In 1717, Lady Mary Wortley Montagu, an English aristocrat living in Constantinople with her husband, a diplomat, heard about inoculation from her acquaintances in the Ottoman court.

1717年，英国贵族玛丽·沃特利·蒙塔古夫人和她当外交官的丈夫住在君士坦丁堡，从奥斯曼帝国宫廷的熟人那里听说了接种疗法。