| 单词 | sporozoite |
| 例句 | A mosquito bite delivers only about 10 “sporozoites,” the form of the parasite that can be transmitted. At Long Last, Can Malaria Be Eradicated? 2022-10-04T04:00:00Z Rather than target the parasite itself, the vaccine targets the sporozoite protein that helps the parasite find the liver. Why the malaria vaccine was so hard to develop 2021-10-07T04:00:00Z R21 and Mosquirix both target the malaria parasite in the sporozoite phase of its life cycle — the phase in which it enters the human body from its mosquito hosts. Malaria Vaccine Shows Promise—Now Come Tougher Trials 2021-04-28T04:00:00Z Mosquirix uses a piece of the parasite — a protein found only on sporozoites’ surface — in hopes of blocking the liver stage of infection. 3 African countries trying out 1st malaria vaccine in babies 2020-01-15T05:00:00Z The bite of an infected mosquito sends immature parasites called sporozoites into the bloodstream. 3 African countries trying out 1st malaria vaccine in babies 2020-01-16T05:00:00Z But within 30 minutes of infection, the sporozoites invade the liver, and begin multiply into an unbeatable army of thousands. At Long Last, Can Malaria Be Eradicated? 2022-10-04T04:00:00Z "The vaccine induces an antibody which prevents the sporozoite from invading the liver," Wirth explained. Why the malaria vaccine was so hard to develop 2021-10-07T04:00:00Z In the early 1970s, research suggested that people gained immunity to P. falciparum if they were bitten by irradiated mosquitoes carrying sporozoites. Building a better malaria vaccine 2019-11-26T05:00:00Z It has a complex life cycle that begins when an infected female mosquito bites a human and spits Plasmodium cells called sporozoites into the bloodstream. First malaria vaccine rolled out in Africa—despite limited efficacy and nagging safety concerns 2019-11-26T05:00:00Z Mosquirix uses a piece of the parasite - a protein found only on sporozoites’ surface - in hopes of blocking the liver stage of infection. 3 African countries trying out 1st malaria vaccine in babies 2020-01-16T05:00:00Z It is made from sporozoites, which are a stage in the parasite’s life cycle that is transmitted by mosquitoes. Astronaut twins, Nepal tornado and malaria vaccine 2019-04-16T04:00:00Z As the team reports today in Science Translational Medicine, no one developed malaria or suffered serious harm in this first phase of human tests, and the vaccine triggered antibodies against the sporozoites. Promising malaria vaccine disables key parasite genes 2017-01-04T05:00:00Z He and Hoffman might collaborate to insert P. vivax genes into attenuated P. falciparum sporozoites, with the aim of providing protection against both. Building a better malaria vaccine 2019-11-26T05:00:00Z It's these parasites that are in the new vaccine, although they are weakened and in their sporozoite stage. Malaria Vaccine Looks Promising in Clinical Trial 2013-08-08T21:09:00Z The vaccine is made from sporozoites, or early-stage parasites extracted from infected mosquitoes, which are the most common carriers of P. falciparum. New Malaria Vaccine Offers Best Protection Yet 2013-08-10T04:05:23Z Many researchers were highly sceptical that sporozoites could be mass-produced in a way that passed the strict quality and safety standards needed for human medicines, notes Fauci. Zapped Malaria Parasite Raises Vaccine Hopes 2013-08-08T22:15:01.480Z When bites deposit a version of the parasite under the skin, they migrate to the liver where each so-called sporozoite produces as many as 30,000 copies of a new parasite form. Promising malaria vaccine disables key parasite genes 2017-01-04T05:00:00Z The company developed a method that involves freezing sporozoites painstakingly dissected by hand from the salivary glands of mosquitoes. Vaccines: The take-home lesson 2012-04-25T17:21:37.957Z Full-grown oocyst crammed with ripe sporozoites; on one side the cyst has burst and the sporozoites are escaping. Encyclopaedia Britannica, 11th Edition, Volume 12, Slice 7 "Gyantse" to "Hallel" 2011-12-26T03:00:11.613Z But they also found fewer sporozoites--the infectious form of the parasite--indicating that the mosquitoes were less infectious at higher temperatures. Global Warming Wilts Malaria 2011-12-22T01:15:05.240Z By successive divisions, usually mitotic, the zygote-nucleus gives rise to eight daughter-nuclei, each of which becomes the nucleus of a sporozoite. Encyclopaedia Britannica, 11th Edition, Volume 12, Slice 5 "Greek Law" to "Ground-Squirrel" 2011-12-05T03:00:51.527Z “I really like this approach,” says Seder, who is helping develop a vaccine of irradiated sporozoites, which are delivered by a cumbersome intravenous injection to stimulate strong immune responses. Promising malaria vaccine disables key parasite genes 2017-01-04T05:00:00Z Box 1: The altruistic approach: Transmission-blocking vaccines Kappe plans to test lower doses of this genetically weakened parasite, and is developing another strain of sporozoite with other genes missing. Vaccines: The take-home lesson 2012-04-25T17:21:37.957Z The sporozoites are carried about by the blood-stream; ultimately, however, apparently by virtue of some chemotactic attraction, they practically all collect in the salivary glands, filling the secretory cells and also invading the ducts. Encyclopaedia Britannica, 11th Edition, Volume 12, Slice 7 "Gyantse" to "Hallel" 2011-12-26T03:00:11.613Z Inside the liver, the sporozoites change form and then grow and divide into thousands of merozoites. Mosquito lab handles "world's most dangerous animals" 2011-10-20T11:28:01Z One company—Seattle BioMed—uses exactly this approach, irradiating parasites in the sporozoite stage, to prevent them from maturing, and then injecting parasite fragments into patients. Three Promising Vaccine Strategies against Malaria 2011-10-18T22:15:00.373Z Instead, he hopes to develop ways to grow the weakened sporozoites in laboratory cultures and put them in traditional vaccine vials for later injection. Promising malaria vaccine disables key parasite genes 2017-01-04T05:00:00Z Apparently, a vaccine made from the parasitic cells—called sporozoites when they're at this stage—triggers an immune reaction that a vaccine based on a single protein or protein fragment can't, scientists concluded. New Hope for 'Crazy' Malaria Vaccine 2011-09-08T20:05:54Z With the bite of an infected mosquito, the minute sickle-like sporozoites are injected into the blood. Encyclopaedia Britannica, 11th Edition, Volume 12, Slice 7 "Gyantse" to "Hallel" 2011-12-26T03:00:11.613Z After one or two weeks, tens of thousands of the resulting sporozoites swarm up to the mosquito's salivary gland. Malaria's Tenacious Buzz 2010-07-09T22:09:00Z I.-IV represents the schizogony, commencing with infection of an epithelial cell by a sporozoite or merozoite. Encyclopaedia Britannica, 11th Edition, Volume 6, Slice 5 "Clervaux" to "Cockade" Within these nodules further division and development takes place until finally the nodule is burst open and many thousand minute rod-like organisms, sporozoites, are turned loose into the body-cavity of the mosquito. Insects and Diseases A Popular Account of the Way in Which Insects may Spread or Cause some of our Common Diseases Studies suggested that sporozoites achieve this level of protection by activating so-called CD8+ T cells that secrete a molecule called interferon γ in the liver. New Hope for 'Crazy' Malaria Vaccine 2011-09-08T20:05:54Z Many authors consider that Schneider was mistaken in attributing many sporozoites to this form, and would unite with it the genus Diplospora. Encyclopaedia Britannica, 11th Edition, Volume 6, Slice 5 "Clervaux" to "Cockade" On the other hand, the sporozoites may lie in the salivary gland alive and virulent for several weeks. Insects and Diseases A Popular Account of the Way in Which Insects may Spread or Cause some of our Common Diseases The liberated sporozoites creep out and proceed to infect the epithelial cells. Encyclopaedia Britannica, 11th Edition, Volume 6, Slice 5 "Clervaux" to "Cockade" The nodules or cysts on the walls of the stomach of the mosquito may contain as many as ten thousand sporozoites, and as many as five hundred cysts may occur on a single stomach. Insects and Diseases A Popular Account of the Way in Which Insects may Spread or Cause some of our Common Diseases |
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