications and bloodstream infections. Which Medical Issues Drive Up Insurance Costs for Companies? 2015-07-24T04:00:00Z J&J; just applied to the Food and Drug Administration for approval of biologic drug daratumumab, a likely multibillion seller for blood cancer multiple myeloma. Johnson & Johnson edges Street views with weak 2Q 2015-07-14T04:00:00Z Cheng’s brother, Thomas, a popular cardiologist and university professor in Minneapolis, died Feb, 25, 2008, of multiple myeloma at the age of 55. For one of its developers, the New Horizons probe crosses eras on Earth 2015-07-12T04:00:00Z Weber is battling multiple myeloma and he’s bringing courage and joy to face it everyday, an inspiring read. Who Is In Charge of the Sacramento Kings? 2015-06-28T04:00:00Z “If I’m going to get this disease, I’m so fortunate to get it now as opposed to 15 years ago,” says Bob Dickey, 49, who was diagnosed with multiple myeloma in 2011. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z Velcade, approved by the Food and Drug Administration in 2003, is used to treat multiple myeloma, a blood cancer, by disrupting the protein disposal system. Irwin Rose, Nobel-Winning Biochemist, Dies at 88 2015-06-02T04:00:00Z The experimental drug, elotuzumab, reduced the risk of cancer progression and death by 30 percent when doctors combined it with the standard two-drug therapy for multiple myeloma, researchers found. New Drug Shows Potential for Blood Cancer 2015-06-02T04:00:00Z In 2013, Beth was diagnosed with multiple myeloma, a cancer that attacks the bone marrow’s plasma cells. Ordained priest recalls early career as female sports writer 2015-05-17T04:00:00Z What started as a sore back turned into a diagnosis of multiple myeloma, a cancer that eats and weakens cells and bones. When cancer levels life’s playing field 2015-05-13T04:00:00Z The diagnosis: Stage 3 multiple myeloma, the most advanced form. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z In another study, an experimental drug for relapsed multiple myeloma being developed by Bristol-Myers Squibb and AbbVie reduced the risk of cancer progression by about 30 percent when added to two existing drugs. B Vitamin Is Found to Help People Prone to Some Types of Skin Cancer 2015-05-13T04:00:00Z Food and Drug Administration for treatment of relapsed multiple myeloma alongside lenalidomide and dexamethasone. New Drug Shows Potential for Blood Cancer 2015-06-02T04:00:00Z “I will die someday but it is not likely to be the result of multiple myeloma,” he writes at the end of the book, after a series of positive results from his doctors. The Most Heartbreaking Moments in Tom Brokaw's Cancer Memoir 2015-05-12T04:00:00Z All along, we’ve shared data generated by this study — the most robust look at multiple myeloma seen to date — with the global research community. Want Precision Medicine? Share Your Data 2015-05-11T04:00:00Z Jenny Ahlstrom, a mother of six in Salt Lake City, hopes medical advances will continue against multiple myeloma. New Weapons in the Fight Against Multiple Myeloma 2016-01-04T05:00:00Z Johnson & Johnson’s experimental treatment for multiple myeloma, daratumumab, is also generating excitement. Company Creates Bioethics Panel on Trial Drugs 2015-05-07T04:00:00Z He was on vacation on the Outer Banks of North Carolina, “on his third or fourth bout with multiple myeloma,” when he started writing the novel, his wife said. John D. Steinbruner, scholar of foreign and defense policy, dies at 73 2015-04-24T04:00:00Z Her first reaction was to ask him a few questions about multiple myeloma, “but we were both in a wilderness of uncertainty,” he writes. The Most Heartbreaking Moments in Tom Brokaw's Cancer Memoir 2015-05-12T04:00:00Z The cause was multiple myeloma cancer, his daughter Anne Patterson Finn said. Robert Patterson Jr., Lawyer and Judge Who Fought for the Accused, Dies at 91 2015-04-24T04:00:00Z The study found that patients treated with Kyprolis after a second onset of multiple myeloma lived twice as long as those treated with Velcade, a drug marketed by Johnson & Johnson and Takeda Pharmaceutical Co., Amgen says a study found its cancer drug more effective than rival drug 2015-03-01T05:00:00Z Food and Drug Administration to treat multiple myeloma, a cancer of the blood. Farydak Approved for Multiple Myeloma 2015-02-24T05:00:00Z Comparable results were obtained for multiple myeloma, colorectal adenocarcinoma and glioblastoma, where most of the significant features were measured in haematopoietic, intestine mucosa and brain tissues, respectively. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z The cause was multiple myeloma, said his wife, Mary Sullivan. Washington-area obituaries of note 2015-02-09T05:00:00Z Also Tuesday, Amgen applied for European approval and full U.S. approval of Kyprolis, a medicine for relapsed patients with the blood cancer multiple myeloma. Correction: Earns-Amgen story 2015-01-28T05:00:00Z Also Tuesday, Amgen applied for European approval and full U.S. approval of Kyprolis, a medicine for relapsed patients with the bone cancer multiple myeloma. Amgen tops Street 4Q forecasts 2015-01-27T05:00:00Z In November, an FDA advisory committee recommended against approving Farydak for people with relapsing multiple myeloma, saying its benefits did not outweigh its risks. Farydak Approved for Multiple Myeloma 2015-02-24T05:00:00Z Mrs Bone, who was diagnosed with bone marrow cancer in January 2013, used an online blog to document her battle with multiple myeloma. Woman behind Pulp hit record dies 2015-01-02T05:00:00Z Determined to cover the stories that mattered to him, he went to Africa after having been declared to be in remission from multiple myeloma, a cancer of the plasma cells. Michel du Cille: A Photographer With Compassion and Respect 2014-12-12T05:00:00Z Stem cells drawn from newborns’ umbilical cord blood are sometimes used to treat medical conditions, especially bone and blood cancers like multiple myeloma or lymphoma by replacing dysfunctional blood-producing cells in bone marrow. Vast Majority of Life-Saving Cord Blood Sits Unused 2014-12-05T05:00:00Z The cause was multiple myeloma, said his wife, Amelia J. Gearey Dyer. Mark Dyer, Episcopal bishop and theology professor, dies at 84 Colonel Sherry hand-delivered the final default notice to Kearns at a cancer clinic in the Bavarian village of Bad Heilbrunn, where he was caring for his wife, who was dying of Stage 3 multiple myeloma. Whipping Boy 2014-11-10T05:00:00Z I look forward to him beating multiple myeloma and sharing words of wisdom for many years to come. Monday's Mini-Report, 10.27.14 2014-10-27T04:00:00Z Ameena Matthews, one of three outreach workers profiled in the 2011 film "The Interrupters," was diagnosed in January with multiple myeloma, she said in an interview this week. Friends help 'Interrupters' star battling cancer 2014-09-10T04:00:00Z The museum says 69-year-old Elizabeth Egbert died Saturday after battling multiple myeloma. President of Staten Island Museum dies 2014-09-01T04:00:00Z The cause was multiple myeloma, a type of cancer that affects the blood cells, the family said. James J. Schiro, Lead Director at Goldman Sachs, Dies at 68 2014-08-19T04:00:00Z Amgen fell 0.19 percent after a drug failed to extend survival compared with standard care in a trial involving patients with advanced multiple myeloma. Wall Street Is Up Slightly as Weak Data Trickles In 2014-08-14T04:00:00Z The success of a clinical trial of Amgen’s multiple myeloma drug Kyprolis will likely mean that the medicine will remain on the market and serve to ease investor concerns about the biotechnology company’s management team. Trial Succeeds, Amgen CEO Doesn't Have To Quit 2014-08-04T04:00:00Z He passed away, earlier this year, after living with multiple myeloma for longer than his doctors expected. Fathers and Sons in Gaza 2014-07-26T04:00:00Z Goldman, which announced the change late Thursday, said Mr. Schiro had received a diagnosis of multiple myeloma, a cancer of the plasma cells. Goldman Sachs Names Ogunlesi New Lead Director 2014-07-25T04:00:00Z High-dose chemotherapy in combination with stem cell transplants is an option for patients with multiple myeloma, a form of blood cancer that originates in the bone marrow. Spectrum Pharma's cancer drug meets main goal in trial 2014-04-23T11:28:12Z Such conditions include cancers like leukemia, certain lymphomas, multiple myeloma and aplastic anemia; inherited disorders like sickle cell anemia and thalassemia; and severe immune deficiency disorders in newborns. Well: Lifesaving Procedure With an Image Problem 2014-04-21T04:01:41Z The company said the FDA verbally notified them about the hold, which will affect all trials of the treatment, including its thrombocythemia and multiple myeloma mid-stage studies. Geron says FDA halts testing of lead drug 2014-03-12T09:56:20Z In 1996, Neal was found to have multiple myeloma, a rare cancer of the plasma cells that inhibits the production of healthy blood cells. End of the Ride for Lance Armstrong 2014-03-01T18:42:43Z The cause was complications related to multiple myeloma, according to Rutgers University, where Dr. Rona was a professor of earth and planetary sciences. Peter Rona, 79, Explorer of Ocean Depths, Dies 2014-02-27T02:42:26Z The injectable drug, Captisol-enabled melphalan, an improved form of common chemotherapy drug melphalan, is being tested in patients with multiple myeloma undergoing stem cell transplants. Spectrum Pharma's cancer drug meets main goal in trial 2014-04-23T11:28:12Z The same association applied to deaths from many specific cancers including esophagus, colon and rectum, liver, gallbladder, pancreas and kidney, as well as non-Hodgkin lymphoma and multiple myeloma. New evidence on how weight, diet and exercise can help reduce cancer risk 2014-02-18T13:10:15Z I remember where I was, what time it was, even the weather that morning when I was diagnosed with multiple myeloma. Despite Cancer, Brokaw Has Hopeful Future 2014-02-13T20:35:26Z Lenalidomide is a drug with clinical efficacy in multiple myeloma and other B cell neoplasms, but its mechanism of action is unknown. [Report] Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells 2014-01-16T18:57:00.943Z The cause was multiple myeloma, according to Yale University, where she was the Larnard professor of history. Cynthia Russett, Historian of Women, Dies at 76 2013-12-18T20:58:41Z Thalidomide is still being used today to treat illnesses like leprosy and multiple myeloma. Australia Thalidomide case settled 2013-12-02T08:18:07Z Similarly, in a case of multiple myeloma, a subclone that was barely detectable at diagnosis was shown to be dominant towards the end of the disease. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z These included Kyprolis, which was granted “accelerated approval”, based on a smaller clinical trial than usual, for use as a last-ditch treatment for patients with multiple myeloma. Drug firms and cancer: Lucrative lifesavers 2013-08-29T15:01:24Z The crown jewel of Onyx, which is based in South San Francisco, Calif., is Kyprolis, which was approved in the United States last July as a last-ditch treatment for multiple myeloma, a bone marrow cancer. DealBook: Amgen to Buy Onyx Pharmaceuticals for $10.4 Billion 2013-08-26T01:27:44Z In July the FDA approved Onyx's Kyprolis as a treatment for multiple myeloma, a type of blood cancer. Amgen Buying Cancer Drug Maker Onyx for $10.4B 2013-08-25T22:40:25Z Its crown jewel is Kyprolis, a drug for multiple myeloma that was approved last July and which Onyx fully owns. DealBook: Amgen Said to Be Near Deal to Buy Onyx for $10.5 Billion 2013-08-24T21:15:46Z Sales of the company's flagship blood cancer drug Revlimid, approved for use in multiple myeloma, mantle cell lymphoma and a blood disorder, rose 13 percent to $1.05 billion, driven by market share gains. Celgene raises full-year outlook on strong cancer drug sales 2013-07-25T12:27:29Z The target firm’s crown jewel is Kyprolis, a treatment for multiple myeloma, a type of blood cancer. Drug firms and cancer: Lucrative lifesavers 2013-08-29T15:01:24Z He finally ended up in severe pain at a large teaching hospital where a correct diagnosis was made: multiple myeloma, cancer of the plasma cells. Ask an Expert: Answers About Rheumatoid Arthritis, Part 2 2013-07-24T12:00:01Z Onyx also won approval last year for its first wholly owned drug, a treatment for multiple myeloma called Kyprolis. DealBook: Onyx Explores a Sale After Rebuffing a Bid by Amgen 2013-06-30T17:01:52Z The cause was multiple myeloma, a cancer of the plasma cells, said Kevin McKinney, a senior associate athletic director at the University of Wyoming, where Robinson starred in the 1960s. Flynn Robinson, Sharpshooting N.B.A. Guard, Dies at 72 2013-05-25T04:25:29Z In patients with multiple myeloma or non-Hodgkin’s lymphoma, however, and in some donors, stem cells don’t mobilize well with filgrastim and other drugs in its class. Painkillers Could Prove Helpful in Stem-Cell Transplants 2013-03-13T21:45:08.747Z The drug is being studied to treat multiple myeloma, a cancer that starts in plasma cells in bone marrow and disrupts the production of normal blood cells. Aeterna Zentaris to stop late-stage cancer drug trial, shares fall 2013-03-11T18:25:56Z The drug, known generically as carfilzomib, was initially approved to treat multiple myeloma, a type of blood cancer, in patients who did not respond to other medicines. Onyx to test cancer drug for wider use 2013-01-07T18:53:26Z Velcade, which generated sales of $740 million in the 12 months ended October, is one of the leading treatments for multiple myeloma. Watson seeks approval of generic version of cancer drug Velcade 2012-12-28T15:47:58Z The prevalence of three cancers were significantly higher — multiple myeloma, prostate and thyroid — but only in rescue and recovery workers, and not in the rest of the exposed population. No Clear Link Between Cancer and 9/11 Debris, New York Health Dept. Study Finds 2012-12-18T21:05:52Z In a controversial move, the FDA approved thalidomide’s use in multiple myeloma in 1998. From the Holocaust to Thalidomide: A Nazi Legacy 2012-11-08T15:15:04.543Z Thalidomide is still sold today, but as a treatment for multiple myeloma, a bone marrow cancer and leprosy. Grünenthal Group Apologizes to Thalidomide Victims 2012-09-01T19:15:46Z They showed success in mice with multiple myeloma, and other groups soon reported similar findings in animal models of leukemia and lymphoma. Cancer-Fighting Compound Might Double as Reversible Male Contraceptive 2012-08-16T19:45:00.197Z Approves Drugs for Cancer and Myeloma New drugs for breast cancer and multiple myeloma won approval from the Food and Drug Administration on Friday, expanding options for patients in advanced stages of those diseases. F.D.A. Approves Afinitor and Kyprolis for Breast Cancer and Myeloma 2012-07-21T00:58:28Z About 21,700 people will be diagnosed with multiple myeloma this year and 10,710 will die from the disease, according to the American Cancer Society. FDA approves Onyx blood cancer drug Kyprolis 2012-07-20T17:18:19Z In 2012, about 21,700 new cases of multiple myeloma will be diagnosed in the United States, and about 10,710 people will die from the disease, according to the American Cancer Society. FDA OKs Onyx's Kyprolis for multiple myeloma 2012-07-20T16:19:42Z In one case, Celgene dramatically raised the price of thalidomide after it was found to be effective not just against complications of HIV and leprosy, but the blood cancer multiple myeloma. Immune Reversal: Unsuccessful Pfizer AIDS Drug Might Help Transplant Patients 2012-07-11T21:57:33Z It is also being tested as a treatment for newly diagnosed multiple myeloma patients. Onyx soars to life high on favorable FDA panel vote 2012-06-21T15:24:45Z Celgene slid after the company said it withdrew the submission of its maintenance treatment of multiple myeloma, Revlimid, to an FDA committee. Stock Futures Edge Up 2012-06-21T12:55:43Z The injectable drug Kyprolis treats multiple myeloma, a form of cancer that causes tumors to grow in the bone marrow, preventing the production of normal blood cells. FDA approves Onyx blood cancer drug Kyprolis 2012-07-20T17:18:19Z Months later, he got more bad news: Doctors noticed he was anemic and investigated, leading to diagnosis of a second cancer - multiple myeloma, a blood cancer normally seen in the elderly. Experts say science lacking on 9/11 and cancer 2012-06-20T11:46:04Z Logistics Hang Over a Ruling on 9/11 Cancer About five years ago, Patricia Workman’s bones started breaking, and she was found to have multiple myeloma, a cancer of the bone marrow. Ahead of Ruling on Cancer, Worry of Strain on 9/11 Victims’ Fund 2012-05-29T01:26:16Z Proceeds from the fundraiser and barbeque are being donated to the Seattle Cancer Care Alliance for breast cancer and multiple myeloma research. Support Monday's 'Pink Softball Game': Glacier Peak vs. Shorecrest 2012-05-07T20:28:03Z Onyx Pharmaceuticals soared after the company said its multiple myeloma treatment, Kyprolis, received a positive vote from a Food and Drug Administration committee. Stock Futures Edge Up 2012-06-21T12:55:43Z The notorious thalidomide caused birth defects in the 1960s when some countries used it for morning sickness, but today it treats multiple myeloma. NIH, companies aim to teach old drugs new tricks 2012-05-03T17:44:10Z Doctors don't know what causes multiple myeloma, but say genetics plays a role and that it is more common in black men. Experts say science lacking on 9/11 and cancer 2012-06-20T11:46:04Z A month later she was given a diagnosis of multiple myeloma and began chemotherapy at her oncologist’s office near her home in Tampa. Some insurers try selling health plans at consumer-friendly retail outlets 2012-02-27T21:26:17Z She died last March of multiple myeloma at the age of 75. City Room: Geraldine Ferraro to Be Remembered at Forham With Law Center 2012-02-15T20:16:15Z Amgen said it was also testing Xgeva in other cancers, including breast and lung cancer and multiple myeloma, or cancer of a type of white blood cell. FDA staff unsure about new use for Amgen's Xgeva 2012-02-06T15:18:07Z Similarly, studies of multiple myeloma identified ways of targeting CSCs by cellular processes that regulate postnatal stem-cell and tissue homeostasis, involving telomerase for example, and these are now being applied to other tumour types. Perspective: A model disease 2011-12-14T18:21:18.327Z Patients often survive for many years after being diagnosed with multiple myeloma, and the focus of research is widening from prolonging patients' lives to ensuring that those lives are more comfortable. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z In multiple myeloma, however, these same monoclonal plasma cells explode in numbers and become malignant, causing anaemia, bone destruction and kidney failure. Aetiology: The path to disease 2011-12-14T18:21:15.300Z Ben's case illustrates the importance of imaging technologies in the treatment of multiple myeloma. Imaging: Seeing is believing 2011-12-14T18:21:13.753Z But multiple myeloma poses a daunting challenge for scientists. Genetics: Profiling a shape-shifter 2011-12-14T18:21:12.203Z In this way, multiple myeloma serves as a model to improve cancer treatment as a whole. Perspective: A model disease 2011-12-14T18:21:18.327Z It was the use of bisphosphonates for multiple myeloma that led to further revelations. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z There is still a great deal of information to be collected, says Ola Landgren, who heads multiple myeloma research at the NCI. Aetiology: The path to disease 2011-12-14T18:21:15.300Z Cancerous skeletal lesions, which resemble pits in the bone, are a hallmark of multiple myeloma. Imaging: Seeing is believing 2011-12-14T18:21:13.753Z In the chain of events leading to multiple myeloma, two factors seem to dictate the disease process: the internal genetic alterations within cancerous plasma cells, and their external environment in the bone marrow. Genetics: Profiling a shape-shifter 2011-12-14T18:21:12.203Z His group was investigating the drug resistance that inevitably occurred in patients with multiple myeloma, a cancer affecting blood plasma cells. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z The inflammation in rheumatoid arthritis is related to the activity of the cell's cytokines, which are also involved in the progression of multiple myeloma. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z Some studies suggest that firefighters generally seem to contract multiple myeloma at higher rates, and farm workers may too. Aetiology: The path to disease 2011-12-14T18:21:15.300Z Pat Killingsworth was 51 when he learned that he had multiple myeloma. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z Why can drugs send patients with multiple myeloma into seemingly complete remission 80–90 of the time but never cure them? Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Epstein injected these animals with fresh bone-marrow cells from patients with multiple myeloma. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z In the summer of 2011, it entered clinical trials to treat multiple myeloma with bone metastases. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z But in multiple myeloma, this genetic rearrangement leads to one or several unwanted mutations, setting off a chain reaction that results in the cells overexpressing and creating unchecked clones. Aetiology: The path to disease 2011-12-14T18:21:15.300Z This doesn't happen in patients undergoing treatment for multiple myeloma. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z If we had a way of killing these cells, he says, we could cure multiple myeloma. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z A phase II trial in patients with multiple myeloma and other blood cancers will begin soon, according to the drug's developer, Onyx Pharmaceuticals. Drugs: More shots on target 2011-12-14T18:21:03.017Z This might sound like a convoluted system, but that's not unusual for animal models of multiple myeloma. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z Unlike many other forms of cancer, multiple myeloma does not lend itself to early warnings. Diagnostics: The early bird 2011-12-14T18:20:59.480Z And some are quick to point out that such cures have been achieved in some patients with multiple myeloma treated with protocols that are far less aggressive than total therapy. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z Proponents of the cancer stem-cell idea say it explains why, in multiple myeloma and other cancers, drugs that can seem to miraculously and rapidly shrink tumours do not lead to long-term survival. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z And as with other drugs for multiple myeloma, nearly all patients develop resistance to bortezomib. Drugs: More shots on target 2011-12-14T18:21:03.017Z In 5T33MM mice, her team found that the bone marrow surrounding multiple myeloma cells is much lower in oxygen than the bone marrow around healthy cells. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z The definition of multiple myeloma is based on clinical signs such as anaemia or elevated blood calcium levels. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Blood tests revealed rising levels of monoclonal protein — a hallmark of multiple myeloma — and X-rays exposed several lesions in the bones around his hips, sternum, ribs and head. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z These ideas can be tested, Wicha and others believe, in patients with multiple myeloma who have used existing drugs to achieve clinical remission, with all their cancerous plasma cells eradicated. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Lenalidomide, a derivative of thalidomide and also approved in 2006 for use in multiple myeloma, is now preferred over thalidomide because it is less likely to cause peripheral neuropathy. Drugs: More shots on target 2011-12-14T18:21:03.017Z A molecule that doesn't affect xenograft tumours is unlikely to work in patients with multiple myeloma, for example. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z Currently, patients are diagnosed as having MGUS, smouldering myeloma or multiple myeloma according to three major factors. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Treating people with multiple myeloma is the most common reason for autotransplants, with more than 10,000 operations performed annually in the United States alone. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z These assumptions led to confusion and debates about whether cells that were more differentiated, or less rare, could be considered cancer stem cells — a controversy that is particularly relevant to multiple myeloma. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Some of the treatments being developed for multiple myeloma seem to be nearly as effective as stem-cell transplants, which are offered to younger patients as a highly effective but brutal treatment. Drugs: More shots on target 2011-12-14T18:21:03.017Z But myeloma xenografts are generated from lab-grown cell lines, which don't behave much like the primary multiple myeloma cells found in patients' bone marrow. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z Table 1: Stratification strategy There are various ways of assessing the risk of patients with early signs of multiple myeloma progressing to the full-blown disease. Diagnostics: The early bird 2011-12-14T18:20:59.480Z In the meantime, researchers who study multiple myeloma remain divided about when, if and how to use transplantation therapy. Stem cells: Transplants on trial 2011-12-14T18:21:06.080Z The central question in multiple myeloma is whether the cells with these properties — the ability to recapitulate the disease and to self-renew — are plasma cells or the B cells that give rise to plasma cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z In multiple myeloma, plasma cells reproduce furiously, creating piles of damaged proteins that must be cleared from the cell. Drugs: More shots on target 2011-12-14T18:21:03.017Z Low oxygen, or hypoxia, is known to play a role in other forms of cancer, but this was the first evidence of it in multiple myeloma. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z The sequencing of 38 genomes of multiple myeloma tumours earlier this year led to certain genetic mutations being shown to play a major role in the pathogenesis of myelomas. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z The bar for what constitutes good news about multiple myeloma is low. Multiple myeloma 2011-12-14T18:20:56.743Z By the late 1990s, several labs were using variations of the serial transplantation method on multiple myeloma. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z About 20,500 Americans will be diagnosed with multiple myeloma in 2011 and 10,600 will die from the disease, according to American Cancer Society estimates. Takeda drug cuts myeloma death risk in 5-year study 2011-12-12T18:56:21Z Even if the model does catch on, it will not necessarily render other animal models of multiple myeloma irrelevant. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z The presence of more than one lesion is known as multiple myeloma. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z “The synergies would be the greatest on the multiple myeloma side with Takeda,” which would otherwise compete with Onyx, Shah said in a telephone interview from Mumbai. Onyx Spurs Pfizer Talk With Cancer Drug as Patent Cure: Real M&A 2011-12-01T05:57:02Z Furthermore, autologous stem-cell replacement — the only treatment that has ever cured multiple myeloma — probably eliminates cancer stem cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Food and Drug Administration accepted a new drug application for carfilzomib for the potential treatment of patients with relapsed, refractory multiple myeloma. Onyx Shares Climb on Optimism of Possible Sale of Company 2011-11-29T21:27:03Z He was just 15 when his father died of multiple myeloma. Well: Patients, Too, Turn to the Internet for Fund-Raising 2011-11-21T22:17:13Z The origins of cancer: multiple myeloma begins in white blood cells in the bone marrow. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z Potential buyers are studying Onyx’s business and its carfilzomib drug, which treats a cancer of plasma cells known as multiple myeloma, one of the people said. Onyx Spurs Pfizer Talk With Cancer Drug as Patent Cure: Real M&A 2011-12-01T05:57:02Z In this respect, multiple myeloma has another advantage: researchers can take repeat biopsies from patients' bone marrow and blood more easily than they can from a solid tumour in a lung, breast or brain. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z “My husband’s firehouse was right there, and they were down there for days at the beginning,” said Wiebicke, 51, whose husband developed multiple myeloma about two years ago. Firefighter Cancer Risk Seen From World Trade Center Exposure 2011-09-01T23:09:09Z Dr. Landrigan said his researchers were looking especially hard at multiple myeloma, because they had already found eight cases — an unusually high number — in responders younger than 45. Not Enough Evidence to Link 9/11 and Cancer, a Federal Report Says 2011-07-27T01:49:52Z Many researchers believe that multiple myeloma is best tackled by 'personalized medicine', a much-touted approach where treatments are tailored to an individual's genetic make-up. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z In 1991, Mr. Brady learned he had multiple myeloma, a disease of the plasma cells. In the Garden: On City Rooftops, Scrappy Green Spaces in Bloom 2011-06-23T04:20:02Z “This puts us way ahead of the curve compared to solid tumours,” says Matsui, and this is one reason why some of the first trials to test the cancer stem-cell theory are in multiple myeloma. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Doxorubicin, also available under multiple brands and as a generic from Teva and others, is used to treat non-Hodgkin's lymphoma, multiple myeloma, acute leukemias and other cancers. U.S. cancer drugs shortage has doctors scrambling 2011-06-07T17:41:53Z VHA cancer patients were also slightly more likely to get surgery to cure colon cancer, and to get the recommended treatments for lymphoma and multiple myeloma. Cancer care up to par at veterans' hospitals 2011-06-06T21:36:59Z Figure 1: Until the late 1990s, life expectancy with multiple myeloma using the best available treatments, such as melphalan and prednisone, was just three to four years. Overview: Multiple lines of attack 2011-12-14T18:20:57.937Z According to documents presented in Brooklyn federal court, Hogan was prescribed Zometa in 2003 after being diagnosed with multiple myeloma, a type of cancer that affects blood plasma cells. U.S. jury finds Novartis not liable for jaw disease 2011-05-26T21:46:07Z From a research standpoint, Wicha says, proving the cancer stem-cell theory in multiple myeloma is exciting because it could lead to a validation of the model for other cancers. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z In 2005, he developed multiple myeloma, a cancer of the blood, and on Jan. 9 of this year, he died. The 9/11 Casualties Still to Come 2011-05-04T14:05:00Z In September 2009 he was diagnosed with multiple myeloma, a devastating form of blood cancer. Pacific Biosciences' $600 Million Decoder Ring 2011-04-28T21:00:00Z The cause was multiple myeloma, said his daughter Kimberly Smith Hall. Homer Smith, Innovative College Football Coach, Dies at 79 2011-04-15T04:42:53Z In 1998, she was diagnosed with multiple myeloma, a rare blood cancer, but continued to lead an active life. Geraldine Ferraro, first woman on presidential ticket, dies 2011-03-28T19:18:04Z In 1998, she was diagnosed with the multiple myeloma that would ultimately kill her, but not without a trademark Ferraro fight. Geraldine Ferraro, one tough Democrat 2011-03-26T18:27:00Z The cause was complications from multiple myeloma, a blood cancer that she had battled for 12 years, her family said in a statement. Geraldine A. Ferraro, First Woman on Major Party Ticket, Dies at 75 2011-03-26T19:49:50Z Taken together, our findings greatly expand the mechanisms by which NF-κB may be activated in multiple myeloma. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z The company is also conducting a combination study for the treatment of non-Hodgkin lymphoma and multiple myeloma. UPDATE 2-Seattle Genetics, Pfizer in $208 mln antibody tech deal 2011-01-06T14:56:28Z But a mid-stage Phase II study of SRT501 in patients with multiple myeloma was suspended last May after some patients with the disease, which is a type of blood cancer, developed kidney problems. Glaxo drops version of resveratrol "red wine" drug 2010-12-01T18:39:00Z But Xgeva did not work well in multiple myeloma, a cancer of the bone marrow, so it is not approved for patients with that cancer or other blood and lymphatic cancers. Prescriptions: F.D.A. Approves a Bone Drug for Cancer Patients 2010-11-19T13:30:00Z As expected, the drug, which will be sold under the brand name Xgeva, was not approved for use in patients with multiple myeloma, a cancer of the blood, according to FDA's Erica Jefferson. FDA OKs Amgen's bone drug in certain cancers 2010-11-19T02:43:00Z Whether such non-coding mutations contribute to multiple myeloma pathogenesis remains to be established. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z It recently obtained approval to begin Phase III studies in multiple myeloma, or cancer of the bone marrow, in rheumatoid arthritis, asthma and in multiple sclerosis. UPDATE 1-AB Science wins skin cancer study shortcut 2010-10-05T15:45:00Z Glaxo suspended new enrollment in a clinical trial of its resveratrol formulation for multiple myeloma earlier this year after some patients developed kidney failure. Glaxo Censures Sale of Supplements 2010-08-13T15:05:00Z July 26, 2010, 8:04 am Onyx Sees Promise in Myeloma Drug A new last-ditch treatment for patients with multiple myeloma, a cancer of the bone marrow, might be getting closer to market. Onyx Sees Promise in Myeloma Drug 2010-07-26T12:04:00Z The third trial, which involved patients with a variety of tumor types, including multiple myeloma, showed similar results for both drugs. FDA OKs Amgen's bone drug in certain cancers 2010-11-19T02:43:00Z Another approach to identify biologically relevant mutations in multiple myeloma is to look not at the frequency of mutation of individual genes, but rather of sets of genes. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Primarily because of its drug Revlimid for multiple myeloma, Celgene is already a leader in the market for drugs to treat cancers of the blood. Celgene to Buy Abraxis BioScience for $2.9 Billion 2010-07-01T04:21:00Z In one study of about 600 patients made public on Thursday, use of the drug lenalidomide after stem-cell transplant sharply cut the recurrence of multiple myeloma, a cancer of the bone marrow. Study Finds Certain Drugs Can Keep Some Forms of Cancer in Remission Longer 2010-05-21T00:10:00Z April 21 Maintenance Therapy for Multiple Myeloma Dr. Philip Greipp of the Mayo Clinic offers advice about follow-up care for multiple myeloma after a stem cell transplant. When Pain Relievers Cause Bleeding 2010-04-23T14:45:00Z With no cure in hand, the goal for most patients with multiple myeloma is to keep treating relapses as long as treatments are available. Personal Health: Cancer Survival Demands Steady Scientific Progress 2010-04-12T20:54:00Z We first considered gene sets based on existing insights into the biology of multiple myeloma. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z PD-0332991, which Pfizer is developing under license from Onyx, is being tested in human trials for other cancers such as multiple myeloma and mantle cell lymphoma. Pfizer, Onyx drug offers hope against brain cancer 2010-03-30T17:00:00Z Alexander was diagnosed with multiple myeloma, a cancer of the bone marrow, in 2005, four years after his career ended in Oakland. Former NFL linebacker Elijah Alexander dead at 39 2010-03-25T20:37:00Z Figure 2: Mutations likely to affect protein translation and/or homeostasis in multiple myeloma. a, Alignment of human, yeast and bacterial RNB domain of DIS3. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Protein homeostasis may be particularly important in multiple myeloma because of the enormous rate of production of immunoglobulins by multiple myeloma cells. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z One top-ranking gene set was of particular interest because it did not relate to genes known to be important in multiple myeloma. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Interestingly, a recent RNA interference screen in multiple myeloma showed that IRF4 was required for multiple myeloma survival, consistent with its role as a putative oncogene. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Figure 1: Evidence for transcription-coupled repair and functional importance of statistically significant mutations. a, Intronic mutation rates subdivided by gene expression rates in multiple myeloma. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Figure 1: Evidence for transcription-coupled repair and functional importance of statistically significant mutations. a, Intronic mutation rates subdivided by gene expression rates in multiple myeloma. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Figure 2: Mutations likely to affect protein translation and/or homeostasis in multiple myeloma. a, Alignment of human, yeast and bacterial RNB domain of DIS3. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Additional multiple myeloma genomes will be required to establish the definitive genomic landscape of the disease and determine accurate estimates of mutation frequency in the disease. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z For example, activation of the NF-κB pathway is known in multiple myeloma, but the basis of such activation is only partially understood. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Whether these mutations are unique to multiple myeloma or are common to other cancers remains to be determined. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Informed consent from multiple myeloma patients was obtained in line with the Declaration of Helsinki. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z |
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