| 单词 | acetylcholine |
| 例句 | By this means a precise balance is struck and the body never builds up a dangerous amount of acetylcholine. Silent Spring 1962-09-27T00:00:00Z These acetylcholine receptors are distributed throughout the brain, and are especially involved in the functioning of dopamine in the striatum. Do our genes make us more sensitive? 2013-01-24T22:40:00Z Their research, published in Nature Communications, unveils the existence of traveling waves of the neurochemical acetylcholine in the striatum, a region of the brain responsible for motivating actions and habitual behaviors. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z While beta-amyloid aggregation impacts the production of acetylcholine, the subsequent loss of this chemical messenger further increases Alzheimer's pathology, creating a vicious loop. Researchers reveal link between Alzheimer's and sex hormones 2023-10-17T04:00:00Z Researchers have long thought that our attention span was directed by only one neurotransmitter, acetylcholine, which excites neurons and causes them to fire electrical signals. Scientists find new evidence to explain how we pay attention 2023-09-21T04:00:00Z One of these circuits involves the neurotransmitter acetylcholine, which affects activity in multiple parts of the brain. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z Spinal motor neurons, which synapse on muscle cells, use acetylcholine as their neurotransmitter. Fundamentals of Biology 2015-01-01T00:00:00Z The team led by Goldberg discovered that acetylcholine is also released in the striatum in wave-like patterns. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z Additionally, acetylcholine has been shown to be essential for normal memory and cognition. Researchers reveal link between Alzheimer's and sex hormones 2023-10-17T04:00:00Z They discovered that two types of neurons in the claustrum, which send output signals to different parts of the brain, respond in opposing ways to acetylcholine and GABA. Scientists find new evidence to explain how we pay attention 2023-09-21T04:00:00Z Targeting acetylcholine receptors can change pain responses, but the mechanisms by which naturally produced acetylcholine regulates pain control circuitry in the vIPAG had not been explored. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z These neurons use such neurotransmitters as dopamine, acetylcholine, serotonin and others. Fundamentals of Biology 2015-01-01T00:00:00Z The new study proposes a mathematical mechanism by which simultaneous waves of acetylcholine and dopamine arise, which may represent how this balance is realized. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z Activation of the parasympathetic nervous system causes release of acetylcholine on the target organ. Concepts of Biology 2013-04-25T00:00:00Z Neurons that extend to structures deep in the brain were excited by acetylcholine while neurons that extend to structures on the surface of the brain were inhibited by GABA. Scientists find new evidence to explain how we pay attention 2023-09-21T04:00:00Z One might expect that the body would take advantage of this and release more acetylcholine in a painful scenario, but instead, the researchers saw the opposite effect -- it was being suppressed. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z In skeletal muscle, contraction is stimulated at each cell by nervous impulses that releases acetylcholine at the neuromuscular junction, creating action potentials along the cell membrane. Fundamentals of Biology 2015-01-01T00:00:00Z First description of acetylcholine waves: in the striatum of healthy behaving animals. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z In patients with myasthenia gravis, an autoimmune disease, muscle-cell receptors that induce contraction in response to acetylcholine are targeted by antibodies. Concepts of Biology 2013-04-25T00:00:00Z That means it interferes with the action of the brain neurotransmitter acetylcholine. How good is Nexletol against heart attacks? 2023-03-22T04:00:00Z When the team tested the effects of boosting acetylcholine in mice that had tolerance to opioids, they saw the same long-lasting analgesic effects. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z All skeletal muscle and many smooth muscle contractions are stimulated by the binding of the neurotransmitter acetylcholine. Fundamentals of Biology 2015-01-01T00:00:00Z The research was conducted using state-of-the-art genetic tools and advanced imaging techniques, allowing the team to visualize the acetylcholine waves in awake, behaving animals. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z Hallucinations caused by a suppression or loss of acetylcholine tend to be “formed,” Professor ffytche said, that is concrete and recognizable, usually taking the form of people, objects and landscapes. How Can Tainted Spinach Cause Hallucinations? 2022-12-18T05:00:00Z THC may also interact with other receptors involved in memory as well, such as acetylcholine and serotonin. Does pot really make your memory worse? Here's what the science says 2022-10-17T04:00:00Z That's because the acetylcholine receptor is part of a different pathway than that used by opioids -- the two operate independently, and if tolerance develops in the opioid circuits, acetylcholine's effects are not altered. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z Once released, the acetylcholine stays in the cleft and can continually bind and unbind to postsynaptic receptors. Biology for AP Courses 2022-06-09T00:00:00Z Additionally, imaging techniques were employed to observe the interaction between acetylcholine and dopamine in vitro. A wave theory for a neurochemical balance in the brain 2023-10-30T04:00:00Z Furthermore, hallucinations caused by a lack of acetylcholine are linked to the memory system, so they tend to involve people the sufferer knows or recognizes, he said. How Can Tainted Spinach Cause Hallucinations? 2022-12-18T05:00:00Z Figure 12.18 Ligand-Gated Channels When the ligand, in this case the neurotransmitter acetylcholine, binds to a specific location on the extracellular surface of the channel protein, the pore opens to allow select ions through. Anatomy and Physiology 2013-06-19T00:00:00Z The results of this work point to multiple opportunities to develop new pain-relieving drugs, either by stimulating the release of acetylcholine or targeting ⍺7 receptors. Alternative pain control circuits in the brain produce relief similar to opioids without the downsides 2023-09-20T04:00:00Z Secretion of these hormones is stimulated by acetylcholine release from preganglionic sympathetic fibers innervating the adrenal medulla. Biology for AP Courses 2022-06-09T00:00:00Z Botox limits movement by blocking acetylcholine, the chief neurotransmitter. Will Getting Botox Now Prevent Future Wrinkles? 2022-03-22T04:00:00Z Botox works by blocking the release of acetylcholine, a compound that makes muscles contract. Alan Scott, researcher who pioneered medical uses of Botox, dies at 89 2021-12-21T05:00:00Z Nicotine will bind to the nicotinic receptor and activate it similar to acetylcholine. Anatomy and Physiology 2013-06-19T00:00:00Z “We know that during the daytime there are very specific neurotransmitters like dopamine, serotonin, acetylcholine that really help in promoting wakefulness,” she said. Why it’s hard to fall asleep, and tips to make it easier 2021-12-28T05:00:00Z Nerve impulses traveling down motor neurons cause the release of the acetylcholine from vesicles in the axon terminus into the synapse between the neuron and the muscle fiber. Biology for AP Courses 2022-06-09T00:00:00Z “We know that, during the daytime, there are very specific neurotransmitters like dopamine, serotonin, acetylcholine that really help in promoting wakefulness,” she said. Why it’s hard to fall asleep, and tips to make it easier 2021-12-16T05:00:00Z Found in some drugs, pesticides and chemical nerve agents, cholinesterase inhibitors block the breakdown of a key chemical in the body, acetylcholine, that transmits signals between nerve cells. World Digest: Aug. 28, 2020 2020-08-28T04:00:00Z However, when acetylcholine binds to the muscarinic receptor, of which there are several variants, it might cause depolarization or hyperpolarization of the target cell. Anatomy and Physiology 2013-06-19T00:00:00Z The technique is based on research suggesting that the neurotransmitter acetylcholine causes airway constriction, excess mucus and inflammation in COPD. Research round-up: COPD 2020-05-12T04:00:00Z Actin binding sites are covered by acetylcholine to which the troponin complex is attached. Biology for AP Courses 2022-06-09T00:00:00Z When a type of T cell called a CD4+ T cell is activated by antigen recognition, it secretes acetylcholine in response to the hormone noradrenaline6. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z Researchers have also found that some bacteria can synthesize neurotransmitters, such as dopamine or acetylcholine, as well as precursor chemicals such as tryptophan, which is used to make the mood-regulating chemical serotonin. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z There is also an acetylcholine receptor known as the muscarinic receptor. Anatomy and Physiology 2013-06-19T00:00:00Z TLD is intended to produce a longer-lasting effect than anticholinergic inhalers, which deliver a chemical to block the action of acetylcholine, by disrupting the production of acetylcholine by nerves. Research round-up: COPD 2020-05-12T04:00:00Z In patients with the autoimmune disease myasthenia gravis, muscle cell receptors that induce contraction in response to acetylcholine are targeted by antibodies. Biology for AP Courses 2022-06-09T00:00:00Z A: Japanese researchers noted that eggplant is rich in acetylcholine, a neurotransmitter with an effect on blood pressure. Eggplant might lower high blood pressure 2020-01-29T05:00:00Z All block an enzyme that regulates levels of the neurotransmitter acetylcholine in muscles, causing muscle spasms, difficulty breathing, and sometimes death. Genetic modification could protect soldiers from chemical weapons 2020-01-22T05:00:00Z Both of these receptors are named for drugs that interact with the receptor in addition to acetylcholine. Anatomy and Physiology 2013-06-19T00:00:00Z I understand that it teaches the brain to prefer it to a natural neurotransmitter, acetylcholine, which, among other boons, promotes mental agility. The Art of Dying 2019-12-16T05:00:00Z The body produces antibodies against nerve cells, which prevents the nerve cells from releasing acetylcholine during signal transmissions to muscle. Biology for AP Courses 2022-06-09T00:00:00Z That means it alters the action of a brain chemical called acetylcholine, which is crucial for cognitive function and memory. Breaking down the effects of biotin supplements 2019-11-13T05:00:00Z Current treatments, such as atropine and diazepam, work by blocking acetylcholine receptors, but they must be administered right away and can’t always prevent permanent neurological damage. Genetic modification could protect soldiers from chemical weapons 2020-01-22T05:00:00Z The synaptic end bulbs of the motor neurons secrete acetylcholine, which binds to receptors on the sarcolemma. Anatomy and Physiology 2013-06-19T00:00:00Z Like other nerve agents, the known Novichok agents bind to acetylcholinesterase, an enzyme that dismantles the neurotransmitter acetylcholine after it’s released into synapses. Poison used in recent attack on Russian spy may soon be banned 2019-10-23T04:00:00Z The body produces antibodies against acetylcholine, which prevents acetylcholine from transmitting signals from nerves to muscle. Biology for AP Courses 2022-06-09T00:00:00Z Anticholinergic medications target acetylcholine, an important chemical messenger in the parasympathetic nervous system that dilates blood vessels and regulates muscle contractions, bodily secretions and heart rate, among other functions. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z One possibility might be the release of the neurotransmitter acetylcholine from cells called cholinergic interneurons16,17. Closing in on what motivates motivation 2019-05-21T04:00:00Z The binding of acetylcholine opens ligand-gated ion channels, increasing the movement of cations across the sarcolemma. Anatomy and Physiology 2013-06-19T00:00:00Z Without rapid medical intervention, the buildup of acetylcholine blocks brain signals from reaching muscles that control respiration and maintain blood pressure. Poison used in recent attack on Russian spy may soon be banned 2019-10-23T04:00:00Z The body produces antibodies against receptors in muscle, which prevents acetylcholine from binding and completing nerve signal transmission. Biology for AP Courses 2022-06-09T00:00:00Z In the brain, acetylcholine plays a key role in attention, concentration, and memory formation and consolidation. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z Once inside cells, they inhibit an important enzyme whose normal function is to break down acetylcholine, a neurotransmitter that helps muscles contract. ‘Nanoscavengers’ could protect people from sarin gas, other nerve agents 2019-01-02T05:00:00Z This activates efferent neurons to release acetylcholine at the neuromuscular junctions, producing detrusor contraction and bladder emptying. Anatomy and Physiology 2013-06-19T00:00:00Z Muscarine is a mimic of the neurotransmitting brain chemical acetylcholine, which helps translate electrical impulses into muscle action, among other roles. Magic Mushroom Drug Evolved to Mess with Insect Brains 2018-10-20T04:00:00Z The body produces antibodies against acetylcholine, which prevents acetylcholine from breaking down after signal transmission is complete. Biology for AP Courses 2022-06-09T00:00:00Z Seniors are more susceptible to adverse effects from these medications for several reasons: Their brains process acetylcholine less efficiently. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z When too much acetylcholine builds up, victims experience violent muscle spasms and eventually stop breathing. ‘Nanoscavengers’ could protect people from sarin gas, other nerve agents 2019-01-02T05:00:00Z The lack of muscle tone, known as hypotonicity or flaccidity, may indicate that the LMN is not conducting action potentials that will keep a basal level of acetylcholine in the neuromuscular junction. Anatomy and Physiology 2013-06-19T00:00:00Z The most famous acetylcholine mimic, however, is nicotine. Magic Mushroom Drug Evolved to Mess with Insect Brains 2018-10-20T04:00:00Z The poison form the krait snake’s bungarotoxin binds irreversibly to acetylcholine receptors interfering with acetylcholine binding at the synapse. Biology for AP Courses 2022-06-09T00:00:00Z In the late 1970s, researchers discovered that deficits in an enzyme that synthesizes acetylcholine were present in the brains of people with Alzheimer’s disease. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z That means it interferes with a crucial brain chemical called acetylcholine. Does antidepressant sleep aid cause dementia? 2018-05-06T04:00:00Z They block acetylcholine, a chemical messenger that carries signals across the nervous system. Dementia risk linked to some medicines 2018-04-25T04:00:00Z All nerve agent victims are given atropine, which blocks muscarinic acetylcholine receptors. U.K. attack shines spotlight on deadly nerve agent developed by Soviet scientists 2018-03-19T04:00:00Z This inhibition of the enzyme essentially increases neurotransmission at synapses that release acetylcholine. Biology for AP Courses 2022-06-09T00:00:00Z To various degrees, each of these drugs blocks an important chemical messenger in the brain, acetylcholine. In older adults, some drugs may produce symptoms that imitate dementia 2019-07-26T04:00:00Z The body uses a molecule called acetylcholine to send messages between cells – when an acetylcholine molecule “arrives”, it causes an electrical impulse to be sent. Nerve Agents: What Are They and How Do They Work? 2018-03-09T05:00:00Z In the predictive-coding model, the typical brain, too, starts with a high precision and gradually dials it down, possibly by adjusting the concentrations of chemical messengers such as norepinephrine and acetylcholine. Does autism arise because the brain is continually surprised? 2018-03-09T05:00:00Z “The lower acetylcholine in humans corresponds to our decreased aggression, compared to most other apes. It’s a concert really.” Cocktail of Brain Chemicals May Be a Key to What Makes Us Human 2018-01-24T05:00:00Z Parasympathetic neurons are responsible for releasing norepinephrine on the target organ, whereas sympathetic neurons are responsible for releasing acetylcholine. Biology for AP Courses 2022-06-09T00:00:00Z Humans also had less acetylcholine, a neurochemical linked to dominant and territorial behavior, than gorillas or chimpanzees. Dopamine may have given humans our social edge over other apes 2018-01-22T05:00:00Z As acetylcholine builds up in the synapses, victims may develop chorea and dance ghoulishly before collapsing and writhing in seizures. How to defeat a nerve agent 2018-01-04T05:00:00Z The clincher was that the ill soldiers responded to atropine, which binds to and blocks acetylcholine receptors, reducing the effects of excess levels of the neurotransmitter. Seeking answers for Iran’s chemical weapons victims—before time runs out 2018-01-04T05:00:00Z Also in the mix is the neurotransmitter acetylcholine, higher levels of which are associated with aggression. Cocktail of Brain Chemicals May Be a Key to What Makes Us Human 2018-01-24T05:00:00Z The axons of the preganglionic neurons release acetylcholine on the postganglionic neurons, which are generally located very near the target organs. Biology for AP Courses 2022-06-09T00:00:00Z Epibatidine can't “recognize” the poison frogs' acetylcholine receptor, but acetylcholine can—sparing the frogs the effects of their own toxic brew. Now We Know Why Poison Frogs Don't Poison Themselves 2017-09-28T04:00:00Z Many early efforts sought to relieve memory loss by blocking the degradation of the neurotransmitter acetylcholine. Stop Alzheimer’s before it starts 2017-07-11T04:00:00Z By this means, a precise balance is struck, and the body never builds up a dangerous amount of acetylcholine. Silent Spring—I 2017-01-03T05:00:00Z It acts by blocking an enzyme called cholinesterase, which causes a toxic buildup of acetylcholine, an important protein that carries signals from nerve cells to their targets. A Strong Case Against a Pesticide Does Not Faze E.P.A. Under Trump 2017-05-15T04:00:00Z Effects of acetylcholine release on target organs include slowing of heart rate, lowered blood pressure, and stimulation of digestion. Biology for AP Courses 2022-06-09T00:00:00Z Some poison frogs carry a morphine-like compound called epibatidine, which works just like the compound acetylcholine, which sends messages between nerve cells. Now We Know Why Poison Frogs Don't Poison Themselves 2017-09-28T04:00:00Z The human genome codes for an extra, non-functioning acetylcholine receptor protein not found in other animals. The shock tactics set to shake up immunology 2017-05-02T04:00:00Z These so-called anticholinergic drugs block the action of an important neurotransmitter called acetylcholine that normally binds to these special receptors to signal the glands to work. A Dry Side Effect 2017-04-24T04:00:00Z The rapid breakdown of acetylcholine after it is released stops the signaling action and permits another signal to be transmitted to another neuron, muscle, or gland. Sickness that lasts a lifetime: Survivors of the gas attack in Syria face long-term illness 2017-04-13T04:00:00Z Excitation–contraction coupling transduces the electrical signal of the neuron, via acetylcholine, to an electrical signal on the muscle membrane, which initiates force production. Biology for AP Courses 2022-06-09T00:00:00Z In fact, it works so well it can hijack the role of acetylcholine, wreaking havoc. Now We Know Why Poison Frogs Don't Poison Themselves 2017-09-28T04:00:00Z When stimulated, the T cells release another neurotransmitter, called acetylcholine, which then binds to macrophages in the spleen. The shock tactics set to shake up immunology 2017-05-02T04:00:00Z Drugs working to block 5-HT6 are designed to promote the release of acetylcholine, a neurotransmitter needed for normal cognition. Lundbeck gives up on Alzheimer's drug, rival to Axovant pill 2017-02-08T05:00:00Z Sarin and these insecticides inhibit enzymes that rapidly break down acetylcholine after it is released from a synapse to terminate the signal. Sickness that lasts a lifetime: Survivors of the gas attack in Syria face long-term illness 2017-04-13T04:00:00Z DPH, like many other drugs, affects brain function through the neurochemical acetylcholine. The sleep aid/antihistamine that can cause memory loss 2016-11-20T05:00:00Z After sequencing the DNA of poison frog species that employ epibatidine, Tarvin and her colleagues found that the frogs' own receptors for acetylcholine were ever-so-slightly misshapen, results the team recently published in Science. Now We Know Why Poison Frogs Don't Poison Themselves 2017-09-28T04:00:00Z Cholinergic neurons are found in distinct subcortical regions of the brain and use acetylcholine as a neurotransmitter. The road to restoring neural circuits for the treatment of Alzheimer's disease : Nature : Nature Research 2016-11-08T05:00:00Z The neurons produce acetylcholine, a chemical that helps brain cells transmit information to one another, but its role in controlling appetite wasn’t previously known, researchers said. Brain Cells That May Play a Key Role in Appetite 2016-10-17T04:00:00Z The drugs, known as anticholinergics, stop a chemical called acetylcholine from working properly in the nervous system. Medicines for allergies, colds and other common ailments tied to brain changes 2016-04-21T04:00:00Z Anticholinergic drugs block the neurotransmitter acetylcholine in the brain. The Cold Medicine That's Linked to Cognitive Problems 2016-04-18T04:00:00Z Acetylcholine and epibatidine bind to the nerve receptor at the same place, so if mutations changed the receptor's shape too much, acetylcholine wouldn't be able to do its crucial day-to-day job. Now We Know Why Poison Frogs Don't Poison Themselves 2017-09-28T04:00:00Z Nicotine mimics the neurotransmitter acetylcholine, which affects learning and memory. Smart drugs: A dose of intelligence : Nature : Nature Publishing Group 2016-03-01T05:00:00Z For instance, there is a neurotransmitter in the brain called acetylcholine, which is the main agent in memory formation. The truth about “smart drugs”: They probably won’t make you smart unless you already are 2016-01-26T05:00:00Z These pesticides work by blocking an enzyme called acetylcholinesterase, which breaks down a neurotransmitter called acetylcholine. Third Lion Dies from Poisoning in Kenya 2015-12-09T05:00:00Z These drugs block the substance acetylcholine, which is involved in learning, memory and muscle contractions. For allergy symptoms, steroid sprays may be your best option 2015-09-28T04:00:00Z These subunits lack several residues identified as necessary for the binding of acetylcholine26, so it is unlikely that they function as acetylcholine receptors. The octopus genome and the evolution of cephalopod neural and morphological novelties : Nature : Nature Publishing Group 2015-08-11T04:00:00Z The researchers particularly focused on such drugs that block acetylcholine, a neurotransmitter in the brain associated that effects in both the peripheral and central nervous systems. Study Links Allergy And Depression Medications To Increased Risk For Dementia 2015-01-29T05:00:00Z All of the drugs in question are anticholinergics – meaning they block a neurotransmitter called acetylcholine. Study: Popular Over-The-Counter Drugs May Increase Dementia Risk 2015-01-29T05:00:00Z Her team explained that the anticholinergic class of medications work by blocking a neurochemical called acetylcholine, in both the brain and body. Use of Certain Allergy, Depression Meds Tied to Higher Odds for Dementia 2015-01-26T05:00:00Z Organophosphate pesticides are a class of chemicals called irreversible cholinesterase inhibitors, meaning that they permanently block the enzyme that degrades the neurotransmitter, acetylcholine. Crocodile Bile Expert Suspects Toxic Pesticide In Mozambique Tainted Beer Tragedy 2015-01-14T05:00:00Z A study by researchers from Laval University in Quebec revealed similar findings: Diets high in monounsaturated fats increased the production and release of the neurotransmitter acetylcholine, which is critical for learning and memory. Get the New Skinny on Dietary Fat 2015-01-07T05:00:00Z While persons who suffer from Alzheimer’s disease are generally deficient in acetylcholine, there is no direct evidence at this time that long term use was a direct factor in the development of this neurodegenerative disease. Study Links Allergy And Depression Medications To Increased Risk For Dementia 2015-01-29T05:00:00Z The researchers also considered the effects of chronic fear on acetylcholine -- a neurotransmitter involved in the body's responses to stress that dampens the inflammatory response. Terrorism Fears May Shorten Your Life, Study Finds 2014-12-23T05:00:00Z Low levels of acetylcholine in the brain have been linked to memory problems. Unexpected ways to wake up your brain 2014-10-29T04:00:00Z One theory is that these Lewy bodies interfere with the production of two neurotransmitters, dopamine and acetylcholine. Why Alzheimer's Drugs Keep Failing 2014-07-14T04:00:00Z ACh, acetylcholine. c, Key molecular innovations underlying neural organization in ctenophores. The ctenophore genome and the evolutionary origins of neural systems : Nature : Nature Publishing Group 2014-05-20T04:00:00Z Humans and chimpanzees share high-density innervation for neurotransmitters serotonin, dopamine acetylcholine in the prefrontal cortex. What's Special, Or Not, About Human Brain Anatomy 2014-05-06T19:29:53Z Plus, aging slows production of acetylcholine, a neurotransmitter vital to learning and memory. 7 Tricks to Improve Your Memory 2014-04-08T09:45:49Z The reason sage may have an effect is because it contains a cholinesterase inhibitor, a chemical which prevents the breakdown of the neurotransmitter, acetylcholine. Unexpected ways to wake up your brain 2014-10-29T04:00:00Z As connections between brain cells are lost there are fewer neurotransmitter chemicals, such as dopamine and acetylcholine, available to carry messages from one brain cell to another. Why Alzheimer's Drugs Keep Failing 2014-07-14T04:00:00Z ACh, acetylcholine. c, Key molecular innovations underlying neural organization in ctenophores. The ctenophore genome and the evolutionary origins of neural systems : Nature : Nature Publishing Group 2014-05-20T04:00:00Z Over the course of the 1970s, neuroscientists like Quik learned that the nicotine molecule fits into receptors for the neurotransmitter acetylcholine like a key into a lock. Will a Nicotine Patch Make You Smarter? [Excerpt] 2014-02-09T14:00:00Z With the enzyme blocked, the signaling molecule, acetylcholine, builds up, pushing nerves into a constantly aroused, or “on,” state. Nerve agents most deadly of recognized chemical weapons 2013-08-21T21:39:07Z Eggs are a great source of choline, a necessary building block for the neurotransmitter acetylcholine, which helps you concentrate and recall information. 7 Foods That Boost Your Brainpower 2013-05-20T13:35:36Z They work by delaying the breakdown of the neurotransmitter acetylcholine by inhibiting the enzyme acetylcholinesterase. Why Alzheimer's Drugs Keep Failing 2014-07-14T04:00:00Z The vagus nerve releases a neurotransmitter called acetylcholine that catalyzes increased focus and calmness. Breathing and Your Brain: Five Reasons to Grab the Controls 2013-05-14T04:19:12Z By managing to slip through doors marked “Acetylcholine Only,” nicotine revealed a special family of acetylcholine receptors hitherto unknown. Will a Nicotine Patch Make You Smarter? [Excerpt] 2014-02-09T14:00:00Z This contrasts with some concepts that didn’t seem to need to be animated: Spinning a molecule of acetylcholine in 3D space is fun but doesn’t seem entirely useful. Born Again Textbooks 2013-01-31T14:15:05.437Z The idea is also supported by the fact that during REM sleep acetylcholine is raised back to waking levels, as this promotes the activity of these plasticity-related genes. Sleep On It 2012-11-20T14:45:00.323Z Dopamine and acetylcholine are thought to play an important role in regulating brain functions, such as memory, learning, mood and attention. Why Alzheimer's Drugs Keep Failing 2014-07-14T04:00:00Z A direct benefit of more acetylcholine is a decrease in feelings of anxiety. Breathing and Your Brain: Five Reasons to Grab the Controls 2013-05-14T04:19:12Z It causes depletion of dopamine in the brain stem and depletion of acetylcholine in the cortex due to abnormal protein deposits that are called Lewy bodies, after the scientist who discovered them. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z The alkaloid acts in a similar manner to the brain’s own signaling molecule, acetylcholine. Remember It Well: A New Type of On-Switch for Memory 2012-11-05T19:48:53.437Z In patients with COPD, the new drug competes with acetylcholine, blocking the receptors and preventing the airways from closing up. Therapeutics: Strength in numbers 2012-09-26T17:22:52.530Z Among them: the beginning of shrinkage in the frontal and temporal lobes; the loss of nerve fiber coating; and a decrease in the neurotransmitter acetylcholine. Question Mark: Why Can’t I Remember What This Week’s Question Is? 2012-09-20T17:44:59Z Aricept and several drugs like it work by keeping an enzyme called cholinesterase from breaking down acetylcholine, an important neurotransmitter for memory and thinking that declines as Alzheimer's progresses. New drug for Alzheimer's symptom relief shows promise 2012-07-18T15:30:30Z Functional brakes are chemical compounds such as Lynx1 — a molecule, identified by Hensch and his colleagues, that shifts the balance of excitation and inhibition in the cortex by dampening the effect of the neurotransmitter acetylcholine. Neurodevelopment: Unlocking the brain 2012-07-04T17:20:51.997Z Called anticholinergics, the drugs block the action of the neurotransmitter acetylcholine, sometimes as a direct action, but often as a side effect. The Consumer: Cocktail of Popular Drugs May Cloud Brain 2012-02-27T22:43:46Z Thence they are ingested into the cell, where they disable another protein, SNAP-25, the role of which is to help release a chemical messenger called acetylcholine. Arthritis and botulinum toxin: Something to celebrate 2011-12-08T16:17:05Z The nutrient is a precursor to the brain chemical acetylcholine, which plays a key role in memory and other cognitive functions; low acetylcholine levels are associated with Alzheimer's. Choline-rich diet tied to sharper memory 2011-11-23T22:32:10Z This acetylcholine induced insulin secretion from the cultured islets in a dose-dependent manner. [Editors' Choice] The Nerve of Those {beta} Cells 2011-07-05T19:27:24.540Z The researchers were investigating medicines which affect a chemical in the brain - acetylcholine. Common medicines linked to death 2011-06-24T00:07:16Z Cholinesterase inhibitors increase levels of the brain chemical acetylcholine, which may slow mental decline in Alzheimer's patients. Common drug ineffective in early Alzheimer's-study 2011-04-11T20:30:50Z They then fused the exosomes with targeting proteins from the rabies virus, which binds to acetylcholine receptors in brain cells, so the exosome would target the brain. 'Drugs to the brain' breakthrough 2011-03-20T19:25:37Z It may be possible, for example, to use acetylcholine boosters to increase the effectiveness of brain training programs for staving off senescence and cognitive decline with age. Understanding the Brain's Brake Pedal in Neural Plasticity 2011-02-22T13:15:08.463Z Stimulating this nerve releases chemicals such as acetylcholine and norepinephrine that trigger changes in the brain. Device treatment may silence ringing in the ears 2011-01-12T21:36:52Z The toxin blocks the ability of acetylcholine, one of the body’s chemical neurotransmitters, to control muscle contraction. Remarkable Creatures: Good to Be King in Snake-Eat-Snake World 2010-10-25T19:53:00Z Organophosphates are designed to attack the nervous systems of bugs by affecting message-carrying chemicals called neurotransmitters including acetylcholine, which is important to human brain development. Study links pesticides to attention problems 2010-08-19T07:15:00Z These drugs appear to work by slowing the loss of acetylcholine in the brain, a chemical critical to cognitive function. Best bets to hold off Alzheimer's disease 2010-07-30T23:58:00Z Using pharmacological and molecular labeling studies, Hensch and his colleagues found that Lynx1 works by blocking receptors for the neurotransmitter acetylcholine. Understanding the Brain's Brake Pedal in Neural Plasticity 2011-02-22T13:15:08.463Z And it keeps up the production of acetylcholine and dopamine. The Talents of a Middle-Aged Brain 2010-04-30T17:21:00Z Biochemists have carefully mapped exactly how neurotoxins block the acetylcholine receptor of many species, and they have discovered that the toxins do not bind to the cobra’s receptor. Remarkable Creatures: Good to Be King in Snake-Eat-Snake World 2010-10-25T19:53:00Z In the brain, levamisole may affect the same acetylcholine receptors activated by nicotine, another addictive drug that raises dopamine levels — and another possible clue to levamisole's lure. 2010-01-20T22:35:00Z It inactivates an enzyme which controls the transmission of nerve impulses to muscle, acetylcholine esterase. History of Phosphorus Well, I know that some of them suppress the enzymic action with acetylcholine, which means that the nerves simply act as though their synapses had been shorted through. Damned If You Don't It is a basic building material that the body uses to make acetylcholine, the most generalized neurotransmitter in the body. How and When to Be Your Own Doctor Mutations have altered the snake’s receptor in such a way that, because the toxin cannot bind to the receptor, the acetylcholine function is undisturbed. Remarkable Creatures: Good to Be King in Snake-Eat-Snake World 2010-10-25T19:53:00Z Sometimes an attacking mongoose is bitten, but it has another line of defense against the venom — its acetylcholine receptor has also evolved so that the cobra neurotoxin cannot bind to it. Remarkable Creatures: Good to Be King in Snake-Eat-Snake World 2010-10-25T19:53:00Z As the body ages, levels of acetylcholine surrounding the nerves drop and in consequence, the nerves begin to deteriorate. How and When to Be Your Own Doctor Phosphatidyl choline is another precursor used by the body to build acetylcholine and helps maintain the nervous system. How and When to Be Your Own Doctor Every time a nerve impulse is transmitted from one nerve cell to the next, a molecule of acetylcholine is consumed. How and When to Be Your Own Doctor |
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