This can be caused surgical removal or autoimmune destruction of the parathyroid gland, as well as congenital problems involving the parathyroid gland like DiGeorge syndrome, or deficiency in magnesium which is needed for parathyroid hormone production.

原因可能是手术切除了甲状旁腺，或者自身免疫性疾病对甲状旁腺的攻击，也可能是因为像DiGeorge综合征这种累及甲状旁腺的先天性疾病，或者缺少合成甲状旁腺激素必要的元素：镁。