FSGS is usually treated with steroids, although it has an inconsistent response, and for that reason, especially in adults— FSGS can involve more and more segments of the kidney's glomeruli to the point where it causes chronic renal failure.

FSGS通常用类固醇治疗，不过治疗反应并不一致；因此，尤其在成人中，FSGS可累及越来越多肾小球的节段，直至慢性肾衰。