There's a good model of Huntington's disease in sheep.

绵羊可能会患上亨廷顿舞蹈症。

In people with Huntington disease, this repeat goes on for 36 or more times in a row.

而对于HD患者，该段重复序列拷贝达到36次以上。

For example, genetic testing may be used to confirm a diagnosis of cystic fibrosis or Huntington's disease.

例如，基因检测可用于确认囊性纤维化或亨廷顿病的诊断。

Scientists aim to use the sheep as models to study disorders of the brain, such as Huntington's disease.

科学家旨在以绵羊为模型来研究脑紊乱疾病，如享廷顿病。

This phenomenon is called anticipation, which means that Huntington disease families often show earlier symptom onset with each generation.

HD家族中连续后代中有发病提前倾向，称为早现现象。

Huntington disease is an autosomal dominant genetic disorder, which means that one affected copy of a gene is enough to cause disease.

HD是一种常染色体显性遗传病，意味着可以代代相传。

CAG codes for the amino acid glutamine, so people with Huntington disease patients will have 36 or more glutamines in a row in the huntingtin protein.

因为CAG序列对应的是谷氨酰胺（氨基酸），所以在HD患者体内，huntingtin蛋白质上会有36个以上连续的谷氨酰胺。

This increased dopamine helps explain why neuroleptics, which are dopamine receptor antagonists, and tetrabenazine which depletes dopamine, are used to treat chorea in patients with Huntington disease.

多巴胺水平的增高解释了为什么神经抑制剂-多巴胺受体拮抗剂和丁苯那嗪（中枢多巴胺耗竭剂）被用来治疗亨廷顿病患者的舞蹈症。

This explains why a mutation like the one that causes Huntington's disease, another degenerative neurological disorder, hasn't been eliminated by natural selection.

这就解释了为什么像导致亨廷顿病（另一种退行性神经系统疾病） 的突变还没有被自然选择消除。

Individuals with these disorders all suffer from tics, which are quick, nonrhythmic movements or vocalizations that happen over and over, and are not caused by some other disorder like Huntington's disease or substance abuse.

上述三种疾病的患者都有抽动症状，即快速、无规律的动作或发声；这种持续存在的抽动并不是其他疾病的并发症，纵然亨廷顿病、药物滥用等也会导致类似抽动的症状。

Being able to change larger pieces of the genome, as is the case with prime editing, makes it possible to treat diseases where errors stretch over a long distance, like Huntington's disease.

能够改变基因组的较大片段（就像主要编辑的情况一样）可以治疗错误延伸到很远距离的疾病，比如亨廷顿氏病。