Over time, this lack of stimulation can cause zona fasciculata to physically shrink or become atrophic.

时间一长，过少的刺激会导致束状带缩小或萎缩。

This causes a decrease in CRH and ACTH, which in turn, shuts down cortisol production from the zona fasciculata.

这会降低CRH和ACTH，反过来阻止束状带制造皮质醇。

The excess ACTH overstimulates zona fasciculata of both adrenal glands, which grow larger and secrete excess cortisol.

过多的ACTH会过度刺激两个肾上腺的束状带，使其增大并分泌过多的皮质醇。

In both adrenal adenomas and carcinomas, the cells of the zona fasciculata within the adrenal cortex start dividing abnormally and secrete excess cortisol.

在肾上腺腺瘤和肾上腺癌中，肾上腺皮质里束状带的细胞开始异常分裂并分泌过多皮质醇。

With less ACTH floating around, the zona fasciculata gets less stimulation to make cortisol, and eventually, cortisol levels go back down to the normal range again.

随着ACTH减少，束状带受刺激产生皮质醇减少，最后，皮质醇水平降低到正常范围内。

The adrenal cortex is the outer part of the adrenal gland and is subdivided into three layers- the zona glomerulosa, the zona fasciculata, and the zona reticularis.

肾上腺皮质是肾上腺的外层部分，皮质又分为三层：球状带、束状带和网状带。