The main criticisms are that it medicalises normal behaviour and that the strict categories of mental illness it creates are increasingly at odds with what research suggests is actually going on in the brain.

一是正常行为被误判，正常人服用药物；二是科学家不断发现，书中对于精神疾病的严格分类和研究发现的大脑实际的运作情况不一致。