| 单词 | acetyl |
| 例句 | A dozen more in Rhode Island last spring involved a similar chemical called acetyl fentanyl. Death of actor Philip Seymour Hoffman spotlights fentanyl scourge 2014-02-05T02:17:36Z Cholesterol synthesis starts with acetyl CoA, and the components of triglycerides are picked up by acetyl CoA and enter the citric acid cycle. Concepts of Biology 2013-04-25T00:00:00Z Histone protein charge becomes more positive when acetyl groups are added. Biology for AP Courses 2022-06-09T00:00:00Z The other two carbon atoms form acetic acid and combine with a compound called coenzyme A to form acetyl CoA. Miller & Levine Biology 2018-01-01T00:00:00Z Therefore, when glucose levels are low, triglycerides can be converted into acetyl CoA molecules and used to generate ATP through aerobic respiration. Anatomy and Physiology 2013-06-19T00:00:00Z An autopsy determined that the woman’s death was caused by mixed drug toxicity, specifically from fentanyl and an analogue of fentanyl called acetyl fentanyl, the release said. Man gets 20 years for selling drugs in overdose death 2020-10-15T04:00:00Z Acetyl CoA can be used in a variety of ways by the cell, but its major function is to deliver the acetyl group derived from pyruvate to the next pathway in glucose catabolism. Concepts of Biology 2013-04-25T00:00:00Z New drugs are being developed that decrease DNA methylation and prevent the removal of acetyl groups from histone proteins. Biology for AP Courses 2022-06-09T00:00:00Z As the Krebs cycle unfolds, this acetyl CoA transfers the two carbon atoms to a four-carbon molecule that is already present in the cycle. Miller & Levine Biology 2018-01-01T00:00:00Z In both cases, fat stores are liberated to generate energy through the Krebs cycle and will generate ketone bodies when too much acetyl CoA accumulates. Anatomy and Physiology 2013-06-19T00:00:00Z ACSS2 does not modify the histones directly, but rather generates acetyl groups that are then coupled to histones by a separate class of enzymes known as acetyltransferases. EpiVario: mixing psychotherapy and small-molecule drugs 2020-06-29T04:00:00Z Like the conversion of pyruvate to acetyl CoA, the citric acid cycle in eukaryotic cells takes place in the matrix of the mitochondria. Concepts of Biology 2013-04-25T00:00:00Z When unmodified, the histone proteins have a large positive charge; by adding chemical modifications like acetyl groups, the charge becomes less positive. Biology for AP Courses 2022-06-09T00:00:00Z These include processes that add or remove either methyl groups on DNA or acetyl groups on DNA-binding proteins called histones. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Figure 24.15 Ketone Oxidation When glucose is limited, ketone bodies can be oxidized to produce acetyl CoA to be used in the Krebs cycle to generate energy. Anatomy and Physiology 2013-06-19T00:00:00Z When he began his investigation, which has never been fully reported on, Buemi just wanted to figure out how an envelope of acetyl fentanyl had made its way to South Florida. The China Connection: How One D.E.A. Agent Cracked a Global Fentanyl Ring 2019-10-16T04:00:00Z Two carbon atoms come into the citric acid cycle from each acetyl group. Concepts of Biology 2013-04-25T00:00:00Z Then, the first step of the cycle begins: This is a condensation step, combining the two-carbon acetyl group with a four- carbon oxaloacetate molecule to form a six-carbon molecule of citrate. Biology for AP Courses 2022-06-09T00:00:00Z She said: “I first maintain a healthy cellular routine where I maximise the function of my mitochondria with supplements such as NAD+, acetyl L-carnitine, magnesium etc.” Peeled eyeballs, isolation tanks and neuroplastic goals: is Grimes’s ‘training regime’ for real? 2019-07-17T04:00:00Z When you eat more glucose or carbohydrates than your body needs, your system uses acetyl CoA to turn the excess into fat. Anatomy and Physiology 2013-06-19T00:00:00Z Buemi had a hunch that the same drug ring responsible for moving Molly into South Florida might also be importing the acetyl fentanyl pills. The China Connection: How One D.E.A. Agent Cracked a Global Fentanyl Ring 2019-10-16T04:00:00Z They energize the entry of the acetyl group into the citric acid cycle. Concepts of Biology 2013-04-25T00:00:00Z The two acetyl carbon atoms will eventually be released on later turns of the cycle; thus, all six carbon atoms from the original glucose molecule are eventually incorporated into carbon dioxide. Biology for AP Courses 2022-06-09T00:00:00Z Several years ago, Oberdoerffer followed a hunch that cells might use another simple chemical unit, an acetyl group, on mRNA. Hidden layer of gene control influences everything from cancer to memory 2019-07-01T04:00:00Z Oxaloacetate and acetyl CoA combine to form citrate, which can cross the mitochondrial membrane and enter the cytoplasm. Anatomy and Physiology 2013-06-19T00:00:00Z Buemi had by then received the acetyl fentanyl pills from Li Li: 50 of them, five strips of 10 wrapped neatly in paper, tucked inside a letter-size Canada Post envelope. The China Connection: How One D.E.A. Agent Cracked a Global Fentanyl Ring 2019-10-16T04:00:00Z Two carbon dioxide molecules are released on each turn of the cycle; however, these do not contain the same carbon atoms contributed by the acetyl group on that turn of the pathway. Concepts of Biology 2013-04-25T00:00:00Z During the conversion of pyruvate into the acetyl group, a molecule of carbon dioxide and two high- energy electrons are removed. Biology for AP Courses 2022-06-09T00:00:00Z She then inventoried vials of fine powder, acetyl fentanyl and other fentanyl variations before securing them in plastic evidence baggies. DEA chemists solved mystery of drug causing mass overdoses 2019-03-02T05:00:00Z As previously explained, fatty acids can be converted into acetyl CoA and processed through the Krebs cycle to make ATP. Anatomy and Physiology 2013-06-19T00:00:00Z Using the acetyl fentanyl seizure as evidence, Buemi obtained email-search warrants for the addresses he knew to be associated with Li Li. The China Connection: How One D.E.A. Agent Cracked a Global Fentanyl Ring 2019-10-16T04:00:00Z The synthesis of cholesterol starts with acetyl CoA and proceeds in only one direction. Concepts of Biology 2013-04-25T00:00:00Z Cholesterol synthesis starts with acetyl groups, and the components of triglycerides come from glycerol-3-phosphate from glycolysis and acetyl groups produced in the mitochondria from pyruvate. Biology for AP Courses 2022-06-09T00:00:00Z When agents raided his lab, federal prosecutors said, they seized more than 11 kilograms of acetyl fentanyl, an analog 15 times more powerful than morphine. Fentanyl smuggled from China is killing thousands of Americans - Los Angeles Times 2018-10-19T04:00:00Z Pyruvate, lactate, and alanine from muscle cells are not converted into acetyl CoA and used in the Krebs cycle, but are exported to the liver to be used in the synthesis of glucose. Anatomy and Physiology 2013-06-19T00:00:00Z China has long prohibited the nonmedical sale of fentanyl itself, and last fall, it added several analogs including acetyl fentanyl to a list of controlled narcotics. The Chinese Connection Fueling America’s Fentanyl Crisis 2016-06-22T04:00:00Z The opiate antidote Narcan, which is used to reverse the effects of heroin, is less effective against acetyl fentanyl and may require higher doses to prevent overdose, officials said. 2 women who died after snorting tainted cocaine identified 2016-06-06T04:00:00Z They energize the acetyl group in the citric acid cycle. Biology for AP Courses 2022-06-09T00:00:00Z The dealer, who later would be sentenced to 20 years in prison after pleading guilty to drug distribution charges, soon was slinging heroin laced with acetyl fentanyl to his customers, prosecutors said. Fentanyl smuggled from China is killing thousands of Americans - Los Angeles Times 2018-10-19T04:00:00Z When excess acetyl CoA is produced that cannot be processed through the Krebs cycle, the acetyl CoA is converted into triglycerides and fatty acids to be stored in the liver and adipose tissue. Anatomy and Physiology 2013-06-19T00:00:00Z And in March, four men in the Los Angeles area were charged with participating in a ring that sold acetyl fentanyl and imported chemicals and equipment from China. The Chinese Connection Fueling America’s Fentanyl Crisis 2016-06-22T04:00:00Z The last acetyl fentanyl death in King County was in 2015. 2 women who died after snorting tainted cocaine identified 2016-06-06T04:00:00Z The synthesis of cholesterol starts with acetyl groups and proceeds in only one direction. Biology for AP Courses 2022-06-09T00:00:00Z In May 2015, when the Department of Justice bumped acetyl fentanyl up to a schedule I controlled substance, chemists made slight alterations to produce new, but functionally similar analogues. Synthetic opiate makers stay step ahead of US drug laws as overdose cases rise 2016-04-11T04:00:00Z If excess acetyl CoA is created and overloads the capacity of the Krebs cycle, the acetyl CoA can be used to synthesize ketone bodies. Anatomy and Physiology 2013-06-19T00:00:00Z Last spring, Chinese customs agents seized 70 kilograms of the narcotics fentanyl and acetyl fentanyl hidden in a cargo container bound for Mexico. The Chinese Connection Fueling America’s Fentanyl Crisis 2016-06-22T04:00:00Z Not only is fentanyl being produced in Mexico but that an analog called acetyl fentanyl is made in China, according to the Drug Enforcement Administration. This drug now rivals heroin as a killer, and the drug war is to blame 2016-03-20T04:00:00Z Fatty acids are catabolized in a process called beta-oxidation that takes place in the matrix of the mitochondria and converts their fatty acid chains into two carbon units of acetyl groups. Biology for AP Courses 2022-06-09T00:00:00Z Dr Toner has overcome that, though, by decorating it with molecular titbits called acetyl groups. Wait not in vain 2016-02-04T05:00:00Z In the cytoplasm, citrate is converted back into oxaloacetate and acetyl CoA. Anatomy and Physiology 2013-06-19T00:00:00Z An earlier study by Berger’s group indicated that variations in the number of a chemical entity called an acetyl group on proteins called histones, which serve as the scaffolding for DNA, might be important. Bipolar drug turns foraging ants into scouts 2015-12-31T05:00:00Z Some inhibit enzymes that either add or remove acetyl groups from histones, and can treat a range of conditions from epilepsy to cancer. Epigenetics: The genome unwrapped : Nature : Nature Publishing Group 2015-12-01T05:00:00Z In the mitochondria, acetyl CoA continues on to the citric acid cycle. Biology for AP Courses 2022-06-09T00:00:00Z An inquest in Cardiff heard it was found to be acetyl fentanyl, which is five times stronger than heroin. Legal high 'five times stronger than heroin' killed dad - BBC News 2015-05-07T04:00:00Z But in late June, Pennsylvania public health officials announced that acetyl fentanyl was responsible for 50 overdose deaths there, as well as five non-fatal overdoses. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z So Simola and his colleagues treated different sets of minors and majors with chemicals that affected the addition or removal of acetyl groups from histones. Bipolar drug turns foraging ants into scouts 2015-12-31T05:00:00Z In the last few months, states around the East Coast have reported major problems with doses spiked with acetyl fentanyl, a powerful drug usually given as a last-resort painkiller to seriously ill people. Philip Seymour Hoffman’s death: Eight questions about heroin you were afraid to ask 2014-02-03T20:39:38Z Through a series of steps, citrate is oxidized, releasing two carbon dioxide molecules for each acetyl group fed into the cycle. Biology for AP Courses 2022-06-09T00:00:00Z Therefore, the CDC recommends that states observing clusters or increases in opioid-related overdose deaths undertake more detailed testing to identify whether acetyl fentanyl is a cause. CDC Issues Alert On Deadly New Designer Drug, Acetyl Fentanyl 2013-08-29T20:40:00Z The North Carolina Department of Health and Human Services issued a health advisory today after conclusively linking three drug overdose deaths with acetyl fentanyl, a designer opioid drug. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z Another inhibits an enzyme that adds acetyl groups. Bipolar drug turns foraging ants into scouts 2015-12-31T05:00:00Z The team's result was based on an assay that used a peptide bearing a tag that would fluoresce when the acetyl group was removed. Red Wine's Link to Health Gains Support 2013-03-08T22:15:00.543Z Prior to the start of the first step, a transitional phase occurs during which pyruvic acid is converted to acetyl CoA. Biology for AP Courses 2022-06-09T00:00:00Z Four additional cases were identified later up through May 26th, bringing the acetyl fentanyl death total to 14. CDC Issues Alert On Deadly New Designer Drug, Acetyl Fentanyl 2013-08-29T20:40:00Z By November, the drug appeared to spread to Louisiana when two more deaths from acetyl fentanyl were identified by the Jefferson Parish coroner’s office in the New Orleans suburb of Metairie. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z This switches genes on and off by plastering either their DNA or the proteins which support that DNA in chromosomes with clusters of atoms called methyl and acetyl groups. Cancer and epigenetics: Cancer?s epicentre 2012-04-03T16:18:14Z A white crystalline solid, from ammonia by replacement of an equivalent of hydrogen by acetyl. Webster's Unabridged Dictionary 2012-03-24T02:00:23.513Z These markers are methyl, acetyl and other chemical groups that attach to the DNA, turning some genes off and others on. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z However, subsequent detailed analysis by the CDC revealed that the drug was a chemical relative called acetyl fentanyl. CDC Issues Alert On Deadly New Designer Drug, Acetyl Fentanyl 2013-08-29T20:40:00Z Thus, development of a validated testing procedure to quantify acetyl fentanyl and acetyl norfentanyl in human samples is critical to accurately diagnosing human morbidity and mortality from this deadly emerging drug of abuse. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z At first glance, these scribes seem quite ordinary—methyl, acetyl, and phosphoryl groups, clinging to proteins associated with DNA, or sometimes even to DNA itself, looking like freeloaders at best. Epigenetics: A Turning Point in our Understanding of Heredity 2012-01-16T16:45:00.190Z By long heating the acid is converted into its anhydride, which, however, is obtained more readily by heating the silver salt of the acid with acetyl chloride. Encyclopaedia Britannica, 11th Edition, Volume 12, Slice 2 "Gloss" to "Gordon, Charles George" 2011-10-31T02:00:28.703Z Therefore, glucose is the primary source of the acetyl units used for both amino sugar biosynthesis and nuclear protein acetylation. Branched tricarboxylic acid metabolism in Plasmodium falciparum 2011-01-19T18:25:11.737Z Most concerning to public health officials is that acetyl fentanyl is truly a new designer drug in that no previous reports exist documenting overdose deaths with this chemical. CDC Issues Alert On Deadly New Designer Drug, Acetyl Fentanyl 2013-08-29T20:40:00Z While acetyl fentanyl is not an approved drug, its chemical structure is closely related to the prescription pain killing opioid, fentanyl. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z They form acetyl esters, or acetates, which can be separated from each other and identified by their crystal forms and melting points. The Chemistry of Plant Life It cannot be converted into coumarin by heating alone, but it is readily transformed on heating with acetic anhydride or acetyl chloride. Encyclopaedia Britannica, 11th Edition, Volume 7, Slice 6 "Coucy-le-Château" to "Crocodile" Assuming that the difference of 13 p.ct. is due to loss of water by internal condensation, it appears that for each acetyl group entering, 2 mol. Researches on Cellulose 1895-1900 Drug Enforcement Agency hasn’t yet reported on just how widespread acetyl fentanyl use is across the country, their Drug and Chemical Evaluation section released this one-page informational PDF in December. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z Last October, we wrote about an acetyl fentanyl warning from the U.S. Acetyl Fentanyl Deaths Spread To The Southeast 2014-02-20T01:38:00Z The determination of the acetyl by saponification is also subject to an error sufficiently large to preclude the results being applied to solve the point. Researches on Cellulose 1895-1900 |
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