Alright the next dopamine-directed class of therapies are inhibitors of COMT, catecholamine-O-methyltransferase, which is an enzyme that degrades dopamine and levodopa.

下一个针对多巴胺的治疗药物是COMT抑制剂；COMT，即儿茶酚胺-O-甲基转移酶，是一种可以降解多巴胺和左旋多巴的酶。

So, here another useful drugs come into play, namely Selegiline and Rasagiline, which selectively inhibit MAO-B, and Tolcapone, which inhibits COMT.

因此，另一种有用的药物开始发挥作用，即塞来吉林和拉沙吉林，它们选择性地抑制MAO-B和Tolcapone，后者抑制COMT。

However, lets not forget that dopamine is also susceptible to breakdown by COMT as well as MAO-B, which convert dopamine to 3-methoxytyramine (3-MT) and 3,4dihydroxyphenylacetic acid (DOPAC) respectively.

然而，我们不要忘记多巴胺也容易被COMT分解如MAO-B，可将多巴胺转化为3-甲氧基酪胺（3-MT）和3，4-二羟基苯乙酸（DOPAC）分别。

Finally, excess dopamine in the synapse is reuptaken back into the neuron, or into glial cells where it gets metabolized by Monoamine Oxidase (abbreviated MAO) and Catechol-O-methyltransferase (abbreviated COMT).

最后，突触中过量的多巴胺被重新吸收回神经元或胶质细胞由单胺氧化酶（简称MAO）和儿茶酚-O-甲基转移酶代谢的细胞（缩写COMT）。

COMT inhibitors like entacapone and tolcapone are only given with levodopa to prevent the enzyme from breaking it down outside the central nervous system, thus allowing more of it to enter the brain.

COMT抑制剂，例如恩他卡朋和托卡朋与左旋多巴一起用于治疗，只是为了防止左旋多巴在中枢神经系统外被分解，从而使更多左旋多巴进入脑中。

Another agent that is used in combination with Levodopa and Carbidopa is Entacapone, which inhibits peripheral COMT and thus just like Carbidopa, it prolongs the time that Levodopa is available to the brain.

另一种与左旋多巴和卡比多巴联合使用的药剂是恩他卡彭，它能抑制外周血细胞凋亡，因此就像卡比多巴一样，它延长了左旋多巴对大脑有效。