Methods A total of 16 patients with bilateral large soft drusen were studied prospectively.

方法双眼黄斑部有多个（>10个）大的（直径＞63µm）玻璃膜疣者16例。

So both cross-sectionally and prospectively researches have focused on the role of insulin resistance in the worsening of glucose tolerance.

因此，横断面研究和前瞻性研究的研究焦点都在于胰岛素抵抗在糖耐量减低中的作用。