However, replicating the complex biochemical environment of a major organ is a steep challenge. Extrusion-based bioprinting may destroy a significant percentage of cells in the ink if the nozzle is too small, or if the printing pressure is too high.

然而，复制主要器官复杂的生化环境是一项严峻的挑战。挤压式生物打印可能会破坏墨水里很大一部分的细胞，如果喷头太小或打印压力太高。