Ibuprofen should also be avoided in patients who have a heart condition such as atrial fibrillation who are on blood-thinning agents such as warfarin, rivaroxaban, or apixaban, as ibuprofen or NSAIDs in general increase the risk of bleeding.

布洛芬也应避免用于患有心脏疾病（如房颤）并正在服用血液稀释剂（如华法林、利伐沙班或阿哌沙班）的患者，因为布洛芬或非甾体抗炎药通常会增加出血的风险。