Treatment of essential thrombocythemia depends on risk of blood clots.

原发性血小板增多症的治疗取决于血栓形成的风险。

In rare cases, essential thrombocythemia can develop into myelofibrosis and acute leukemia.

少数原发性血小板增多症案例会发展为骨髓纤维化或急性白血病。

But more commonly, essential thrombocythemia is usually found unintentionally when elevated platelet levels are found on a routine complete blood count.

但原发性血小板增多症常常是做常规全血细胞计数时发现血小板增多，而被无意发现的。

All right, as a quick recap, essential thrombocythemia is a slowly progressive disease where the bone marrow produces too many platelets.

得！快速回顾一下：原发性血小板增多症是骨髓产生过多血小板的缓慢进展的疾病。

Now, some individuals with essential thrombocythemia can have symptoms like fatigue, headache, dizziness, nausea, tinnitus or ringing in the ears, and numbness in the hands and feet.

有些原发性血小板增多症的患者，会有疲乏、头痛、晕眩、恶心、耳鸣（耳朵里有声音）以及手足麻木等症状。

In essential thrombocythemia there's a genetic mutation that occurs in the Janus Kinase 2 gene, also called JAK2, or somewhere along this pathway of cell signalling.

患有原发性血小板增多症时，Janus Kinase 2（JAK2）基因或这条细胞信号转导通路的某处发生了基因突变。