Hence, changes in cell function and an overall physiological change.

因此，细胞功能的改变和整体的生理变化。

And it was these ideas, combined with advances in technology, that produced the overall change.

正是这些想法与技术进步相结合，才产生了全面的变化。

If a figure fluctuates, it moves up and  down, but the overall change is small.

如果数字波动，它上移和下移， 但是总体变化是小的。

To make matters worse, all this loss from the bones makes them thin and weak, which is part of a process called renal osteodystrophy, which describes the overall bone changes that happen in people with chronic kidney disease.

更糟的是，随着磷酸盐的流失，骨头变得又瘦又弱，这是肾性骨营养不良过程的一部分，肾性骨营养不良说的是慢性肾病患者骨骼的整体变化过程。