| 单词 | mutation |
| 例句 | Cancer kids are essentially side effects of the relentless mutation that made the diversity of life on earth possible. The Fault in Our Stars 2012-01-10T00:00:00Z Tested on the fruit fly, the same organism Muller had used in his original work with X-rays, mustard gas also produced mutations. Silent Spring 1962-09-27T00:00:00Z Koyré had a vast influence in America, and his Bachelardian conception of an intellectual mutation was adopted by Thomas Kuhn in The Structure of Scientific Revolutions. The Invention of Science 2015-09-17T00:00:00Z Plants treated with various phenols suffered profound destruction of chromosomes, changes in genes, a striking number of mutations, “irreversible hereditary changes.” Silent Spring 1962-09-27T00:00:00Z Since mutations are random nucleotide changes, most of them are harmful or lethal, coding into existence nonfunctional enzymes. Cosmos 1980-01-01T00:00:00Z Most of these mutations, when expressed, would be lethal. Cosmos 1980-01-01T00:00:00Z In August’s case, the doctors were able to identify one of the “single nucleotide deletion mutations” that made war on his face. Wonder 2012-02-14T00:00:00Z The similarities between genomes must explain the likeness between parents and their children, and mutations and recombination might explain their differences. The Gene 2016-06-02T00:00:00Z Over time mutation lets animal diseases jump to people: avian influenza becomes human influenza, bovine rinderpest becomes human measles, horsepox becomes human smallpox. 1491 2005-10-10T00:00:00Z You cannot use just the genotype—BRCA1 mutation—to predict the final outcome with certainty. The Gene 2016-06-02T00:00:00Z By three billion years ago, a number of one-celled plants had joined together, perhaps because a mutation prevented a single cell from separating after splitting in two. Cosmos 1980-01-01T00:00:00Z In humans, a mutant BRCA1 gene increases the risk for breast cancer—but not all women carrying the BRCA1 mutation develop cancer. The Gene 2016-06-02T00:00:00Z If a mutation inactivated even one function, the mold would be unable to grow—unless the missing ingredient was supplied back into the broth. The Gene 2016-06-02T00:00:00Z As animals struggled to survive, the best-adapted variants—the fittest mutations—were serially selected. The Gene 2016-06-02T00:00:00Z Another woman with the same mutation might develop an indolent variant; and yet another might not develop breast cancer at all. The Gene 2016-06-02T00:00:00Z Numerous plant mutations affect the reproductive system itself. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Mutations in these genes can lead to the accumulation of DNA damage—and thus, more mutations—ultimately leading to cancer. The Gene 2016-06-02T00:00:00Z As far as we can tell, changes in social patterns, the invention of new technologies and the settlement of alien habitats resulted from genetic mutations and environmental pressures more than from cultural initiatives. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z Similarly, the changes required to transform wild plants into crops can in principle be brought about by alternative new mutations or alternative courses of selection to yield equivalent results. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Possibly he was imagining what it would be like to discover a whole new population of carriers of the 5-alpha-reductase mutation. Middlesex: A Novel 2002-06-05T00:00:00Z When I was a college undergraduate in the early 1950’s, I was fortunate enough to work in the laboratory of H. J. Muller, a great geneticist and the man who discovered that radiation produces mutations. Cosmos 1980-01-01T00:00:00Z The environment selects those few mutations that enhance survival, resulting in a series of slow transformations of one lifeform into another, the origin of new species.* Cosmos 1980-01-01T00:00:00Z Most of the wild plant species from which our crops were derived vary genetically from area to area, because alternative mutations had become established among the wild ancestral populations of different areas. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z And what of the many other pesticides that interfere with cell division, break chromosomes, cause mutations? Silent Spring 1962-09-27T00:00:00Z We might call it the Tree of Knowledge mutation. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z The mutation in the hemophilia gene, which affects the clotting of blood, had likely arisen spontaneously in Queen Victoria at birth. The Gene 2016-06-02T00:00:00Z If the mutation rate is too high, we lose the inheritance of four billion years of painstaking evolution. Cosmos 1980-01-01T00:00:00Z Radium causes mutations that can turn into cancer, and at high doses it can burn the skin off a person’s body. The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z Their children inherited these mutations and thus generated new species, thereby driving evolution. The Gene 2016-06-02T00:00:00Z Nor is it the result of some quirky genetic mutation. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z They use terms like “germline mosaicism,” “chromosome rearrangement,” or “delayed mutation” to explain why their science is not an exact science. Wonder 2012-02-14T00:00:00Z Maize originated, litis postulated, in a strange, wholesale mutation of teosinte, to which Indians added and subtracted features through intensive breeding. 1491 2005-10-10T00:00:00Z If those desirable mutants proceeded to interbreed with normal plants, the mutation would immediately be diluted or lost. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z The effect of radiation on the mutation rate in flies had two immediate implications. The Gene 2016-06-02T00:00:00Z But it’s more important to understand the consequences of the Tree of Knowledge mutation than its causes. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z Rifkin and many others believed that any manipulation of DNA, even in a controlled laboratory setting, was dangerous because it might lead to genetic mutations and make it possible to engineer “designer babies.” The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z “I’ve always been interested in your cases. I studied them in medical school. Only one in a million such mutations prove beneficial. You’re remarkable people.” The Ear, the Eye, and the Arm 1994-04-01T00:00:00Z Significant changes in social behaviour cannot occur, in general, without genetic mutations. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z The explanation is that occasional individual almond trees have a mutation in a single gene that prevents them from synthesizing the bitter-tasting amygdalin. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Hemophilia is caused by a single mutation that disables a protein in the clotting of blood. The Gene 2016-06-02T00:00:00Z Over time, it should have accumulated mutations, almost all of them tiny alterations in unused DNA that didn't affect the mitochondria’s functions. 1491 2005-10-10T00:00:00Z It is thought that the virus went through a series of very rapid mutations at the time of its jump from primates to humans, which enabled it to establish itself successfully in people. The Hot Zone 1994-01-01T00:00:00Z But, no matter how well trained, medical eyes couldn’t spot a reces-sive mutation hiding out on a fifth chromosome. Middlesex: A Novel 2002-06-05T00:00:00Z The idea is that about 15,000 years ago a chance mutation let the virus “jump the species barrier,” as scientists say, and infect human beings. 1491 2005-10-10T00:00:00Z Even Darwin, among the strongest original proponents of the fundamental mutability of nature, would have found this rate of mutation surprising. The Gene 2016-06-02T00:00:00Z In contrast, most ancient Southwest Asian crops exhibit just one of the alternative wild variants or alternative transforming mutations, suggesting that all modern varieties of that particular crop stem from only a single domestication. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Many of the most distinguished research men in this field look with suspicion on any agent that damages the chromosomes, interferes with cell division, or causes mutations. Silent Spring 1962-09-27T00:00:00Z In the view of these men any mutation is a potential cause of cancer. Silent Spring 1962-09-27T00:00:00Z But if a mutation disrupts the function of an enzyme, then the normal gene must specify the information to make the normal enzyme. The Gene 2016-06-02T00:00:00Z Was there experimental proof that identifiable mutations in real genes were responsible for variation? The Gene 2016-06-02T00:00:00Z Had they been repeatedly domesticated independently, they would exhibit legacies of those multiple origins in the form of varied chromosomal arrangements or varied mutations. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z There are countless people under words like “germline mosaicism,” “chromosome rearrangement,” or “delayed mutation.” Wonder 2012-02-14T00:00:00Z With reproduction, mutation and the selective elimination of the least efficient varieties, evolution was well under way, even at the molecular level. Cosmos 1980-01-01T00:00:00Z A cosmic ray striking a different gene, producing a different mutation, can have small consequences early but profound consequences late. Cosmos 1980-01-01T00:00:00Z Even the language of his thoughts—variation, mutation, survival, and selection—bore striking similarities to Darwin's. The Gene 2016-06-02T00:00:00Z Even a cursory look confirmed a striking result: the newly born flies had accumulated mutations—dozens of them, perhaps hundreds. The Gene 2016-06-02T00:00:00Z Finally, their wild ancestors required very little genetic change to be converted into crops—for instance, in wheat, just the mutations for nonshattering stalks and uniform quick germination. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Then in 1927, a professor of zoology in a Texas university, Dr. H. J. Muller, found that by exposing an organism to X-radiation, he could produce mutations in succeeding generations. Silent Spring 1962-09-27T00:00:00Z For Darwin’s theory to work, heredity had to possess constancy and inconstancy, stability and mutation. The Gene 2016-06-02T00:00:00Z In 1994 Neel and Wallace sifted through mitochondrial DNA from eighteen widely dispersed Indian groups, looking for mutations that had occurred since their common ancestors left Asia. 1491 2005-10-10T00:00:00Z We can sequence human DNA, and identify genetic mutations that cause, for example, diabetes. The Invention of Science 2015-09-17T00:00:00Z “You are a side effect,” Van Houten continued, “of an evolutionary process that cares little for individual lives. You are a failed experiment in mutation.” The Fault in Our Stars 2012-01-10T00:00:00Z It is a long wait before a mutation makes an organism work better. Cosmos 1980-01-01T00:00:00Z Sing now, O Muse, of the recessive mutation on my fifth chromosome! Middlesex: A Novel 2002-06-05T00:00:00Z Muller’s experiments demonstrated that heredity could be manipulated quite easily: the mutation rate was itself quite mutable. The Gene 2016-06-02T00:00:00Z In this light, one can examine a crop widespread in prehistoric times and ask whether all of its varieties show the same wild mutation or same transforming mutation. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Two million years ago, genetic mutations resulted in the appearance of a new human species called Homo erectus. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z Many chemicals used as pesticides — herbicides as well as insecticides — belong to this group of substances that have the ability to damage the chromosomes, interfere with normal cell division, or cause mutations. Silent Spring 1962-09-27T00:00:00Z Only cells that had been transformed by a virus or a genetic mutation had the potential to become immortal. The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z But we may easily be doing so now by inadvertence, for many chemicals, like radiation, bring about gene mutations. Silent Spring 1962-09-27T00:00:00Z But Gogol, already short and catchy, resists mutation. The Namesake 2003-09-01T00:00:00Z We’re supposed to do a report on germ line cell mutations in fruit flies instead. From Twinkle, with Love 2018-05-22T00:00:00Z Could the effects of this germinal mutation be undone? Brave New World 1932-01-01T00:00:00Z Multiple genetic mutations are identified in human cancers, leading to a deeper genetic understanding of that disease. The Gene 2016-06-02T00:00:00Z A mutation is a change in a nucleotide, copied in the next generation, which breeds true. Cosmos 1980-01-01T00:00:00Z And yet it is that improbable event, a small beneficial mutation in a nucleotide a ten-millionth of a centimeter across, that makes evolution go. Cosmos 1980-01-01T00:00:00Z Before then, new varieties of organisms could arise only from the accumulation of random mutations—the selection of changes, letter by letter, in the genetic instructions. Cosmos 1980-01-01T00:00:00Z Variation has been maintained by occasional contact between different islands of speakers, and perhaps also by random mutations. The Lives of a Cell 1974-01-01T00:00:00Z Random mutations created a deepening depression in the light-sensitive spot. The Sun Is Also a Star 2016-11-01T00:00:00Z A man can trust his luck, but a society can’t; and cultural change, like random mutation, may make things chancier. The Left Hand of Darkness 1969-03-01T00:00:00Z Of these, nine had distinct patterns of small mutations that the researchers could 'not find in any databases or in the literature.” 1491 2005-10-10T00:00:00Z My grandparents, unaware of their genetic mutation, concentrated on die more blatant disqualifications. Middlesex: A Novel 2002-06-05T00:00:00Z In wild wheat and barley, a common single-gene mutation blocks shattering. 1491 2005-10-10T00:00:00Z We would cross two varieties to see what new forms emerged from the rearrangement of the parental genes, and from natural and induced mutations. Cosmos 1980-01-01T00:00:00Z Recombination is also a form of “mutation”—except whole chunks of genetic material are swapped between chromosomes.* The Gene 2016-06-02T00:00:00Z Were mutations sudden and spontaneous, or were abundant natural genetic variations already present in wild populations? The Gene 2016-06-02T00:00:00Z "The worst cases cause mutation. Some might grow boils or develop black lumps, but others suffer from warped bones and muscles—even their skulls change shape, and new limbs grow where they shouldn't." City of the Plague God 2021-01-12T00:00:00Z Not even twenty minutes had passed after we’d scarfed down the entire plate of cookies, when Tamika’s gut interrupted my explanation of mutations in DNA over thousands of generations to create a new species. Sir Fig Newton and the Science of Persistence 2022-03-22T00:00:00Z Although discussions of mutations usually refer to those in the germ cells, which may then make their effect felt in future generations, there may also be mutations in the body cells. Silent Spring 1962-09-27T00:00:00Z Hugo de Vries had proposed that mutations were responsible for variation: changes in genes created changes in forms that could be selected by natural forces. The Gene 2016-06-02T00:00:00Z He became rather technical; spoke of the abnormal endocrine co-ordination which made men grow so slowly; postulated a germinal mutation to account for it. Brave New World 1932-01-01T00:00:00Z Then another mutation severed this last connecting thread, and they went their separate evolutionary ways. Sapiens: A Brief History of Humankind 2011-01-01T00:00:00Z Sanskrit and Latin words could be traced back to mutations and variations in an ancient Indo-European language, and English and Flemish had arisen from a common root. The Gene 2016-06-02T00:00:00Z In December 2010, more than a decade after Pena first told me about his project, his team published the results: some of the mutations matched. 1491 2005-10-10T00:00:00Z Second, a mutation is just a variation by another name. The Gene 2016-06-02T00:00:00Z Finally, the hereditary changes called mutations provide the raw material for evolution. Cosmos 1980-01-01T00:00:00Z It cannot be seen as death; barring mutation, the descendants are simply the first cell, living all over again. The Lives of a Cell 1974-01-01T00:00:00Z The evolution of life requires a more or less precise balance between mutation and selection. Cosmos 1980-01-01T00:00:00Z One woman with the BRCA1 mutation might develop an aggressive, metastatic variant of breast cancer at age thirty. The Gene 2016-06-02T00:00:00Z Mutations in genes that specified the basic elements of the body plan were more difficult to identify, since the mutations sharply decreased the survival of organisms. The Gene 2016-06-02T00:00:00Z The chemosterilants of this group are alkylating agents, which are extremely reactive chemicals, capable of intense cell destruction, damage to chromosomes, and production of mutations. Silent Spring 1962-09-27T00:00:00Z The scientists searched for a stem cell donor carrying a genetic mutation that prevents expression of an HIV receptor called CCR5. Hopes rise for Aids cure after bone-marrow transplant rids man of HIV 2019-03-05T05:00:00Z Older men are more likely than young ones to father a child who develops autism or schizophrenia, because of random mutations that become more numerous with advancing paternal age, scientists reported on Wednesday. Motherlode Blog: Older Fathers Linked to Risk of Autism and Schizophrenia 2012-08-22T18:49:29Z A vegetable pisto in the second course was accompanied by a white tempranillo, made with a recently discovered mutation of the red grape. Cultured Traveler: Beyond the Vines in Rioja, Spain 2012-10-19T17:23:02Z The faulty gene can be traced back to “founder mutations” that have remained in communities because of the tendency to marry within the fold. ‘I was not willing to die for my breasts': the young women opting for mastectomies 2018-05-12T04:00:00Z The study analysed lung biopsies from 16 people, including current smokers, ex-smokers, adults who had never smoked and children, looking for the mutations that can lead to cancer. Lungs damaged by smoking can 'magically' heal – study 2020-01-29T05:00:00Z Swift never goes into this big long thing about well, there was a genetic mutation and therefore these people became small, and all the rest. ArtsBeat Blog: Errol Morris Interviews Stephen King 2011-11-10T14:39:00Z Scientific and medical advances mean we can screen for some of the genetic mutations which might suggest Downs, or that we have cochlear implants for the deaf. Andrew Solomon: “The conditions I’ve written about have been brutally stigmatized” 2012-11-24T22:00:00Z Despite Morrow’s confirmed atheism and his gleeful mockery of religious fundamentalism, in Chloe he’s created a character capable of surprising spiritual mutation. James Morrow’s satiric novel ‘Galápagos Regained’ takes on Darwin and God 2015-01-13T05:00:00Z I love working with preëxisting texts and formats, and seeing what new mutations can come from combining them. R. Sikoryak’s “Get the Picture” 2019-12-23T05:00:00Z His work showed that the mutations built up by the age of 10, in line with the gut being colonised with bugs after birth. Common toxin made in gut can cause bowel cancer, scientists find 2020-02-27T05:00:00Z Perhaps the holy grail of medicine, “curing cancer” is a misnomer – there’s too many different types, too many mutations, for a blanket solution. 'Some beautiful things are happening': behind Jim Allison's quest to cure cancer 2019-12-24T05:00:00Z Their conversation began with basics: how they’re faring in the pandemic, family, work, lactose tolerance as mutation, and interests. Date Lab: Their vibe was ‘neither serious nor humorous’ 2020-09-25T04:00:00Z Like genes and gene complexes, when an ideology is replicated—or passed from one person or group to another — it undergoes mutations. How religious fundamentalism hijacks your brain, as explained by a neuroscientist 2018-09-10T04:00:00Z But the variability of mutations of the coronavirus, the rates of vaccination, and changing guidance at state and local levels could begin to chip away at that. Hold on to Your Masks 2021-08-05T04:00:00Z Women’s bodies are strange and unreliable in these stories, prone to mutation and disappointment. Samantha Hunt’s imagination runs wild in 'The Dark Dark' 2017-08-25T04:00:00Z People with genetic mutations cannot possibly time-travel, it is a flawed concept. What's the most outrageous prediction for the future? 2010-10-21T11:00:00Z “The typical woman with a BRCA1 mutation will benefit to a large extent from an oophorectomy at age 35,” says the study’s lead researcher, Dr. Steven Narod of the University of Toronto. Don’t remove your ovaries just yet 2014-02-25T20:19:00Z Cells monitor themselves for mutations and induce cell death, also known as apoptosis, when necessary. How microbes in food can impact your body’s defenses against cancer 2023-02-28T05:00:00Z But with its smidgen of hope and its rejection of nihilism, “The Last of Us” has a few key mutations that make it a variant of interest. Review: ‘The Last of Us’ Is a Zombie Thriller About Single Parenting 2023-01-12T05:00:00Z It turns out they're both carriers for a genetic mutation that causes hearing loss. Born deaf, 11-year-old is among nation's top spellers 2016-05-24T04:00:00Z Maybe it was some sort of mutation that people could move to a beat, and were able to be so cohesive in society and could be stronger than others. You know it feels good to dance. These scientists reveal why. 2021-11-10T05:00:00Z He’s not born with some mutation or some special skill. Q&A: Benjamin Walker on Becoming an Axe-Wielding President in Abraham Lincoln: Vampire Hunter 2012-06-20T16:00:44Z Research published last year identified mutations in three genes that likely contribute to some cases of stuttering. 'King's Speech' earns praise from kids who stutter 2011-02-05T01:06:25Z If genetic mutations interfere with these proper behaviors, they can lead to the breakdown of cellular cooperation and the emergence of cancer. How microbes in food can impact your body’s defenses against cancer 2023-02-28T05:00:00Z Tumor DNA differs from normal healthy DNA due to mutations of the nucleotide sequences. Medical breakthrough: New blood test could be a quick accurate way to detect solid cancers 2014-04-07T16:00:00Z The three biologists who won the 1995 Nobel Prize in Physiology had absolutely no idea what might happen when they fed male fruit flies chemicals that they hoped would cause mutations in the flies’ sperm. Science doesn’t know everything 2013-06-02T18:00:00Z They contended that allowing corporations to own patents over human genes stifled cancer research and allowed them to charge exorbitant rates for patients who wish to be tested for the BRCA1 mutation. Patient wins high court challenge against company's cancer gene patent 2015-10-06T04:00:00Z Some genes in today's horses were absent altogether from the ancient ones, showing they arose from recent mutations. Ancient DNA reveals history of horse domestication 2014-12-15T05:00:00Z King’s agenda is more small-town focused, suggesting that sudden alterations to normality create a different survival ballgame in which social and philosophical issues are subject to mutation. Under the Dome has already got me thinking about busting out 2013-07-10T02:49:26Z And their track Vessels includes the immortal chat-up line: "You are a triumph of natural selection/ Every mutation leading to your perfection." New band of the day ? No 998: Tall Ships 2011-04-05T14:55:34Z Donald Trump is a new mutation of the radical right — hostile to diversity and democracy — and it is difficult to have communion with anyone who supports the mutant. Art is not an escape — it’s our most powerful weapon against apathy 2016-11-26T05:00:00Z A week later I got the results: positive for the mutation, which meant a 50-85 percent lifetime risk of getting breast cancer. My decision to keep my breasts: When Angelina Jolie’s choice is different from your own 2015-03-29T04:00:00Z If David Bowie’s non-stop mutations taught the children of rock-and-roll to crave variety, it only makes sense that the breadth of Bowie scholarship continues to grow. David Bowie remembered by his admirers, collaborators and friends 2017-04-21T04:00:00Z Later she learned that many in her father’s side of the family carried the BRCA1 genetic mutation, which prevents the suppression of tumor growth. ‘Dangerous Boobies’: One woman’s experience ‘breaking up with’ her breasts 2017-09-14T04:00:00Z Not long after Mackenzie was diagnosed, they discovered they both carry the SMA genetic mutation. How we stay together: 'I’m very happy to be proven wrong by my wife regularly' 2020-06-27T04:00:00Z Around 100 years ago, plant breeders in Germany found natural mutations that produced "sweet lupins" with far lower levels of bitter alkaloids. Is this the protein plant of the future? New study finds "sweetness gene" that makes lupins tastier 2023-10-02T04:00:00Z We're guessing the answer is a genetic mutation ... or a radioactive spider ... or just plain old good business sense. Close-up: Chicago's giant Marilyn Monroe statue: some like it not 2011-07-21T14:22:22Z Each wrinkle in Cutler's tunes finds a counterpart in the movement, which is basically folk-dance subjected to whimsical mutations. Baryshnikov is one of the gang in Mark Morris' 'A Wooden Tree' 2012-10-05T17:37:02Z To read it is to enter a world at once entirely recognisable yet utterly abstruse, where the Beatles, David Bowie and Queen rule the roost, but only in the bizarrest of out-takes and mutations. Britain's rarest record – yours for £200,000 2012-11-22T19:30:02Z Put any pair of human beings under a microscope, and strange mutations and strains come into discomfiting focus. Theater Review: ‘AdA,’ Plays by Neil LaBute and Marco Calvani at La MaMa 2012-10-05T22:24:29Z So was Lemon Drop, which emerged as a yellow sport, or mutation, of the heirloom Snow White Cherry. Tomato growers’ never-ending crusade for the holy grail 2015-09-08T04:00:00Z The Bad Batchers, unlike the other Republic clone soldiers, each possesses a significant mutation that is manifested physically or through abilities. Omega is the MVP of "The Bad Batch," a Star Wars clone who's destined to be different 2021-08-14T04:00:00Z The team found 139 regularly mutated genes and a sophisticated way to test for more than one mutation at a time. Medical breakthrough: New blood test could be a quick accurate way to detect solid cancers 2014-04-07T16:00:00Z The research showed how breast cancer mutations build up as leftover tumour cells grow and spread. Blood test may help predict breast cancer relapse 2015-08-26T04:00:00Z It turns out that short sleepers, as they are known, may have a genetic mutation, as Arianna Huffington pointed out in her 2016 book, “The Sleep Revolution: Transforming Your Life One Night at a Time.” Sleep Is the New Status Symbol 2017-04-08T04:00:00Z Every revelation registers in the gifted Amalric's gaze: infinitesimal physical mutations, emotional detonations. 'The Blue Room' a tantalizing mystery of lovers on trial 2014-10-02T04:00:00Z Its cast of characters included a “calorie man” who scours Southeast Asia in search of new food sources to replace crops ravaged by bad weather and plant mutations. Imagining a thirsty future in Paolo Bacigalupi’s ‘The Water Knife’ 2015-05-28T04:00:00Z The Second Suite traverses lively march and dance mutations on its way to another rousing finale, a Tarantella à la russe. Review: Daniil Trifonov and His Teacher Dazzle With Dual Virtuosity 2018-03-02T05:00:00Z They were inspired by Cornelia Hesse-Honegger, a scientific illustrator whose vivid watercolors document the mutations found in insects in nuclear disaster zones. Textiles Are Part of the Fabric of Milan Design Week 2023-04-11T04:00:00Z But the majority of the population doesn’t carry those mutations, and so the real risk for the rest of us is simply not determined by our genes. It's not just in the genes: the foods that can help and harm your brain 2018-02-12T05:00:00Z In fact, studies are now revealing how HPV damages the genes in our cells and triggers the mutations of cancer. We have a vaccine for six cancers, so why are less than half of kids getting it? 2017-02-06T05:00:00Z Discussing the genetic mutation pattern of the virus now feels as mundane as talking about the weather. Fall Preview: The Thrill is Back. So Is the Anxiety. 2021-09-17T04:00:00Z Film genres are slippery, with cross-pollination and mutation the order of the day. Mark Kermode’s Secrets of Cinema – from Oscar-winning strategies to 007’s debt to Hitchcock 2020-03-15T04:00:00Z According to the park, the anomaly is likely the result of a genetic mutation. Two-headed turtle found on South Carolina beach 2021-07-26T04:00:00Z As people started growing the domesticated tomato in more northerly latitudes, they inadvertently selected a variety with a natural mutation which resulted in a slower clock. How understanding plant body clocks could help transform how food is grown 2023-06-06T04:00:00Z She still gets ready to perform by moving through slow progressions and mutations of the chords, feeling her way toward the song. Alicia Keys Goes From Spark to Fire 2012-09-30T05:34:03Z The aim is to understand key triggers – what saves some women with the mutation and why – and “to develop non-surgical methods to prevent these cancers”. ‘I was not willing to die for my breasts': the young women opting for mastectomies 2018-05-12T04:00:00Z There’s a sense, too, of cultures in mutation. Review: ‘Barber Shop Chronicles’ Offers an Exhilarating Sanctuary 2019-12-04T05:00:00Z Jucker noted people with these mutations developed symptoms of Alzheimer’s at well-defined ages, allowing the team to measure levels of NfL a known number of years before symptoms are expected to become apparent. Blood test could detect Alzheimer's over 10 years earlier – study 2019-01-21T05:00:00Z But, as Sherlock’s stakes have risen, and as the guns and assassins have multiplied, it is starting to feel worryingly like we are watching villains be taken to task by a mutation named Sherlock Bond. Sherlock is slowly and perversely morphing into Bond. This cannot stand 2017-01-03T05:00:00Z “If the exposure is taking place within the first decade of life, we may need to diagnose it within the first decade of life and treat it to avoid the mutations being generated,” he said. Common toxin made in gut can cause bowel cancer, scientists find 2020-02-27T05:00:00Z This is down to the long-standing desire of conifer connoisseurs to discover branch mutations and from them propagate slow-growing versions known as dwarf conifers. Winter wonders: Conifers revive the sleeping garden. But remember, less is more. 2020-12-01T05:00:00Z My feeling is that his mutation was down to a classic atomic‑age lab accident. Russia’s new movie superhero: a bear called Arsus that looks like Putin 2016-09-02T04:00:00Z The study found nine out of every 10 lung cells in current smokers had mutations, including those that can cause cancer. Lungs damaged by smoking can 'magically' heal – study 2020-01-29T05:00:00Z Now, they are grappling with marketing strategies as they find themselves at a tangent to the biggest news story of the last two years: Covid-19 and its growing list of mutations. What’s in a Name? If It’s Omicron, a Minor Marketing Challenge. 2021-12-15T05:00:00Z "Patients who have the specific mutation that causes chronic myeloid leukaemia will respond to the use of Gleevec and will go into remission quite profoundly," says Adams. Genetics: The number crunchers who are saving lives 2010-05-29T23:05:00Z Dunn said "Geek Love" also reflects her concerns with "the volcanic and terrifying possibilities of genetic mutation and the whole issue of the cult." Katherine Dunn has died; the 'Geek Love' author once took the world by storm 2016-05-12T04:00:00Z Someone decided it would be a good thing to perpetuate this mutation. How fancy cats evolved: The science of our most adorable pets 2015-05-25T04:00:00Z If you have a mutation in the gene, your safety mechanism isn’t working. ‘I was not willing to die for my breasts': the young women opting for mastectomies 2018-05-12T04:00:00Z The mutations are raw material on which Darwinian natural selection may act, or not, to produce new adaptations. The Pandemic’s Future — and Ours 2020-11-03T05:00:00Z It is triggered by a genetic mutation which interferes with chemical messages that help to control cell division, leading to the uncontrolled growth of white blood cells. Genetics: The number crunchers who are saving lives 2010-05-29T23:05:00Z My argument stresses the plasticity that our brains were endowed with when this mutation occurred. Colin Blakemore: how the human brain got bigger by accident and not through evolution 2010-03-28T00:05:00Z “Then it’s about repeating these accidental mutations so the final outcome is something I could never imagine.” Art Rooted in Nature Blooms at TEFAF 2023-03-02T05:00:00Z The pandemic is not the only factor, and the future of movies and moviegoing may depend less on virus mutations or consumer preferences than on corporate strategy. Our Film Critics Discuss the Future of Movies 2021-09-14T04:00:00Z In this version the mutation was caused by French nuclear tests in the Pacific. Japan's fantasy films act as a buffer against the reality of the natural world 2011-03-29T12:59:01Z Jean-Yves is mad with ideas for synthesiser, sound mutation, and aural space. Todd Rundgren: 'What I'm doing isn't even really music' – a classic interview from the vaults 2013-03-13T13:01:33Z As a younger man, the child of the Hemingway generation, he had taken it for granted that books, particularly novels, were where consciousness would change, where cultural mutation would be registered. The Strange Prophecies in Norman Mailer’s “The Armies of the Night” 2018-07-11T04:00:00Z But surveillance capitalism is also many other things: “a parasitic economic logic … a rogue mutation of capitalism … a new collective order based on total certainty” and “an overthrow of the people’s sovereignty.” How Tech Companies Manipulate Our Personal Data 2019-01-18T05:00:00Z Basically, Bismuth is messing with his images’ DNA, creating mutations. Julien Bismuth tinkers with the DNA of his images at the Box 2015-10-16T04:00:00Z Absent, too, is any discussion of the other cancers that the gene mutation predicts. Angelina Jolie, meet Nate Silver 2013-05-15T16:59:00Z Bray Poor’s sound design has a similar quality of bewildered mutation. Review: In ‘10 out of 12’ at Soho Rep, the Audience Tunes In to the Crew 2015-06-10T04:00:00Z To me, that’s what the show’s basically about: change — invention, mutation, transformation, but without utopian overlays. Review: New Museum Triennial Casts a Wary Eye on the Future 2015-02-26T05:00:00Z We don’t know if language colonized a freak mutation or if the mutation was itself driven by the absolute need for language. Diamondbacks 1, Story 0 2022-09-04T04:00:00Z But a mutation in the wrong gene in the wrong cell can “dramatically change the behaviour of the cells and instruct them to behave more like a cancer”, Campbell told AFP. Lungs damaged by smoking can 'magically' heal – study 2020-01-29T05:00:00Z As our cells divide and our bodies age, and as mutations accumulate inexorably upon mutations, cancer might well be the final terminus in our development as organisms. Cancer: The new normal? 2011-01-17T17:35:24Z A major challenge was to distinguish cancer-causing mutations in these fragments of DNA from the more common and largely harmless mutations in DNA shed from normal cells in the body. AI program could check blood for signs of lung cancer 2020-03-25T04:00:00Z Not the least of the challenges that classical music faces is the increasingly unworkable celebrity-maestro model—a twentieth-century mutation, stemming from a disproportionate emphasis on the music of prior eras. The Berlin Philharmonic Searches for a Messiah 2015-05-13T04:00:00Z If we have any hope that 2018 will mark the beginning of a new era in fantasy film-making, this could be a very welcome mutation indeed. Future shock: unearthing the most cutting-edge sci-fi movies of 2018 2018-01-03T05:00:00Z King was a singular personality, a mutation of the common man, a New Yorker unafraid to just ask the question. Perspective | Larry King’s long run made the case that there’s no such thing as a dumb question 2021-01-24T05:00:00Z It used to be one of their most glorious pieces: now, a lot of its magic has been squashed by a clunky focus on Fukushima, and Ralf Hütter singing: "Chain reaction, and mutation/ Contaminated population." Kraftwerk at Tate Modern, night two: Radio-Activity 2013-02-08T14:53:56Z These new mutations that appear in offspring, Dr. Turek said, have been shown to “increase by two for every year of a father’s age above 40.” Diary of a Sperm Banker 2014-04-04T22:42:40Z He and his colleagues studied mice with a gene mutation that conferred a condition similar to Alzheimer’s by producing a faulty amyloid protein. Does our immune system hold the key to beating Alzheimer’s disease? 2019-03-03T05:00:00Z Explaining how the chromosome damage that the drug was hysterically asserted to cause might actually lead to favorable mutations, she muses that “five years from now, I’ll probably be a wife and mother.” Did They Wear Flowers in Their Hair? See the Happy Hippies in 1967 2017-08-10T04:00:00Z Although the origins of the cordyceps mutation remain unknown, many believe the fungus contaminated some common worldwide grocery staple, like flour. ‘The Last of Us’ Season 1, Episode 3: One More Good Day 2023-01-29T05:00:00Z The Crigler brothers’ condition is genetic, Dr. Kao told Fox News Digital, though doctors were unable to find the genetic mutation that caused them both to have enlarged hearts. Identical twin brothers each receive heart transplants: 'Quite unique' 2022-03-23T04:00:00Z As soon as you hit space, you feel your body is going through a period of mutation.…There’s no blood in your head, you have a hard time swallowing. T Magazine: Big Sky 2011-05-17T19:47:38Z I thought to myself, if I was marked by a genetic mutation, I might not ever have a baby. My deep, dark secret 2013-02-15T23:40:00Z But it's much more comfortable to discuss repertoire with artists, going over details about possible cuts in a piece, different mutations, arrangements. The woman behind the 'puzzle' of planning an SSO season 2012-08-23T20:51:06Z Other microbes can promote cancer by inducing mutations in healthy cells that make it more likely for cellular cheaters to emerge and outcompete cooperative cells. How microbes in food can impact your body’s defenses against cancer 2023-02-28T05:00:00Z In that sense, Bowie’s mutations were a manifestation of his generosity. David Bowie taught us the limitless potential of renewal 2016-01-11T05:00:00Z You repeated this process over many successive generations, throwing in some mutations along the way. Former Christian fundamentalist: Science robbed me of my faith 2013-09-09T00:00:00Z At age 28, the budding comedian found out that she, too, carries the mutation. ‘Dangerous Boobies’: One woman’s experience ‘breaking up with’ her breasts 2017-09-14T04:00:00Z The post-Covid “Curb” season wrapped production a few mutations ago, in May, when the virus seemed to be fizzling into oblivion. Wondering When the Pandemic Will End? On TV, It Already Has. 2022-01-07T05:00:00Z It's not their fault they have an aberrant mutation that makes them believe nonsense. The Serpent's Promise by Steve Jones – digested read 2013-05-05T17:29:01Z Yes, there are cases in which a single mutation in one of the 3bn bases in DNA causes disease. Identically Different: Why You Can Change Your Genes by Tim Spector – review 2012-08-08T09:30:03Z How to represent these mutations in artistic form? 5 Art Gallery Shows to See Right Now 2020-11-25T05:00:00Z There’s styles you can’t play now without being retro — rockabilly, for instance — but there are always new mutations of punk. A tale of two punks: The Fastbacks’ Kurt Bloch and D.O.A.’s Joe Keithley 2013-08-24T15:12:34Z The radioactivity of the water has caused a mutation in the offspring of the crocodiles. Herzog's Cave of Forgotten Dreams: the real art underground 2011-03-17T23:00:01Z This is based on the rate at which species produce new mutations. Long tail: dogs may have lived with humans for 30,000 years 2015-05-21T04:00:00Z Mass spectrometry data taken by military satellites indicates that the quickly swelling mutation is “an almost exact match to the Andromeda strain.” Review | Michael Crichton’s classic thriller ‘The Andromeda Strain’ gets a deadly sequel 2019-11-11T05:00:00Z “He calls his dancing animated mutation,” Schoo says, “and he strove to animate every piece of his body — on the table, on the floor, using the entire bar.” | New York’s Latest Dance Craze, From Street to Screen 2014-03-31T20:44:26Z The pain-free Tuscans are different: a mutation in a single gene called SCN9A means they feel pain mutedly, if at all. TV review: Horizon: The Secret World of Pain, Outside the Court, Episodes 2011-02-01T08:00:03Z Maybe all those things — barking dog, musical chairs, natural disaster, biological mutation — are occurring, as it were, simultaneously. Richard McGuire’s ‘Here’ 2015-10-12T04:00:00Z After genetic testing, a diagnosis finally arrived: Turner Syndrome, a chromosomal abnormality resulting from a prenatal mutation. 2010-01-29T21:20:00Z When that was translated back into Morse code and then into English, a mutation occurred in the sentence from the Bible. A Space Odyssey: Making Art Up There 2017-03-23T04:00:00Z The authors themselves are leading the search for a quantum mechanism in genetic mutations, which might be giving evolution itself a helping hand. Nature, the physicist 2014-11-20T05:00:00Z Another thing that’s been learned about Ebola is the mutation rate. ‘The Hot Zone’ Author Tracks Ebola’s Evolution 2014-10-19T04:00:00Z Jillian knows that she has probably inherited the gene mutation that caused it, and may have passed it along to Natalie. Review: ‘Informed Consent’ Tests the Ethics of Genetic Research 2015-08-18T04:00:00Z With all due respect to cyclo-cross and kamikaze downhill mountain biking, and every other mutation that two wheels have taken in recent years, this is what a bike was really intended for, no? A Bicycle Tour Through Remote Southwest Canyon Country 2010-07-31T04:30:00Z “If enough of these ‘driver mutations’ accumulate, then the cell will become a full-blown cancer.” Lungs damaged by smoking can 'magically' heal – study 2020-01-29T05:00:00Z She was also identified as a carrier of the gene mutation increasing the risk of developing the disease. EastEnders 'breaking cancer taboo' 2014-11-18T05:00:00Z We really ought to give ourselves a collective pat on the back for doing as well as we have in a universe of constant media change and mutation. Why McLuhan's chilling vision still matters today 2011-07-20T18:00:15Z The gene sequences are then compared and used to work up a genetic fingerprint for the mutation that causes the disease. IVF technique that tests embryos for genetic disorders has first success 2014-07-27T04:00:00Z A title informs us that we are in “the new dark ages,” and it does feel as if the world is enduring medieval times all over again, albeit with lab-created beings and freakish mutations. Five Science Fiction Movies to Stream Now 2023-02-17T05:00:00Z Sauvignon gris is a color mutation of sauvignon blanc that produces a less aggressively grassy, more floral wine than its better-known relative. At just $10, this Italian red blend is your ideal chocolate dessert pairing 2021-10-28T04:00:00Z I had barely removed my coat before the doctor started rattling off the things I had tested negative for: antiphospholipid antibodies, lupus anticoagulant, Factor V Leiden, prothrombin gene mutation. My four miscarriages: why is losing a pregnancy so shrouded in mystery? 2020-05-05T04:00:00Z He calls Hollywood action movies "a mutation of the fireside dragon story". "Last Storyteller" Delaney knows how to get attention 2012-02-02T19:15:19Z Huntington’s disease is officially described as a neurodegenerative disease that most often strikes in midlife, and is caused by a mutation in either of two copies of a gene called Huntingtin. The stories behind Huntington’s disease 2013-05-16T00:32:25Z Everyone exists in a state of unceasing mutation, and sometimes it takes more than one ensemble member to create a single role. Review: ‘A Midsummer Night’s Dream’ Tailored for Multitaskers 2015-09-20T04:00:00Z It's something I've never explored, developing a character that could have mutations anywhere along the road that would be embraced or not. 'Alphas' star David Strathairn on why he continues to act 2011-07-06T17:35:05Z She’s always shown forensic interest in the way we speak and the stories we tell, from making up her own language for 2006’s “The Internationalist” to tracing the mutation of culture in “Mr. Burns.” From ‘The Simpsons’ to ‘The Twilight Zone.’ And Now, Trump. 2019-02-06T05:00:00Z My suggestion is that the sudden expansion of the brain 200,000 years ago was a dramatic spontaneous mutation in the brain of Mitochondrial Eve or a relative which then spread through the species. Colin Blakemore: how the human brain got bigger by accident and not through evolution 2010-03-28T00:05:00Z The technique allows doctors to select embryos that are free of dangerous mutations carried by one or both parents even if the precise nature of the genetic defect is unknown. IVF technique that tests embryos for genetic disorders has first success 2014-07-27T04:00:00Z It may be that the Johnson family suffers an extreme mutation of the publicity gene, but it could also be taken as evidence of the general human difficulty in refusing invitations to appear on TV. Why did Rachel Johnson agree to that documentary? 2010-10-21T07:00:00Z The suspended wire forms are Arkin’s “shadow paintings,” one of several installation elements that convey fragility and mutation. In the galleries: These landscapes are something short of idyllic 2017-02-03T05:00:00Z Violence is implied, both by the contortions of the weightlifters’ faces and by the mutations that take place as Finley translates televised images into enamel on canvas. The stomach-churning, visceral power of Chris Finley's weightlifter portraits 2017-06-27T04:00:00Z Of the two spike mutations, one was found in 788 viruses around the world, with the other present in only 32. Scientists concerned that coronavirus is adapting to humans 2020-05-10T04:00:00Z Body horror is a subset of the horror film genre that depicts the destruction, degeneration or mutation of the human body. "The Whale" is a horror film that taps into our fear of fatness 2023-01-30T05:00:00Z A single base pair mutation allows adults to drink milk. Paleofantasy: What Evolution Really Tells Us About Sex, Diet, and How We Live by Marlene Zuk – review 2013-04-24T06:30:03Z When only one copy of the gene carries the mutation, the person is a carrier. The college class that could reveal your real father 2013-09-14T23:00:00Z Genetic changes that appear in the body’s cells are a normal part of ageing, and many of these mutations are harmless so-called “passenger mutations”. Lungs damaged by smoking can 'magically' heal – study 2020-01-29T05:00:00Z Balanchine was the 20th century’s most important heir to that tradition, and the agent of its mutation into a new modernity. Dance Review: Paris Opera Ballet Leaps Across the Centuries 2010-12-23T12:30:02Z It's an evolved genetic trait that likely occurred as an evolutionary mutation and distinguishes salmon from other types of fish. The color of farmed salmon comes from adding an antioxidant to their feed 2023-03-17T04:00:00Z The Playlist this week reported comments from Noomi Rapace, the only human member of the crew of the Prometheus to survive the movie intact and without obvious mutations, suggesting that process is finally under way. How will Prometheus 2 engineer a route forward? 2013-03-01T15:59:58Z After one grower noticed that a mutated branch on his Red Delicious tree bore deep crimson red fruits, other Delicious growers raced to spot similar mutations that would produce vibrant, striking red apples. The Red Delicious isn’t actually delicious anymore. So, why do we keep producing them in bulk? 2023-09-04T04:00:00Z Or a single, fortuitous genetic mutation had occurred, out of which all of human civilization eventually flowed. Does Autism Hold the Key to What Makes Humans Special? 2020-12-08T05:00:00Z Have we lost or have we gained from the mutation of interaction? Life Zucks 2010-10-18T10:21:00Z “A nuclear meltdown changes people,” Emily muses early in the novel, “and I don’t mean radiation sickness or ‘Twilight Zone’ kinds of mutations in babies.” Review: ‘Close Your Eyes, Hold Hands,’ by Chris Bohjalian The Baltimore artist grafts her countenance onto gnarled pieces of wood in ways that suggest mutation and decay, but always with the primacy of self- image. In the galleries: 3 artists explore 3-D 2015-08-19T04:00:00Z Not everyone would have been susceptible, but some would, and through them — with the help of genetic mutation — art would propagate itself in forms appropriate to the social and historical development of its hosts. Art Review: Armory Show, Modern and Contemporary, at Piers 92 and 94 2012-03-08T23:15:02Z It’s hard to imagine how the Catalan peasants of yore might react to the espadrille’s modern mutations. All Hail the Humble Espadrille! 2010-08-16T13:10:00Z It feels as though Lawrence is a mutation in my literary genes that I carry unwillingly. This Week in Fiction: Yiyun Li on Fairy Tales 2017-05-01T04:00:00Z But it could also be argued that in becoming a new mother, Rain has once more become a stranger to herself, surviving yet another personality mutation brought about by circumstance. Cunning, Damaged and Deranged: The Latest Thrillers by Women 2019-10-25T04:00:00Z He knew he and they were a kind of mutation, and that empowered him to push himself and his fans as far and fast as they would go. When Bowie met Burroughs 2013-03-09T09:01:00Z I inherited the BRCA1 gene mutation, which means that one day – if unchecked – those two modest little breasts are bound to turn on me. Don’t touch my breasts, hon 2012-10-08T01:00:00Z One of the eyes of the puppy is a nine-headed deer, and there’s some kind of mutation in the lady’s hands. Lupe Fiasco: Album 'was destroying me' 2011-03-02T04:08:47Z “Breasts and Eggs” is about this kind of mutation, this irrepressibility. A Japanese Literary Star Joins Her Peers on Western Bookshelves 2020-04-07T04:00:00Z Instead, we went to a company called Traitomic who screened a huge number of seeds of narrow-leafed lupin until they found one which naturally had exactly the mutation we were looking for. Is this the protein plant of the future? New study finds "sweetness gene" that makes lupins tastier 2023-10-02T04:00:00Z The activity-director mutation runs strong among the women in my family. It’s Their Wedding, and Their Wedding Planning 2018-05-31T04:00:00Z Ms. Bernstein’s rough-hewn beasts are both comic and foreboding in their mutations of the human form. What to See in New York Art Galleries This Week 2018-05-10T04:00:00Z Colin Smith, the geneticist from Surrey, tells me how he's got mutation on a particular gene. My own genome project 2013-06-08T18:45:00Z That mutation was so advantageous that it survived and thrived, producing today’s 7,000 languages from Albanian to Zulu. Noam Chomsky 2016-03-23T04:00:00Z Independent Projects, a hybrid art fair and exhibition installed in the former Dia Art Foundation space on West 22nd Street in Chelsea, is a welcome mutation. Independent Projects Unveils New Art Fair Concept: A Show 2014-11-07T05:00:00Z Rose does not carry the "breast cancer genes" BRCA1 and BRCA2, but she did inherit a rare genetic mutation which might predispose her to the disease. Miss America contestant to undergo preventative double mastectomy 2013-01-11T19:22:35Z What other unintended mutations might this breeding have caused in these varieties, and what effects might they have on the people who eat them? Not just a fad: the surprising, gut-wrenching truth about gluten 2018-08-07T04:00:00Z It’s a white mutation of the red trousseau, another grape variety you’ve probably never heard of. Four natural wines to electrify your taste buds, starting at $15 2019-03-29T04:00:00Z Dr. Allison explained to me a few years ago, "You work with melanoma because it's accessible. It's a bad disease. It has many mutations. People want to deal with it because it's so bad." I was the new Nobel Prize winner’s lab rat 2018-10-01T04:00:00Z Either way, the result is intense inbreeding and the accumulation of deleterious recessive mutations—a phenomenon known as “inbreeding depression.” How fancy cats evolved: The science of our most adorable pets 2015-05-25T04:00:00Z As they grapple with their own risk, the story poses a wrenching question: Would you want to know if you carried a fatal genetic mutation? New in Paperback: ‘Hillbilly Elegy,’ ‘Compass’ 2018-05-25T04:00:00Z "You would think that UV just causes mutations, but it doesn't, you need a gene to be active for it," Kenyon says. Cynthia Kenyon: 'The idea that ageing was subject to control was completely unexpected' 2013-03-17T00:05:44Z The festival, in a statement Wednesday, called Aronofsky a key figure in contemporary film, saying his work "constantly engages the evolution and mutations of the many languages of art." Aronofsky to head Venice jury 2011-04-28T12:16:05Z At what stage of cellular development a stem cell acquires the genetic mutation that turns it into a cancer stem cell remains unknown. Arsenic contamination of food and water is a global public health concern 2023-06-05T04:00:00Z And seeded among the cycles and mutations is the essence of relativity: Here’s the world in entirety. Review: ‘The Lost Time Accidents’ asks the big questions about where we are 2016-02-23T05:00:00Z Unlike with GMOs, this introduces only minor modifications, which are indistinguishable from natural mutations. What’s the latest on GMOs and gene-edited foods — and what are the concerns? 2023-05-09T04:00:00Z And that’s not to mention peritoneal cancer, the risk of which also increases dramatically with the mutation. Angelina Jolie, meet Nate Silver 2013-05-15T16:59:00Z A survey of 700 epidemiologists by The New York Times in December found that the doctors were still worried about the longevity of immunity, the mutation of the virus and vaccine distribution. You’re Invited to the Wedding, if You Show Proof of Vaccination 2021-01-27T05:00:00Z A more extreme mutation called Boneys - skeletal creatures that are an effective but not quite menacing combination of stunt work and CGI - will eat anything, including corpses. Review: 'Warm Bodies' could use more heat 2013-01-30T17:16:04Z Like everything else, concerts went through some managed mutation from communal experience to isolated screen time. What it felt like to lose time — and all the other things coronavirus took away Finally, they discover the mother of these mutations, a rat as big as a cow. Stephen King’s Reign of Terror Continues in a New Novel 2018-05-22T04:00:00Z Enzie and Genny are sexless mutations of Gertrude Stein and Alice B. Toklas, running salons in their Harlem apartment, overstuffed with the most interesting people. Review: ‘The Lost Time Accidents’ asks the big questions about where we are 2016-02-23T05:00:00Z They have pandemic potential because by replicating through RNA, it means they undergo rapid mutation, and by spreading through droplets or aerosols, it means they can spread very quickly, very widely. Former FDA commissioner: ‘We remain almost equally vulnerable to threat from the next pandemic’ 2021-09-09T04:00:00Z Hyperdub is a mutation of British electronic music, infected by Jamaican soundsystem culture," he told the Guardian last year: "From dub and reggae, through jungle, right up to grime, dubstep and funky. Label of love: Hyperdub 2010-05-12T14:01:00Z Is there a place for a vision of future humanity in the grip of an eldritch religion that sees salvation in alien mutation? Video Game Review: Space Zombies, Prepare to Meet Your Mower 2011-02-01T19:52:29Z They show songs in steady mutation, with Mr. West trying out different lyrical approaches to the same portion of music. Kanye West Is Fixing His Album in Public. You’ll Want to Read the Edits. 2016-02-19T05:00:00Z The film changes tone, even form, with its hero’s every new mood and mutation. The Master of Cinematic Vulgarity: Ken Russell (1927-2011) 2011-11-28T20:17:50Z In any case, the risk of genetic mutations rises with older fathers, too, although you won't hear as much about that in the news because men aren't quite as satisfying to needle. Forget Kirstie Allsopp's advice – listen to me, the Nigel Farage of fertility 2014-06-03T04:00:00Z During the many hours of painstaking transcription of these improvisations that followed, I frequently noticed this mutation of themes over one piece, and often even between improvs separated by days and weeks. How Turner's paintings inspired jazz composer Tim Whitehead's new record 2010-09-23T21:45:00Z The fire-breathing, reptilian monster - a combination of the Japanese words for whale and gorilla - is a mutation caused by nuclear testing. New Godzilla film to be made in Japan 2014-12-08T05:00:00Z The picnickers illustrate what a broad church punk has become via its myriad mutations over the years: neither the threat to public morals of old nor an irrelevant retro cult. Punk is still the sound of youth rebellion 2012-06-01T15:39:56Z “I deliberately create a moment of mutation,” she explained. Art Rooted in Nature Blooms at TEFAF 2023-03-02T05:00:00Z He likes to call his films “musical comedies,” which is an apt enough phrase if each word is broadly defined, but he also speaks of them in terms of “mutation” and “contamination.” Film: ‘Tabu,’ Newest Genre Breaker From Miguel Gomes 2012-12-23T03:49:46Z The study, published in the Lancet Oncology, found survival chances were the same for women with or without the mutation, whatever treatment they had. ‘I was not willing to die for my breasts': the young women opting for mastectomies 2018-05-12T04:00:00Z Genetic causes are thought to be responsible for about a third of cases of ASD, while the rest are believed to be caused by a combination of environmental factors, mutations, and rare genetic variants. New test can detect autism in children, scientists say 2018-02-18T05:00:00Z Random mutations and genetic crossover between the fittest individuals in the population produced a new, slightly more evolved population. Former Christian fundamentalist: Science robbed me of my faith 2013-09-09T00:00:00Z He has been experimenting with flowers since the 1990s, breeding – he claims – hybrid blooms that attest to genetic mutation. Mat Collishaw: still sensational 2013-04-26T15:30:00Z The vineyard now has six acres of nebbiolo, comprising seven different clonal selections, each a mutation of nebbiolo with subtly different characteristics. Leaving It All Behind for the Love of Nebbiolo 2019-03-07T05:00:00Z Evolution does not “design” anything; it’s a process that occurs as a result of the entirely random phenomenon of genetic mutation. We pledge allegiance to the United States of Inc.: Corporations become nation-states in Silicon Valley’s latest utopian management scheme 2015-07-04T04:00:00Z You tweeted, “An emerging view, alternate to Darwin’s random mutations & natural selection is that consciousness may be the driver of complexity/evolution.” Deepak Chopra Has Never Been Sick 2019-10-17T04:00:00Z Your risk of carrying the mutation jumps from 1:800 to 1: 2 if your sister, mother or daughter tests positive. ‘I was not willing to die for my breasts': the young women opting for mastectomies 2018-05-12T04:00:00Z “From creation to collecting to production to politics, everything is in mutation, transformation at Luma,” Hoffmann said in an interview at her home in London a week before the opening. A Space for Cultivating Creativity, 13 Years in the Making 2021-06-25T04:00:00Z Researchers found that a toxin secreted by a particular strain of the microbe E coli creates distinct mutations in DNA, which contribute to an estimated one in 20 bowel cancers in Britain. Common toxin made in gut can cause bowel cancer, scientists find 2020-02-27T05:00:00Z Scientists will be concerned if more extensive mutations in the spike protein arise, not only because they may alter how the virus behaves. Scientists concerned that coronavirus is adapting to humans 2020-05-10T04:00:00Z The creature’s orange coloring is caused by a genetic mutation, the Cambridge Chronicle reports, only occurring in about "1 in 30 million lobsters." Restaurant receives '1 in 30 million' orange lobster, plans to donate to aquarium 2020-06-11T04:00:00Z It is constantly changing to acquire and shed mutations, at the same time gaining and losing virulence and shifting host adaptability. Spillover: Animal Infections and the Next Human Pandemic by David Quammen – review 2012-10-11T07:00:01Z And it only takes a single genetic mutation for a bacteria strain to render the antibiotic useless. The ‘superantibiotics’ that could save us from bacteria apocalypse 2017-10-23T04:00:00Z Other, newer emotions are unnamable: “There was no specific word for the feeling one had of simultaneous stagnation and mutation.” Reclaiming the Past in the Internet’s ‘Infinite Present’ 2018-01-19T05:00:00Z These mutations however, differ patient to patient, so it is difficult to pinpoint the exact mutation that red flags DNA as cancer. Medical breakthrough: New blood test could be a quick accurate way to detect solid cancers 2014-04-07T16:00:00Z There's a shapeshift or mutation on nearly every page, but a favourite of mine is Echo and Narcissus, who turn into the disembodied voice and woodland flower they lend their names to. Ch-ch-changes 2010-07-29T11:27:00Z While previous studies have shown that mutations in the genes that encode epigenetic factors can affect an individual's cancer susceptibility, little is known about how the levels of these factors impact cancer progression. AI model can help predict survival outcomes for patients with cancer 2023-11-16T05:00:00Z Using computational mapping techniques and plant experiments, the team in the group of Dr Balk have identified the exact mutations and their locations on the pea genome. Genetic discovery promises high-iron vegetables and cereals 2023-11-15T05:00:00Z In people with thalassemia, the genetic mutation can cause severe anemia. The world’s first gene therapy for sickle cell and thalassemia has been approved 2023-11-16T05:00:00Z In people with thalassemia, the genetic mutation can cause severe anemia and patients typically require blood transfusions every few weeks, and injections and medicines for their entire life. UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia 2023-11-16T05:00:00Z "People with these breast cancer mutations, their cancers rely on polymerase theta's repair pathway to keep the tumors alive and repair DNA damage in the cancerous tissue," said Stroik, a postdoctoral researcher in Ramsden's lab. Scientists piece together DNA repair pathway implicated in breast, ovarian, and prostate cancers 2023-11-15T05:00:00Z Furthermore, knowledge of the three-dimensional structure enabled the researchers to introduce targeted mutations in the L-Cry protein to further characterize its functioning as a photoreceptor. How marine bristle worms use a special protein to distinguish between sunlight and moonlight 2023-11-13T05:00:00Z The identified mutations are valuable because they maintain high levels of iron accumulation but not so much that the iron becomes very toxic to the plant. Genetic discovery promises high-iron vegetables and cereals 2023-11-15T05:00:00Z He spoke of revenge and punishment for the Hamas attacks and said that Jews were a “unique mutation,” a people whose religious and national identity were one. West Bank violence is growing. Will it open another front in the Israel-Hamas war? 2023-11-13T05:00:00Z Two of the trial’s ten participants, nearly all born with various gene mutations resulting in high cholesterol levels, had a heart attack or cardiac arrest, in one case possibly related to the treatment. Base editing, a new form of gene therapy, sharply lowers bad cholesterol in clinical trial 2023-11-11T05:00:00Z The research includes analysis of evolutionary data to determine which mutations in phage and bacteria can lead to infection and resistance. Bacteria-virus arms race provides rare window into rapid and complex evolution 2023-11-09T05:00:00Z Somewhat ironically, with their high turnover and mutation rates, helper viruses and their satellites turn out to be evolutionary hot spots for antiviral weaponry. Vampire viruses prey on other viruses to replicate themselves 2023-11-09T05:00:00Z These mutations have been at the centre of a long-standing mystery. Genetic discovery promises high-iron vegetables and cereals 2023-11-15T05:00:00Z And we’ve introduced some mutations that affect the development of that process. Small Collections of Cells Determine How a Body Takes Its Shape 2023-11-09T05:00:00Z Based on how quickly the lice reproduce and accumulate the genetic mutations that lead to microsatellites, the researchers could estimate when the lice of Indigenous Americans might have hybridized with European lice. Lice DNA records the moment Europeans colonized the Americas 2023-11-07T05:00:00Z Changes in this information, called mutations, may ruin the function of the affected proteins. Epigenetic changes are paramount in cancer progression 2023-11-06T05:00:00Z Precision oncology specifies treatment based on the exact genetic mutations that drive the cancer in the first place. Precision Cancer Drugs Glitter with Promise—If You Can Get Them 2023-11-03T04:00:00Z Because of the large size of the pea genome, researchers had not been able to find the mutations which cause iron accumulation. Genetic discovery promises high-iron vegetables and cereals 2023-11-15T05:00:00Z I think sometimes mutations in development work like that. Small Collections of Cells Determine How a Body Takes Its Shape 2023-11-09T05:00:00Z Over time, small changes, mutations, can occur in both the gene and pseudogen. New Nijmegen method reveals hidden genetic variations 2023-11-01T04:00:00Z This covers virtually all gene mutations, gene accessibility and its consequences. Epigenetic changes are paramount in cancer progression 2023-11-06T05:00:00Z Though this approach is important to weed out shifty cancers that have evolved their way past a drug, it doesn’t address mutations in other cases that have yet to be targeted at all. Precision Cancer Drugs Glitter with Promise—If You Can Get Them 2023-11-03T04:00:00Z The two high iron mutations at the centre of this longstanding genetic puzzle were created in the 1990s by two different research groups, in Germany and the USA. Genetic discovery promises high-iron vegetables and cereals 2023-11-15T05:00:00Z It is already known that changes, mutations, in parts of DNA that do not contain genes can increase the risk of cancer and affect how genes function. DNA organization influences the growth of deadly brain tumors in response to neuronal signals 2023-10-31T04:00:00Z A mutation found may originate from the pseudogen and have no meaning. New Nijmegen method reveals hidden genetic variations 2023-11-01T04:00:00Z Deafness due to mutations in otorferlin’s gene is rare— it explains up to 8% of cases of inherited deafness—but the results offer hope for treating other genetic forms of deafness. News at a glance: Avian flu, a gene-therapy setback, and an opera about a fraudulent researcher 2023-11-01T04:00:00Z "Our goal is to demonstrate in a living test animal that this swap leads to fewer mutations and fewer resulting tumors, and those experiments are being planned." First mice engineered to survive COVID-19 like young, healthy humans 2023-11-01T04:00:00Z In 2008, John Speakman, an eminent British biologist, coined the “drifty gene” hypothesis: As human survival came to depend less on escaping predators, random gene mutations allowed our upper weight limits to drift higher. Bariatric Surgery at 16 2023-10-31T04:00:00Z The team has ruled out Neanderthal heritage, since these populations do not have this mutation. The genetic heritage of the Denisovans may have left its mark on our mental health 2023-10-30T04:00:00Z If you add that mutation to the normal gene, you would make a wrong diagnosis. New Nijmegen method reveals hidden genetic variations 2023-11-01T04:00:00Z With nearly double the number of mutations on the spike protein than other strains, Pirola has a stronger ability to bind to our cells and is thus more infectious. Has the winter COVID variant arrived? Here's why experts are closely monitoring the JN.1 strain 2023-10-29T04:00:00Z Those trademark points stem from a genetic mutation known as the Himalayan gene, which was discovered in the breed in 2005. How Siamese cats change their colors 2023-10-27T04:00:00Z A small number of children with severe obesity are born with leptin deficiency, a gene mutation identified by Sadaf Farooqi, a professor at the University of Cambridge’s Institute of Metabolic Science. Bariatric Surgery at 16 2023-10-31T04:00:00Z A genetic mutation causes the cells to become crescent-shaped, which can block blood flow and cause excruciating pain, organ damage, stroke and other problems. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z Psoriasis -- a chronic skin condition -- is not caused or spread by spontaneous genetic mutations in the skin, new research suggests. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z In 2007, Bayer began to breed a short corn for the region’s farmers by selecting varieties with a mutation that limits transport of another growth hormone, auxin, in the stalk. How shrinking corn could help farmers—and the environment 2023-10-25T04:00:00Z The Himalayan mutation naturally occurs in South Asian domestic cats, says Leslie Lyons, a feline geneticist at the University of Missouri who first identified the mutation in Siamese cats. How Siamese cats change their colors 2023-10-27T04:00:00Z Though it’s rare, Farooqi cites the extreme effect of this mutation as a clear illustration of the “very strong” impact that biology has upon appetite. Bariatric Surgery at 16 2023-10-31T04:00:00Z These mutations accumulate in the gene pool, primarily affected by a population's size and practices like marrying within a small community, according to researchers. Study suggests that having common ancestors can jeopardize fertility for generations 2023-10-25T04:00:00Z Confirming that psoriasis is not caused by any somatic mutations enables researchers to continue to explore other avenues. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z But it also indicates that genetic mutations are at the most fundamental level not just random events, as Darwin’s theory suggests. Do we live in a computer simulation like in The Matrix? My proposed new law of physics suggests so 2023-10-25T04:00:00Z Mixed breeds can also carry the genetic mutation. How Siamese cats change their colors 2023-10-27T04:00:00Z "We should know a patient's Fas status -- particularly the mutations around the discovered epitope -- before even considering giving them CAR T," Tushir-Singh said. Researchers identify 'switch' to activate cancer cell death 2023-10-23T04:00:00Z But much of the information about the effects of a population's mutation load is based on genetic theory, with limited direct evidence concerning the effects on evolutionary fitness, or fertility. Study suggests that having common ancestors can jeopardize fertility for generations 2023-10-25T04:00:00Z Over time, all cells in our bodies will accumulate mutations, known as somatic mutations. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z Instead, genetic mutations take place according to the second law of infodynamics, in such a way that the genome’s information entropy is always minimized. Do we live in a computer simulation like in The Matrix? My proposed new law of physics suggests so 2023-10-25T04:00:00Z Domestic rats, color-pointed gerbils, and American minks can also carry the mutation. How Siamese cats change their colors 2023-10-27T04:00:00Z "Antimicrobial resistance can occur when microorganisms acquire genetic information, either by mutation, recombination or transfer of antibiotic resistance genes from the bacterial gene pool," said Professor Erica Donner from the University of South Australia. How to slow the spread of deadly 'superbugs' 2023-10-23T04:00:00Z Previous studies have examined many proteins comprising the synaptonemal complex, how they interact with each other, and have identified various mutations linked to male infertility. Why do some men not produce sperm? 2023-10-20T04:00:00Z While some of these mutations can lead to cancer, many are harmless. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z Under atovaquone treatment, parasites with this mutation will come to dominate the infection. Potential for injectable 'chemical vaccine' for malaria using atovaquone 2023-10-20T04:00:00Z In 2021 the journal Gene reported a dachshund with a different mutation on the same Himalayan gene that produced Siamese-type coloration, a rare occurrence in dogs, Lyons says. How Siamese cats change their colors 2023-10-27T04:00:00Z For tens of thousands of years, evolution shaped tomatoes through natural mutations. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z Modeling different mutations in a potentially crucial region in the human protein enabled the team to predict which of these might disrupt protein function. Why do some men not produce sperm? 2023-10-20T04:00:00Z When a mutation gives the cell an advantage over its neighbours, it is known as a driver mutation, and this allows the mutated cells to grow and spread. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z To restore its function, the research team utilized a technique called error-prone polymerase chain reaction to introduce random mutations in the H3R gene. Restoring the function of a human cell surface protein in yeast cells 2023-10-19T04:00:00Z "Each species has its own mutation in the same gene, but then have been bred to have the specific coloration," she says. How Siamese cats change their colors 2023-10-27T04:00:00Z They found the SlCLV3 mutations produced more predictable effects when certain other mutations were also present. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z Just a single mutation, predicted from the modeling experiments, was verified as the culprit of infertility in mice. Why do some men not produce sperm? 2023-10-20T04:00:00Z Recently, research has begun to explore the possibility of driver mutations causing non-cancerous diseases by impacting the function of the tissue or influencing the spread of disease through the body1. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z In this respect, substance use coercion is a mutation of the odious "pickup artist" movement, the point at which the target has been fully undermined and psychologically manipulated into submission. More than peer pressure, coercing people through drug use is on the rise. Here's how we can fight it 2023-10-19T04:00:00Z While there’s no overarching advantage or disadvantage to the mutation in these domestic animals, Lyons says, it “does come with some health concerns, too,” including eye issues. How Siamese cats change their colors 2023-10-27T04:00:00Z Remarkably, the most beneficial effect involved two mutations that arose millennia ago and were central in tomato domestication. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z For some time, they were a small outpost, in which random mutations would make larger differences in the population -- more of what's called "genetic drift" -- as the 1800s became the 1900s. 200-year-old DNA helps map tiny fly's genetic course to new lands, modern times 2023-10-12T04:00:00Z In previous work by Wellcome Sanger Institute scientists, these mutations have been shown to have an impact on diseases such as inflammatory bowel disease2. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z Taken together, the TUG1-RPA-DHX9 interaction is an indispensable mechanism for regulating R-loops in regions that are known to be susceptible to DNA damage and mutations. Brain tumor treatment by targeting TUG1, a gene that controls replication stress 2023-10-12T04:00:00Z The Himalayan mutation causes fur to darken as the cat ages, though any sort of trauma or change to the cat's fur can alter its hues. How Siamese cats change their colors 2023-10-27T04:00:00Z However, individual mutations, whether natural or engineered, don't work alone. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z Bacteria can pick up such defenses through random DNA mutations, or by swapping "resistance genes" with other bacteria via a process called horizontal gene transfer. Dangerous ‘Superbugs’ Are on the Rise. What Can Stop Them? 2023-10-13T04:00:00Z The team identified four new driver mutations that gave skin cells an advantage over their neighbours, all found in both psoriasis patches and other skin tissue. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z In a previous study, EVE allowed researchers to discern disease-causing from benign mutations in genes linked to various conditions, including cancers and heart rhythm disorders. An AI tool that can help forecast viral outbreaks 2023-10-11T04:00:00Z The team extended their findings in mice to human patients harboring mutations in the coding sequence of the MOF gene. Epigenetic regulator MOF drives mitochondrial metabolism 2023-10-09T04:00:00Z Each operates in a sea of thousands of so-called "background" mutations. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z By making these gene transfers, bacteria can quickly spread such mutations to additional bacterial populations in the body and in the environment. Dangerous ‘Superbugs’ Are on the Rise. What Can Stop Them? 2023-10-13T04:00:00Z However, these mutations were found in patients who had been prescribed psoralens along with those who hadn't, suggesting that it could have come from environmental exposure. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z EVEscape outperformed experimental approaches in predicting which of those mutations would be most prevalent. An AI tool that can help forecast viral outbreaks 2023-10-11T04:00:00Z The challenge now, the team says, is to find small mutations in the other ANP32 genes that better ward off the viral polymerase but still allow the proteins to function. In ‘proof of concept,’ CRISPR-engineered chickens shrug off flu 2023-10-10T04:00:00Z And what if just one could dramatically alter the desired outcome of an engineered mutation? You say genome editing, I say natural mutation 2023-10-19T04:00:00Z In rare instances, mutations in the bird flu virus allow it to infect people and cause serious illness. Bird flu: Scientists see gene editing hope for immune chickens 2023-10-10T04:00:00Z They found minimal differences in the types of mutations seen in healthy skin versus psoriasis patches and only a slight increase in the number of mutations. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z Additionally, EVEscape predicted which antibody-based therapies would lose their efficacy as the pandemic progressed and the virus developed mutations to escape these treatments. An AI tool that can help forecast viral outbreaks 2023-10-11T04:00:00Z An analysis of the viruses that grew in the modified birds revealed something more disturbing, however: mutations in their polymerase genes. In ‘proof of concept,’ CRISPR-engineered chickens shrug off flu 2023-10-10T04:00:00Z They then combined those mutations with others in genes that work with SlCLV3. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z By introducing a variety of cysteine-targeted mutations, he hypothesized he could learn more about which cysteines were most relevant to cancer cells. New cancer drug targets uncovered using base editing and chemical proteomics 2023-10-05T04:00:00Z In addition to this, no functional differences were seen between psoriasis and non-psoriasis tissue, suggesting that the condition is not linked to a specific somatic mutation in the skin. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z The researchers first developed EVE, short for evolutionary model of variant effect, in a different context: gene mutations that cause human diseases. An AI tool that can help forecast viral outbreaks 2023-10-11T04:00:00Z Early trials have shown the drug to be effective in treating 3% to 5% of bowel cancers which have a particular gene mutation. Woman's bowel cancer disappears thanks to 'miracle' drug 2023-10-06T04:00:00Z Altogether, they created 46 tomato strains with different combinations of mutations. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z They then tested how well cancer cells with the mutation grew. New cancer drug targets uncovered using base editing and chemical proteomics 2023-10-05T04:00:00Z This is a major problem because it can lead to mutations that cause ouer cells to stop working normally or to become cancerous. Preventing spread of parasitic DNA in our genomes 2023-10-02T04:00:00Z When people get cancer, it typically arises when some of their own cells gain mutations and multiply out of control. Bizarre Cancer Has Been Spreading Among Shellfish for Centuries, Studies Find 2023-10-02T04:00:00Z "I'm just so thankful to Dr Barrington and his team that I got the chance and that he had looked into the mutation and looking at these new therapies," she said. Woman's bowel cancer disappears thanks to 'miracle' drug 2023-10-06T04:00:00Z Mutations in one gene produced predictable changes in tomato size, but mutations in another yielded random outcomes. You say genome editing, I say natural mutation 2023-10-19T04:00:00Z In addition, their work now makes it possible to investigate other disease-related mutations in actin -- an approach that may ultimately contribute to the development of new therapeutic strategies for these diseases. Through the backdoor: How phosphate escapes from actin 2023-09-28T04:00:00Z And widespread use of doxycycline as a preventive measure could — theoretically — contribute to mutations that make bacteria impervious to the drug. U.S. health officials propose using a cheap antibiotic as a ‘morning-after pill’ against STDs 2023-10-02T04:00:00Z His research continues to explore ways for mRNA vaccines to provide more enduring protection against COVID-19 by training the immune system to recognize pieces of the virus that are much less prone to mutation. Scientists whose work on mRNA paved the way for first COVID-19 vaccines win Nobel Prize 2023-10-02T04:00:00Z It is already routinely used to treat endometrial cancer, which has the same gene mutation found in colorectal cancer. Woman's bowel cancer disappears thanks to 'miracle' drug 2023-10-06T04:00:00Z "Once you start making 10, 20 mutations, the probability of having unanticipated results may increase." You say genome editing, I say natural mutation 2023-10-19T04:00:00Z Researchers at the Max Planck Institute for Biological Intelligence studied a genetic mutation in zebrafish that eliminates all connections between retina and brain throughout development. Vision in the brain: Hardwired for action 2023-09-28T04:00:00Z FOP is caused by mutations in the gene ACVR1 which lead to abnormal formation of bone outside of the normal skeleton in soft tissue including muscles, tendons and ligaments throughout the body. Drug trial shows reduced abnormal bone formation in those with fibrodysplasia ossificans progressiva 2023-09-28T04:00:00Z By mixing their genes, they generated a large amount of genetic diversity, a faster mechanism than waiting for new mutations to accumulate slowly. Explosion in fish biodiversity due to genetic recycling 2023-09-29T04:00:00Z A new study of bat embryos in BMC Biology reveals a crucial step in how these once land-bound animals evolved to fly—and it may involve a gene known for detrimental mutations in humans. Mutated Gene That Causes Webbed Limbs in Humans May Have Given Bats Wings 2023-10-01T04:00:00Z Recent scrutiny has focused on pregnancy tests that purport to screen for mutations that can lead to Down syndrome, cystic fibrosis and genetic defects. FDA wants to regulate thousands of lab tests that have long skirted oversight 2023-09-29T04:00:00Z "It is now possible to relate all known mutations to their function, in order to understand their chemical consequences and, as a result, understand the causes of metabolic disorders." A close-up of biological nanomachines: Researchers take a deep look at peroxisomal processes 2023-09-27T04:00:00Z Given that single base-pair mutations ⎯ also known as point mutations ⎯ are responsible for thousands of diseases, the split editor could have broad therapeutic applications. Split gene-editing tool offers greater precision 2023-09-21T04:00:00Z The mutation gives rise to a novel protein structure -- a so-called neoepitope -- that can be recognized as foreign by the patient's immune system. Mutation-specific peptide vaccine against midline gliomas used in patients 2023-09-21T04:00:00Z A mutation in a particular gene called Ripk4 may have enabled the change. Mutated Gene That Causes Webbed Limbs in Humans May Have Given Bats Wings 2023-10-01T04:00:00Z "Studies indicate that the pfkelch13 R561H mutation is increasing, but there still may be a window of opportunity to delay its spread and avert high numbers of treatment failures," Boni said. New strategies reduce treatment failure in malaria by up to 81% 2023-09-21T04:00:00Z Tumors that produce a large number of proteins with easily identifiable mutations are compatible with immunotherapy. Improvements in human genome databases offer a promising future for cancer research 2023-09-21T04:00:00Z "This tool has the potential to correct nearly half of the disease-causing point mutations in our genome," said Hongzhi Zeng, the lead author of the study and a graduate student in the Gao lab. Split gene-editing tool offers greater precision 2023-09-21T04:00:00Z These patients, who could not be enrolled in the trial protocol, suffered from diffuse midline gliomas with H3K27M mutation that progressed after standard therapy. Mutation-specific peptide vaccine against midline gliomas used in patients 2023-09-21T04:00:00Z In humans and laboratory mice, mutations to Ripk4 can alter the skin to create patagiumlike structures and cleft lips, among other issues. Mutated Gene That Causes Webbed Limbs in Humans May Have Given Bats Wings 2023-10-01T04:00:00Z The team modeled the impacts of these strategies on projected treatment failures and the frequency of the R561H mutation within the Plasmodium genome three, five and ten years into the future. New strategies reduce treatment failure in malaria by up to 81% 2023-09-21T04:00:00Z For example, RNA-seq could be used to identify which genes a cancer cell is using to make proteins and identify any mutations in those proteins. Improvements in human genome databases offer a promising future for cancer research 2023-09-21T04:00:00Z Those mutations can alter the virus's behaviour - making it spread faster, for example. What you need to know about Covid as new variant rises 2023-09-23T04:00:00Z In earlier studies, Imhof and his team had discovered that well-nourished fruit flies live longer if their chameau levels are lowered through mutations. Sometimes beneficial, sometimes damaging: The double role of the enzyme chameau 2023-09-20T04:00:00Z A chance mutation might have been the key that opened the sky to bats. Mutated Gene That Causes Webbed Limbs in Humans May Have Given Bats Wings 2023-10-01T04:00:00Z Many of the genetic mutations that directly cause a condition, such as those responsible for cystic fibrosis and sickle-cell disease, tend to change the amino acid sequence of the protein they encode. AI Tool Pinpoints Genetic Mutations That Cause Disease 2023-09-21T04:00:00Z They found that the mutation drives premature skull fusion by inducing the abnormal proliferation of a type of bone-making stem cell -- the DDR2+ stem cell -- that had never been described before. Newly discovered bone stem cell causes premature skull fusion 2023-09-20T04:00:00Z In August 2023, scientists around the world started tracking the spread of yet another version with a large number of mutations. What you need to know about Covid as new variant rises 2023-09-23T04:00:00Z Comprehensive molecular analyses revealed that chameau mutations result in a failure to properly regulate the genes and proteins required for energy storage and expenditure. Sometimes beneficial, sometimes damaging: The double role of the enzyme chameau 2023-09-20T04:00:00Z The contribution of only maternal mtDNA is believed to confer an evolutionary advantage by limiting the risk of accumulations of mtDNA mutations that cause disease in offspring. Mature sperm lack intact mitochondrial DNA 2023-09-18T04:00:00Z A new tool based on the AlphaFold network can accurately predict which mutations in proteins are likely to cause health conditions — a challenge that limits the use of genomics in healthcare. AI Tool Pinpoints Genetic Mutations That Cause Disease 2023-09-21T04:00:00Z Craniosynostosis arises from one of several possible gene mutations, and occurs in about one in 2,500 babies. Newly discovered bone stem cell causes premature skull fusion 2023-09-20T04:00:00Z One in three women who had the FVL gene mutation and three of the medical conditions examined also suffered a blood clotting event. Women given new insight into blood clot risk 2023-09-19T04:00:00Z The researchers believe they have pinpointed 89% of all the key mutations. Google DeepMind AI speeds up search for disease genes 2023-09-19T04:00:00Z Originally a paediatrician, she moved to researching the rare hereditary disorder Gaucher disease, in which fatty substances build up in various organs because of a mutation in the GBA1 gene. Life-Changing Cystic Fibrosis Treatment Wins $3-Million Breakthrough Prize 2023-09-15T04:00:00Z So when researchers and doctors find a missense mutation they’ve never seen before, it can be difficult to know what to make of it. AI Tool Pinpoints Genetic Mutations That Cause Disease 2023-09-21T04:00:00Z In the study, which appears Sept. 20 in Nature, the researchers examined in detail what happens in the skull of mice with one of the most common mutations found in human craniosynostosis. Newly discovered bone stem cell causes premature skull fusion 2023-09-20T04:00:00Z Since 2014, the Netherlands has banned the breeding of Scottish Fold cats, whose ears are bent forward due to a genetic mutation, and Bambino cats, which are short-legged and hairless. Breeder fined for short-snouted bulldogs as Netherlands tackles overbreeding 2023-09-14T04:00:00Z They have classified 0.1% of letter changes, or mutations, as either benign or disease causing. Google DeepMind AI speeds up search for disease genes 2023-09-19T04:00:00Z Nicknamed Pirola, BA.2.86 has more than 30 distinct mutations compared with its predecessors. How evasive and transmissible is the newest omicron offshoot, BA.2.86? 4 questions answered 2023-09-14T04:00:00Z It also does well at spotting problem variants identified in laboratory experiments that measure the effects of thousands of mutations at once. AI Tool Pinpoints Genetic Mutations That Cause Disease 2023-09-21T04:00:00Z Experts believe this formulation will also help protect against newer variants, including a rare type called BA.2.86, which has more than 35 distinct mutations in its spike protein, compared with XBB.1.5. CDC Recommends Updated COVID Boosters for Everyone This Fall 2023-09-12T04:00:00Z Scientists, including Ferguson, believe the solid coloring is likely due to one or more genetic mutations that haven’t yet been identified. Another rare spotless giraffe found—the first ever seen in the wild 2023-09-12T04:00:00Z The Omicron offshoot carries more than 35 mutations in key portions of the virus compared with XBB.1.5, the dominant variant through most of 2023 and the target of the updated shots. Moderna says updated COVID vaccine is effective against newer variant 2023-09-06T04:00:00Z A preliminary study reported that BA.2.86 features 33 distinct spike mutations when compared to its precursor, BA.2. How evasive and transmissible is the newest omicron offshoot, BA.2.86? 4 questions answered 2023-09-14T04:00:00Z Computational predictions currently have a minimal role in diagnosing genetic diseases, says Marsh, and recommendations from physicians’ groups say that these tools should provide only supporting evidence in linking a mutation to a disease. AI Tool Pinpoints Genetic Mutations That Cause Disease 2023-09-21T04:00:00Z BA.2.86 is not yet considered a variant of concern but it has a high number of mutations. Winter Covid and flu jabs begin as plans discussed for risk groups 2023-09-04T04:00:00Z Recently a new variant called BA.2.86 was detected, and it has more than 35 new mutations, compared with XBB.1.5. When Will the Next COVID Vaccine Be Available, and Who Should Get It? 2023-09-01T04:00:00Z It has an astonishing 35 new mutations compared with XBB.1.5, Here’s where L.A. County is seeing COVID outbreaks this summer 2023-09-01T04:00:00Z Among the new mutations that BA.2.86 carries, 14 reside within an area of the spike protein called the receptor binding domain, which binds to the receptors on host cells. How evasive and transmissible is the newest omicron offshoot, BA.2.86? 4 questions answered 2023-09-14T04:00:00Z It elaborated near the end of the assessment that “the large number of mutations in this variant raises concerns of greater escape from existing immunity from vaccines and previous infections compared with other recent variants.” NOT REAL NEWS: A look at what didn’t happen this week 2023-09-01T04:00:00Z But scientists want to monitor it, because it has a large number of mutations and it is not clear how rapidly it is spreading. Winter Covid and flu jabs begin as plans discussed for risk groups 2023-09-04T04:00:00Z Scientists know approximately how long it takes for mutations to pile up in our genes, and by looking at variations in genes across different populations, they can estimate how long ago those groups diverged. Human ancestors may have survived a brush with extinction 900,000 years ago 2023-08-30T04:00:00Z The BA.2.86 variant is not yet considered a variant of concern but it has a high number of mutations. Covid: New BA.2.86 variant found in Scotland 2023-08-31T04:00:00Z While mutations can be cause for concern, it's important to remember that not all mutations lead to increased danger. How evasive and transmissible is the newest omicron offshoot, BA.2.86? 4 questions answered 2023-09-14T04:00:00Z Sanders’s team had previously tied the mutation to mtDNA damage in brain tissue. A blood test for Parkinson’s disease? 2023-08-29T04:00:00Z Experts believe the animal's rare coloring is probably due to a gene mutation. Reticulated Giraffe Born At Tennessee Zoo Has No Spots 2023-08-30T04:00:00Z Because identifying flies with desirable mutations is time intensive and can become a bottleneck, BugEra developed a technique that allows DNA extraction and screening of hundreds of individuals per day. How Gene-Edited Insects Are Providing Food, Fuel and Waste Disposal 2023-08-28T04:00:00Z The virus has mutated thousands of times and will continue to do so, but not every mutation is advantageous or makes things worse for humans. The names for COVID variants are a confusing alphabet soup. Here's why it got so muddled 2023-08-28T04:00:00Z The animal’s rare coloring is likely due to some sort of mutation in one or more genes, she says. Extremely rare spotless giraffe born in U.S. zoo 2023-08-23T04:00:00Z It is a descendant of the omicron variant XBB.1.9.2 and has one notable mutation that helps it to evade antibodies developed by the immune system in response to earlier variants and vaccines. What to Know About the New Dominant COVID Variant 2023-08-21T04:00:00Z After Omicron appeared, SARS-CoV-2 evolution began to follow a somewhat predictable course: successful new variants emerged from circulating lineages after gaining a few key mutations that enabled their spread. Why a Highly Mutated Coronavirus Variant Has Scientists on Alert 2023-08-21T04:00:00Z While it shares about 30 of the same spike mutations, which allow the virus to attach itself more easily to receptors in cells, it also has 30 unique ones. A new COVID variant nicknamed "Pirola" is raising global alarm but don't freak out yet 2023-08-20T04:00:00Z None of its mutations have been genetically different enough or spread enough severe illness to warrant moving on from Omicron to the next Greek letter, Pi, according to the WHO's system. The names for COVID variants are a confusing alphabet soup. Here's why it got so muddled 2023-08-28T04:00:00Z Scientists are keeping an eye on the new lineage, named BA.2.86, because it has 36 mutations that distinguish it from the currently-dominant XBB.1.5 variant. Eris, BA.2.86: Do I need to worry about COVID again? 2023-08-19T04:00:00Z That mutation “may mean that more people are susceptible because the virus can escape a little bit more of that immunity,” Pekosz said. What to Know About the New Dominant COVID Variant 2023-08-21T04:00:00Z The World Health Organization classified EG.5 as a "variant of interest", indicating that it should be more closely watched than others because of mutations that might make it more contagious or severe. Pfizer's updated COVID shot effective against 'Eris' variant in mice study 2023-08-17T04:00:00Z Specifically, there are about 57 mutations of the spike protein, which potentially increase its ability to cause infection, said Dr. Rajendram Rajnarayanan, of the New York Institute of Technology campus in Jonesboro, Arkansas. A new COVID variant nicknamed "Pirola" is raising global alarm but don't freak out yet 2023-08-20T04:00:00Z But large-scale DNA sequencing over the past decade or so has toppled that view, showing that human DNA starts to accrue mutations early in embryonic development and continues to change throughout life. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Its many mutations make BA.2.86 "radically different in its structure" compared to earlier variants, Topol said. Eris, BA.2.86: Do I need to worry about COVID again? 2023-08-19T04:00:00Z Experts are more apprehensive about other emerging variants that carry the same immune evading mutation as EG.5, plus another mutation that makes the virus more transmissible. What to Know About the New Dominant COVID Variant 2023-08-21T04:00:00Z And mutations in the virus don’t necessarily make it more dangerous. COVID-19 hospitalizations in the US are on the rise again, but not like before 2023-08-08T04:00:00Z Most variants have around 20 to 30 mutations, he added. A new COVID variant nicknamed "Pirola" is raising global alarm but don't freak out yet 2023-08-20T04:00:00Z For decades, the conventional wisdom held that a person’s somatic cells could pick up mutations but that these genome alterations were rare and not a major cause of health problems. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z "The mutations that Eris has wouldn't necessarily be expected to change its severity or symptom profile relative to previously dominant XBB variants." Latest COVID mutation EG.5 seems to be driving a recent surge in cases 2023-08-08T04:00:00Z “No single variant has been that impactful, but the overall accumulation of these mutations is having significant impact.” What to Know About the New Dominant COVID Variant 2023-08-21T04:00:00Z The zoo said while Napo and Inka had very different coat colours, there was "no such species as a black panther" and Inka's dark colouring was a result of a genetic mutation known as melanism. Chester Zoo hopes new black jaguar will help viable population aim 2023-08-04T04:00:00Z "It's picked up a lot of immune evasive mutations that our immune systems haven't seen yet," Johnson told Salon in a phone interview. A new COVID variant nicknamed "Pirola" is raising global alarm but don't freak out yet 2023-08-20T04:00:00Z But scientists now know that our genomes are riddled with somatic mutations. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z One of the differences between EG.5 and its immediate ancestor is that it has another spike protein mutation that effectively allows the virus to attach to receptors in cells even more easily. Latest COVID mutation EG.5 seems to be driving a recent surge in cases 2023-08-08T04:00:00Z Despite the growing number of mutations, it is highly unlikely these new variants will cause a surge akin to the one that occurred in the winter of 2022 with the first omicron variant, Topol said. What to Know About the New Dominant COVID Variant 2023-08-21T04:00:00Z Mrs Watson was told her cancer was a particular mutation and very aggressive, which meant a limited chance of survival. Banbury bowel cancer woman raises £60,000 for treatment 2023-08-03T04:00:00Z Zou compares fine-tuning an AI to gene editing in biology—AI parameters are analogous to DNA base pairs, and fine-tuning is like introducing mutations. Yes, AI Models Can Get Worse over Time 2023-08-02T04:00:00Z A portion can trigger cancers, however, and other mutations may drive different illnesses or cause premature deaths. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Massively resentful of his human-caused mutation, he dedicates himself to wiping humans from the face of the Earth with a gang of really, really ugly mutant associates. Review: 'TMNT: Mutant Mayhem' a funny, worthy trip through the sewers 2023-08-01T04:00:00Z Antonio’s condition is caused by mutations in a gene that helps produce a protein called collagen 7, which holds together both skin and corneas. Gene therapy eyedrops restored a boy’s sight. Similar treatments could help millions 2023-07-24T04:00:00Z The researchers failed to find any known FTD mutations — not surprising, in retrospect, given the limited number of samples. The Vanishing Family 2023-07-20T04:00:00Z According to Arsenoglou, the Association has put together a “task force” of specialist veterinarians to monitor the spread of the mutation as well as to inform both fellow vets and activists of the latest developments. COVID-19 mutation caused far fewer cat deaths than claimed, Cyprus veterinary leader says 2023-07-19T04:00:00Z The brain can also incur damage as neurons and other cells accumulate mutations. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Normally green or brown it is believed occasionally a genetic mutation causes them to turn pink. Amateur photographer snaps pink grasshopper in Lincoln 2023-07-18T04:00:00Z Over the course of this historic pandemic — from pants-on-fire emergency to slow, steady simmer, from the very first virus to its nth mutation — there has been remarkable consistency in who gets sick and dies: As pandemic precautions fall, seniors remain the most likely to die of COVID in U.S. 2023-07-14T04:00:00Z Sure enough, the families had a mutation of the tau protein, which is now understood to be one of three major brain proteins associated with inherited FTD. The Vanishing Family 2023-07-20T04:00:00Z Measures have already been enacted to prevent the export of the mutation through mandatory medical check-ups of all felines destined for adoption abroad. COVID-19 mutation caused far fewer cat deaths than claimed, Cyprus veterinary leader says 2023-07-19T04:00:00Z In addition, researchers estimate that fetal mutations that may modify brain development account for about 3% to 5% of the risk of developing autism spectrum disorder. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z And the researchers concluded that aspartame is not directly making cancerous mutations in people's DNA. Aspartame advice unchanged despite cancer question 2023-07-13T04:00:00Z While most cancers are caused by genetic mutations in DNA that trigger genes in normal cell growth to become oncogenes, skin cancer is caused by excessive sun exposure. Yes, some sunscreens contain cancer-causing chemicals — but the sun is still far more dangerous 2023-07-13T04:00:00Z And their children — all their descendants — might carry the mutation, too. The Vanishing Family 2023-07-20T04:00:00Z Spread through contact with cat feces, neither the virus or its mutation can be passed on to humans. COVID-19 mutation caused far fewer cat deaths than claimed, Cyprus veterinary leader says 2023-07-19T04:00:00Z Studies have also linked mosaic brain mutations to a variety of other neurological disorders, including schizophrenia and Alzheimer’s disease. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z The results revealed a previously unknown degree of similarity in key genetic mutations. Man’s best friend shares man’s worst struggle: Cancer 2023-07-12T04:00:00Z With a genetic predisposition, the inheritable mutations are frequently found in DNA repair genes. Nonsmokers and lung cancer: What to know now | Provided by Providence Swedish 2023-07-10T04:00:00Z They had all inherited, in essence, a coin flip — a 50 percent chance that they carried the mutation. The Vanishing Family 2023-07-20T04:00:00Z Hemophilia is caused by mutations that prevent the production of proteins needed for blood clotting. Gene therapy for severe hemophilia is approved by FDA 2023-06-29T04:00:00Z Plenty of other mysteries about somatic mutations remain—for example, whether certain tissues accumulate more mutations than others. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z |
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