| 单词 | antitumour |
| 例句 | Knowing how CD4 and CD8 T cells are stimulated, and by which type of dendritic cell, is central to understanding and manipulating antitumour immune responses in the clinic2. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z The administration of two antibodies that, respectively, target these two inhibitory proteins is used widely to drive an antitumour immune response2. Pancreatic cancer hidden in plain sight 2020-04-21T04:00:00Z A team including Vedanta’s scientists showed how each strain in isolation could enhance antimicrobial or antitumour immunity in mouse models10. Fighting cancer with microbes 2020-01-28T05:00:00Z One component of the antitumour function of B cells is B-cell activation. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment 2020-01-14T05:00:00Z In people undergoing immunotherapy, a greater longevity of antitumour T cells correlates with a better therapeutic outcome3. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z Despite many publications suggesting that DC1s are crucial for antitumour immune responses in humans, the evidence is still indirect and debated11,12. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Writing in Nature, Wei et al.1 report that depletion of the protein REGNASE-1 extends the survival of antitumour CD8 T cells and enhances their function, enabling the cells to fight cancer more effectively. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z Clinicians are therefore moving ahead with testing microbiome modulation, especially in patients receiving checkpoint-inhibitor drugs designed to rev up the body’s antitumour immune response. Fighting cancer with microbes 2020-01-28T05:00:00Z In addition to these synergistic results, each study highlights a unique role for B cells or TLS in antitumour immunity. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment 2020-01-14T05:00:00Z “We used to like to rank cells as ‘good’ and ‘bad’, in terms of pro- or antitumour, but the system is much more complex, with most cells co-expressing both good and bad programs.” Cellular censuses to guide cancer care 2019-03-25T04:00:00Z However, this difference did not affect the efficiency of the antitumour treatment, suggesting that toxicity due to cytokines is independent of the antitumour effects of this treatment. Adrenaline fuels a cytokine storm during immunotherapy 2018-12-11T05:00:00Z Figure 1 | Boosting T cells to enable a sustained antitumour response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z Finally, targeting T cells to brain tumours is only a first, albeit crucial, step in triggering an effective antitumour T-cell response against glioblastoma. T cells engineered to home in on brain cancer 2018-09-04T04:00:00Z These papers are technologically savvy, use patient populations that are statistically robust and bring B cells and TLS to the forefront of antitumour immunity. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment 2020-01-14T05:00:00Z Once in the tumour, the virus replicates until the tumour cells rupture, while also producing a signalling protein that draws a strong antitumour response from the immune system. Therapeutics: Spoilt for choice : Nature : Nature Research 2017-11-07T05:00:00Z It is generally assumed that the production of cytokines and their role in the activation of immune cells contributes to the efficiency of antitumour immune responses14. Adrenaline fuels a cytokine storm during immunotherapy 2018-12-11T05:00:00Z Therefore, if T cells are REGNASE-1 deficient, they are better equipped to sustain high numbers of cytotoxic CD8 T cells in tumours and produce a prolonged antitumour response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z More than half of the known natural products with antimicrobial, antitumour or antiviral activity are of bacterial origin. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z Current evidence indicates that B cells actually impede antitumour responses in most mouse models of cancer13–15. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment 2020-01-14T05:00:00Z “The immunology is sound and the antitumour effects are pretty significant,” he says. Cancer vaccines: Material breach 2013-12-18T18:51:03.601Z This strategy may be adapted to increase enrolment of patients with tumour types that demonstrate early signals of antitumour activity while excluding those who lack preliminary response. Tumour heterogeneity in the clinic 2013-09-18T17:22:34.247Z By contrast, T cells that express REGNASE-1 produce a short-lived antitumour response that fails to overcome tumour inhibition of the immune response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z An indirect way of preventing antitumour T-cell responses is by the generation of an immunosuppressive environment. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z There are clear biomarkers for B-cell subsets, but linking these subsets to functions in human tumours would allow us to design treatments that optimize specific antitumour activities. New predictors for immunotherapy responses sharpen our view of the tumour microenvironment 2020-01-14T05:00:00Z Hundreds of posters at conferences claim that a gene or protein represents an effective antitumour target, he complains, without adequately showing what type of tumour it's most active in. Translational research: The American way 2011-10-12T17:21:08.897Z In breast cancer, assessment of pro- and antitumour immunity revealed that high macrophage content relative to cytotoxic T-cell content was correlated with a worse outcome than those with a low content. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z |
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