My mom is a Jew from Libya and my dad is Ashkenazi from Eastern Europe.

我的母亲是利比亚的犹太人，我的父亲是是东欧的阿什肯纳齐人。

My mom is 100-percent Ashkenazi Russian Jewish, and my dad is 50-percent Korean and 50-percent Belgian.

我妈妈是百分之百的德系犹太人，我爸爸一半韩国一半比利时血统。

WELL, FIRST OF ALL, WE'RE NOT ASHKENAZI AND WE'RE NOT SEPHARDI.

好吧，首先，我们不是 ASHKENAZI，也不是 SEPHARDI。

Ashkenazi Jews for instance are vulnerable to Tay-Sachs.

例如， 亚述犹太人易感泰桥氏症。

His father was Hermann Einstein, an Ashkenazi Jew from Buchau in Wurttemberg.

他的父亲是赫尔曼·爱因斯坦，一位来自符腾堡州布豪的德系犹太人。

Its name is yiddish for little grandmother and is thought to have originated in Ashkenazi communities of Poland and the Ukraine.

它的名字是意第绪语，意思是小祖母，认为起源于波兰和乌克兰的阿什肯纳齐社区。

But the unusual prevalence of the Tay-Sachs mutation in Ashkenazi populations may be another example of heterozygote advantage.

但德系人群中 Tay-Sachs 突变的异常流行可能是杂合子优势的另一个例子。

For example, Ashkenazi Jewish ancestry is associated with higher rates of BRCA-1 mutations, which is a genetic risk factor for breast cancer.

例如，德系犹太血统与较高的 BRCA-1 突变率有关，而 BRCA-1 突变是乳腺癌的遗传风险因素。

So, we know that there are clear differences in IQ scores among American racial groups, between whites and Asians, African Americans, Ashkenazi Jews.

因此， 我们知道美国各种族之间的智商得分存在巨大差异。

As I said, because of my Jewish background, I was aware of the unusually high rate of Tay-Sachs in the Ashkenazi population.

正如我所说， 由于我的犹太背景，我知道德系犹太人中的 Tay-Sachs 比率异常高。

It's a great example of why not every set of Ashkenazi parents should hope that their daughter marries " a nice Jewish boy." (Laughter) (Audience) Woo-hoo!

这是一个很好的例子，说明为什么不是所有的德系犹太人父母都希望他们的女儿嫁给“一个好犹太男孩”。（笑声）（观众）哇哦！

The unusually high rate of the Tay-Sachs mutation in Ashkenazi Jews today may relate to advantages the mutation gave this population in the past.

今天德系犹太人中异常高的 Tay-Sachs 突变率可能与该突变在过去给该人群带来的优势有关。

The data hinted that the persistence of the Tay-Sachs mutation among Ashkenazi Jews might be explained by the benefits of being a carrier in an environment where tuberculosis was prevalent.

数据暗示，德系犹太人中 Tay-Sachs 突变的持续存在可能是由于在结核病流行的环境中作为携带者的好处。

But the hypothesis that these Ashkenazi grandparents had been less likely to die of TB specifically because at least some of them were Tay-Sachs carriers was novel and compelling.

但是，这些阿什肯纳兹祖父母之所以不太可能死于结核病是因为至少他们中的一些人是泰-萨克斯携带者，这一假设是新颖而引人注目的。

Even if the Tay-Sachs mutation persisted because carriers were more likely to survive, reproduce and pass on their genetic material, why did this resistance mechanism proliferate among the Ashkenazi population in particular?

即使 Tay- Sachs 突变持续存在是因为携带者更有可能存活、繁殖和传递他们的遗传物质， 为什么这种抵抗机制在 Ashkenazi 人群中特别扩散？

This winnowing effect together with a strong cultural predilection for marrying and reproducing only within the Ashkenazi community, would have amplified the relative frequency of carriers, boosting TB resistance but increasing the incidence of Tay-Sachs as an unfortunate side effect.

这种风选效应加上仅在德系犹太人社区内结婚和生育的强烈文化偏好， 会增加携带者的相对频率，增强结核病抵抗力， 但不幸的副作用是会增加泰-萨克斯病的发病率。