So, they cannot make enough haemoglobin.

因此，他们不能制造足够的血红蛋白。

They can do this because inside the red blood cells, there is a very important molecule called haemoglobin.

它们之所以能做到这一点，是因为在红血球内部，有一种非常重要的分子，叫做血红蛋白。

Never mind, said he, chuckling to himself. The question now is about haemoglobin.

这没有什么，他格格地笑了笑，现在要谈的是血色蛋白质的问题。

The carbon monoxide permanently binds to haemoglobin in your blood, blocking oxygen from binding.

一氧化碳会永久地与你血液中的血红蛋白结合，阻止氧气的结合。

But the most common cause of low haemoglobin levels, or anaemia, is lack of iron.

但导致血红蛋白水平低或贫血的最常见原因是缺铁。

Sickle Cell Anemia affects a protein in the red blood cells. This protein is called haemoglobin.

镰状细胞性贫血影响红细胞中的一种蛋白质。这种蛋白质被称为血红蛋白。

The body needs a particular amount of haemoglobin to work correctly.

人体需要一定数量的血红蛋白才能正常工作。

This means they have fewer haemoglobin molecules to help move and hold oxygen.

这意味着它们有较少的血红蛋白分子来帮助运输和保存氧气。

There are many reasons why haemoglobin levels may drop.

导致血红蛋白水平下降的原因有很多。

And they become sticky. Bad haemoglobin also causes red blood cells to die more quickly than healthy red blood cells.

并且血液会变得粘稠。不良血红蛋白还会导致红细胞比健康红细胞更快死亡。

It's plant-based haemoglobin so it's that kind of irony taste, you know, that you have with meat.

它是基于植物的血红蛋白， 所以它有一种讽刺的味道， 你知道，你有肉。

The company reckons its base-editing drug will work better than CRISPR-Cas9 and deliver higher levels of haemoglobin.

该公司认为，其碱基编辑药物将比 CRISPR-Cas9 效果更好，并能提供更高水平的血红蛋白。

Both are caused by genetic faults in the instructions for making haemoglobin, a protein that helps red blood cells carry oxygen.

这两种疾病都是由于血红蛋白（一种帮助红细胞携带氧气的蛋白质）制造指令中的基因缺陷引起的。

The reason is that, besides its well-known role in haemoglobin, the oxygen-transporting molecule in the blood, iron is also involved in many aspects of brain development.

因为除了在血液中的氧气运输分子——血红蛋白中发挥着众所周知的作用外，铁元素还在许多方面参与了大脑的发育。

If we had an approach that could go beyond cutting and essentially find and replace, correct that defect and restore the normal haemoglobin protein, that should be a definitive cure.

如果我们有一种方法可以超越切割并从根本上找到和替换，纠正该缺陷并恢复正常的血红蛋白，那应该是一种彻底的治愈方法。

It involves collecting blood stem cells from a patient, editing a gene within them to restart the production of a type of haemoglobin that is usually produced only when a baby is in the womb, and re-injecting those stem cells.

它包括从患者体内采集血液干细胞，编辑其中的基因以重新启动一种通常只在婴儿在子宫内时产生的血红蛋白，然后重新注射这些干细胞。