Sickled cells snag and pile up– sometimes blocking the vessel completely.

镰状细胞阻碍并堆积— —有时会完全阻塞血管。

Sickled red blood cells can also get stuck in the cerebral vasculature, causing strokes and Moya-moya disease - which is named for " puff-of-smoke" -like collateral vessels that bypass blocked arteries.

镰状红细胞也会嵌顿在脑脉管系统中，造成中风与脑底异常血管网症（Moya-moya病/烟雾病）；该病以代偿阻塞动脉而形成的“烟雾状”侧枝循环命名。

So it's included in the newborn blood spot screen in some countries, and can also be identified with a blood smear looking for sickled cells, or by identifying HbS using protein electrophoresis.

因此在某些国家，它被纳入新生儿血斑筛查，同时也可以通过血涂片来寻找镰状细胞，或通过蛋白质电泳鉴定HbS等来确诊。

Carriers are less susceptible to malaria, because they make some sickled red blood cells, but they make enough normal red blood cells that they aren't negatively affected by sickle cell anemia.

携带者不易感染疟疾， 因为他们会产生一些镰状红细胞，但他们会产生足够多的正常红细胞， 因此不会受到镰状细胞性贫血的负面影响。

The pointed shape and stiffness of the sickled red blood cells makes them much more likely to get stuck in the blood vessels and cause blockages which can result in severe pain and organ damage.

病态红细胞的尖状和僵硬使它们更容易卡在血管中，造成阻塞，从而导致严重的疼痛和器官损伤。

The pointy shape and stiffness of the sickled red blood cells makes them much more likely to get stuck in the blood vessels and cause blockages which can result in severe pain and organ damage.

病态红细胞的尖尖形状和僵硬使它们更容易卡在血管中，造成阻塞，从而导致严重的疼痛和器官损伤。