| 单词 | somatic |
| 例句 | It was different from sperm-and-egg sex in several important ways: somatic cells were cells of the body, like skin cells, and their union produced offspring every few hours. The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z The technical name for this was somatic cell fusion, but some researchers called it “cell sex.” The Immortal Life of Henrietta Lacks 2010-02-02T00:00:00Z It’s fitting that a key somatic principle, Eddy said, is the idea of slowing down. ‘Slowing Down to Feel’: Moving Our Minds Around Our Bodies 2021-01-22T05:00:00Z Milk containing a high number of somatic cells is poorer nutritionally and of a lower quality, and can suggest low animal welfare standards. UK anti-obesity drive at risk from new US trade deal, doctors warn 2018-03-18T04:00:00Z In its arrangements, the Turtle Island Quartet opted to use the minimal amount of information possible to make space for the somatic experience of the music: listening and feeling. How Do You Write Down a Scratching, Crunching Violin ‘Chop’? 2021-08-27T04:00:00Z Like much of her scholarship, it begins with somatic knowledge of the self. Review | Melissa Febos’s ‘Girlhood’ brilliantly illuminates how women are conditioned to be complicit in their own exploitation 2021-03-27T04:00:00Z Perhaps the problem is more psychological than somatic. The Secret Price of Pets 2018-07-04T04:00:00Z Viktor Ruban, a dance artist, scholar and activist, said he views these as a somatic practice that comes “from the impulse of the body.” What Does a Dancing Body Feel Like in Ukraine? ‘I Am a Gun.’ 2022-08-24T04:00:00Z Her books are contraptions intended to produce a series of psychological and somatic responses in her readers. In Gory, Majestic Fiction, a Hard Look at the Holocaust’s Stubborn Silences 2019-12-24T05:00:00Z Radical healing may require somatic modalities that involve a less linguistic, more undivided experience of emotion in the body, which language as a highly cerebral process can actively prevent. How Patriarchy Imprinted Itself on the Family Who Created Jell-O 2018-08-24T04:00:00Z If left untreated, pain roots itself into a person’s psyche, compounding or even creating somatic illness through stress and depression. The science of white working class pain: Trump’s appeal is rooted in the body as well as the mind 2017-01-08T05:00:00Z Many I spoke to have experience in somatic work, which places a spotlight on the internal experience of moving: feeling sensations within the body. What Does a Dancing Body Feel Like in Ukraine? ‘I Am a Gun.’ 2022-08-24T04:00:00Z “We’ll be giving work on body structure and centering,” he said, as well as on grounding, balancing and “many other applicable things from somatic work.” What Does a Dancing Body Feel Like in Ukraine? ‘I Am a Gun.’ 2022-08-24T04:00:00Z At Movement Research, an array of classes allow participants to become acquainted with a range of eye-opening somatic — or body-mind awareness — practices. DanceAfrica, Dormeshia and Contact Improvisation (for One) 2020-05-19T04:00:00Z “I really think of sound as a social technology and as a somatic technology and a tool of the herd and a tool of the species,” Fure said. Composers Find Transcendence, and Inspiration, at the Club 2023-03-10T05:00:00Z At this point, my son, somatic critic, rolled over and went to sleep. What We’re Reading with Our Kids this Summer 2016-06-01T04:00:00Z They are not into the somatic experience; they don’t really improvise. An Artist-Run Dance Space That’s ‘All Presentation, Baby’ 2023-04-21T04:00:00Z Yet Smoczynska and her cast still manage to conjure something somatically beguiling, akin to being put in a trance. ‘The Silent Twins’ Review: Keeping the World at Bay 2022-09-15T04:00:00Z She said this approach and the record’s fascination with hindsight is influenced by her recent interest in somatic, or “body-based” therapy. Pop Is Obsessed With What’s Next. So U.S. Girls Revisited Her Past. 2020-03-04T05:00:00Z It’s a surprise to see how effectively somatic classes work on Zoom. DanceAfrica, Dormeshia and Contact Improvisation (for One) 2020-05-19T04:00:00Z The shocks of the movie are crass and somatic, not disconcerting or social. Octavia Spencer’s Horror Movie, “Ma,” Is a Misfire Fit for the Moment 2019-05-31T04:00:00Z Seeing this for the first time – and second, and third – provoked a bizarre somatic reaction landing somewhere between absolute hilarity and horror. As "PEN15" draws to a close, we're left in the hell of seventh grade, exactly as it should be 2021-12-04T05:00:00Z “Her books are contraptions intended to produce a series of psychological and somatic responses in her readers,” our critic Parul Sehgal writes. 9 New Books We Recommend This Week 2020-01-02T05:00:00Z The hope is that you emerge from a somatic class and bring some of that awareness into your everyday life. ‘Slowing Down to Feel’: Moving Our Minds Around Our Bodies 2021-01-22T05:00:00Z It originates in the body — taking charge in deeper, more somatic ways and dancing as if the camera isn’t even there. There’s No Social Distancing for Dancers. How Can the Show Go On? 2020-07-24T04:00:00Z Horror movies are made to trigger somatic responses, right? No sweets for the sweet in new "Candyman," which neglects the legend's seductively scary legacy 2021-08-29T04:00:00Z "Fishes" is a somatic pairing with "Review," the acclaimed real-time one-shot episode near the end of Season 1. "The Bear" hides crusts of meaning and trauma in an episode about the Feast of the Seven Fishes 2023-06-29T04:00:00Z She is all business, and handles rhythmic challenges with the easy somatic grace of youth. NSO lineup is all-American, from composers to featured artists 2015-12-03T05:00:00Z But there’s a barrier between her somatic understanding of the master’s form and the verbalization of it. Balanchine and Cunningham: The Titans of 20th-Century Dance 2019-05-31T04:00:00Z I also tried somatic healing, boxing, Buddhist meditation, Ayahuasca and finally, because it was offered to me for free by a publicist, Botox. 52 Hours at Breakup Boot Camp 2018-06-02T04:00:00Z Mr. Smith’s trumpet is all the things that electrified music ostensibly isn’t: slow, shapely, somatic, preverbal. The Best Albums of 2017 2017-12-06T05:00:00Z For Ospina, somatic upsets express the psychic fallout of violent conflict in Colombia, where women wrestle with how to steer a life. Love’s Perils, Trauma’s Wounds: New Story Collections 2021-10-15T04:00:00Z At his most memorable, Mr. Phoenix plays wounded, stunted souls whose agonies are expressed almost reluctantly in halting words and somatic contortions, as in his brutal performance in Paul Thomas Anderson’s “The Master.” Movie Review: ‘Her,’ Directed by Spike Jonze 2013-12-17T22:54:49Z This process within the body, called somatic evolution, is what leads cancer cells to grow and make people sick. How microbes in food can impact your body’s defenses against cancer 2023-02-28T05:00:00Z We're talking the somatic definition of the term, not the jingoistic version. HBO's skate show "Betty" grows up, and not even a pandemic can break its momentum 2021-06-12T04:00:00Z If in any doubt, Bak-Maier recommends paying attention to “somatic responses”, such as feeling mysteriously tired, achey or queasy, when faced with taking action on your goal. Struggling with New Year's resolutions? We can help 2019-01-10T05:00:00Z Animals, according to somatic therapists, tremble and quiver to discharge stress. Hysteria or Healing? Examining the Power of the Shaking Body 2023-11-13T05:00:00Z Paranoia is an intellectual shading on a somatic experience, a physical reality that is fear. Are literary classics obsolete? 2012-05-31T00:00:00Z “There always felt like there was something physically stuck, a somatic feeling’” Mr. Styer said. Can You Poison Your Way to Good Health? 2021-01-01T05:00:00Z US rules on milk production allow it to contain more than double the amount of somatic cells – white blood cells that fight bacterial infections – than are found in British milk. UK anti-obesity drive at risk from new US trade deal, doctors warn 2018-03-18T04:00:00Z “It brings a somatic quality to the treatment that you don’t have in talk therapy or even cognitive behavioral therapy,” Feinstein told Salon in an email. Some swear tapping pressure points melts away anxiety. Does it actually work? 2023-10-31T04:00:00Z Confirming that psoriasis is not caused by any somatic mutations enables researchers to continue to explore other avenues. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z But recently the interest of spine radiologists has shifted to finding the pain generator in local low back pain, which can be classified as somatic pain. Readers Respond to the June 2023 Issue 2023-10-21T04:00:00Z Instead of substances, partygoers use tools such as meditation, breathwork and somatic movement to get in the flow and connect with one another. Malibu mayor says Kardashian party violated permit — a trend city leaders say is growing 2023-09-25T04:00:00Z These DNA changes introduce a diversity to the body’s somatic, or nonreproductive, cells that may be as important to health as the more pervasive alterations inherited from parents. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z “It brings a somatic quality to the treatment that you don’t have in talk therapy or even cognitive behavioral therapy.” Some swear tapping pressure points melts away anxiety. Does it actually work? 2023-10-31T04:00:00Z Over time, all cells in our bodies will accumulate mutations, known as somatic mutations. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z Up to 80 percent of people with the condition have the so-called somatic form, in which the disturbing noises are generated or altered by head or neck movements. New Tinnitus Therapy Can Quiet Torturous Ringing in the Ears 2023-07-13T04:00:00Z Reproductive cloning of animals uses a process called somatic cell nuclear transfer. Dubai camel cloning caters to races, beauty pageants 2023-05-25T04:00:00Z For decades, the conventional wisdom held that a person’s somatic cells could pick up mutations but that these genome alterations were rare and not a major cause of health problems. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z The PNS is then subdivided into the autonomic nervous system and the somatic nervous system. Fundamentals of Biology 2015-01-01T00:00:00Z In addition to this, no functional differences were seen between psoriasis and non-psoriasis tissue, suggesting that the condition is not linked to a specific somatic mutation in the skin. Psoriasis not caused by spontaneous mutations in skin cells 2023-10-26T04:00:00Z The study involved 99 people with somatic tinnitus, each of whom were given a prototype device for home treatment over the course of the study. New Tinnitus Therapy Can Quiet Torturous Ringing in the Ears 2023-07-13T04:00:00Z A somatic cell contains two matched sets of chromosomes, a configuration known as diploid. Concepts of Biology 2013-04-25T00:00:00Z But scientists now know that our genomes are riddled with somatic mutations. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z The somatic has voluntary control of skin, bones, joints, and skeletal muscle. Fundamentals of Biology 2015-01-01T00:00:00Z Despite the focus on somatic gene editing, the summit, the last in a series of three, could not avoid the shadow of He’s experiment. Gene-editing summit touts sickle cell success, while questions on embryo editing linger 2023-03-12T05:00:00Z “You can call something psychosomatic, but in the end, it’s somatic. How long can we ignore what is there?” Your Brain Could Be Controlling How Sick You Get—And How You Recover 2023-02-27T05:00:00Z Figure 6.2 There are 23 pairs of homologous chromosomes in a female human somatic cell. Concepts of Biology 2013-04-25T00:00:00Z Plenty of other mysteries about somatic mutations remain—for example, whether certain tissues accumulate more mutations than others. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Motor neurons and somatic neurons are all excitatory neurons. Fundamentals of Biology 2015-01-01T00:00:00Z Gray’s appearance was designed to underscore the rapid clinical advances in somatic cell gene editing—making noninheritable changes to a person’s DNA—and redirect attention away from the controversial prospect of heritable changes. Gene-editing summit touts sickle cell success, while questions on embryo editing linger 2023-03-12T05:00:00Z They spent two years completing the certificate in somatic psychotherapy and practices program at Antioch University during the pause. 7 choreographers on how dance changed in Southern California in 2022 2022-12-05T05:00:00Z Human somatic cells have 46 chromosomes consisting of two sets of 22 homologous chromosomes and a pair of nonhomologous sex chromosomes. Concepts of Biology 2013-04-25T00:00:00Z Researchers also want to determine whether some somatic mutations benefit us. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Specialties include somatic experiencing and working with dreams and creative expressive therapies. Use these mental health resources to help yourself — or anyone else 2022-09-22T04:00:00Z Figure 16.1 The genetic content of each somatic cell in an organism is the same, but not all genes are expressed in every cell. Biology for AP Courses 2022-06-09T00:00:00Z Some ethicists argue that we should distinguish between somatic cell interventions and germ-line interventions when discussing the morality of human genetic modification. Introduction to Philosophy 2022-06-15T00:00:00Z Telomerase is not active in adult somatic cells. Concepts of Biology 2013-04-25T00:00:00Z However, what’s good for specific cells isn’t necessarily good for the tissues they inhabit—cancer is a prime example—and whether any somatic changes improve our overall health is unclear. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z In 2013, they received a master’s degree in clinical mental health counseling at Portland State University in Portland, Ore., with an emphasis on interpersonal neurobiology and somatic psychotherapy. L.A. is due for a transformation. This three-card tarot reading will reveal what kind 2022-08-17T04:00:00Z Body cells are called somatic cells and have double the number of chromosomes found in reproductive cells. Biology for AP Courses 2022-06-09T00:00:00Z In somatic cell interventions, genetic changes cannot be inherited or passed to a patient’s offspring. Introduction to Philosophy 2022-06-15T00:00:00Z While all somatic cells within an organism contain the same DNA, not all cells within that organism express the same proteins. Concepts of Biology 2013-04-25T00:00:00Z In contrast, some somatic mutations occur in less than 1% of cells in a tissue. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z The sensations that lead to autonomic functions can be the same sensations that are part of initiating somatic responses. Anatomy and Physiology 2013-06-19T00:00:00Z It is not active in adult somatic cells. Biology for AP Courses 2022-06-09T00:00:00Z “I think somatically it speaks to the interest of these players who still have a lot to give to a club,” Thorrington said. LAFC hopeful Bale can join club within a couple weeks 2022-06-26T04:00:00Z Adult somatic cells that undergo cell division continue to have their telomeres shortened. Concepts of Biology 2013-04-25T00:00:00Z Work by other groups will include probing how somatic mutations affect gene activity and developing new approaches for sequencing the genomes of single cells. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z A more complex example of somatic function is conscious muscle movement. Anatomy and Physiology 2013-06-19T00:00:00Z Mutations can affect either somatic cells or germ cells. Biology for AP Courses 2022-06-09T00:00:00Z You talk about the somatic interpretation of things. Watching her mother's dementia led her to write a book about the moment the self ceases to exist 2022-05-09T04:00:00Z Then they suffer all the detritus of those psychological phenomena: anxiety, depression, inefficiency, lack of intrinsic motivation, contingent self-worth, burnout, academic entitlement, somatic symptoms like stomach aches, sleep loss, and more. Sprinting upstream: The incredible pressure faced by college-bound high schoolers 2022-05-01T04:00:00Z Lysenko, by contrast, argued that both environmental and somatic factors could also influence heredity. Americans don't like talking about it, but the Soviet Union produced a golden age of science 2022-04-10T04:00:00Z In the somatic nervous system, the thalamus is an important relay for communication between the cerebrum and the rest of the nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z If many mutations accumulate in a somatic cell, they may lead to problems such as the uncontrolled cell division observed in cancer. Biology for AP Courses 2022-06-09T00:00:00Z She was treated with traditional talk therapy and somatic therapy, a form of body-centered therapy, to explore the effect of stress on her body. After quitting BLM, co-founder Patrisse Cullors is healing: ‘I really thought I was gonna die’ 2022-01-13T05:00:00Z The idea was to use a technology that didn’t exist when the zoo had stored the samples: somatic cell nuclear transfer. In a conservation first, a cloned ferret could help save her species 2022-01-13T05:00:00Z When metrics are used that more accurately gauge their symptoms — including irritability, aggression, risk-taking, substance and alcohol abuse, somatic complaints — men are nearly depressed as women, according to a 2013 study. For many men, apps can be ‘an important gateway to mental health’ 2021-11-19T05:00:00Z The hypothalamus has both somatic and autonomic functions. Anatomy and Physiology 2013-06-19T00:00:00Z When a threshold signal is detected, nerves of the somatic nervous system that innervate skeletal muscle are stimulated. Biology for AP Courses 2022-06-09T00:00:00Z The result is a somatic landscape that seeks to cultivate a sense of collectivity during a distressingly isolating and disjointed time. An immersive sonic experience marks the Industry's return to live performance 2021-11-19T05:00:00Z The history of somatic treatments for mental disorders also provides a reason for caution. Has the Drug-Based Approach to Mental Illness Failed? 2020-10-17T04:00:00Z To understand the extent of somatic mutation in a human tissue, and the origin of skin cancers, a previous study2 used DNA sequencing of small biopsies of normal epidermis. Seeds of cancer in normal skin 2020-10-06T04:00:00Z However, some aspects of the somatic system use voluntary muscles without conscious control. Anatomy and Physiology 2013-06-19T00:00:00Z The nematode C.elegans has roughly 1000 somatic cells and scientists have studied the fate of each of these cells during their development in the nematode life cycle. Biology for AP Courses 2022-06-09T00:00:00Z This process, called somatic hyper-mutation, generates a lineage of related cells with different abilities to bind to the antigen that the BCR recognizes. Both naive and memory B cells respond to flu vaccine 2020-09-15T04:00:00Z It’s important to remain open to the possibility that somatic treatments may be helpful, at least for some patients. Has the Drug-Based Approach to Mental Illness Failed? 2020-10-17T04:00:00Z This carefully conducted study offers an unprecedented view of the landscape of somatic mutations in normal melanocytes, providing new clues about the origins of melanoma and presenting many intriguing observations that should motivate further research. Seeds of cancer in normal skin 2020-10-06T04:00:00Z From this brief video, only some of the descending motor pathway of the somatic nervous system is described. Anatomy and Physiology 2013-06-19T00:00:00Z Human somatic cells consist of 46 chromosomes—22 pairs of autosomal chromosomes and a pair of sex chromosomes. Biology for AP Courses 2022-06-09T00:00:00Z That experience of care, imbued with the knowledge of the somatic impacts of racism, loomed large for the Black Visions organizers. How a New Wave of Black Activists Changed the Conversation 2020-08-25T04:00:00Z It’s a history of one somatic treatment after another being initially hailed as curative, or extremely helpful, and then failing the test of time. Has the Drug-Based Approach to Mental Illness Failed? 2020-10-17T04:00:00Z With it, we reduce the huge circumambient room for error to a manageable somatic circumference. John Updike: My innermost swing thoughts - Golf Digest 2020-05-07T04:00:00Z This reflex is similar to the somatic reflex, but the efferent branch is composed of two neurons. Anatomy and Physiology 2013-06-19T00:00:00Z Somatic cells have 46 chromosomes and are diploid, whereas gametes have half as many chromosomes as found in somatic cells. Biology for AP Courses 2022-06-09T00:00:00Z He admits the findings are potentially controversial, as they minimize the perceived contribution to aging of environmental “somatic” mutations acquired throughout life. Rare ‘killer’ mutations present at birth could be taking years off your life 2020-04-24T04:00:00Z I’m also writing a book on somatic hearing, which is about the experience of receiving sound and the frequencies felt in the bones and in the muscular system. Kaitlyn Aurelia Smith's lockdown listening: 'Doing handstands, that’s the time for music' 2020-04-23T04:00:00Z Is knowing about somatic hypermutation in a Southern blot really making me a better physician and health policy researcher and advocate? A Major Medical Licensing Exam Is Going Pass/Fail, and it's About Time 2020-03-12T04:00:00Z In addition, every muscle fiber in a skeletal muscle is supplied by the axon branch of a somatic motor neuron, which signals the fiber to contract. Anatomy and Physiology 2013-06-19T00:00:00Z In somatic cells, an enzyme called telomerase no longer functions. Biology for AP Courses 2022-06-09T00:00:00Z This might involve considering, say, whether a set of genomic variants is somatic or present in the germline and so inherited. Genomics: data sharing needs an international code of conduct 2020-02-04T05:00:00Z But the sheer distance between the two places—and the 16-hour time difference—present significant logistical, psychological and somatic challenges. Here's how the American Presidents Cup team will travel from the Bahamas to Royal Melbourne - Golf Digest 2019-12-04T05:00:00Z She was particularly taken with Miyazaki’s scientific approach to studying the somatic and psychological effects of time outdoors. How Hipcamp Became the Airbnb of the Outdoors 2019-12-02T05:00:00Z The motor fibers, both somatic and autonomic, emerge as the ventral nerve root. Anatomy and Physiology 2013-06-19T00:00:00Z No, the mutations causing the cancer are in somatic cells, not reproductive germ cells. Biology for AP Courses 2022-06-09T00:00:00Z Antibody diversity arises when somatic recombination joins gene segments together, and when a subsequent process called somatic hypermutation operates, during the course of the antibody response, on the recombined gene segments encoding antibody variable regions. The advent and rise of monoclonal antibodies 2019-11-03T04:00:00Z The medical terms used since 2013 are somatic symptom disorder, which includes people with real symptoms, and illness anxiety disorder, in which patients without unusual symptoms worry excessively about getting sick. Health anxiety tends to rise after age 50. It doesn’t have to take over your life. | Produced by Advertising Publications 2019-10-08T04:00:00Z That finding suggested the plants were somehow eliminating harmful mutations in their somatic cells and accumulating beneficial ones for their reproductive cells. Meet the monkeyflower, a weed that may hold the key to zebra stripes and other biological mysteries 2019-08-29T04:00:00Z Simple somatic reflexes do not include the higher centers discussed for conscious or voluntary aspects of movement. Anatomy and Physiology 2013-06-19T00:00:00Z No, UV light only affects adult, somatic cells. Biology for AP Courses 2022-06-09T00:00:00Z They have a blunt somatic force, but there has to be something else to act on. The machine always wins: what drives our addiction to social media 2019-08-23T04:00:00Z While most mental illnesses becomes less common with age, El-Gabalawy said somatic symptom disorder does increase with age and illness. Health anxiety tends to rise after age 50. It doesn’t have to take over your life. | Produced by Advertising Publications 2019-10-08T04:00:00Z But flowers, which contain both kinds of germ cells—pollen and ova—form from active somatic tissue at the tips of growing stems. Meet the monkeyflower, a weed that may hold the key to zebra stripes and other biological mysteries 2019-08-29T04:00:00Z The general senses also include the visceral senses, which are separate from the somatic nervous system function in that they do not normally rise to the level of conscious perception. Anatomy and Physiology 2013-06-19T00:00:00Z Skeletal muscle is under voluntary, somatic nervous system control and is found in the muscles that move bones. Biology for AP Courses 2022-06-09T00:00:00Z It is therefore crucial to establish an acceptable level of risk to the germ line that allows in vivo somatic editing to proceed. Manage risk of accidental gene editing of germline 2019-04-22T04:00:00Z “On this very sensory, somatic level, I couldn’t bond with another human being,” she said. The Challenge of Going Off Psychiatric Drugs 2019-04-01T04:00:00Z Moreover, there is no objection to using gene editing in somatic cells to treat an individual patient in a way that does not pass along those changes. NIH and top scientists call for moratorium on gene-edited babies 2019-03-13T04:00:00Z The simple, single neuronal connection is the basis of somatic reflexes. Anatomy and Physiology 2013-06-19T00:00:00Z Muscle contraction speed increases as the somatic nervous system responds to local conditions and makes muscle contraction speed up or slow down. Biology for AP Courses 2022-06-09T00:00:00Z Most of the scientific community strongly supports editing somatic cells to treat diseases including sickle cell anemia, Huntington’s disease and Duchenne muscular dystrophy. Scientists Call for a Moratorium on Editing Inherited Genes 2019-03-13T04:00:00Z And they stress that they are not calling for a moratorium on genome editing of somatic cells, which would not affect future generations. A controversial new call to ban editing and implanting human embryos 2019-03-13T04:00:00Z But Wei notes that the same national approval will now be required for clinical research relying on editing somatic cells, such as those in the blood, that are not passed on to future generations. China tightens its regulation of some human gene editing, labeling it ‘high-risk’ 2019-02-28T05:00:00Z If a reflex is a limited circuit within the somatic system, why do physical and neurological exams include them to test the health of an individual? Anatomy and Physiology 2013-06-19T00:00:00Z A typical body cell, or somatic cell, contains two matched sets of chromosomes, a configuration known as diploid. Biology for AP Courses 2022-06-09T00:00:00Z Genome editing in somatic cells holds promise for treating many genetic diseases. CRISPR twins: a condemnation from Chinese academic societies 2018-12-18T05:00:00Z It was done after they were born, so these were somatic, not germline, edits. An ‘epic scientific misadventure’: NIH head Francis Collins ponders fallout from CRISPR baby study 2018-11-30T05:00:00Z But all these cases involved gene editing of so-called somatic cells, not sperm or eggs; such changes are not passed on to the patient’s children. CRISPR bombshell: Chinese researcher claims to have created gene-edited twins 2018-11-26T05:00:00Z The important regions of the CNS that play a role in somatic processes can be separated into the spinal cord brain stem, diencephalon, cerebral cortex, and subcortical structures. Anatomy and Physiology 2013-06-19T00:00:00Z Figure 10.3 There are 23 pairs of homologous chromosomes in a female human somatic cell. Biology for AP Courses 2022-06-09T00:00:00Z Scientists have seen hints that such genomic reshuffling—known as somatic recombination—happens in our brain. ‘Landmark study’ shows brain cells revamp their DNA to make new proteins, perhaps sparking Alzheimer’s disease 2018-11-21T05:00:00Z Taken together, Lee and colleagues’ work reveals the surprising existence of a phenomenon known as somatic gene recombination in the brain. A newly discovered mechanism driving neuronal mutations in Alzheimer’s disease 2018-11-20T05:00:00Z Michael, he said, was suffering from a somatic symptom disorder, popularly known as psychosomatic illness. Leaping from specialists to ERs fails to solve this young boy’s odd ailments 2018-10-19T04:00:00Z The special and somatic senses connect to the lateral nuclei, where their information is relayed to the appropriate sensory cortex of the cerebrum. Anatomy and Physiology 2013-06-19T00:00:00Z Body cells are called somatic cells and have the same number of chromosomes as reproductive cells. Biology for AP Courses 2022-06-09T00:00:00Z On the other hand, somatic recombination may promote Alzheimer’s disease in some people by producing harmful versions of the protein or by damaging brain cells in other ways, the scientists conclude. ‘Landmark study’ shows brain cells revamp their DNA to make new proteins, perhaps sparking Alzheimer’s disease 2018-11-21T05:00:00Z Conversely, does the level of OTX2 affect the fitness of somatic cells? How to lose your inheritance 2018-10-02T04:00:00Z In some cases, people who develop somatic disorders may experience sensations such as nausea or pain from a pulled muscle more intensely or frequently than expected. Leaping from specialists to ERs fails to solve this young boy’s odd ailments 2018-10-19T04:00:00Z Sensory tests address the various submodalities of the somatic senses: touch, temperature, vibration, pain, and proprioception. Anatomy and Physiology 2013-06-19T00:00:00Z Gametes contain half the number of chromosomes of somatic cells. Biology for AP Courses 2022-06-09T00:00:00Z Chun and his colleagues did not detect signs of somatic recombination in cells from other organs or in a different gene that’s active in the brain. ‘Landmark study’ shows brain cells revamp their DNA to make new proteins, perhaps sparking Alzheimer’s disease 2018-11-21T05:00:00Z In 1968, we were both in our prime, already beginning our slide into somatic decline. A groovy Now & Then that’s all about the ‘Then’ — Paul Dorpat’s 1968 Sky River Rock Festival 2018-08-30T04:00:00Z That emotion is stored, Damasio says, as a somatic marker and becomes permanently associated with your memories of that university. Review | Can neuroscience merge science with the humanities? 2018-08-23T04:00:00Z The human is a diploid organism, having 23 homologous pairs of chromosomes in each of the somatic cells. Anatomy and Physiology 2013-06-19T00:00:00Z Somatic cells have 23 chromosomes and are diploid, whereas gametes have half as many chromosomes are are present in somatic cells. Biology for AP Courses 2022-06-09T00:00:00Z But if somatic recombination occurs in neurons, Proukakis says, it could also be involved in other brain diseases, such as Parkinson’s disease. ‘Landmark study’ shows brain cells revamp their DNA to make new proteins, perhaps sparking Alzheimer’s disease 2018-11-21T05:00:00Z In patients with somatic symptom disorder, chronic symptoms result in excessive concern, fear and distress that something is seriously the matter, prompting them to seek repeated exams that rarely relieve their fears despite negative findings. A New Approach to Treating Hypochondria 2018-06-18T04:00:00Z This sounds like it could be a somatic mutation, which can not be inherited. Why Was This Teenager Bleeding So Excessively? 2018-03-13T04:00:00Z While all somatic cells contain the exact same genome, different cell types only express some of those genes at any given time. Anatomy and Physiology 2013-06-19T00:00:00Z A cloned toy poodle produced from somatic cells derived from an aged female dog. The Hidden Dogs of Dog Cloning 2018-03-10T05:00:00Z The latest edition of the Diagnostic and Statistical Manual of Mental Disorders replaced hypochondriasis with two alternatives: somatic symptom disorder and illness anxiety disorder. For people with severe health anxiety, the Internet can be a terrible place 2018-02-02T05:00:00Z And it all began with Dolly the sheep: she was cloned in 1996 using a method called somatic cell nuclear transfer. These cute monkey clones might be the key to better human medicine 2018-01-24T05:00:00Z In 1996, Dolly the sheep became the first mammal cloned using a technique called somatic cell nuclear transfer. Monkey Clones Created in the Lab. Now What? 2018-01-24T05:00:00Z In skeletal muscle, this sequence begins with signals from the somatic motor division of the nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z The cloned macaque monkeys are the latest application of a test-tube technique called somatic cell nuclear transfer pioneered 20 years ago with the creation of the cloned sheep named Dolly. China Breaks a Cloning Barrier: Primates 2018-01-24T05:00:00Z But, Lovell-Badge added, given the success of somatic cell nuclear transfer in other animals, it was not surprising that the method worked in macaques. Zhong Zhong and Hua Hua: first primates born using Dolly the sheep cloning method 2018-01-24T05:00:00Z The table also indicates for each gene whether germline or somatic ranking better explains the observed variation and includes gene annotation for the tissue-specific gene sets. Maternal age generates phenotypic variation in Caenorhabditis elegans 2017-11-28T05:00:00Z This outcome suggests that human embryos employ different DNA repair mechanisms than do somatic or pluripotent cells, probably reflecting evolutionary requirements for stringent control over genome fidelity in the germline. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z A homologous pair of chromosomes is the two copies of a single chromosome found in each somatic cell. Anatomy and Physiology 2013-06-19T00:00:00Z Its adherents tend to be regular, simple folk, who may not articulate a Jacksonian paradigm but understand its governing philosophy by somatic impulse. Down the Breitbart Hole 2017-08-16T04:00:00Z But using this method, called somatic cell nuclear transfer, on humans could be extremely unsafe, because the clone could have serious developmental disorders, Knoepfler says. Orphan Black is ending, but how far has human cloning come? 2017-08-11T04:00:00Z The functional effect of the mutations was annotated using Annovar43 and the variants were assessed for their confidence and split into somatic and non-somatic calls. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z Should we engage only in “somatic” gene editing: changing genes in affected tissues where they can’t be passed on to the next generation? Opinion | New gene-editing tool could cure disease. Or customize kids. Or aid bioterrorism. 2017-06-28T04:00:00Z How do somatic stem cells differ from embryonic stem cells? Anatomy and Physiology 2013-06-19T00:00:00Z Elderly patients often deny feeling sad or "blue" but acknowledge having the somatic symptoms of depression: poor appetite, insomnia, constipation, general weakness. Could Be the Thyroid; Could Be Ennui. Either Way, the Drug Isn’t Helping. 2017-04-21T04:00:00Z Comparison of recovery for germline SNPs and somatic variants was performed by Fisher’s exact test. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens : Nature : Nature Research 2017-03-21T04:00:00Z Predicted structural variants in the MB samples were considered somatic if they were detected in less than 1% of the 1000 Genomes Project samples. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z Although it is known that gross chromosomal abnormalities are remarkably common in early human embryos6, our understanding of early embryonic somatic mutations is very limited. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z Secondly, control of the body can be somatic or autonomic—divisions that are largely defined by the structures that are involved in the response. Anatomy and Physiology 2013-06-19T00:00:00Z It is intended to deprive you of all *externally caused* sensations - those termed "somatic." What a Sensory Isolation Tank Taught Me About My Brain 2016-12-29T05:00:00Z Comparison of recovery for germline SNPs and somatic variants was performed by Fisher’s exact test. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens : Nature : Nature Research 2017-03-21T04:00:00Z Therefore, the immediate 3′ and 5′ nucleotides of all somatic SNVs were extracted from the reference genome and the obtained trinucleotides were converted to pyrimidine context resulting in 96 possible mutation types. The whole-genome landscape of medulloblastoma subtypes : Nature : Nature Research 2017-07-18T04:00:00Z We assumed that additional 100 somatic mutations were further acquired during late cell doublings. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z Voluntary responses are governed by the somatic nervous system and involuntary responses are governed by the autonomic nervous system, which are discussed in the next section. Anatomy and Physiology 2013-06-19T00:00:00Z Detailed methods for library hybrid capture, read alignments and somatic variant calling are documented in Supplementary Information 3. Integrated genomic and molecular characterization of cervical cancer : Nature : Nature Research 2017-01-22T05:00:00Z What is less controversial, and already happening, is gene therapy that targets “somatic” cells, in which the changes are not heritable. Ethicists advise caution in applying CRISPR gene editing to humans 2017-02-14T05:00:00Z In addition, for the normal germline BAM, putative variants with less than 8× coverage of the reference allele or greater than one somatic variant-supporting read or 1% somatic variant allele fraction were removed. Integrated genomic characterization of oesophageal carcinoma : Nature : Nature Research 2017-01-03T05:00:00Z The early human embryonic mutation rate estimated here indicates that, using similar methods to those introduced in mice5, reconstruction of cell lineage trees using somatic mutations should be possible in humans. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z Some somatic motor responses are reflexes, and often happen without a conscious decision to perform them. Anatomy and Physiology 2013-06-19T00:00:00Z The ‘somatic mutations’ panel shows the presence or absence of mutations for 7 of the identified SMGs. Integrated genomic and molecular characterization of cervical cancer : Nature : Nature Research 2017-01-22T05:00:00Z "We suspect that the accumulation of damage with age, especially mutations in the individual cells of the body, somatic mutations, ultimately places a limit on lifespan," Milholland said. Ripe old age: humans may already have reached maximum lifespan 2016-10-05T04:00:00Z Shifting within mindful awareness to a focus on the body may involve a functional shift away from linguistic conceptual facts toward the nonverbal imagery and somatic sensations of the right hemisphere. How Meditation Can Help Make Your Mind Happier 2016-09-07T04:00:00Z In contrast to normal tissues, which are composed of multiple somatic cell clones, a breast cancer derives from a single somatic cell. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z Any sensory or integrative functions that result in the movement of skeletal muscle would be considered somatic. Anatomy and Physiology 2013-06-19T00:00:00Z The ‘somatic mutations’ panel shows the presence or absence of mutations for 7 of the identified SMGs. Integrated genomic and molecular characterization of cervical cancer : Nature : Nature Research 2017-01-22T05:00:00Z He argued that people who develop the other form are born with two normal alleles, both of which must become mutated in two 'sporadic' events in somatic cells, so the cancer develops later in life. Alfred G. Knudson (1922-2016) : Nature : Nature Research 2016-08-23T04:00:00Z In some cases, doctors find themselves in sticky situations, such as when a patient exhibits hypochondria or somatic symptom disorder, characterized by excessive or unrealistic worries about his or her health. Why to Trust Your Hunch You're Sick – Even if Tests Say Otherwise 2016-08-16T04:00:00Z A list of somatic mutations catalogued in this study. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z The somatic nervous system is traditionally considered a division within the peripheral nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z Then, they sequenced the genes of the 343 tumors taken from those patients for evidence of “somatic” mutations. A genetic link found between red hair, freckles and skin cancer 2016-07-12T04:00:00Z And because the germline mutation affects all somatic cells, these children are more prone to developing multiple tumours in both eyes. Alfred G. Knudson (1922-2016) : Nature : Nature Research 2016-08-23T04:00:00Z I thought, at least in theory, we should be able to reprogram somatic cells back into the embryonic state so we can make ES-like stem cells directly from skin or blood cells. Dolly at 20: The inside story on the world’s most famous sheep 2016-06-28T04:00:00Z We assumed that additional 100 somatic mutations were further acquired during late cell doublings. Somatic mutations reveal asymmetric cellular dynamics in the early human embryo : Nature : Nature Research 2017-03-21T04:00:00Z However, this misses an important point: somatic refers to a functional division, whereas peripheral refers to an anatomic division. Anatomy and Physiology 2013-06-19T00:00:00Z When somatic illusions strike, in other words, they strike our very sense of who we are. What the Science of Touch Says About Us 2016-05-16T04:00:00Z The summit statement acknowledged the many “promising and valuable” uses for gene editing of somatic cells — which don’t transmit the human genome to succeeding generations. It’s too early for gene-editing of human reproductive cells, experts conclude 2015-12-03T05:00:00Z Several scientists expressed concern on Tuesday the germline controversy might hamper research on non-reproductive cells, known as somatic cells, that could potentially help people with inherited or infectious diseases. Too early to use gene editing in embryos: scientist 2015-12-02T05:00:00Z There appeared to be broad agreement at the meeting that "somatic" cell editing, in which the changes are done in non-reproductive cells and are not passed along, posed few risks. Ethicists square off over editing genes in human embryos 2015-12-01T05:00:00Z The description of this withdrawal reflex was simplified, for the sake of the introduction, to emphasize the parts of the somatic nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z “Rodents as animal models have come of age, and our ability to bring modern molecular-genetic approaches to age-old questions on somatic sensation is now incredibly powerful.” What the Science of Touch Says About Us 2016-05-16T04:00:00Z “Complex bereavement is complicated and can also give rise to other psychiatric and somatic conditions, such as major depression and hypertension,” said Therese Rando, a psychotherapist who has written several books on grief. Parental Grief Has Often Been a Factor in Presidential Politics 2015-10-22T04:00:00Z The discovery and translation of inherited determinants of drug response and somatically acquired genetic variants in cancer are prominent pharmacogenomic components of these and other initiatives. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z While the trauma is very real and still very present, Patel said some of EB’s wounds were somatic — his quiet voice became almost muted, the words unable to pass through his throat. Running for their lives, Ethiopians seek a safer track in Washington 2015-09-26T04:00:00Z The autonomic nervous system regulates organ systems through circuits that resemble the reflexes described in the somatic nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z The study of haptic intelligence leads to even deeper questions about the somatic self. What the Science of Touch Says About Us 2016-05-16T04:00:00Z All cells except those involved in reproduction are known as somatic. Why the Case Against Designer Babies Falls Apart 2015-07-30T04:00:00Z In cancer, both inherited and somatically acquired variants can influence a patient's response to treatments. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z The different consequences of human genome modification in either somatic cells or the germ line, and the modification of the ecosystem through gene drives, call for different ethical and policy evaluations. Regulate gene editing in wild animals 2015-05-11T04:00:00Z The main difference between the somatic and autonomic systems is in what target tissues are effectors. Anatomy and Physiology 2013-06-19T00:00:00Z Key to all discussion and future research is making a clear distinction between genome editing in somatic cells and in germ cells. Don’t edit the human germ line 2015-03-11T04:00:00Z The best predictors of local somatic mutation density are epigenomic features derived from the most likely cell type of origin of the corresponding malignancy. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z And some somatically acquired genetic variants direct the choice of 'targeted' anticancer drugs for individual patients. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z He reported in May 2013 using the Dolly technique, known more formally as somatic cell nuclear transfer, to derive stem cells from cloned human embryos, including from a baby with an inherited disorder. Stem cell pioneer joins forces with stem cell fraudster 2015-02-10T05:00:00Z Whereas the basic circuit is a reflex arc, there are differences in the structure of those reflexes for the somatic and autonomic systems. Anatomy and Physiology 2013-06-19T00:00:00Z In general, researchers who want to investigate the clinical uses of genetically engineered somatic cells must secure people’s informed consent. Don’t edit the human germ line 2015-03-11T04:00:00Z Cancer is a disease potentiated by mutations in somatic cells. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z But researching somatic cloning of mammoths with a small number of Asian elephants might enhance elephant conservation. Can scientists bring mammoths back to life? 2015-02-06T05:00:00Z Pathway alterations include homozygous deletions, focal amplifications and somatic mutations. Comprehensive genomic characterization of head and neck squamous cell carcinomas : Nature : Nature Publishing Group 2015-01-27T05:00:00Z The output of a somatic reflex is the lower motor neuron in the ventral horn of the spinal cord that projects directly to a skeletal muscle to cause its contraction. Anatomy and Physiology 2013-06-19T00:00:00Z The judges wrote that the plaintiffs, rancher Jason Abraham and veterinarian Gregg Veneklasen, failed to prove that the organization's stud registry committee colluded to bar horses created through somatic cell nuclear transfer, or cloning. U.S. court rules horse association free to reject clones from registry 2015-01-15T05:00:00Z Instead, different human genomic regions vary by up to fivefold in the local density of cancer somatic mutations1, posing a fundamental problem for statistical methods used in cancer genomics. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z The process, known as somatic cloning, tempted us with the idea that if we could obtain just a single working nucleus from any cell, we could reproduce the entire animal. Can scientists bring mammoths back to life? 2015-02-06T05:00:00Z Pathway alterations include homozygous deletions, focal amplifications and somatic mutations. Comprehensive genomic characterization of head and neck squamous cell carcinomas : Nature : Nature Publishing Group 2015-01-27T05:00:00Z Figure 15.6 Comparison of Somatic and Visceral Reflexes The afferent inputs to somatic and visceral reflexes are essentially the same, whereas the efferent branches are different. Anatomy and Physiology 2013-06-19T00:00:00Z Once the somatic cell nucleus is in place, a lab worker uses electricity to fuse the nucleus and oocyte together into a reconstructed embryo that’s implanted into a surrogate mother. For $100,000, You Can Clone Your Dog 2014-10-22T04:00:00Z First, most of the somatic mutations observed in cancers may arise before the epigenetic changes linked to neoplastic progression. Cell-of-origin chromatin organization shapes the mutational landscape of cancer : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Attempts at somatic cloning of mammalian cells that have been frozen for years have failed, with one possible exception. Can scientists bring mammoths back to life? 2015-02-06T05:00:00Z They also provide exhaustive accounts of the different kinds of delusions — persecutory, grandiose and somatic, among others — that left this lay reader, at least, exhausted. Book review: ‘Suspicious Minds ,” on culture and madness, by Joel Gold and Ian Gold The somatic senses are those that usually make up the conscious perception of the how the body interacts with the environment. Anatomy and Physiology 2013-06-19T00:00:00Z What’s likely is that knowing too much about somatic feedback throws a wrench in the circuitry, undercutting the message the body sends to itself. How Smiling Can Backfire 2014-09-16T04:00:00Z Likewise, while Lupski thinks that somatic variation is significant, he is not yet convinced that it’s helpful. Garbled DNA Might Be Good for You 2014-09-12T04:00:00Z By reconstructing the mammoth genome through a mosaic of samples, scientists might be able to engineer a cell nucleus and then use the somatic cloning method that led to Dolly the sheep. Can scientists bring mammoths back to life? 2015-02-06T05:00:00Z DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. Comprehensive molecular profiling of lung adenocarcinoma : Nature : Nature Publishing Group 2014-07-08T04:00:00Z The sensory exam tests the somatic senses, meaning those that are consciously perceived. Anatomy and Physiology 2013-06-19T00:00:00Z This cloning method, called somatic cell nuclear transfer, can be used only on species for which we have cellular material. The Mammoth Cometh 2014-02-27T10:00:19Z If a somatic mutation happens during development in a rapidly dividing tissue, it may be present in hundreds or millions of cells. Garbled DNA Might Be Good for You 2014-09-12T04:00:00Z Males appear to hijack the longevity and stress resistance pathways normally employed by the mothers to slow reproduction and somatic aging in times of stress. [Report] Mating Induces Shrinking and Death in Caenorhabditis Mothers 2014-01-30T19:26:14.273Z As researchers seek to duplicate Obokata’s methods and results on their own, it remains to be seen whether the process will work for human somatic cells. New Approach To Reprogramming May Speed Up Delivery Of Stem Cells 2014-01-30T17:28:00Z The resulting difference in pain threshold is due to the fact that the upper region is innervated by visceral sensory fibers, and the lower region is innervated by somatic sensory fibers. Anatomy and Physiology 2013-06-19T00:00:00Z Our results provide a genetic identikit of an ancient dog and demonstrate the robustness of mammalian somatic cells to survive for millennia despite a massive mutation burden. [Report] Transmissable Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage 2014-01-23T19:26:41.142Z In his eyes, the downsides of somatic mutation in the brain are obvious, and any potential benefit is yet to be proven. Garbled DNA Might Be Good for You 2014-09-12T04:00:00Z As patients with scleroderma and antibodies against RPC1 are at increased risk for cancer, we hypothesized that the “foreign” antigens in this autoimmune disease are encoded by somatically mutated genes in the patients’ incipient cancers. [Research Article] Association of the Autoimmune Disease Scleroderma with an Immunologic Response to Cancer 2014-01-09T18:56:14.192Z The variations in the extent of bone reduction are presumably due to somatic chimaerism with regard to disruption. e, Proportions of mild and strong bone phenotypes induced by disruption of by sgRNA/Cas9. Elephant shark genome provides unique insights into gnathostome evolution 2014-01-08T18:21:42.027Z What special features are evident in sperm cells but not in somatic cells, and how do these specializations function? Anatomy and Physiology 2013-06-19T00:00:00Z Pregnenolone antagonized most of the known behavioral and somatic effects of THC. [Report] Pregnenolone Can Protect the Brain from Cannabis Intoxication 2014-01-02T19:26:43.858Z Most genome scientists assume that this DNA diversity, called “somatic mutation” or “structural variation,” is bad. Garbled DNA Might Be Good for You 2014-09-12T04:00:00Z The subclonal structure and transcription status of underlying somatic mutations reveal the trajectory of tumour progression in patients with cancer. Mutational landscape and significance across 12 major cancer types 2013-10-16T17:22:05.383Z First, the genome assembly suggests a close linkage of immunoglobulin and T-cell receptor genes, compatible with the notion that the somatically diversifying antigen receptor genes evolved from a common ancestor via en bloc duplications. Elephant shark genome provides unique insights into gnathostome evolution 2014-01-08T18:21:42.027Z The brain superimposes this experience onto the sensory homunculus where the somatic nerves are connected. Anatomy and Physiology 2013-06-19T00:00:00Z In a sense, the somatic cells sacrifice their genetic "immortality" to protect the germ-line cells. Debate on Evolution of Multicellular Organisms Starts to Gain Focus 2013-09-30T22:45:00.843Z Whether somatic mutations are largely beneficial, or even an essential source of human diversity and adaptability, will be harder to answer. Garbled DNA Might Be Good for You 2014-09-12T04:00:00Z Tumours with zero detected somatic mutations were also excluded, resulting in mutations from 2,611 tumours for downstream clustering analysis. Mutational landscape and significance across 12 major cancer types 2013-10-16T17:22:05.383Z The variations in the extent of bone reduction are presumably due to somatic chimaerism with regard to disruption. e, Proportions of mild and strong bone phenotypes induced by disruption of by sgRNA/Cas9. Elephant shark genome provides unique insights into gnathostome evolution 2014-01-08T18:21:42.027Z The remaining thoracic aorta branches are collectively referred to as parietal branches or somatic branches, and include the intercostal and superior phrenic arteries. Anatomy and Physiology 2013-06-19T00:00:00Z It may be helpful to differentiate between macroevolution and microevolution in the somatic evolution of DCCs. Selection and adaptation during metastatic cancer progression 2013-09-18T17:22:42.817Z Such relaxation of constraints on genome structure is reminiscent of other mitotic lineages such as cancer cells and somatic tissues. Genomic evidence for ameiotic evolution in the bdelloid rotifer Adineta vaga 2013-08-21T17:50:58.107Z We used the clinical correlation module of MuSiC to examine how clinical features correlate with somatic events within individual tumour types. Mutational landscape and significance across 12 major cancer types 2013-10-16T17:22:05.383Z Exome sequencing of UTUCs from 19 individuals with documented exposure to AA revealed a remarkably large number of somatic mutations and an unusual mutational signature attributable to AA. [Research Articles] Mutational Signature of Aristolochic Acid Exposure as Revealed by Whole-Exome Sequencing 2013-08-07T18:55:10.757Z The special senses are all primarily part of the somatic nervous system in that they are consciously perceived through cerebral processes, though some special senses contribute to autonomic function. Anatomy and Physiology 2013-06-19T00:00:00Z The global pattern of somatic alterations, determined from analysis of 417 samples, is shown in . Comprehensive molecular characterization of clear cell renal cell carcinoma 2013-07-03T17:20:51.807Z But alongside several outstanding research groups at Cardiff University, I will also aim to advance research using embryonic stem cells and reprogrammed somatic cells to advance understanding of neuronal dysfunction. Science plan lands 'star' researcher 2013-06-17T06:07:03Z We designed a strategy for investigating this reprogramming, which consisted of identifying a large number of tissue-restricted genes that are epigenetically silenced in normal somatic cells and then detecting their expression in cancer. [Research Articles] Ectopic Activation of Germline and Placental Genes Identifies Aggressive Metastasis-Prone Lung Cancers 2013-05-22T18:55:05.923Z Many in genetics and aging research speak about two different kinds of cells: somatic cells and the germ line cells mentioned earlier. Prolonging the buzz with Grandma 2013-05-22T12:45:03.507Z The motor components of the somatic nervous system begin with the frontal lobe of the brain, where the prefrontal cortex is responsible for higher functions such as working memory. Anatomy and Physiology 2013-06-19T00:00:00Z As expected, they wrote, somatic cell nuclei introduced into cytoplasts under these conditions developed into normal blastocysts. Viable Human Embryonic Stem Cells Created By Cloning 2013-05-17T12:47:40Z The third type are somatic stem cells, cells isolated from a specific organ—like the human ear. Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z So if you somatically allocate to growth, for instance, you have less to allocate towards maintenance and reproduction. Kate Clancy s Short Grant Rant: On Broken Promises 2013-01-27T21:45:00.250Z In the somatosensory cortex, cells form columns that respond to specific somatic stimulus modalities. The entorhinal grid map is discretized 2012-12-11T21:22:10.423Z Reflexes are the simplest circuits within the somatic nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z The left panel shows non-silent somatic mutation patterns and frequencies for significantly mutated genes. Comprehensive molecular portraits of human breast tumours 2012-10-03T18:22:40.017Z A role for somatic mutation in the cancer hallmark of avoiding immune destruction is suggested by the presence of inactivating mutations in the HLA-A gene. Comprehensive genomic characterization of squamous cell lung cancers 2012-09-26T17:23:20.903Z The coloured bars show cases that are significantly enriched or suppressed in somatic mutations. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Variants found as expected in the tumour but absent in the normal DNA were designated somatic. Recurrent R-spondin fusions in colon cancer 2012-08-29T17:52:03.740Z The nervous system can be divided into two functional parts: the somatic nervous system and the autonomic nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z The left panel shows non-silent somatic mutation patterns and frequencies for significantly mutated genes. Comprehensive molecular portraits of human breast tumours 2012-10-03T18:22:40.017Z As described in , we verified somatic mutations by performing an independent hybrid-recapture of 76 genes in all samples. Comprehensive genomic characterization of squamous cell lung cancers 2012-09-26T17:23:20.903Z The suppression of somatic mutation is consistent with important functional roles of these elements within tumour cells, highlighting a potential alternative set of targets for examination in cancer. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z Indels that were present in the tumour and absent in the normal sample were designated somatic and are reported in . Recurrent R-spondin fusions in colon cancer 2012-08-29T17:52:03.740Z The somatic nervous system causes contraction of skeletal muscles. Anatomy and Physiology 2013-06-19T00:00:00Z All coding somatic SNVs identified in the combined cohort are listed in . Dissecting the genomic complexity underlying medulloblastoma 2012-08-01T17:52:34.853Z Left, alterations in oxidative stress response pathway genes as defined by somatic mutation, copy number alteration or up- or downregulation. Comprehensive genomic characterization of squamous cell lung cancers 2012-09-26T17:23:20.903Z The coloured bars show cases that are significantly enriched or suppressed in somatic mutations. An integrated encyclopedia of DNA elements in the human genome 2012-09-05T17:21:22.380Z The background mutation rate, fi, was determined by multiplying the number of synonymous somatic variants by and normalizing by the total number of protein-coding nucleotides. Recurrent R-spondin fusions in colon cancer 2012-08-29T17:52:03.740Z The defining characteristic of the somatic nervous system is that it controls skeletal muscles. Anatomy and Physiology 2013-06-19T00:00:00Z We conclude that duplication is a somatic event highly specific to Group 4 medulloblastoma. Subgroup-specific structural variation across 1,000 medulloblastoma genomes 2012-08-01T17:52:08.330Z Left, alterations in oxidative stress response pathway genes as defined by somatic mutation, copy number alteration or up- or downregulation. Comprehensive genomic characterization of squamous cell lung cancers 2012-09-26T17:23:20.903Z The somatic mutation rates varied considerably among the samples. Comprehensive molecular characterization of human colon and rectal cancer 2012-07-18T17:21:40.967Z Remaining variations present in the tumour sample but absent in the matched normal were predicted to be somatic. Recurrent R-spondin fusions in colon cancer 2012-08-29T17:52:03.740Z The same is not true for somatic reflexes. Anatomy and Physiology 2013-06-19T00:00:00Z Recurrent somatic alterations in breast cancer have been described, including mutations and copy number alterations, notably ERBB2 amplifications, the first successful therapy target defined by a genomic aberration. Sequence analysis of mutations and translocations across breast cancer subtypes 2012-06-20T17:22:32.787Z Distinct phenotypes in oestrogen-receptor-positive breast cancer are associated with specific patterns of somatic mutations that map into cellular pathways linked to tumour biology, but most recurrent mutations are relatively infrequent. Whole-genome analysis informs breast cancer response to aromatase inhibition 2012-06-20T17:22:05.433Z But it fails to mention that we are increasingly aware of the neurobiology of somatic memory, i.e. body and emotional memory without any semantic or narrative component. Letters: Memory’s Many Roots (1 Letter) 2012-06-18T22:15:30Z The monthly somatic mutation screens catch cancer so early nowadays.” UGS (Universal Genome Sequencing) in the Mid-21st Century 2012-06-09T18:45:02.963Z Central control of autonomic reflexes is different than for somatic reflexes. Anatomy and Physiology 2013-06-19T00:00:00Z Top bar plot shows somatic mutation rate of 25 sequenced melanoma genomes, in decreasing order. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z We have to deal simply with the old questions of what is constitutionally in the germ, what is acquired by the body, and lastly, whether the somatically acquired is inherited. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z Together with the lack of recurrent mutations, our data indicate that neuroblastoma carry few early somatic tumour-driving mutations with amino-acid-changing consequences. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z “I walk,” he said, “in order to somatically medicate myself against the psychosis of contemporary urban living.” Matt Green?s Goal Is to Walk Every Street in New York City 2012-03-24T15:23:47Z The afferent branch of the somatic and visceral reflexes is very similar, as many somatic and special senses activate autonomic responses. Anatomy and Physiology 2013-06-19T00:00:00Z Top bar plot shows somatic mutation rate of 25 sequenced melanoma genomes, in decreasing order. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z There are numerous cases which can not be explained as transmissions of somatic acquirements even if this transmission could be established in certain cases. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z The small variant, structural variant and splice-site somatic tables were merged on the gene symbol, and unique tumour IDs were counted to obtain a final list of recurrent gene affecting variants. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z Man has probably 16 chromosomes in the somatic cell, and the mature male and female germ cells in man contribute eight chromosomes each to the nucleus of the impregnated ovum. Essays In Pastoral Medicine 2012-03-05T03:00:09.993Z Which of the following represents a sensory input that is not part of both the somatic and autonomic systems? Anatomy and Physiology 2013-06-19T00:00:00Z In the development of the threadworm of the horse according to Boveri, the very first cleavage of the ovum establishes a distinction between somatic and reproductive cells. Herbert Spencer 2012-02-29T03:00:20.773Z Disease.—Perhaps in the realm of disease more than in any other has an interest in the inheritance of somatic acquirements been manifested. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z Subsequently, gene symbol, amino acid change and effect categories were extracted from gene-GSXXX-ASM.tsv files for all genomes and added as annotation to the somatic output results. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z Candidate somatic events in the primary tumour and relapse genomes were identified and selected for hybridization capture-based validation using methods described in . Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z The trigeminal nerve is a mixed nerve that carries the general somatic senses from the head, similar to those coming through spinal nerves from the rest of the body. Anatomy and Physiology 2013-06-19T00:00:00Z Putative somatic sequence mutations, and structural alterations identified using CREST, were validated by PCR and sequencing. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z Only such a condition as this would rank as the inheritance of a somatic modification. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z CallDiff with somatic output was performed on all of the 87 tumour/lymphocyte pairs and processed. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z A single clone containing all of the cluster 5 mutations was detected in the relapse sample; clone 5 evolved from clone 4, but gained 78 new somatic alterations after sampling at day 170. Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing 2012-01-25T18:51:09.287Z As described in this video, the nervous system has a way to deal with threats and stress that is separate from the conscious control of the somatic nervous system. Anatomy and Physiology 2013-06-19T00:00:00Z A notable finding was a high frequency of somatic alterations targeting histone modification in ETP ALL. The genetic basis of early T-cell precursor acute lymphoblastic leukaemia 2012-01-11T18:21:11.777Z In the few cases where permanent inheritable changes were seemingly produced they were more reasonably interpreted as the effects of direct action on the germ-cells than as examples of inherited somatic modifications. Being Well-Born An Introduction to Eugenics 2012-05-22T15:16:53.140Z We ran CallDiff with somatic output on all of the 87 tumour/lymphocyte pairs and processed the somatic output files as described in the small variants section earlier. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z The objectors chose to forget that the sexual function is neither purely psychic nor merely somatic. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z Motor control from the cerebrum, as well as sensory input from somatic, visual, and vestibular senses, are important to cerebellar function. Anatomy and Physiology 2013-06-19T00:00:00Z Those genes that helped somatic cells live longer and age more slowly maintained the quality of the cell's membranes and proteins. Egg Timer: Separate Biological Clocks Govern Female Fertility and Life Span 2011-12-06T00:15:09.730Z These characteristics probably relate to the chromatin diminution described previously for some ascaridoids, indicating that our assembly represents the somatic genome of this parasite. Ascaris suum draft genome 2011-11-23T18:21:44.707Z Variants with somatic scores lower than 0.1 or of types insertion/substitution, but which were validated by Sanger sequencing, were maintained in the table. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z And so we shall not be surprised to discover that the true neuroses are the direct somatic consequences of sexual disturbances. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z For no matter how faintly or how fitfully the substance of heredity may be modified by somatic tissues, the Lamarckian principles are hypothetically allowed some degree of play. Darwin, and After Darwin, Volume 2 Post-Darwinian Questions: Heredity and Utility 2011-10-16T02:00:14.153Z "This study shows that the conventional approach to somatic cell nuclear transfer is inefficient in humans," said Professor Mary Herbert of Newcastle University and Newcastle Fertility Center. Scientists use cloning to make human stem cells 2011-10-05T17:18:21Z In this way we get a simple classification of the cells which form, for example, a human being, namely, germ-cells and body-cells, the latter often being termed “somatic.” Embryology The Beginnings of Life 2011-09-12T02:00:28.483Z From this germinal protoplasm, which makes the germ-cells, he distinguishes the somatic protoplasm which makes the mortal, somatic cells. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z By physicians, of course, the dream was considered as a non-psychic act, as the manifestation of somatic irritations in the psychic life. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z Therefore the hereditary effect, if subsequent to the period of embryonic germination, must have been produced on germ-plasm as this occurs diffused through the somatic tissues. Darwin, and After Darwin, Volume 2 Post-Darwinian Questions: Heredity and Utility 2011-10-16T02:00:14.153Z Inner arcs represent somatic fusion transcripts identified in at least one of the 11 genomes. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z Put in another way the body, or somatic cells, contribute absolutely nothing to the original material or germ-plasm of which the germ-cells are composed. Embryology The Beginnings of Life 2011-09-12T02:00:28.483Z In his opinion, somatic cells and germ-cells were sharply distinct at their first appearance in evolution, and have remained so ever since. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z Let us assume as a hypothesis for everything which follows, that the dream is not a somatic but a psychic phenomenon. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z The law banned human cloning, although after a review in 2005 the law was amended the next year to allow therapeutic cloning, or somatic cell nuclear transfer. Australia Stem Cell Regs Withstand Scrutiny 2011-07-08T16:21:55Z Purple circles indicate the position of genes with at least two confirmed somatic mutations with circle diameter proportional to the number of cases with cSNVs detected in that gene. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z Unlike embryonic stem cells, the use of somatic -- or adult -- stem cells, as in this case, is not controversial as they are derived from adult tissue samples and not destroyed human embryos. South Korea back in stem cell spotlight with new treatment 2011-07-07T06:01:52Z The phyletic origin of the somatic cells depended directly upon an unequal separation of the determinants contained in the germplasm. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z Unfortunately it may be assumed here again that the cases are frequent in which the somatic stimulus which operated during the night can no longer be traced after waking, and has thus become unverifiable. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z Australian researchers have so far generated over 50 embryonic stem cell lines from surplus embryos, and three research groups have been licensed to attempt somatic cell nuclear transfer. Australia Stem Cell Regs Withstand Scrutiny 2011-07-08T16:21:55Z The total number of cases in which each gene contained either cSNVs or confirmed somatic mutations is shown at the top. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z The use of somatic stem cells in treatment is not unprecedented for patients who do not respond to conventional therapy. South Korea back in stem cell spotlight with new treatment 2011-07-07T06:01:52Z The twofold nature of the process of development is a cardinal point in his theory, linked to his doctrine of immortality for unicellular organisms and germ-cells and mortality for somatic cells. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z This must, of course, be a question only of twitching, like spasmodic reactions, a question only of psychic phenomena such as follow directly upon somatic stimulation. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z Taken together, these results indicate that human iPSs like hESCs and in contrast to somatic cells, rely more on glycolysis than on oxidative phosphorylation for energy production. [Editors' Choice] A Curious Case of Cellular Metabolism 2011-07-06T20:25:30.993Z Table 1: Overview of cSNVs and confirmed somatic mutations in most frequently mutated genes We expected tumour suppressor genes to show strong selection for the acquisition of nonsense mutations. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z Hearticellgram-AMI takes somatic stem cells extracted from the patient's own bone marrow that are then cultured and directly injected into the damaged heart. South Korea back in stem cell spotlight with new treatment 2011-07-07T06:01:52Z The somatic cells, on the other hand, are endowed only with fragments of germplasm, and hence they are incapable of preserving the species, and are doomed to death. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z If the sensory stimulus is not always externally induced, it may be instead a stimulus proceeding from the internal organs, a so-called somatic stimulus. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z Figure 1: Profile of somatic mutations in four CLL genomes. a, Distribution of somatic alterations. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia 2011-07-06T17:21:01.303Z Purple circles indicate the position of genes with at least two confirmed somatic mutations with circle diameter proportional to the number of cases with cSNVs detected in that gene. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z The delicate cells of the brain become fatigued by sympathy with the somatic cells and it is harder to secure those nervous connections necessary for thought. Psychotherapy 2011-06-19T02:00:20.053Z Between somatic cells and reproductive cells Weismann places a gulf that cannot be bridged. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z But let us not overlook the fact that many recognized experiences testify to the derivation of dreams from the somatic stimulus. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z The presence of several point mutations in cis, located near the transcriptional start site of a gene that is highly expressed in the germinal centre, is a characteristic feature of somatic hypermutation. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia 2011-07-06T17:21:01.303Z Inner arcs represent somatic fusion transcripts identified in at least one of the 11 genomes. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z "This reopens the whole need for SCNT, which will be controversial," said Lanza, of Advanced Cell Technology, referring to somatic cell nuclear transfer, the scientific term for cloning. Stem-cell rejection shocks scientists 2011-05-14T04:24:22Z The reproductive cells, like unicellular organisms, are regarded as immortal, the somatic cells as mortal. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z The matter stands thus: If the dream is a somatic phenomenon, it does not concern us. A General Introduction to Psychoanalysis 2011-12-06T03:00:21.763Z The patterns of somatic mutation, supported by functional and clinical analyses, strongly indicate that the recurrent , and mutations are oncogenic changes that contribute to the clinical evolution of the disease. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia 2011-07-06T17:21:01.303Z The total number of cases in which each gene contained either cSNVs or confirmed somatic mutations is shown at the top. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z These somatic signs are quite noticeable in most of these cases, and by early recognition proper treatment, with change of climate, frequently prolongs life for years. Degeneracy Its Causes, Signs and Results 2011-05-02T02:00:17.657Z From this point of view, the immortality of unicellular organisms and of the germplasm breaks down, and, above all, the artificial distinction between somatic cells and reproductive cells. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z Their somatic characters are remarkably homogeneous; they have a tawny white skin, much hair on the face, straight hair, dark brown eyes, a narrow, generally aquiline nose, and a very short and high head. Man, Past and Present 2011-03-28T02:00:29.283Z Figure 1: Profile of somatic mutations in four CLL genomes. a, Distribution of somatic alterations. Whole-genome sequencing identifies recurrent mutations in chronic lymphocytic leukaemia 2011-07-06T17:21:01.303Z Genes with roles in histone modification were frequent targets of somatic mutation. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z A powerful way to understand the molecular basis of cancer is to sequence either the entire genome or the protein-coding exome, comparing tumour to normal from the same patient to identify the acquired somatic mutations. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z Between somatic cells and reproductive cells there is no strong contrast, no gulf that cannot be bridged. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z Do not, he said, think that I mean the flesh which invests and covers me, and bid you eat that; nor suppose either that I command you to drink my sensible and somatic blood. Encyclopaedia Britannica, 11th Edition, Volume 9, Slice 8 "Ethiopia" to "Evangelical Association" 2011-03-05T03:00:24.537Z As shown in , focal somatic deletions affecting the locus were commonly observed in these tumours, as expected. The genomic complexity of primary human prostate cancer 2011-02-09T18:22:53.550Z We analysed the RNA-seq data to determine whether any of the somatic mutations in the 109 recurrently mutated genes showed evidence for allelic imbalance with expression favouring one allele. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z The latter he regarded as arising directly from the egg-cell, and never from somatic cells. The Biological Problem of To-day Preformation Or Epigenesis? The Basis of a Theory of Organic Development 2011-08-29T02:01:04.170Z Farther forward, the bullet would hit the somatic sensory cortex, which is responsible for comprehending touch. Bullet's path mey determine Giffords's injuries 2011-01-11T03:20:01Z Conceivably, somatic rearrangements may occur within regions of closed chromatin in tumour cells lacking ETS gene fusions. The genomic complexity of primary human prostate cancer 2011-02-09T18:22:53.550Z We observed an enrichment of somatic mutations affecting genes involved in transcriptional regulation and, more specifically, chromatin modification. Frequent mutation of histone-modifying genes in non-Hodgkin lymphoma 2011-08-17T17:21:43.793Z And that underscores his determination to be an omniscient and omnipresent commentator on health-related affairs, one-stop shopping for all your somatic curiosities and some of your spiritual and intellectual ones to boot. Mehmet Oz - Dr. Does-It-All 2010-04-16T16:06:00Z The team focused on specific aberrations in the genetic code known as somatic copy-number alterations, in which segments of a tumor's genome contain extra copies of a piece of DNA or lack the segment altogether. Genome study shows what cancers have in common 2010-02-17T21:08:00Z He made a small adjustment, however, bringing his own somatic state into a closer harmony with that of the creature, and the desired level of contented appreciation rose. Fair and Warmer These are the products of the somatic cells; the disease lies deeper in their germinal constitution. The Social Direction of Evolution An Outline of the Science of Eugenics Equatorial plate from a somatic cell of a male larva, 23 chromosomes. Studies in Spermatogenesis Part II In order to determine the number and character of the chromosomes in the male somatic cells, several male pupæ were sectioned. Studies in Spermatogenesis Part I Contributions from all lands have conspired to produce this effect, the somatic school of psychologists in Germany having exerted, probably, the most influence. Chapters in the History of the Insane in the British Isles Tensor became uncomfortably aware that he had better be careful of his induced somatic sympathy. Fair and Warmer I had attained total somatic consciousness; I was able to analyze the exact relationship of the drug to the molecular structure of my own protoplasm. Last Resort No male somatic cells were found in mitosis, but they would, if found, show the same conditions as in the spermatogonia. Studies in Spermatogenesis Part II Equatorial plate from dividing somatic cell of male pupa, showing 19 large and 1 small chromosome. 205-206. Studies in Spermatogenesis Part I It is to nature what in Weismann's theory the germ plasm is to the somatic cell. Monophysitism Past and Present A Study in Christology He could not recall ever before permitting such an unusual somatic state. Fair and Warmer Above all, in order to distinguish between dementia, idiocy, cretinism, and an imitation of these forms, a minute somatic examination is necessary. Criminal Man According to the Classification of Cesare Lombroso Equatorial plate from somatic tissues of a male pupa, 27 large chromosomes, 1 small one. Studies in Spermatogenesis Part II Nature and the spiritual, without this embodied intelligence, this somatic being, called man or angel or ape, are as ermine on a wax figure. The Book of Khalid Turning now to consider these influences by themselves, we have to distinguish between those that are somatic or physical and those that are psychical in nature. The Sexual Life of the Child "You simply can't imagine the violent somatic compulsions one encounters under such a balance." Fair and Warmer Perhaps a few, some isolate few remembered that time of chaos a season ago—but it was fleeting recall at best, as somatic responses rose to blot it out. The Beginning In one of the Elateridæ, where the spermatogonial number is 19, the female somatic number is 20, and in Aphrophora the numbers in male and female cells are respectively 23 and 24. Studies in Spermatogenesis Part II It is well known how Weismann was led, by his hypothesis of the continuity of the germ-plasm, to regard the germinal cells—ova and spermatozoa—as almost independent of the somatic cells. Creative Evolution That's why a good laugh is a medicine; it allows us to get rid of psychic poison, just as a good sweat rids us of somatic poison. A Dominie in Doubt Dorsal to this, in 6, comes a space lined by somatic mesoblast, and continuous with p.p., the pleuro-peritoneal cavity, or body cavity of the embryo. Text Book of Biology, Part 1: Vertebrata Voice production for the purpose of speaking and singing implies a coöperation of the psychic and the physiological, a co-ordination of processes that are psychic, and physical, somatic or physiological. Voice Production in Singing and Speaking Based on Scientific Principles (Fourth Edition, Revised and Enlarged) As in several of the forms studied, material was collected for examination of the somatic cells, but no favorable cases of mitosis were to be found. Studies in Spermatogenesis Part II The few features of known cause indicate that special somatic characteristics are determined largely or wholly by industrial and other arts, which are primarily shaped by environment. The Siouan Indians The somatic or historical sense is in every case the first that must be ascertained. History of Dogma, Volume 2 (of 7) The tadpole has, at first, a straight tubular heart, burrowed out in somatic mesoblast, and produced forward into a truncus arteriosus. Text Book of Biology, Part 1: Vertebrata The defect is at the distal end of the combination—i.e., in the physical, somatic or bodily part of the process to express the same idea by the use of different terms. Voice Production in Singing and Speaking Based on Scientific Principles (Fourth Edition, Revised and Enlarged) This would seem to be a favorable form for determining the chromosome conditions in somatic cells, but no clear equatorial plates were found in either larvæ or pupæ. Studies in Spermatogenesis Part II A somatic delusion is one centering upon alterations in the organs or their functions. Applied Psychology for Nurses The Scripture has a threefold sense because, like the cosmos, alongside of which it stands like a second revelation, as it were, it must contain a pneumatic, psychic, and somatic element. History of Dogma, Volume 2 (of 7) The somatic cells probably lost their immortal qualities, on this immortality becoming useless to the species. The Birth-Time of the World and Other Scientific Essays Both originate in the infantile life and result from the transformation which our psychic and somatic organism has undergone since the infantile period. Dream Psychology Psychoanalysis for Beginners Turning now to the female larvæ to determine the somatic number, the oögonia proved to be more favorable for counting. Studies in Spermatogenesis Part II To-day an understanding of the life history, of the patient's somatic and functional assets and problems, likes and dislikes, the problem presented by the family, etc.! A Psychiatric Milestone Bloomingdale Hospital Centenary, 1821-1921 Note 15: It is possible that the heightened adhesion is only the result of a special intensive somatic sexual manifestation of former years. Three Contributions to the Theory of Sex He bases the appearance of death on variations in the reproductive cells, encouraged by the ceaseless action of natural selection, which led to a differentiation into perishable somatic cells and immortal reproductive cells. The Birth-Time of the World and Other Scientific Essays On the other hand, the pediatrists seem to lack the point of view which alone makes comprehensible the whole series of phenomena, on the somatic as well as on the psychic side. Dream Psychology Psychoanalysis for Beginners These somatic cells, being mortal, differ altogether from the germ-cells and the protozoa. The Whence and the Whither of Man A Brief History of His Origin and Development through Conformity to Environment; Being the Morse Lectures of 1895 He makes it only too clear that by "somatic Christianity" he means that faith which is based on the gospel history. Christian Mysticism In order to bring the question to a decision, it was only necessary to have one other circumstance, viz., a regular concurrence of the inversion with the psychic and somatic signs of hermaphroditism. Three Contributions to the Theory of Sex The sex glands are especially important as endocrine organs; in fact the somatic cells are organized around the germ cells, as pointed out above. Taboo and Genetics A Study of the Biological, Sociological and Psychological Foundation of the Family Metabolic chemical processes may thus be found to furnish a key to complex and subtle sexual variations, alike somatic and psychic, although we must still regard such processes as arising on an inborn predisposition. Studies in the Psychology of Sex, Volume 2 Sexual Inversion But, 2, there are nutritive, somatic cells, which nourish and transport the germ-cells, and after their discharge die. The Whence and the Whither of Man A Brief History of His Origin and Development through Conformity to Environment; Being the Morse Lectures of 1895 Moreover, we have seen from the evidence given in my preceding article that the germ-cells issuing from a parent’s body can, and do, respond to profound impressions made on the somatic cells. The Humour of Homer and Other Essays Thus we must recognize that inversion and somatic hermaphroditism are totally independent of each other. Three Contributions to the Theory of Sex As far back as forty years ago, a writer showed that corporal punishment had the most powerful somatic stimulative effects. The Education of the Child And yet the albino itself shows no somatic pattern or pigment. The Project Gutenberg Encyclopedia Volume 1 of 28 The germ-plasm contains representatives of the whole army; a somatic cell only representatives of one special arm of a special training. The Whence and the Whither of Man A Brief History of His Origin and Development through Conformity to Environment; Being the Morse Lectures of 1895 Now the ideals of religion are invoked that the soul may have a better and regenerated somatic organism with which to serve Jesus and the Church. Youth: Its Education, Regimen, and Hygiene The same also holds true in the somatic androgyny. Three Contributions to the Theory of Sex Moreover, somatic sexual characters where they do occur have no common characteristics either in structure or position in the body. Hormones and Heredity All three sons married, and two of them had only normal children, judged of course by somatic characters. The Project Gutenberg Encyclopedia Volume 1 of 28 But the very constitution of the germ-plasm and its relation to the body absolutely forbids the transmission of acquired somatic characteristics and of the special effects of use and disuse. The Whence and the Whither of Man A Brief History of His Origin and Development through Conformity to Environment; Being the Morse Lectures of 1895 If whatever is physiologically wrong is morally wrong, and whatever is physiologically right is morally right, we have an important ethical suggestion from somatic conditions. Youth: Its Education, Regimen, and Hygiene What distinguishes the impulses from one another and furnishes them with specific attributes is their relation to their somatic sources and to their aims. Three Contributions to the Theory of Sex By 'modification reversible' he means a change in the ovum which will produce in the next generation a somatic modification similar to that by which it was produced. Hormones and Heredity Most characters, somatic or psychic, are the products not of the action of one internal secretion alone, but of the interlinked activities of all of them. The Glands Regulating Personality The centre of control is therefore not to be sought in individual cells, whether germ-cells or somatic, but in the organism. The Whence and the Whither of Man A Brief History of His Origin and Development through Conformity to Environment; Being the Morse Lectures of 1895 As you have seen so many North American Indians, you will be able to give interesting explanations of their somatic relations to the South American Indians. Louis Agassiz: His Life and Correspondence The only attention given to somatic sexual manifestations occurring before the age of puberty was in connection with degenerative manifestations, and these were referred to as a sign of degeneration. Three Contributions to the Theory of Sex Here we have again merely the same influence, chemical in this case, acting simultaneously on somatic cells and germ-cells, which is not the inheritance of acquired characters at all. Hormones and Heredity Growth, as a general name for the mutations, the ensemble of somatic and psychic differentiation, from year to year, passes through five epochs that are standard for the normal. The Glands Regulating Personality They have more energy, feel clearer mentally, have fewer unwanted somatic symptoms. How and When to Be Your Own Doctor Whatever changes had taken place in the somatic characteristics of mankind since the Exodus, they had not altered the compatibility of human germ plasm. The Lani People The same result follows in all three cases, namely, a state which can be designated as "sexual excitation" and which manifests itself in psychic and somatic signs. Three Contributions to the Theory of Sex It does not follow that the primary sex-character or the somatic characters are exclusive in either sex. Hormones and Heredity Long ago, Hippocrates, revered founder of the art of medicine, recognized that there was a specific affinity of disease for individuals with more or less the same characteristic somatic and psychic traits and trends. The Glands Regulating Personality The typical divisions are often spoken of as somatic. Darwin and Modern Science I say IT, as if the desire were an entity, a personality, but what I mean is that the somatic and cerebral activities of a desire become so organized as to operate as a unit. The Foundations of Personality Let us hope that he has indeed a potency and importance out of all proportion to his somatic insignificance. The Evolution of Modern Medicine A Series of Lectures Delivered at Yale University on the Silliman Foundation in April, 1913 On the chromosome theory as formulated by Morgan this factor must be in the somatic chromosomes and not in the sex-chromosomes, and must be present in every zygote. Hormones and Heredity So social instinct and the capacity for inhibition, the ability to control himself conceptually and somatically, are poor. The Glands Regulating Personality This is especially striking in the gonotokonts, but it applies also to the somatic tissues. Darwin and Modern Science And it is undeniable that predictions, premonitions, etc., may be very vivid, and have considerable somatic influence. Criminal Psychology; a manual for judges, practitioners, and students The previous work had suggested that somatic delusions are perhaps more of the nature of illusions in the sense that somatic bases for somatic false beliefs are as a rule found. The Journal of Abnormal Psychology, Volume 10 In Lepidoptera among insects the evidence concerning castration tends to prove that hormones from the gonads play no part at all in the development of somatic sexual characters. Hormones and Heredity The pragmatic test has been and will be the probability that the correction of the somatic or psychic condition would have prevented or will prevent the consent to the crime. The Glands Regulating Personality This doubling of the somatic number of chromosomes is now known in a number of plants and animals. Hormones and Heredity Hence, it is in no way sufficient to consider only the physiological traits of the somatic life of woman, i. e., menstruation, pregnancy, child-birth, the suckling period, and finally the climacterium. Criminal Psychology; a manual for judges, practitioners, and students Dr. Southard wishes to try to map out these defects in the cerebral structures and thus reason backwards to the somatic inferiority. The Journal of Abnormal Psychology, Volume 10 Two other methods are conceivable by which the influence of somatic hormones might be evident. Hormones and Heredity Any break in the somatic or psychic equilibrium, a blow or an infection, or a startling thing seen, or a worrisome thought felt, will start a process going. The Glands Regulating Personality Theory supposes that somatic modifications by means of hormones affect the determinants in the gametes. Hormones and Heredity Just as important as these phenomena are the somatic results of psychic irritation. Criminal Psychology; a manual for judges, practitioners, and students E. E. SOUTHARD, Boston: Are all these somatic explanations of metaphysics? The Journal of Abnormal Psychology, Volume 10 At the same time there are some somatic sex-characters, e.g. in insects and birds, which do not appear to be correlated with changes in the gonads, and which are probably gametogenic, not somatogenic in origin. Hormones and Heredity So by analogy we may explain all somatic and psychic differentiation as functions of the glands of internal secretion. The Glands Regulating Personality We have here, I think, an example of the essential difference between mutations and somatic modifications. Hormones and Heredity This means clearly that the somatic manifestations of inner excitement are so closely bound up with the latter that we require the former whenever we want to say anything about the latter. Criminal Psychology; a manual for judges, practitioners, and students Before leaving this nightmare, I want to call attention again to the somatic elements. The Journal of Abnormal Psychology, Volume 10 The latter conception is the more general, for cases of somatic sexual characters exist which cannot be said to have a use or function. Hormones and Heredity Or because somatic changes are minor, the psychic will dominate the picture. The Glands Regulating Personality This would be the result in the first generation in which a somatic modification affected the factors in the chromosomes. Hormones and Heredity Woman is not only somatically and psychically rather different from man; man never is able wholly and completely to put himself in her place. Criminal Psychology; a manual for judges, practitioners, and students And it may be generally stated that the clinician can get very valuable points concerning the somatic interiors of his patients by reasoning back from the contents of their somatic delusions. The Journal of Abnormal Psychology, Volume 10 In conclusion I will briefly consider the attempts which have been made to prove the influence of somatic modifications or characters on the gametes by direct experiment. Hormones and Heredity Adolescence is the period of stress and strain throughout the somatic and psychic organism because of the volcanic upheavals in the sex glands. The Glands Regulating Personality The question therefore is whether the somatic modification is inherited. Hormones and Heredity The fact that Proteus does not rapidly become as deeply coloured when exposed to light as ordinary Amphibia shows that the gametic factors for pigmentation have been modified as well as the somatic tissues. Hormones and Heredity Perhaps something can be obtained if we limit ourselves to a study of cases with pronounced somatic renal symptoms and signs, cases with the renal facies and the like. The Journal of Abnormal Psychology, Volume 10 This was held to prove that the somatic characters of the "foster mothers" were transmitted. Hormones and Heredity The material summarized in the preceding paragraphs furnish some slight inkling of the vast dominion of Sex, in all its relations, somatic and spiritual, over which the glands of internal secretions rule. The Glands Regulating Personality The question remains, therefore, where are the factors of the somatic sex-characters? Hormones and Heredity A second homotypic division takes place in which each chromosome splits into two as in somatic divisions, and thus we have 4 gametes with 7 chromosomes each. Hormones and Heredity There then seems to be more reality about somatic than about personal delusions: the contents of somatic delusions are rather more apt to correspond with demonstrable realities than the contents of personal delusions. The Journal of Abnormal Psychology, Volume 10 By his studies of parasitic castration Geoffrey Smith was led to formulate a theory for the explanation of somatic sex-characters different from that of hormones. Hormones and Heredity Without the maternal instinct, without the hope of immortality through somatic or spiritual posterity, we should all, who were sane enough, have to condemn ourselves to the futilities of hedonism. The Glands Regulating Personality In the majority of fishes, in which fertilisation is external and no care is taken of the eggs or young, there are no somatic sexual differences. Hormones and Heredity It is no explanation, therefore, to say that these various organs and characters are the expression of sex in the somatic cells. Hormones and Heredity Taken naively, the facts suggest a somatic genesis for somatic delusions exactly in proportion as these delusions are not so much false beliefs as partially true ones. The Journal of Abnormal Psychology, Volume 10 Other cases occur in which the number of chromosomes in the somatic cells is double the ordinary number—namely, 28—and others in which the number is 21. Hormones and Heredity Close observation of the correlation of somatic and psychic development in extreme examples of these children corroborates this view. The Glands Regulating Personality When we examine these somatic differences we find that they can be classified according to their relation to fertilisation and reproduction, including the care or protection of the offspring. Hormones and Heredity The antlers of stags are the best case in favour of the Lamarckian view of the evolution of somatic sexual characters. Hormones and Heredity The somatic phenomena he regards as always subordinate and accessory. The Journal of Abnormal Psychology, Volume 10 |
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