If Leptospira gets to the kidneys, it may infect the interstitium, causing interstitial nephritis, or it may cause an inflammatory reaction that damages the renal tubules, resulting in acute tubular necrosis.

如果钩端螺旋体进入肾脏，它会感染肾间质而引起间质性肾炎，也能引发炎性反应损伤肾小管，导致急性肾小管坏死。