Increase in cAMP causes chloride channels on the cells to increase the secretion of chloride into the lumen while inhibiting the channels that let sodium and chloride back into the cell.

cAMP的增加会导致细胞上的氯离子通道增加氯离子向管腔的分泌，同时抑制使钠和氯离子回到细胞内的通道。