| 单词 | blood-brain barrier |
| 例句 | The significance of raclopride is that when it travels through the bloodstream into the brain—crossing the “blood-brain barrier”—it attaches to dopamine. A Deadly Wandering: A Mystery, a Landmark Investigation, and the Astonishing Science of Attention in the Digital Age 2014-09-23T00:00:00Z Turkey contains no more tryptophan than beef, eggs, fish or chicken, and tryptophan has a hard time getting past the blood-brain barrier, so it’s not an effective sleep inducer on its own. Perspective | Apples keep you healthy, carrots help your eyes: What science says about such folk remedies 2019-10-11T04:00:00Z But endorphins don’t cross into the blood-brain barrier, he explains, so the natural euphoria that long-distance runners experience is likely not caused by endorphins, but by the brain’s endocannabinoid system. Runner’s high: the athletes who use marijuana to improve their training 2016-05-02T04:00:00Z Scientists at the Queensland Brain Institute found the noninvasive technique successfully penetrated the blood-brain barrier to deliver a therapeutic antibody to the brain. Alzheimer’s: ultrasound safely delivers drugs to damaged brains of mice 2017-04-04T04:00:00Z Surprisingly, the antibodies seemed able to get from the bloodstream into the brain, something that is normally blocked by membranes that form a “blood-brain barrier”. Does our immune system hold the key to beating Alzheimer’s disease? 2019-03-03T05:00:00Z The blood-brain barrier essentially made the brain into a "sanctuary" for the leukaemia cells. Cancer: The new normal? 2011-01-17T17:35:24Z About halfway there, it became clear that time was of the essence, because the mushrooms were definitely spreading their magic across the old blood-brain barrier. Maybe the Trump years require magic mushrooms 2018-06-23T04:00:00Z The first challenge scientists faced was creating a compound that would get through the blood-brain barrier, without also causing toxic side-effects or damaging healthy structures in the brain. A decade of deadlock over Alzheimer's treatment may be drawing to a close 2016-11-02T04:00:00Z The agency’s funding also rose dramatically for work examining the blood-brain barrier and stroke or pericytes. Misconduct concerns, possible drug risks should stop major stroke trial, whistleblowers say 2023-11-12T05:00:00Z Intriguingly, unlike other parts of the brain, the area postrema is not separated from the bloodstream by the blood-brain barrier. Heart-brain link offers new potential explanation for fainting 2023-11-01T04:00:00Z "The same Saps that the fungus uses to break the blood-brain barrier also break down the amyloid precursor protein into AB-like peptides," Wu said. Fungal infection in the brain produces changes like those seen in Alzheimer's disease 2023-10-16T04:00:00Z The Tsai lab has also previously shown that as more inflammation occurs in the brain, the blood-brain barrier begins to degrade and neurons begin to have difficulty communicating with each other. Decoding the complexity of Alzheimer's disease 2023-09-28T04:00:00Z Insulin is produced in the pancreas, but it can cross the blood-brain barrier and can then target cells in several brain areas to regulate bodily processes. Period Food Cravings Are Real. A New Brain Finding Could Explain Why They Happen 2023-09-21T04:00:00Z He has also linked the blood-brain barrier to Alzheimer’s disease, partly by showing it helps move beta-amyloid proteins, widely viewed as a cause of the disease, out of the brain. Misconduct concerns, possible drug risks should stop major stroke trial, whistleblowers say 2023-11-12T05:00:00Z In addition, it can make the blood-brain barrier leak. Spending time in space can harm the human body 2023-09-21T04:00:00Z Now, a new study shows the ants’ blood-brain barrier plays a crucial role in this decision, regulating how much of one critical hormone seeps into developing ants’ brains by actively breaking it down. What turns an ant into a soldier or a forager? It may be all in their heads 2023-09-14T04:00:00Z It may cause lung problems that affect blood flow or leaks in the blood-brain barrier. Blood Clotting Proteins Might Help Predict Long COVID Brain Fog 2023-09-01T04:00:00Z “Wi-Fi radiation opens your blood-brain barrier, and all these toxins that are in your body can now go into your brain,” he told Rogan. Column: Why Robert F. Kennedy Jr.'s presidential bid is the second coming of Donald Trump 2023-06-21T04:00:00Z Last year, the Journal of Molecular Neuroscience published an analysis of key “influencers” who have explored the role of the blood-brain barrier in mild cognitive impairment—early symptoms of dementia. Misconduct concerns, possible drug risks should stop major stroke trial, whistleblowers say 2023-11-12T05:00:00Z The blood-brain barrier keeps compounds flowing through your circulatory system out of your brain. Spending time in space can harm the human body 2023-09-21T04:00:00Z The findings, published last week in Cell, suggest the blood-brain barrier may play a previously unappreciated role in influencing social behavior in animals, including mammals, the authors argue. What turns an ant into a soldier or a forager? It may be all in their heads 2023-09-14T04:00:00Z “I think it degrades your mitochondria and it opens your blood-brain barrier.” Column: Robert F. Kennedy Jr. is a threat to your health — and our democracy 2023-06-19T04:00:00Z The fungus has to escape the lungs and get across the blood-brain barrier into a place that’s very tightly controlled. How Fungal Meningitis Outbreaks Can Happen after Cosmetic Procedures and Other Surgeries 2023-05-22T04:00:00Z “The physical symptoms are brutal, however once these microbes cross the blood-brain barrier, what it does to the brain cannot really be put into words,” Vandergrift wrote. Body of DJ Jeffrey Vandergrift found in San Francisco Bay a month after he disappeared 2023-03-23T04:00:00Z It can cross the blood-brain barrier and enter neurons, and receptors for the vitamin populate many human brain regions. Vitamin D Supplements Probably Won’t Prevent Mental Illness After All 2023-03-13T04:00:00Z But that protein was present exclusively in cells that made up the ants’ blood-brain barrier. What turns an ant into a soldier or a forager? It may be all in their heads 2023-09-14T04:00:00Z This is partially due to the fact that 11-OH-THC crosses the blood-brain barrier more easily, traversing the protective layer between the blood vessels in the brain and the brain tissue itself. We asked experts why cannabis edibles produce such a different high than smoking 2023-03-04T05:00:00Z Most autopsy studies have not shown the virus crossing the blood-brain barrier, but fragments of viral RNA can pass through and induce an immune reaction that can contribute to brain tissue damage. Opinion | Long covid is a mystery, but more research could help us understand it 2023-02-14T05:00:00Z Higher VEGF-C concentrations are associated with higher levels of immune cells getting into the brain, she says, and “they're not doing their normal function of maintaining the blood-brain barrier; they're distracted and perhaps activated.” Long COVID Now Looks like a Neurological Disease, Helping Doctors to Focus Treatments 2023-02-14T05:00:00Z But that requires getting around the blood-brain barrier, an inherent roadblock designed to keep viruses and other germs that may be circulating in the bloodstream out of the brain. Promising gene therapy delivers treatment directly to brain 2023-01-23T05:00:00Z One previous study in bees showed that juvenile hormone could bypass the insects’ blood-brain barrier and act on the brain. What turns an ant into a soldier or a forager? It may be all in their heads 2023-09-14T04:00:00Z Because the blood-brain barrier closes as children age, the enzyme therapy will eventually stop reaching their brains, which could lead to damage. Enzyme treatment given directly to fetus prevents symptoms of rare genetic disease 2022-11-09T05:00:00Z This particular part of the hypothalamus is located where the blood-brain barrier is somewhat permeable, which allows immune molecules to leak through. When you feel sick, you can thank your brain – it’s helping you heal 2022-10-13T04:00:00Z We know that when you smoke a tobacco product, it’s a very efficient way to deliver nicotine across the blood-brain barrier. Insider Q&A: FDA official on vaping’s “promise or peril” 2022-09-26T04:00:00Z Or tiny particles can cross the blood-brain barrier, wreaking direct damage. A potential connection between dementia and air pollution 2022-09-19T04:00:00Z Such work could lead to a new appreciation for the blood-brain barrier as more than just a passive wall, but rather an active compartment, Glastad says. What turns an ant into a soldier or a forager? It may be all in their heads 2023-09-14T04:00:00Z The enzyme should also reach the brain more readily, as the blood-brain barrier isn’t fully formed early in fetal development. Enzyme treatment given directly to fetus prevents symptoms of rare genetic disease 2022-11-09T05:00:00Z The glowing gold stars are astrocytes: these cells control the permeability of the blood-brain barrier and are named for their starlike shape. See the Top Entries in the Art of Neuroscience Competition 2022-08-26T04:00:00Z Astrocytes also form the blood-brain barrier—a structure that blocks entrance of toxic substances into the brain. Biology for AP Courses 2022-06-09T00:00:00Z The CNS has a privileged blood supply, as suggested by the blood-brain barrier. Anatomy and Physiology 2013-06-19T00:00:00Z The truth is, in the last months of her life, as the ammonia broke through her blood-brain barrier, she began behaving erratically: calling at all hours, confused and paranoid. A Writer Returns to the Grand Canyon, This Time With His Mother’s Ashes 2022-05-12T04:00:00Z This is difficult, however, because the blood-brain barrier prevents most molecules from passing into the brain. First Gene Therapy for Tay-Sachs Disease Successfully Given to Two Children 2022-02-15T05:00:00Z But if we give steroids that cross the blood-brain barrier to hamsters, and they actually shut this inflammation down, it would suggest that this would also work in human beings. COVID Smell Loss and Long COVID Linked to Inflammation 2022-02-07T05:00:00Z However, scientists have long questioned the role of endorphins in the runner's high sensation, in part because endorphins cannot cross into the brain through the blood-brain barrier, which protects the brain from toxins and pathogens. The "runner’s high" may result from molecules called cannabinoids – the body’s own version of THC 2022-01-04T05:00:00Z Astrocytes are important for maintaining the chemical environment around the neuron and are crucial for regulating the blood-brain barrier. Anatomy and Physiology 2013-06-19T00:00:00Z The same protein may be able to whisper its chemical message across the notoriously choosy blood-brain barrier and trigger anti-inflammatory processes in the brain. This Protein Could Boost Brain Function without Exercise 2021-12-08T05:00:00Z It is a reminder that the brain, notwithstanding the blood-brain barrier, is by no means impenetrable. How COVID Might Sow Chaos in the Brain 2021-11-10T05:00:00Z Researchers have found signs that the virus can establish a foothold of sorts on the periphery of the brain, where the protective blood-brain barrier opens up to allow key molecules to slip through. How does COVID-19 change the brain? This scientist is finding out 2021-11-05T04:00:00Z But in that case, the substances would have to be able to pass through the protective and mostly impermeable blood-brain barrier that separates our brains from the rest of our bodies. How exercise may help keep our memory sharp 2021-08-28T04:00:00Z The CNS has a privileged blood supply established by the blood-brain barrier. Anatomy and Physiology 2013-06-19T00:00:00Z The team also found that clusterin readily attached to the cells that form the blood-brain barrier. This Protein Could Boost Brain Function without Exercise 2021-12-08T05:00:00Z These star-shaped cells help maintain several key functions in the central nervous system and maintain the semipermeable boundary known as the blood-brain barrier. Scientists see path for the coronavirus to invade the brain 2021-05-05T04:00:00Z Indeed, researchers hypothesized that, because individuals with Alzheimer's disease and dementia experience damage to the blood-brain barrier, they may be more susceptible to COVID-19 — just as they are to other diseases. People with dementia are twice as likely to contract COVID-19, according to new study 2021-02-09T05:00:00Z Importantly, they also confirmed that irisin flows to and crosses the blood-brain barrier. How exercise may help keep our memory sharp 2021-08-28T04:00:00Z The blood that nourishes the brain and spinal cord is behind the glial-cell–enforced blood-brain barrier, which limits the exchange of material from blood vessels with the interstitial fluid of the nervous tissue. Anatomy and Physiology 2013-06-19T00:00:00Z Studies show that eating protein-rich foods such as milk and turkey on their own actually decreases the ability of tryptophan to cross the blood-brain barrier. How Foods May Affect Our Sleep 2020-12-10T05:00:00Z Those places include the area postrema in the brainstem, which lies outside the blood-brain barrier because its job is to detect toxins and trigger vomiting in response. Scientists see path for the coronavirus to invade the brain 2021-05-05T04:00:00Z There’s something about it — a tenderness, a modesty, a matter-of-factness — that, like a good martini, crosses my blood-brain barrier as soon as I see it. Perspective | This is the painting I’d take home, if I could 2020-12-09T05:00:00Z The blood-brain barrier, which protects the organ from harmful substances, complicates the delivery of any potentially therapeutic compound. Is gene therapy ready to treat some forms of autism? 2020-10-14T04:00:00Z In the case of carbon dioxide, as the concentration of CO2 in the blood increases, it readily diffuses across the blood-brain barrier, where it collects in the extracellular fluid. Anatomy and Physiology 2013-06-19T00:00:00Z Subsequent experiments by the scientists showed that the protein probably does not breach the blood-brain barrier and act directly on the brain, Dr. Villeda says. How Exercise May Bolster the Brain 2020-07-15T04:00:00Z But it doesn’t touch the area known as the blood-brain barrier, where blood vessels and the brain exchange important nutrients, despite social media posts that claim it does. NOT REAL NEWS: A look at what didn’t happen this week 2020-07-10T04:00:00Z The researchers couldn’t find much Gpld1 in the brains of the exercising mice, however—it doesn’t seem to cross the blood-brain barrier. Protein from blood of exercising mice rejuvenates brains of ‘couch potato’ mice 2020-07-09T04:00:00Z The researchers hope opening this blood-brain barrier will help the brain clear toxic proteins. Aiming ultrasound at the brain raises hope of new treatments 2020-06-24T04:00:00Z Those in the brain are part of the blood-brain barrier. Anatomy and Physiology 2013-06-19T00:00:00Z Other scientists think inflammation or defects in the blood-brain barrier may play a critical role. A Harder Look at Alzheimer’s Causes and Treatments 2020-04-29T04:00:00Z This week, Facebook posts viewed more than a million times shared a diagram of the nasopharyngeal swab test next to an anatomical picture of the brain, suggesting the swab disrupts the blood-brain barrier. NOT REAL NEWS: A look at what didn’t happen this week 2020-07-10T04:00:00Z Once in a human or horse host, the virus is thought to cross the blood-brain barrier into the central nervous system, where it triggers the host’s immune system to attack brain tissue. Virus Spread by Shrews Linked to Human Deaths from Mysterious Brain Infections 2020-01-08T05:00:00Z Defended by a vigilant immune system and a web of blood vessels—the blood-brain barrier—designed to keep foreign molecules out, the brain makes cancers such as glioblastoma particularly difficult to treat. The Power of Spheres 2019-12-03T05:00:00Z As blood pools in the nervous tissue and the vasculature is damaged, the blood-brain barrier can break down and allow additional fluid to accumulate in the region, which is known as edema. Anatomy and Physiology 2013-06-19T00:00:00Z The medications are more likely to cross the blood-brain barrier. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z The company’s experimental molecules are engineered to pass through a membrane called the blood-brain barrier, which Ryan Watts, the company’s chief executive, said will allow them to more directly influence the brain. Alzheimer’s research is getting a reboot at small companies focused on the immune system 2019-07-03T04:00:00Z The Enbrel molecule is too large to pass through the “blood-brain barrier’’ and directly target TNF-a in brain tissue, the company said. Pfizer had clues its blockbuster drug could prevent Alzheimer’s. Why didn’t it tell the world? 2019-06-04T04:00:00Z A “blood-brain barrier” chip developed by biotech specialist Emulate will be used to study the semi-permeable brain membrane. 'Organs on chips' set for launch to the International Space Station 2019-04-30T04:00:00Z "These devices would navigate the human vasculature, cross the blood-brain barrier, and precisely autoposition themselves among, or even within brain cells," the study's senior author, Robert Freitas, Jr., said in a statement. Human brains could be connected to the internet in 'next few decades,' scientists predict 2019-04-15T04:00:00Z The blood-brain barrier forms a rather impenetrable citadel around the organ, so getting a drug past it remains a challenge. New Strategies Take On the Worst Cancer--Glioblastoma 2019-03-27T04:00:00Z Pfizer said science does not support using Enbrel to prevent Alzheimer’s, particularly because the molecule is too large to cross the blood-brain barrier. Alzheimer’s research is getting a reboot at small companies focused on the immune system 2019-07-03T04:00:00Z The disease makes the brain more susceptible to infection by weakening the blood-brain barrier, so infection may actually occur after a patient has already gotten Alzheimer’s. Could Alzheimer's Be a Reaction to Infection? 2019-03-13T04:00:00Z The chip containing lung cells will be used to study the effect of pathogens on the lungs, while the “blood-brain barrier” chip will be used to study brain disease. 'Organs on chips' set for launch to the International Space Station 2019-04-30T04:00:00Z The brain is shielded from microbial invasion by the so-called blood-brain barrier. Germs in Your Gut Are Talking to Your Brain. Scientists Want to Know What They’re Saying. 2019-01-28T05:00:00Z Chip models of the lung, the intestine, skin, bone marrow ALS—even the blood-brain barrier—have been tested. New Strategies Take On the Worst Cancer--Glioblastoma 2019-03-27T04:00:00Z “That was surprising that this blood-brain barrier breakdown is occurring independently.” ‘Leaky’ brain could be early sign of Alzheimer’s disease: Study 2019-01-15T05:00:00Z Patients typically are given antimicrobial drugs in extremely high doses in order to break through the body’s protective blood-brain barrier. A Silver Bullet Against the Brain-Eating Amoeba? 2019-01-14T05:00:00Z But to make you drowsy, it has to cross the blood-brain barrier. Perspective | Five myths about turkey 2018-11-15T05:00:00Z In particular, the microbes clustered in and around the ends of astrocytes that encircle blood vessels at the blood-brain barrier. Do gut bacteria make a second home in our brains? 2018-11-09T05:00:00Z Delhi government monitors showed the density of fine pollutants — small enough to evade the body’s natural defences and breach the blood-brain barrier — reached 1,665 in Anand Vihar, a central neighbourhood. Firecrackers from Diwali celebrations shroud Delhi in toxic smog 2018-11-08T05:00:00Z GBM tumor cells essentially crawl away from the main tumor mass and embed themselves deep within the normal brain, often hidden behind a protective barrier known at the blood-brain barrier. Why Is Glioblastoma, the Cancer That Killed John McCain, So Deadly? 2018-08-27T04:00:00Z And the injections don’t cross the blood-brain barrier, which means that they can’t prevent or reverse any brain damage. Parents race against time to try and save their son Easton 2018-07-01T04:00:00Z Banks, W. A. & Robinson, S. M. Minimal penetration of lipopolysaccharide across the murine blood-brain barrier. Innate immune memory in the brain shapes neurological disease hallmarks 2018-04-10T04:00:00Z The scientists then injected some animals with a dye that cannot cross a healthy blood-brain barrier and scanned the living animals’ brains. Hits to the Head May Result in Immediate Brain Damage 2018-01-31T05:00:00Z Simply getting medications inside the brain, past what’s called the blood-brain barrier, is a hurdle. Tiny implant opens way to deliver drugs deep into the brain 2018-01-24T05:00:00Z Q: I read somewhere about a statin that is not fat-soluble and doesn’t cross the blood-brain barrier. Are statins linked to memory problems? 2018-01-21T05:00:00Z Until now, scientists thought it was unlikely that the virus would be able to pass from the blood into the brain because of the protective membrane that surrounds the brain - the blood-brain barrier. Common virus to help fight brain cancer 2018-01-03T05:00:00Z Autopsies of two of these patients revealed a complete breakdown of the blood-brain barrier, a membranous wall that largely separates the content of blood from the central nervous system to protect the brain. Cancer immunotherapy company tries to explain deaths in recent trial 2017-11-16T05:00:00Z “Crossing the blood-brain barrier is not easy. Most drugs do not cross.” Perspective | Keeping Kaisy alive: A mom’s fight against her child’s lethal brain cancer leads to Mexico 2017-08-21T04:00:00Z Because it is a small molecule and can cross the blood-brain barrier, the drug would likely not have to be injected directly into the brain. New drug restores memories in brain-damaged mice 2017-07-10T04:00:00Z Babcock agreed that botulism infection is a highly unlikely cause since the toxin released by the bacteria generally does not cross the protective blood-brain barrier. Otto Warmbier was released by North Korea in a coma. What do we know about his medical state? 2017-06-13T04:00:00Z That is crucial, because only tiny amounts of the proteins, referred to as “biomarkers,” dribble across the blood-brain barrier from the cerebrospinal fluid around the brain, where they would be found in larger quantities. How a protein called ‘NFL’ could help the NFL with brain injuries 2017-03-27T04:00:00Z The blood-brain barrier disruption appears to be “a unique mechanism within this setting,” said Mark Gilbert, Juno’s chief medical officer, who presented the company’s report. Cancer immunotherapy company tries to explain deaths in recent trial 2017-11-16T05:00:00Z He then delivered high volumes of drugs directly to their tumors, circumventing the protective blood-brain barrier. A young boy, a devastating brain tumor and parents who ‘will do anything’ 2017-02-06T05:00:00Z His lab is trying to understand how aminoglycosides cross the blood-labyrinth barrier, which has a similar function to the blood-brain barrier but instead of protecting the brain, it protects the ears from harmful substances. Team of deaf scientists probe hearing loss treatments 2016-11-25T05:00:00Z This happens when certain autoantibodies cross the blood-brain barrier, the body’s natural blocking mechanism for protecting the brain, and attach themselves to specific receptors on brain chemicals that carry information between brain cells. Depression sometimes accompanies autoimmune diseases 2016-10-17T04:00:00Z Surgery carries the risk of harming critical areas of the brain, and many drugs do not pass the blood-brain barrier. Cancer in Retreat on One Front: Fewer Children Are Dying 2016-10-10T04:00:00Z To most effectively attack neurological symptoms, the drug must reach the brain, and cyclodextrin is a large molecule that does not cross the blood-brain barrier. Why are people fighting over a promising treatment for a fatal childhood disease? 2016-10-06T04:00:00Z It feels as if we’ve breached some crucial blood-brain barrier in the body politic. The Conspiracy Theorists’ Election 2016-09-27T04:00:00Z Drugs are often blocked by the blood-brain barrier; surgery carries the risk of damaging tissue responsible for vital functions. In Need of Brain Breakthroughs 2016-09-12T04:00:00Z This is probably because of maternal autoantibodies that cross the fetus’s blood-brain barrier, Diamond says. Depression sometimes accompanies autoimmune diseases 2016-10-17T04:00:00Z One concern, he added, is that by breaching the blood-brain barrier, you may open the door to brain infections. Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z The chemotherapy is so strong that it crosses the blood-brain barrier and eliminates damaged immune cells from the central nervous system, he explained. MS Stem Cell Therapy Succeeds But Poses Risks 2016-06-09T04:00:00Z Known as the blood-brain barrier, it's made up of tightly joined cells that line blood vessels in the brain. Early Alzheimer's Linked to Brain 'Leakage' 2016-05-31T04:00:00Z The Harvard researchers report that a virus, fungus or bacterium gets into the brain, passing through a membrane — the blood-brain barrier — that becomes leaky as people age. Infections are the culprit in Alzheimer’s disease, study suggests 2016-05-25T04:00:00Z A virus, fungus or bacterium gets into the brain, passing through a membrane — the blood-brain barrier — that becomes leaky as people age. Could Alzheimer’s Stem From Infections? It Makes Sense, Experts Say 2016-05-25T04:00:00Z While this blood-brain barrier protects the brain from toxins, "it means a challenge for treating brain diseases and disorders, as 99 percent of potential therapeutic drugs are blocked by it," he said. Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z The Auburn treatment is administered by precision-guided injections through holes in the skull, which succeeded in getting therapy beyond what is called the blood-brain barrier. How rare sheep from biblical times may help kids with a deadly genetic disease 2016-05-23T04:00:00Z Normally, the blood-brain barrier blocks medications and other systemic therapies from getting into the brain. Early Alzheimer's Linked to Brain 'Leakage' 2016-05-31T04:00:00Z “If you take enough, it rushes the gate, and some penetrates the blood-brain barrier,” Dr. O’Connell said. Addicts Who Can’t Find Painkillers Turn to Anti-Diarrhea Drugs 2016-05-10T04:00:00Z The technology's potential to cut through a protective layer known as the blood-brain barrier would make it capable of delivering drugs straight to the brain, tackling a crucial issue in treating such diseases. John Grisham book turns spotlight on futuristic cancer treatment 2016-03-14T04:00:00Z Two minutes of low-intensity ultrasound is enough to open the blood-brain barrier for about six hours and increase the concentration of medication five to seven times, he said. Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z And if Zika is directly harming the brain, how is it crossing the blood-brain barrier? How the Zika virus is probably causing birth defects in children 2016-03-04T05:00:00Z The new study adds to evidence that leaks in the blood-brain barrier are detectable in Alzheimer's patients. Early Alzheimer's Linked to Brain 'Leakage' 2016-05-31T04:00:00Z The researchers said they were surprised to find that the laser therapy penetrated the protective blood-brain barrier. Laser Unlocks Blood-Brain Barrier for Chemotherapy, Study Shows 2016-02-24T05:00:00Z The researchers saw that a particular receptor activated the microglia and directed them to the blood-brain barrier breach. Immune Cells Repair Damage to Blood-Brain Barrier in Mice 2016-01-12T05:00:00Z When the so-called SonoCloud was activated, sound waves opened the blood-brain barrier, letting in more chemotherapy, they said. Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z Some researchers, however, still argue that the CGRP-blocking antibodies must be getting past the blood-brain barrier into the brainstem—even in trace amounts—to be effective. Feature: Will antibodies finally put an end to migraines? 2016-01-07T05:00:00Z That was the only way, Freireich believed, to get the drug past the blood-brain barrier. How to Cure Cancer 2015-12-14T05:00:00Z Since that drug does not cross the blood-brain barrier, she switched to an experimental medication, entrectinib, that does. Research making progress on why young non-smokers get lung cancer 2015-12-05T05:00:00Z The blood-brain barrier prevents harmful substances in the blood from getting into the brain. Immune Cells Repair Damage to Blood-Brain Barrier in Mice 2016-01-12T05:00:00Z "One of the reasons glioblastoma, which is one of the most aggressive forms of brain cancer, is very difficult to treat is because the blood-brain barrier prevents medications from getting across." Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z But because most researchers thought it necessary to target migraines in the brain and antibodies are generally too large to pass through the blood-brain barrier, they tended to dismiss the option, Pons says. Feature: Will antibodies finally put an end to migraines? 2016-01-07T05:00:00Z The Canadian team used tiny gas-filled bubbles, injected into the bloodstream of a patient, to punch temporary holes in the blood-brain barrier. Scientists breach brain barrier to treat sick patient - BBC News 2015-11-10T05:00:00Z But we also looked at that blood-brain barrier and that is partially restored. Asthma drug could rejuvenate ageing brains, study suggests 2015-10-27T04:00:00Z However, these findings suggest that these drugs may impair the repair of the blood-brain barrier after a stroke, and the researchers are currently investigating this possibility. Immune Cells Repair Damage to Blood-Brain Barrier in Mice 2016-01-12T05:00:00Z When activated, sound waves cause tiny beads -- called microbubbles -- to vibrate, temporarily opening the blood-brain barrier. Novel Brain Cancer Treatment Taps Into Sound Waves 2016-06-15T04:00:00Z After all, says Ian Le Guillou of the Alzheimer’s Society, a British charity, the disease is thought to damage the blood-brain barrier, an immunological shield which keeps the brain safe from pathogens and toxins. Fungus, the bogeyman 2015-10-22T04:00:00Z The blood-brain barrier keeps pathogens and toxins away from the central nervous system. Scientists breach brain barrier to treat sick patient - BBC News 2015-11-10T05:00:00Z They are large molecules, too big to pass through the blood-brain barrier. Homing In on the Source of Runner's High 2015-10-07T04:00:00Z In experiments with mice, scientists found that immune cells in the brain called microglia are crucial in repairing damage to the blood-brain barrier. Immune Cells Repair Damage to Blood-Brain Barrier in Mice 2016-01-12T05:00:00Z This may mean that the blood-brain barrier prevents DNA in brain tumors from getting into the bloodstream, the authors said. Blood Test May One Day Predict Breast Cancer Relapse 2015-08-26T04:00:00Z He was referring to the fact that the brain is anatomically isolated, guarded by a blood-brain barrier that allows nutrients in but keeps out pathogens and inflammation, the immune system’s typical response to germs. Can the Bacteria in Your Gut Explain Your Mood? 2015-06-23T04:00:00Z When tryptophan passes the blood-brain barrier, it's rapidly converted into serotonin. Why simple carbs are killing your golf game: The Loop 2013-10-16T04:00:00Z Cannabis contains cannabinoid molecules, which are small enough to cross the blood-brain barrier and attach there to receptors, producing a floaty, hey-dude high. Homing In on the Source of Runner's High 2015-10-07T04:00:00Z Sabatine also said that it was difficult to find a mechanism to explain an increase in neurocognitive events, since lipoproteins and monoclonal antibodies don’t cross the blood-brain barrier. Should You Be Worried About The Neurocognitive Side Effects Of The New Cholesterol Drugs? 2015-03-16T04:00:00Z This disrupts the "blood-brain barrier," which protects the brain from germs in the blood, Leinenga said, apparently allowing molecules to enter the brain and activate cells that "eat" amyloid plaque. Ultrasound Used to Attack Alzheimer's-Linked Brain Plaque in Mice 2015-03-11T04:00:00Z When the intestinal barrier was compromised in his model, normally ‘‘beneficial’’ bacteria and the toxins they produce seeped into the bloodstream and raised the possibility they could slip past the blood-brain barrier. Can the Bacteria in Your Gut Explain Your Mood? 2015-06-23T04:00:00Z Safely and temporarily opening the blood-brain barrier is a long-sought goal in medicine. Ultrasound therapies target brain cancers and Alzheimer’s disease 2015-03-11T04:00:00Z Unlike most parts of the brain, the SFO lies outside the blood-brain barrier, meaning it receives significant blood flow. Leading a Mouse to Drink, or Not 2015-02-02T05:00:00Z The waves cause the bubbles to vibrate, temporarily forcing apart the cells of the blood-brain barrier and allowing the medication to infiltrate the brain. Sound Waves Can Heal Brain Disorders 2014-11-15T05:00:00Z Hertz-Picciotto says that in young children, this blood-brain barrier isn't fully formed, which may allow pesticides to reach vulnerable nerve cells just as they are making vital connections to each other. Study Links Pesticide Exposure During Pregnancy to Autism Risk in Kids 2014-06-23T04:00:00Z SCFAs stimulate production of hormones that cross the blood-brain barrier and improve appetite signaling. 12 Foods That Control Your Appetite 2014-06-14T04:00:00Z The premise is that ultrasound causes such bubbles to expand and contract, jostling the cells forming the blood-brain barrier and making it slightly leaky. Ultrasound therapies target brain cancers and Alzheimer’s disease 2015-03-11T04:00:00Z And they worry about other unresolved health issues, such as evidence of cellular damage and the apparent ability of the particles to cross the blood-brain barrier. Silver Too Small to See, but Everywhere You Look 2014-05-23T04:00:00Z Yet when our arteries narrow, the function of the blood-brain barrier may be disrupted, allowing circulating substances to enter the brain. Can Heart Surgery Change a Person's Personality? 2014-03-10T13:00:00Z In their lab studies on rodents the researchers found that the toxin, called epsilon, crossed the blood-brain barrier and killed myelin-producing cells - the typical damage seen in MS. Multiple sclerosis link to food bug 2014-01-29T01:45:54Z Researchers administered a blood test to players to track a protein called S100B that indicates damage to the blood-brain barrier. Is Malcolm Gladwell Right, Should College Football Be Banned? 2013-07-21T22:36:00Z There are test-tube experiments which show it damages DNA and affects the blood-brain barrier. Electrosensitivity: is technology killing us? 2013-03-29T19:00:00Z Lilly researchers developed a genetically engineered antibody that selectively targets insoluble plaques and was able to cross the blood-brain barrier. Lilly tests therapy to rid brain plaques in mice with Alzheimer's 2012-12-05T19:27:14Z Trials with chimpanzees at the time showed it can be taken orally as a pill, is non-toxic and crosses the blood-brain barrier in primate brains, which is vital for an Alzheimer's drug. Why finding new uses for old drugs is a growing business 2012-11-27T18:14:00Z In other words, Big Bird crosses the blood-brain barrier faster than tax rates or entitlement debates. The War on Big Bird: Why Both Parties Tussle Over PBS 2012-10-09T20:50:55Z The qualifier “psychoactive” means that the drug crosses the blood-brain barrier and causes changes in neurochemical function, resulting in amplifying effects on mood, thought, perception and behavior. The Straight Dope on What Bath Salts Do to Your Brain and Why They're Dangerous 2012-06-05T06:38:38Z Calming the cells is difficult, because anti-inflammatory drugs don't easily cross the blood-brain barrier. Nanomaterials Offer Hope for Cerebral Palsy 2012-04-19T14:15:03.623Z “It can be in water, taken up by organisms, stored in fatty tissues and cross the blood-brain barrier,” which prevents most other toxins from entering the brain, he explained. Green Blog: Coastal California Fog Carries Toxic Mercury, Study Finds 2012-03-28T16:58:37Z A well-absorbed form is monomethyl mercury, which binds with proteins and can be transported throughout the body, even across the blood-brain barrier into the brain and through the placenta into a developing fetus. Research shows fog worse than rain in absorbing toxic mercury 2012-03-23T23:29:03Z Mutations in SLC2A1 lead to insufficient glucose getting across the blood-brain barrier, which can cause seizures, learning disabilities, or a condition called microcephaly, which turns a normal brain into a tiny one. How Did Human Brains Get to Be so Big? 2012-02-21T18:15:16.457Z Then follows the second stage of disease as the parasites cross the blood-brain barrier to infect the central nervous system. Bacteria stop sleeping sickness 2012-02-15T00:02:15Z The dendrimers transported the drug across the blood-brain barrier and released it directly into the activated microglia and astrocytes, halting further inflammation and improving motor function. Nanomaterials Offer Hope for Cerebral Palsy 2012-04-19T14:15:03.623Z Now, spurred by genomic research, cancer specialists are beginning to understand the physical and chemical properties that predict which drugs will break through the blood-brain barrier. The Latest Brain Discoveries From Alzheimer's to Autism to Stroke 2011-12-07T15:30:00Z And that’s hard – tryptophan does not passively pass the blood-brain barrier but is imported by a molecular carrier. Myths about myths about Thanksgiving turkey making you sleepy 2011-11-24T02:15:00.247Z Then, when ordinary nicotine molecules enter the system, those antibodies bind to them, making them too large to cross the blood-brain barrier. New Help For Smokers 2011-09-06T11:15:06.590Z They are also found at the blood-brain barrier and as such could be a target for drugs down the road to assist stroke victims and others with brain injuries. Message to Early-Career Scientists: Work to End Third World Diseases 2011-06-28T23:15:00.440Z He and colleagues discovered a reliable way of getting antibody drugs across the blood-brain barrier, a protective fortress that only allows select molecules or nutrients from the bloodstream to enter the brain. Study finds way to get antibody therapies into brain 2011-05-26T00:29:28Z It took advantage of the brain’s own mechanism for getting a necessary nutrient, iron, across the lining of endothelial cells that form the blood-brain barrier. Tricking the Brain Into Taking Its Medicine 2011-05-25T19:35:58Z Melatonin does not require any carriers or transporters to cross the blood-brain barrier. Myths about myths about Thanksgiving turkey making you sleepy 2011-11-24T02:15:00.247Z They are even small enough to slip past the blood-brain barrier and bind to receptors on brain cells, where they trigger a chemical cascade that leads to addiction. New Help For Smokers 2011-09-06T11:15:06.590Z The two serotonin stocks are kept strictly segregated by the blood-brain barrier, however, and are able to perform on entirely independent pathways. Basics: Job Description Grows for Our Utility Hormone 2011-05-02T22:05:21Z When injected into the bloodstream, both drugs “cross the blood-brain barrier very efficiently,” said Dr. Scott Segal, chairman of the department of anesthesiology at Tufts Medical Center in Boston. What?s in a Lethal Injection ?Cocktail?? 2011-04-09T16:06:45Z There’s a big problem with that idea, though: antibodies are too big to cross the blood-brain barrier. Tricking the Brain Into Taking Its Medicine 2011-05-25T19:35:58Z One of the medical challenges with diseases of the brain is getting any treatment to cross the blood-brain barrier. 'Drugs to the brain' breakthrough 2011-03-20T19:25:37Z That made the aminothiazoles look more like cholesterol—which despite its malign everyday reputation is an important component of brains and routinely crosses the blood-brain barrier. Creutzfeldt-Jakob disease: Breaking down the barrier 2011-03-03T10:48:29Z Stuttering problems are neurological, and enzymes are too large to cross the tightly woven blood-brain barrier. Ancient Mutation to Blame for Stuttering ? 2011-02-21T16:15:44Z Endorphins, however, are composed of relatively large molecules, “which are unable to pass the blood-brain barrier,” said Matthew Hill, a postdoctoral fellow at Rockefeller University in New York. Well: Phys Ed: What Really Causes Runner's High? 2011-02-16T05:01:00Z “That someone at Genentech thinks you need to solve the blood-brain barrier problem to deliver neurotherapeutics, that is a stunning advance.” Tricking the Brain Into Taking Its Medicine 2011-05-25T19:35:58Z Scientists at Harvard, the Massachusetts Institute of Technology, Columbia and other institutions are developing ways of injecting the bubbles into the bloodstream and guiding them by ultrasound to the blood-brain barrier. Microbubbles Used to Breach the Blood-Brain Barrier 2011-01-04T16:17:06.967Z But breaching the blood-brain barrier in this way is a crucial step, and one that might be generalised to potential treatments for other brain diseases—Alzheimer’s, for example. Creutzfeldt-Jakob disease: Breaking down the barrier 2011-03-03T10:48:29Z These drugs are small molecules that can cross the blood-brain barrier. Ancient Mutation to Blame for Stuttering ? 2011-02-21T16:15:44Z The work also establishes a timeline: In mice, the blood-brain barrier develops well before birth, researchers from Stanford and the University of California, San Francisco report. Guards of the Blood-Brain Barrier Identified 2010-10-15T14:49:00Z Any would-be cure for Alzheimer’s disease or other brain disorder faces a daunting obstacle: the blood-brain barrier. Tricking the Brain Into Taking Its Medicine 2011-05-25T19:35:58Z Microbubbles are only the latest and most promising in a string of recent projects aimed at solving the blood-brain barrier problem. Microbubbles Used to Breach the Blood-Brain Barrier 2011-01-04T16:17:06.967Z It was among the first shown to broach the blood-brain barrier and reduce levels of beta amyloid in the brain. News Analysis: Failure of Lilly Alzheimer?s Drug Casts Doubt on Anti-Amyloid Efforts 2010-08-18T16:50:00Z This generation of drugs does not cross the blood-brain barrier so would not work against Alzheimer’s. Researchers Find Potential in a New Approach to Alzheimer?s Disease 2010-07-24T03:10:00Z While pericytes were definitely on the short list of key regulators of the blood-brain barrier, many researchers were focusing on astrocytes, the star-shaped brain cells that help the brain’s thinking cells, neurons, do their thing. Guards of the Blood-Brain Barrier Identified 2010-10-15T14:49:00Z Q. Your news release says that tocotrienols, taken orally, cross the blood-brain barrier and that the only way to get tocotrienols into the brain's neurons is through supplementation over time. Can supplement limit stroke damage? 2010-06-07T16:50:00Z The hamsters have hopped off their wheels and are gnawing at the blood-brain barrier, trying to get out of my skull. Eastern Standard Tribe But research suggests that astrocytes don’t develop until after birth, which led some people to erroneously conclude that the blood-brain barrier therefore also doesn’t develop until infancy. Guards of the Blood-Brain Barrier Identified 2010-10-15T14:49:00Z In the future, there may even be genetic tests that tell people how healthy their pericyte population is, says neuroscientist Joan Abbott of the blood-brain barrier group at King's College London. Guards of the Blood-Brain Barrier Identified 2010-10-15T14:49:00Z |
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