| 单词 | CD8 |
| 例句 | Other macaques were treated with an antibody that depletes the CD8+ T cells, eliminating their role in fighting the infection. Pinpointing HIV immune response 2023-11-01T04:00:00Z The study shows that a significant reduction of glycosylation -- a type of protein modification -- on T cell surfaces correlates with increases in CD8+ immune cells infiltrating tumors. Cancer's sweet Achilles heel 2023-10-25T04:00:00Z "We show in this study that CD8+ T cells indeed engage this metabolic pathway, and that an extensively characterized metabolic enzyme known as isocitrate dehydrogenase plays a central role in the process," said Ho. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Naïve T cells can express one of two different molecules, CD4 or CD8, on their surface, as shown in Figure 33.11, and are accordingly classified as CD4+ or CD8+ cells. Biology for AP Courses 2022-06-09T00:00:00Z An intracellular pathogen is presented by a class I MHC molecule, and CD8 interacts with it. Anatomy and Physiology 2013-06-19T00:00:00Z The newer enforcers belong to a category of T cells distinguished by a different surface protein, CD8. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z But assassins need helpers and for the CD8 cells, the helpers are another group of T cells known as CD4 cells. A Cancer Treatment Makes Leukemia Vanish, but Creates More Mysteries 2022-02-02T05:00:00Z In the absence of IDH2 inhibition, those genes are kept under wraps, bolstering the terminally exhausted CD8+ T cell identity. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Because they assist in binding specificity, the CD4 and CD8 molecules are described as coreceptors. Biology for AP Courses 2022-06-09T00:00:00Z These functional distinctions based on CD4 and CD8 markers are useful in defining the function of each type. Anatomy and Physiology 2013-06-19T00:00:00Z CD8 T cells are best known for killing infected or cancerous cells, but in mice, some of them also suppress misdirected T cells. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z After the CD8 cells did their job, they remained in the blood but, unexpectedly, they turned into CD4 cells. A Cancer Treatment Makes Leukemia Vanish, but Creates More Mysteries 2022-02-02T05:00:00Z Aside from their practical applications, these findings indicate that reductive carboxylation is not required for the proliferation of CD8+ T cells, as it appears to be for rapidly growing cancer cells. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z Immunity brought about by neutralizing antibodies and immunity brought about, say, by CD8+ cells complement each other in mysterious ways. Scientists get serious about mixing and matching COVID-19 vaccines 2021-02-27T05:00:00Z Later, the cells become double positives that express both CD4 and CD8 markers and move from the cortex to the junction between the cortex and medulla. Anatomy and Physiology 2013-06-19T00:00:00Z One obstacle was that humans don’t make the distinctive receptors that mark the subset of CD8 cells in mice. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z The genetic modification involved a subset of T cells known as CD8 cells, which are assumed to be the ones that actually kill the cancer. A Cancer Treatment Makes Leukemia Vanish, but Creates More Mysteries 2022-02-02T05:00:00Z "When CD8+ T cells are prepared for treatments involving adoptive cell transfer, they tend to be relatively exhausted, meaning they have a limited ability to proliferate and die pretty quickly after activation," said Jaccard. Disrupting a core metabolic process in T cells may improve their therapeutic efficacy 2023-09-20T04:00:00Z So, they added lactate to CD8+ T cells isolated from mice and grown in dishes and found that these cells became more active when faced with cancer cells than other T cells. How Exercise Might Affect Immunity to Lower Cancer Risk 2020-11-11T05:00:00Z The immune system’s ‘adaptive’ branch, which targets specific invaders, has three principle components: antibodies, CD4+ T cells and CD8+ T cells. COVID research updates: Good timing might help the immune system to control COVID-19 2020-09-21T04:00:00Z However, some human CD8 T cells flaunt comparable receptors, the KIR proteins. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z At first, the CD8 cells seemed to be acting exactly as was hoped in Dr. June’s study. A Cancer Treatment Makes Leukemia Vanish, but Creates More Mysteries 2022-02-02T05:00:00Z A key feature of the process in which immune cells target cancer is the activation of CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z As for me, while my results came back negative for antibodies, my CD8 T-cell memory was said to be consistent with prior exposure to Sars-CoV2. Taking the T-cell test: Did a choir have Covid in January? 2020-07-18T04:00:00Z If so, then reducing CD4 and CD8 T cells could undermine that response. How does COVID-19 kill? Uncertainty is hampering doctors’ ability to choose treatments 2020-04-08T04:00:00Z In contrast, control mice with a full complement of suppressive CD8 T cells didn’t show evidence of autoimmune diseases after infections. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z The first involves antibody-mediated depletion of CD8+ T cells — immune cells previously shown to act in concert with ART to reduce levels of viral transcription5. Reactivation of latent HIV moves shock-and-kill treatments forward 2020-01-21T05:00:00Z Knowing how CD4 and CD8 T cells are stimulated, and by which type of dendritic cell, is central to understanding and manipulating antitumour immune responses in the clinic2. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z The authors investigated how the level of tumour-infiltrating cytotoxic CD8 T cells varied. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z Writing in Nature, Wei et al.1 report that depletion of the protein REGNASE-1 extends the survival of antitumour CD8 T cells and enhances their function, enabling the cells to fight cancer more effectively. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z How the suppressive CD8 cells distinguish T cells with self-destructive tendencies is one of the mysteries scientists still need to answer. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z Given the vast array of direct and indirect effects resulting from depletion of CD8+ T cells9, it will not be easy to define the precise molecular mechanisms underlying this synergy. Reactivation of latent HIV moves shock-and-kill treatments forward 2020-01-21T05:00:00Z The two types of activated T cell then sequentially or simultaneously recognize antigens on DC1s, and CD4 T cells provide effective ‘help’ to CD8 T cells3,4. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z One set consisted of cytotoxic CD8 T cells that express high levels of cancer-killing molecules but that also express ‘immune-checkpoint’ molecules. Identifying the source of tumour-infiltrating T cells 2019-12-10T05:00:00Z Immunotherapy uses immune cells called T cells to target cancer in the clinic; however, these tumour-killing cytotoxic CD8 T cells are short-lived. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z But in cell culture studies, Li and colleagues found, human CD8 T cells carrying KIR proteins killed the gliadin-detecting helper T cells. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z Much immunotherapy research focuses on CD8 T cells. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z For example, CD4 T cells secrete molecules that directly support CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z In addition to putting genes for the CARs into the killer T cells—which are distinguished by the surface protein CD8—the researchers also modified CD4 T cells. Can an immune strategy used to treat cancer also wipe out HIV infections? 2019-08-07T04:00:00Z Therefore, if T cells are REGNASE-1 deficient, they are better equipped to sustain high numbers of cytotoxic CD8 T cells in tumours and produce a prolonged antitumour response. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z To find out how much protection the cells provide against autoimmunity, Li and her colleagues analyzed genetically altered mice that have 50% to 75% fewer of the suppressive CD8 cells than normal. New class of killer T cells may prevent autoimmune diseases 2022-03-08T05:00:00Z These tumours did not respond to immunotherapy, demonstrating that a successful immune response depends on the presence of neoantigens that trigger responses from both CD4 and CD8 T cells. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z CD4 T cells also induce DC1s to express molecules that further boost the activation of CD8 T cells, a process referred to as licensing. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Regulation of this delicate balance depends mainly on the immune system’s two major types of T cell, which are distinguished by the protein — either CD4 or CD8 — that is expressed on their surface. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z Yet the differentiation of T cells into cytotoxic CD8 T cells impairs successful retention of the potential to form long-lived memory cells. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z To try to identify bacteria that might be responsible for boosting CD8+ IFN-γ+ T cells, the authors transferred the microbiota in faecal samples from healthy humans into mice raised under germ-free conditions. A gut punch fights cancer and infection 2019-01-22T05:00:00Z These results highlight the need for a tumour to express neoantigens that are recognized by both CD4 and CD8 T cells to generate a productive response to immunotherapy. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z Whether the interactions of CD4 and CD8 T cells with DC1s are simultaneous or sequential is debated. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z They are called CD4 T cells and CD8 T cells, respectively. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z These combined effects of REGNASE-1 deficiency enabled CD8 T cells and CAR-T cells used for ACT to accumulate and remain active over time in the cancers targeted in the mouse models. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z These CD8+ IFN-γ+ T cells specifically recognized bacterial antigens found in a mixture of the 11 strains. A gut punch fights cancer and infection 2019-01-22T05:00:00Z CD4 helper T cells alone are not sufficient to drive this iNOS expression in macrophages, and CD8 T cells are also required, suggesting an interplay between these three types of cell. Teamwork by different T-cell types boosts tumour destruction by immunotherapy 2019-10-22T04:00:00Z However, antibody-mediated removal of either CD4 or CD8 T cells during the immune response against the primary tumour, or the memory immune response against the secondary tumours, abolished immune-system control of the secondary tumour. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Figure 1 | A regulatory function for T cells that express the protein CD8. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z Intriguingly, the authors show that, for increased persistence, the REGNASE-1-deficient CD8 T cells need to encounter the tumour protein that they recognize. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z The authors investigated the role of CD8+ IFN-γ+ T cells in anticancer responses. A gut punch fights cancer and infection 2019-01-22T05:00:00Z By exploiting CMV’s ability to vigorously provoke an immune response, CD8+ T cells, which recognize infected cells and remove them, moved in after the initial infection to control SIV. Humanity’s viral stowaway is now a defense against our greatest diseases 2018-12-23T05:00:00Z How do DC1s support the activation of both CD8 and CD4 T cells? A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z The peptides that these CD8 T cells recognize in the body are not yet defined. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z It will be worth testing whether engineering CD8 T cells to delete or express low levels of the gene encoding REGNASE-1 would be feasible as part of the manufacturing process for CAR-T cells. Antitumour T cells stand the test of time 2019-12-10T05:00:00Z Both papers report that vaccination boosted immune responses involving CD8+ T cells and CD4+ T cells that recognized the neoantigens. Immune cells track hard-to-target brain tumours 2018-12-18T05:00:00Z In the following years, contrary to typical behavior, it was discovered that these CD8+ T cells were recognizing a diversity of MHC class I and II proteins. Humanity’s viral stowaway is now a defense against our greatest diseases 2018-12-23T05:00:00Z Using genetic manipulation, Ferris et al. show that expression of the receptor protein CD40 in DC1s is essential for the activation of CD4 T cells, effective priming of CD8 T cells and tumour rejection. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Whether the initial proliferation of these regulatory CD8 T cells also depends on peptides presented to them by CD4 cells, or indeed by other types of immune cell, is unknown. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z However, the authors did detect a high frequency of hypocretin-specific CD8+ T cells in blood samples from a person with narcolepsy type 2 who subsequently developed cataplexy. Put to sleep by immune cells 2018-09-18T04:00:00Z As in vaccine studies in people with melanoma6,7, both glioblastoma trials preferentially elicited neoantigen-specific CD4+ T cells, rather than CD8+ T cells. Immune cells track hard-to-target brain tumours 2018-12-18T05:00:00Z In this case, CD8+ T cells were not following the rules. Humanity’s viral stowaway is now a defense against our greatest diseases 2018-12-23T05:00:00Z This study provides compelling genetic evidence that DC1s support CD4 T cells in providing help for tumour-specific immune responses by CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z These modifications might also increase the strength of binding of peptide–MHC complexes to TCRs, and hence their ability to stimulate regulatory CD8 T cells. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z What are the contributions of CD4+ and CD8+ T cells, and are other immune cells or antibodies involved? Put to sleep by immune cells 2018-09-18T04:00:00Z The team investigated this by comparing gene-expression patterns of CD8+ T cells responding to S. epidermidis with those of other types of T-cell population in the mouse skin that did not respond to the bacterium. Killer T cells show their kinder side 2018-03-25T04:00:00Z Vaccinating against cancer with CMV in mice caused a robust CD8+ T cell response, which both prevented the growth of newly implanted tumor cells and killed off established tumors. Humanity’s viral stowaway is now a defense against our greatest diseases 2018-12-23T05:00:00Z The evidence from the genetic removal of CD40 in DC1s indicates the protein’s role in enabling CD4 T cells to aid the responses of CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Saligrama and colleagues’ approach might prove equally revealing in efforts to define a regulatory lineage of CD8 T cells. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z Response to treatment was associated with CD8+ T-effector cell phenotype and, to an even greater extent, high neoantigen or tumour mutation burden. TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells 2018-02-13T05:00:00Z This was surprising because responding CD8+ T cells would be expected to express genes associated with activation of the pathways involved in killing unwanted cells or in the release of pro-inflammatory signalling molecules. Killer T cells show their kinder side 2018-03-25T04:00:00Z Here we show that mouse TRM precursor cells represent a unique CD8+ T cell subset that is distinct from the precursors of circulating memory cell populations at the levels of gene expression and chromatin accessibility. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z However, the authors did not analyse the details of how CD4 T cells influence and license DC1s to activate CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z Finally, Saligrama et al. observed coordinated mobilization of CD4 and CD8 T cells in people with recent-onset multiple sclerosis, suggesting that their findings in mice might also apply to humans. Regulatory T cells subdue an autoimmune disease 2019-08-06T04:00:00Z PD-L1 on tumor cells is sufficient for immune evasion in immunogenic tumors and inhibits CD8 T cell cytotoxicity. Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth 2017-11-28T05:00:00Z It is possible that, if such an equivalent is found, a human T-cell population might fulfil a similar role to that of the CD8+ T cells observed by Linehan and colleagues. Killer T cells show their kinder side 2018-03-25T04:00:00Z In a mouse model of adoptive T cell therapy for melanoma, Runx3-deficient CD8+ tumour-infiltrating lymphocytes failed to accumulate in tumours, resulting in greater rates of tumour growth and mortality. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z IL-12 protein is a cytokine needed for immune responses by CD8 T cells. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z While the man’s HIV levels initially increased, they then dropped and the activity of certain T-cells, including CD8 “killer” T-cells, rose. Cancer drug offers tantalising hope for HIV cure 2017-11-30T05:00:00Z More evidence of outcome switching has to do with the number of certain types of white blood cells, known as CD3, CD4 and CD8 cells, found in each patient's muscle. Is the FDA Withholding Data about a Controversial Drug to Protect Its Manufacturer? 2017-11-29T05:00:00Z The inflammation-induced IgA+ cells promote the progression to hepatocellular carcinoma by suppressing liver cytotoxic CD8+ T cells that prevent the emergence of this aggressive tumour. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z Skin infection generates non-migratory memory CD8+ TRM cells providing global skin immunity. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Whether, similar to mouse cells, human DC1s are more efficient than DC2s at presenting antigens to CD8 T cells is a matter of debate, with research reported that supports either view10. A dendritic cell multitasks to tackle cancer 2020-08-11T04:00:00Z The man then showed a dramatic reduction in reservoirs of HIV-infected cells and increased activity from CD8 “killer” T-cells, a key immune system attack weapon. Cancer drug offers tantalising hope for HIV cure 2017-11-30T05:00:00Z In the CNS, the infection may also trigger an immune response in which a type of immune cell known as CD8 tries to kill the virus but also damages oligodendrocytes and neurons. Aetiology: Neighbourhood watch : Nature : Nature Research 2016-11-29T05:00:00Z Less mortality but more relapses in experimental allergic encephalomyelitis in CD8-/- mice. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z Resident memory CD8 T cells trigger protective innate and adaptive immune responses. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z CD4 "helpers" guide and regulate the immune response, while CD8 "killers" directly attack and destroy tumor cells. Immune Therapy Makes Headway Against a Lymphoma 2016-09-08T04:00:00Z But the findings did show that the particular CD8 cells identified “are the guys that are doing all the work to kill the tumor,” Dr. Rosenblum noted. Chance Collaboration Yields an Advance in Cancer Treatment 2016-08-15T04:00:00Z They were tested with T cells from individuals cured of leishmaniasis, and shown to be immunogenic and to induce CD4+ and CD8 T cell responses in genetically diverse human populations of different endemic regions. [Research Articles] Modular Multiantigen T Cell Epitope-Enriched DNA Vaccine Against Human Leishmaniasis 2014-04-30T18:55:06.281Z Therapeutic effect was associated with marked distant tumor infiltration with activated CD8 and CD4 effector but not regulatory T cells, and was dependent on CD8 cells, natural killer cells, and type I interferon. [Research Articles] Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy 2014-03-05T19:25:33.877Z In vivo RNA interference screens identify regulators of antiviral CD4+ and CD8+ T cell differentiation. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Antigen-specific CD8÷ T cells play a central role in the adaptive immune response to viral infections and to cancer. [Report] Vaccine Activation of the Nutrient Sensor GCN2 in Dendritic Cells Enhances Antigen Presentation 2014-01-16T18:57:07.575Z Results varied for patients whose CD8 cells fell between 20% and 30%, making them prime candidates, Dr. Daud suggested, for a combination immunotherapy regimen to potentially increase their chances of a response. Chance Collaboration Yields an Advance in Cancer Treatment 2016-08-15T04:00:00Z With the differential electrical counting method, device-based CD4 and CD8 T cell counts closely matched control counts obtained from flow cytometry, over a dynamic range of 40 to 1000 cells/μl. [Research Articles] Microfluidic CD4+ and CD8+ T Lymphocyte Counters for Point-of-Care HIV Diagnostics Using Whole Blood 2013-12-04T22:57:30.972Z The inflammatory effect coincided with distant tumor infiltration with tumor-specific CD4 and CD8 T cells, which was dependent on the identity of the virus-injected tumor. [Research Articles] Localized Oncolytic Virotherapy Overcomes Systemic Tumor Resistance to Immune Checkpoint Blockade Immunotherapy 2014-03-05T19:25:33.877Z The transcription factor Runx3 guards cytotoxic CD8+ effector T cells against deviation towards follicular helper T cell lineage. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z CD8 T cell lines specific for these phosphopeptides recognized and killed both leukemia cell lines and human leukocyte antigen–matched primary leukemia cells ex vivo. [Research Articles] MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia 2013-09-18T18:55:08.247Z This antitumor effect was dependent on CD8 T cells. [Research Articles] Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors 2013-02-13T19:25:06.490Z One important diagnostic in HIV disease management is the absolute count of lymphocytes expressing the CD4 and CD8 receptors. [Research Articles] Microfluidic CD4+ and CD8+ T Lymphocyte Counters for Point-of-Care HIV Diagnostics Using Whole Blood 2013-12-04T22:57:30.972Z These CD8 T induced long-term tolerance effectively without compromising general immunity and graft-versus-tumor activity. [Research Articles] Human CD8+ Regulatory T Cells Inhibit GVHD and Preserve General Immunity in Humanized Mice 2013-01-16T20:25:12.707Z Transcriptional insights into the CD8+ T cell response to infection and memory T cell formation. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Notably, healthy individuals showed robust CD8 T cell responses against many of these phosphopeptides within the circulating memory compartment. [Research Articles] MHC Class I-Associated Phosphopeptides Are the Targets of Memory-like Immunity in Leukemia 2013-09-18T18:55:08.247Z We thus identified a link between the route of vaccination and the induction of a mucosal homing program on induced CD8 T cells that controlled their trafficking. [Research Articles] Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors 2013-02-13T19:25:06.490Z Among them are different T-cell types from the adaptive immune system, such as CD4 helper cells that coordinate immune responses and CD8 killer cells that destroy infected, damaged or abnormal body cells. Immunology: A many layered thing 2012-12-19T18:20:51.857Z But it is still not clear, says van der Burg, whether the response comes from CD8 T cells, which destroy HPV-infected cells, or by CD4 T cells, which help other white blood cells fight infection. Pathology: Three questions 2012-08-29T17:51:27.637Z The molecular signature of tissue resident memory CD8 T cells isolated from the brain. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Past attempts to trigger CD8 responses have targeted particular disease-causing protein subunits. Vaccination: A durable design 2012-08-29T17:51:20.337Z HIV-1–specific CD8 T cell responses in these mice were found to closely resemble those in humans in terms of their specificity, kinetics, and immunodominance. [Research Articles] Rapid Evolution of HIV-1 to Functional CD8+ T Cell Responses in Humanized BLT Mice 2012-07-18T19:25:07.723Z Robust CD8 and CD4 T cell priming and boosting to all vaccine antigens were observed in the absence of autoimmunity. [Research Articles] CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients 2012-05-16T18:55:13.183Z Monkeys inoculated intravenously generated high levels of CD8 T cells in their livers specific to the malaria parasite — a key component of immunity to the disease, Hoffman says. Vaccines: The take-home lesson 2012-04-25T17:21:37.957Z Oral infection drives a distinct population of intestinal resident memory CD8+ T cells with enhanced protective function. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z Instead, an immune cell, CD8 cells, that kills virus-infected cells is the best form of defence. Vaccination: A durable design 2012-08-29T17:51:20.337Z Studies of the attenuated parasite vaccine in rodents indicate the crucial protective role of a certain type of immune cell, CD8 T cells, which detect and destroy hepatocytes infected by the malaria parasite. Perspectives: The missing pieces 2012-04-25T17:21:34.587Z The study, published online last week in The International Journal of Obesity, found that the activity of CD8+ T cells, white blood cells that help fight flu infection, also decreased as body mass index increased. Vital Signs: Study Suggests Obesity Hinders Flu Vaccine 2011-10-31T18:33:36Z But the results of the clinical trial, first presented at a meeting a year ago, showed that the vaccine failed to raise an adequate CD8+ response, and it protected only two people. New Hope for 'Crazy' Malaria Vaccine 2011-09-08T20:05:54Z Epigenetic landscapes reveal transcription factors that regulate CD8+ T cell differentiation. Runx3 programs CD8+ T cell residency in non-lymphoid tissues and tumours 2017-12-05T05:00:00Z A type of immune-system cell called a CD8 or 'killer' T cell may exert selective pressure that allows only weaker versions of the virus to survive in controllers. Vaccines: His best shot 2011-05-25T17:20:33.847Z A functional assay that exploits this ability of CD8 T cells would help identify such antigens. Perspectives: The missing pieces 2012-04-25T17:21:34.587Z Studies suggested that sporozoites achieve this level of protection by activating so-called CD8+ T cells that secrete a molecule called interferon γ in the liver. New Hope for 'Crazy' Malaria Vaccine 2011-09-08T20:05:54Z |
| 随便看 |
英语例句辞典收录了117811条英语例句在线翻译词条，基本涵盖了全部常用单词及词组的例句翻译及用法，是英语学习的有利工具。