In early childhood, pancreatic insufficiency is the most prominent effect of CF.

在幼儿时期，CF最主要的影响是造成胰腺功能不全。

As the acinar cells become impaired they produce fewer pancreatic digestive enzymes, which results in pancreatic insufficiency.

当腺泡细胞受损时，它们产生的胰消化酶减少，引起胰腺功能不全。

Individuals with pancreatic insufficiency might require replacement digestive enzymes and nutritional supplements, and those with diabetes might need insulin-replacement therapy.

胰腺功能不全的患者可能需要消化酶替代治疗及营养补充，而糖尿病患者则需要胰岛素替代治疗。

Eventually, this leads to pancreatic insufficiency, which makes it difficult to digest food as well as the destruction of alpha and beta cells, which makes it difficult to produce hormones like insulin.

最终这会导致胰腺功能不全，引起消化不良以及α和β细胞的破坏，从而难以产生胰岛素等激素。感谢 PE、RNA、审核大大！