| 单词 | sickle |
| 例句 | In Noel’s blood, the cells had morphed, mysteriously, into shriveled, scythe-shaped crescents—“sickle cells,” as Irons later described them. The Gene 2016-06-02T00:00:00Z “Of course not, Sheriff. Jane is terrible with a rifle. I was thinking more along the lines of the sickle, a weapon designed specifically for the close-combat techniques of an Attendant.” Dread Nation 2018-04-03T00:00:00Z Dae took a month off from school to care for his mother, who was sick with sickle cell. The Other Wes Moore: One Name, Two Fates 2010-04-27T00:00:00Z She reaches for the sickle and holds it up. First They Killed My Father: A Daughter of Cambodia Remembers 2000-01-01T00:00:00Z The red blood cells of some people of African descent look like sickles or crescent moons. Cosmos 1980-01-01T00:00:00Z “The point of the sickle can pierce a person’s skull.” First They Killed My Father: A Daughter of Cambodia Remembers 2000-01-01T00:00:00Z On the small porch, there are a couple of rocking chairs and hooks holding sickles, a scythe, and extra-sharp swords within close reach, in case shamblers get through the barrier fence. Dread Nation 2018-04-03T00:00:00Z I hold up one of the sickles and point to the curved blade. Dread Nation 2018-04-03T00:00:00Z For instance, the stone sickles, underground storage pits, and other technology that hunter-gatherers of the Fertile Crescent had been evolving to utilize wild cereals were available to the first cereal farmers of the Fertile Crescent. Guns, Germs, and Steel: The Fates of Human Societies 1997-03-01T00:00:00Z Abigail spied him in the field that July of 1801, working alongside the hired hands, swinging his sickle and murmuring obscenities at his political opponents. Founding Brothers: The Revolutionary Generation 2000-10-17T00:00:00Z Jasmine had a blood disease since birth—sickle cell anemia—which can affect almost every part of the body. Look Both Ways 2019-10-08T00:00:00Z Now came, however, the boys out of the barn, and they descended upon us with sickle, froe, and scythe. The Astonishing Life of Octavian Nothing, Traitor to the Nation, Volume II: The Kingdom on the Waves 2009-10-13T00:00:00Z The revelation leaves my mouth dry, and my hands itch for my sickles. Dread Nation 2018-04-03T00:00:00Z More than once I imagine sinking my rusty sickles into his skull. Dread Nation 2018-04-03T00:00:00Z “See if they got a belt to hold my sickles,” I call. Dread Nation 2018-04-03T00:00:00Z It touched draft horses hitched to wagons and sickle blades glittering sharp and ready at the beginning of an autumn day. The Name of the Wind 2007-03-27T00:00:00Z The pain is a distant throb to my desire to do a little sickle work across Bill’s face. Dread Nation 2018-04-03T00:00:00Z The woman grabbed the captive by the hair, hooked the sickle round his throat, and slashed. A Dance with Dragons 2011-07-12T00:00:00Z A white-haired woman stepped toward them through a drift of dark red leaves, a bronze sickle in her hand. A Dance with Dragons 2011-07-12T00:00:00Z “All we’ve got on this kidnapping is that a letter was found, Erlone’s to be released, the letter was signed by ‘Red,’ and there was a hammer and sickle emblem on it. Native Son 1940-03-01T00:00:00Z I breathe heavily, my sickles and hands covered in the inky mess that is a shambler’s blood. Dread Nation 2018-04-03T00:00:00Z Seconds later, festival-goers stream past, many falling out of sight, cut down as they run, like stalks of wheat beneath a sickle. An Ember in the Ashes 2015-04-28T00:00:00Z The saw-like sickles had only lately been put away, and the wheat stood in stooks of eight among the tall stubble of those tin** The Wait still itched. The Once and Future King 1958-01-01T00:00:00Z I take out my sickles, ready to end her, when Katherine makes a choked sound. Dread Nation 2018-04-03T00:00:00Z On the stage, in front of a velvet curtain, were two flags: the Stars and Stripes and the unmistakable and portentous crimson Soviet banner with its hammer and sickle. Endgame 2011-02-01T00:00:00Z I just spin my sickles in my hand, relishing their comfortable weight. Dread Nation 2018-04-03T00:00:00Z Good Friends, the Buddhist aid group with informants in the North, reported in 2009 that one soldier on a state farm was stabbed with a sickle during a fight over corn. Escape from Camp 14: One Man's Remarkable Odyssey from North Korea to Freedom in the West 2013-03-26T00:00:00Z He disappears into a room off the side and returns with a pair of sickles. Dread Nation 2018-04-03T00:00:00Z I drop the sickles, and as I fall to my knees someone kicks me again in the back, the boot digging deep between my ribs. Dread Nation 2018-04-03T00:00:00Z My sickles are heavy at my side and my penny is a warm, comforting weight around my neck. Dread Nation 2018-04-03T00:00:00Z So I go in his shed, put the sledgehammer back, take out the sickle, and go tackle the weeds down by his mailbox. Shiloh 1991-01-01T00:00:00Z A reel feeds the standing grain into the sickle, where it is cut. Hattie Big Sky 2006-09-26T00:00:00Z These clumps grew so large, particularly in the absence of oxygen, that they tugged the membrane of the red cell until the normal disk was warped into a crescent-shaped, dysmorphic “sickle cell.” The Gene 2016-06-02T00:00:00Z “Sir, I ain’t going to need to know how things work when I’m dead from a shambler’s bite. Would you please look at this sickle?” Dread Nation 2018-04-03T00:00:00Z She went first to the barn, where the men were sharpening hoes and sickles in preparation for the summer hay cutting. The Midwife's Apprentice 1995-01-01T00:00:00Z A greyhound, as white as ivory, couching on its hocks and elbows, its tail curved into the bony sickle of the greyhound, watched the old man with the doe-soft eyes of pity. The Once and Future King 1958-01-01T00:00:00Z I knew very well that all he said was ridiculous, not light for their darkness but flattery, illusion, a vortex pulling them from sunlight to heat, a kind of midsummer burgeoning, waltz to the sickle. Grendel 1971-01-01T00:00:00Z Scarlet banners with the hammer and sickle emblem of world revolution were lifted, and they fluttered in the May breeze. Black Boy 1945-01-01T00:00:00Z Everywhere you turned there were college students in T-shirts, signing people up for sickle cell anemia testing and voter registration. One Crazy Summer 2010-01-01T00:00:00Z I didn’t risk taking a gun for these nocturnal excursions, and my sickles were only so fast. Dread Nation 2018-04-03T00:00:00Z And then, after handing her my spare set of sickles, we secure our weapons and are off into the night. Dread Nation 2018-04-03T00:00:00Z The glass bowl shattered along the circular depression in its middle, leaving me with a jagged sickle of a shard. The City Beautiful 2021-10-05T00:00:00Z In the daytime the cows were turned into the high stubble and weeds which had been left by the harvest sickles. The Once and Future King 1958-01-01T00:00:00Z But what made a red blood cell acquire a sickle shape? The Gene 2016-06-02T00:00:00Z The closest thing had been farmers with sickles and scythes in the fields. The Name of the Wind 2007-03-27T00:00:00Z She scanned the fingernails of the little hand she held, and slid a black sickle of dirt from under the thumbnail. The God of Small Things 1997-01-01T00:00:00Z I just pick up my sickles and storm over to where the rest of the girls gather. Dread Nation 2018-04-03T00:00:00Z The sickle Moon was gleaming dimly among the leaves. The Fellowship of the Ring 1954-07-29T00:00:00Z Woolf glanced at War Admiral’s beautiful head, sweeping through the air like a sickle. Seabiscuit: An American Legend 2001-01-01T00:00:00Z “I don’t know where you might be able to find her. Careful boy, that one will steal your heart. Men fall for her like wheat before a sickle blade.” The Name of the Wind 2007-03-27T00:00:00Z I feel better having a real weapon, but I still ache for my sickles. Dread Nation 2018-04-03T00:00:00Z During the day, we train with the few sickles, hoes, knives, stakes, and guns that are available in the camp. First They Killed My Father: A Daughter of Cambodia Remembers 2000-01-01T00:00:00Z Could we be trading Stalin’s sickle for something worse? Between Shades of Gray 2011-03-22T00:00:00Z I drew a swastika on her palm and the hammer and sickle on top of my hand, the Lithuanian flag shredded and falling in between. Between Shades of Gray 2011-03-22T00:00:00Z The blades are rusty, the edges dull, and the pair of sickles I pick up ain’t even weighted properly. Dread Nation 2018-04-03T00:00:00Z How he picked up his sickle, whirled around and sickled the smell that fixed the ghost forever. The God of Small Things 1997-01-01T00:00:00Z I adjust my grip on my sickles and roll my shoulders. Dread Nation 2018-04-03T00:00:00Z I grab my fallen weapon and pick my first target, a Negro girl wearing clothing that looks eerily like mine, and leap, sickle swinging to take the thing down. Dread Nation 2018-04-03T00:00:00Z I pick my way down the wall, jumping too early and dropping a sickle, nearly losing my balance when I hit the bottom. Dread Nation 2018-04-03T00:00:00Z His lips rose again, in a smile as hard and sharp as a sickle. The City Beautiful 2021-10-05T00:00:00Z Still, the dead keep on coming, and I can't do anything but continue to swing my sickles. Dread Nation 2018-04-03T00:00:00Z I grip my sickles, ready to swipe at anything that comes out, but nothing does. Dread Nation 2018-04-03T00:00:00Z She walks with the grace and carriage of a true lady; I slouch along, hands resting on the hilts of my sickles, ready to draw them at the first sign of trouble. Dread Nation 2018-04-03T00:00:00Z He pointed away over the land of Rohan into the darkling West under the sickle moon. The Two Towers 1954-11-11T00:00:00Z Then suddenly, a picture of Met Bong lunging at the fishermans throat with her sickle flashes before my eyes. First They Killed My Father: A Daughter of Cambodia Remembers 2000-01-01T00:00:00Z I thought of her sickleshaped birthmark, the elegant curve of her neck, her luminous eyes. The Kite Runner 2003-05-01T00:00:00Z A quick glance down reveals that my sickles are covered in shamblers blood, and I give them a quick spin to clear some of it off before scrubbing my face clean with my sleeve. Dread Nation 2018-04-03T00:00:00Z The sickle whistles as it slices through the air, singing in the moments before it separates her head from her body. Dread Nation 2018-04-03T00:00:00Z There is only the constant moan of shamblers, the swing of my sickles as I harvest, the inevitable double thump when the creatures fall to the ground, head rolling one way, body the other. Dread Nation 2018-04-03T00:00:00Z There are several sets of sickles and quite a few scythes, but none of them have been cared for. Dread Nation 2018-04-03T00:00:00Z It still needs oil, and it’s nowhere as good as my sickles back home, but it’s better than anything else, and I’m glad for it. Dread Nation 2018-04-03T00:00:00Z I hurry back into the rooms, pushing past Katherine and grabbing the cavalry sword and my sickles. Dread Nation 2018-04-03T00:00:00Z I take my sickles from the sheriff, then open the door. Dread Nation 2018-04-03T00:00:00Z Gogol is accustomed to the scenery, yet he still stares, at the short, dark men pulling rickshaws and the crumbling buildings side by side with fretwork balconies, hammers and sickles painted on their facades. The Namesake 2003-09-01T00:00:00Z “Beneath the signature is a scrawled emblem of the Communist Party, the hammer and the sickle,” said Mr. Dalton. Native Son 1940-03-01T00:00:00Z The sickle was inside me, twisting and stabbing. Salt to the Sea 2016-02-02T00:00:00Z But as I’m trying to yank the sickles through the shambler's neck I get a good look at its face, and my heart stutters to a stop. Dread Nation 2018-04-03T00:00:00Z A deep gash cuts across her face in the shape of a sickle. The Belles 2018-02-06T00:00:00Z The sheriff approaches Katherine, reaching around her to offer me the sickles. Dread Nation 2018-04-03T00:00:00Z A sickle moon threaded itself into the silk. Bone Gap 2015-03-03T00:00:00Z Swords, daggers, spears, sickles, axes, and some weapons Anya couldn’t even name were mounted on the walls, covering every inch of space. Anya and the Dragon 2019-09-24T00:00:00Z He’s got a big old sickle; is cutting weeds along his side of the road. Shiloh 1991-01-01T00:00:00Z Death hacked at me with its sickle, tearing, chopping, unbearable. Salt to the Sea 2016-02-02T00:00:00Z Mist lay there, pale-glimmering in the last rays of the sickle moon. The Two Towers 1954-11-11T00:00:00Z I place my foot behind the shambler's and use my sickle to push it backward. Dread Nation 2018-04-03T00:00:00Z No one took her seriously because she was small and feathered, a strange little dino-bird, but she had a sickle claw and she was not afraid to use it. Breadcrumbs 2011-09-27T00:00:00Z On my right, Katherine has my spare set of sickles out, and on my left, Red Jack has pulled out a long knife from God knows where. Dread Nation 2018-04-03T00:00:00Z The woman was overjoyed at the sight of so much thatching grass and she immediately began to cut it down with her sickle. The Girl Who Married a Lion: and Other Tales from Africa 2004-12-07T00:00:00Z Katherine looks at me, and I point my sickle behind her. Dread Nation 2018-04-03T00:00:00Z Next to it are my sickles, the blades as curved and sharp as Miss Anderson’s tongue. Dread Nation 2018-04-03T00:00:00Z Everywhere you turned there were college students in T-shirts, signing people up for sickle cell anemia testing and voter registration. One Crazy Summer 2010-01-01T00:00:00Z When he woke a dog was licking vomit from his beard, and dark clouds were scuttling across the face of a sickle moon. A Dance with Dragons 2011-07-12T00:00:00Z The normal way to lose an arm, leg, or whatever in Milagro was by having it mangled in tractor sickle bars or crushed beneath a horse. The Milagro Beanfield War 1974-01-01T00:00:00Z It kills me a little to have to give the sheriff even the barest semblance of respect when all I want to do is test the edge of my sickles against his neck. Dread Nation 2018-04-03T00:00:00Z That wall is covered with the same set of weaponry as my locker: twin sickles, a Remington single-action revolver, a rifle, a pair of spiked batons. Dread Nation 2018-04-03T00:00:00Z The black markings on their backs, chests, and shoulder blades stood out in the bright sun, skulls and sickles, women’s faces, and incomprehensible cyphers, as well as skeletons, Virgin Marys, gloomy curves, and lofty quotations. The Bard of Eastern Ukraine, Where Things Are Falling Apart 2016-11-28T05:00:00Z A red hammer and sickle glowed in the center of the wave. Stepping Into the Uncanny, Unsettling World of Shen Yun 2019-03-19T04:00:00Z Prodigy — who died on Tuesday at 42 after being hospitalized for complications related to sickle cell anemia — grew up in a rage. Perspective | How Mobb Deep’s Prodigy changed rap music with 8 words 2017-06-20T04:00:00Z But peel back the oil-spattered pages of history, and you’ll find that the sandwich so closely aligned with the stars and stripes was once also embraced by the hammer and sickle. Even one of Trump’s favorite foods has a hidden Russia connection 2019-07-29T04:00:00Z This widely exhibited object, painted with a hammer and sickle and an image of an embryo in a womb, is priced at $3.5 million, on consignment from a collector. Tefaf Faces Competitive Headwinds 2016-03-11T05:00:00Z “Mrs. Watts’s grin was as curved and sharp as the blade of a sickle. It was plain that she was so well-adjusted that she didn’t have to think any more.” Review: ‘The Complete Stories,’ by Flannery O’Connor 2021-10-21T04:00:00Z In June, NPR reported that Victoria Gray, a woman with sickle cell disease, experienced a significant decrease in her episodes of painful sickle crises in the first year after gene-editing treatment. Once Science Fiction, Gene Editing Is Now a Looming Reality 2020-07-22T04:00:00Z The C in the title – – is done as a hammer and sickle. The Americans – TV review 2013-06-02T05:00:00Z In June the same hammer and sickle will hang in the Metropolitan Opera House in New York. Dance Review: Down on the Dacha, Farmers Showing Off Expressive Footwork 2011-01-23T22:45:37Z The rapper's publicist said in a statement Tuesday that Prodigy was hospitalized a few days ago in Las Vegas "for complications caused by a sickle cell anemia crisis." Hip Hop Artist Prodigy of Mobb Deep Dies at 42 2017-06-20T04:00:00Z To this day, when I picture Big Brother, I imagine a Bollywood-style mafia don, moustachioed and resplendent in burnt orange robes and chunky gold rings shaped like hammers and sickles. Summer readings: Nineteen Eighty-Four by George Orwell 2011-08-06T08:00:02Z Scientists are finalising plans to use gene therapy to treat one of the world’s most widespread inherited diseases – sickle cell anaemia. Gene therapy offers hope for treatment of sickle cell anaemia 2016-10-01T04:00:00Z Her authority drains away, however, when dealing with less material aspects of Victorian life, the sort that can't be deduced from a sickle, snood or tincture. How to be a Victorian by Ruth Goodman – review 2013-07-12T11:00:01Z It will include some of her signature work, notably the “knit paintings” that she had been making for years, machine-generated weavings with loaded images — Playboy logos, Soviet hammers and sickles, commercial brand emblems. The Week Ahead: Oct. 21 — 28 2012-10-21T07:30:05Z On top, above the hammer and sickle of the Maoist Party, is the bow and arrow of the Janatana Sarkar, wrapped in silver foil. Aundhati Roy | Gandhi, but with guns | Part Three 2010-03-27T09:00:00Z A buttery sickle moon nicked the dark sky above Chianti. Fashion Diary: The Men?s Fashion Circuit Parties in Florence 2010-06-18T19:31:00Z Due to complications with his sickle cell anemia, both of Nate’s legs had already been amputated below his knees, along with his left arm and several fingers on his right hand. A student needed medical care and a home. His teachers adopted him. 2023-02-04T05:00:00Z Her Mexican still lifes, with cartridge belts and sickles piled on guitars, exploit the activist potential of visual beauty, though, disappointingly, the show offers no fresh insights into them, or into Modotti’s heavily mythologized life. The Art of Politics, in ‘Agitprop!’ at the Brooklyn Museum 2015-12-17T05:00:00Z When a couple of Bernie Sanders supporters waved a hammer and sickle flag to protest a Trump speech, did that delegitimize Sanders’ message? Outgrowing the cosmetic left: A liberal plea for fake liberalism to grow up 2017-02-25T05:00:00Z She calls it “Better Days” after a group of her mother’s friends who would hold parties, plays and fashion shows to raise money to fight sickle cell anemia, a disease that runs in her family. Inside Art: At Art Basel, an Unslaked Appetite for Buying 2013-06-13T20:36:45Z When I spoke to Day recently by phone, she was finishing an order on Amazon: a prairie-girl costume, a sickle, finger puppets. Candy and Poison 2016-09-14T04:00:00Z Powell, Rush’s co-author, said the musician softened as he reflected on the pain he’d experienced — including the deaths of three of his four children, from complications of sickle cell disease — during interviews for the book. Bobby Rush Lived the Blues. Six Decades On, He’s Still Playing Them. 2021-06-10T04:00:00Z Electrocution by Christmas lights, castration by sickle and impalement by stag antler. Movie Review: ‘Silent Night,’ by Steven C. Miller, With Malcolm McDowell 2012-11-30T01:30:43Z Orthopedic corsets became canvases in their own right, emblazoned with the hammer and sickle. Frida Kahlo’s Home Is Still Unlocking Secrets, 50 Years Later 2019-02-07T05:00:00Z She was surprised by details like embroidered hammers and sickles, but also by the delicacy of its fabric. Sexy Lingerie for Men Is Here 2022-04-13T04:00:00Z If people think Bernie Sanders is advocating communism and point to that hammer and sickle flag as proof, we’d call that hysteria. Outgrowing the cosmetic left: A liberal plea for fake liberalism to grow up 2017-02-25T05:00:00Z Teverow: Fonio is harvested by hand with a sickle and is usually threshed manually to separate the grain from the stalk. Is fonio the ancient grain of the future? 2021-01-11T05:00:00Z Prodigy, one half of New York rapper duo Mobb Deep, died on Tuesday days after being hospitalized for complications related to sickle cell anemia, his publicist said. Prodigy, one half of New York rapper duo Mobb Deep, dead at 42 2017-06-20T04:00:00Z Its plan takes the form, when seen from above, of a hammer and sickle, and it was internationally famous in its day. City of wood 2010-10-23T23:05:00Z The narrow walkway between their walls is paved with hundreds of machetes, sickles and blood-red rubber industrial gloves. Art Review: Jane Alexander’s Work at St. John the Divine 2013-04-25T20:34:53Z The visual humor is apparent; it’s either mimicking the hammer and sickle from the Soviet flag or the star configuration on the Chinese flag. In “Watchmen,” just as in real life, feelings about Vietnam remain uncertain 2019-11-11T05:00:00Z Ms. Johnson was only with the group for its first few years because she was diagnosed with sickle cell anemia. Joan Marie Johnson, member of Dixie Cups singing group, dies at 72 2016-10-11T04:00:00Z Overlapping polychrome circles and squares from the 1920s gave way to the postwar bombast of oversize sickle motifs and quasi-neoclassical rosettes and scrollwork. 4 Books to Inspire Your Inner Designer 2020-05-31T04:00:00Z They are tied with two sickle hooks, too, which I think helped land fish. Outdoor writer Dave Graybill wets line at Brewster sockeye-mania 2014-07-21T04:00:00Z Nate was born with sickle cell anemia, a red blood cell disorder that can lead to other serious medical concerns, such as infections and chronic pain. A student needed medical care and a home. His teachers adopted him. 2023-02-04T05:00:00Z In Mr. Iannucci’s movie, you see the hammer and the sickle in each pale, scheming face, in every prison cell and bootlicker’s smile. Review: The Slapstick Horror of ‘The Death of Stalin’ 2018-03-08T05:00:00Z Another work, by Esan Sommersell, titled “Blackface Trump: Accountable?,” reimagines Mr. Trump as a racial minority, setting his doctored profile against a red background adorned with a yellow Soviet hammer and sickle. How a Quirky Art Prize Tied to the DeVos Family Went Political 2017-09-27T04:00:00Z His Instagram name is Mr. Catch Me a Capitalist, punctuated with a hammer and sickle. The Faces of Young Protesters at New York City’s Climate Strike 2019-09-20T04:00:00Z He added that several other centres in the US were gearing up to start gene therapy trials for sickle cell using similar approaches. Gene therapy offers hope for treatment of sickle cell anaemia 2016-10-01T04:00:00Z In his book “The Last Days of Stalin,” Joshua Rubenstein captures the dictator’s power over the Soviet Union in a quote: “Stalin was inside everyone, like the hammer alongside the sickle in every mind.” Review: The Slapstick Horror of ‘The Death of Stalin’ 2018-03-08T05:00:00Z About 300,000 babies are born globally with sickle cell disease. Gene therapy offers hope for treatment of sickle cell anaemia 2016-10-01T04:00:00Z At Cinerama, the festival will open with Canadian filmmaker Charles Officer's drama "Nurse.Fighter.Boy," about a single mother struggling with her diagnosis of sickle cell anemia. Langston Hughes African American Film Festival gets under way April 17 in Seattle 2010-04-07T23:21:00Z “It’s a sickle,” she exclaimed, grabbing the crescent-shape tool from the top layer. The weird afterlife of banned TSA items 2015-01-22T05:00:00Z He drags behind him, attached by ropes, a heavy train of symbolic hardware: machetes, sickles, toy trucks and tractors, instruments of fertility or destruction, depending on how they’re used. Art Review: Jane Alexander’s Work at St. John the Divine 2013-04-25T20:34:53Z But then I spotted the perfect purchase at one of the clothing stands: new boxer briefs emblazoned with a hammer and sickle on one leg and "CCCP" along the waistband. Frugal Traveler Blog: Saving Rubles in St. Petersburg 2012-09-04T21:23:01Z Davis makes constructions of wood and plastic whose pieces include some shaped like microscopic markers of sickle cell disease. Review | In the galleries: Washington Sculptors Group shows a playful nature 2018-09-27T04:00:00Z Also found were flint tools, including thousands of arrowheads, axes for chopping down trees, sickle blades and knives. Prehistoric city offers glimpse of ancient living near Jerusalem 2019-07-16T04:00:00Z Girl with sickle cell disease had a wish to be on a billboard. Yes, millennials are delaying pregnancy, but this Gen Xer just delivered her first child at 50. 2021-12-07T05:00:00Z He wasn’t able to hold a steady job due to his sickle cell anemia. My mother let him rape me — then stayed married to my dad 2015-10-04T04:00:00Z One case involved a 16-year-old girl with severe sickle cell anemia who was forced to cope with intense pain for long periods of time. Chilling report slams psychiatric hospital 2011-09-28T11:00:00Z Abi was born with sickle cell disease, a red blood cell disorder that can lead to other serious medical complications such as infections, acute chest syndrome and strokes. Girl with sickle cell disease had a wish to be on a billboard. She and her twin now smile at passing cars in Md. 2021-12-06T05:00:00Z The house is made of skin removed from Rodney in operations for the sickle cell anaemia which was to kill him only a year later, aged 37. A little house made of human skin 2012-05-18T11:00:00Z Arthur Chaney, of the 6600 block of South Peoria Street, did not appear in bond court this morning because he was at St. Bernard Hospital and Health Care Center being treated for sickle cell anemia. No bond in Church's Chicken shooting 2011-12-31T19:32:00Z Johnson was only with the group for its first few years because she was diagnosed with sickle cell anemia. A founder of the New Orleans girl group The Dixie Cups dies 2016-10-11T04:00:00Z On the street-facing side, a cement monument, topped by an enormous pair of sculpted fists grasping the hammer and sickle, has been erected in victims’ memory. Why Won’t We Learn from the Survivors of the Rana Plaza Disaster? 2018-04-24T04:00:00Z “Lenin’s Arc” is a visual feast of non-speaking actors dressed in uniforms, waving hammers, sickles and red flags — their faces and clothes daubed with copper, green and brown paint. Romania play reminds people of the good, bad of communism 2016-05-25T04:00:00Z In the ecstatic sculpture “Worker and Collective Farm Worker,” two figures, seemingly bursting with strength and promise, reach skyward, he with a hammer, she with a sickle. Hidden Gems of Europe 2012-10-12T20:14:25Z A red cross becomes a hammer and sickle. A Green New Deal ignites an old red scare 2019-05-07T04:00:00Z The approach treats two inherited blood disorders, including sickle cell disease, which afflicts mostly people of African ancestry, by modifying a patient’s blood stem cells in the lab and returning them. United Kingdom approves first-ever CRISPR treatment, a cure for sickle cell disease and beta thalassemia 2023-11-15T05:00:00Z Both sickle cell disease and thalassemia are caused by mistakes in the genes that carry hemoglobin, the protein in red blood cells that carry oxygen. UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia 2023-11-16T05:00:00Z In trials, 28 out of 29 sickle cell patients were free of severe pain and 39 of 42 beta thalassemia patients no longer needed blood transfusions for at least a year. Casgevy: UK approves gene-editing drug for blood disorders 2023-11-16T05:00:00Z Errors in these processes can give rise to acquired diseases including cancers, such as leukemia, lymphoma, and multiple myeloma, and those, such as sickle cell anemia, present from birth. Researchers chart the contents of human bone marrow 2023-11-14T05:00:00Z "So diabetes, obesity, cardiovascular disease, the whole cardiometabolic space, but also in the rare blood disorders, haemophilia, sickle cell, we believe that we have a stronghold there," he said in an interview. Drugmaker Novo Nordisk seeks obesity, diabetes 'bolt-on' deals 2023-11-10T05:00:00Z The agency approved the therapy, which the companies have called Casgevy, for patients ages 12 or older with sickle cell disease or beta thalassemia. United Kingdom approves first-ever CRISPR treatment, a cure for sickle cell disease and beta thalassemia 2023-11-15T05:00:00Z The agency approved the treatment for patients with sickle cell disease and thalassemia who are 12 years old and over. UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia 2023-11-16T05:00:00Z The treatment for sickle cell disease and beta thalassemia is the first to be licensed using the gene-editing tool known as Crispr, for which its discoverers were awarded the Nobel prize in 2020. Casgevy: UK approves gene-editing drug for blood disorders 2023-11-16T05:00:00Z She is wearing a red medal around her neck with a hammer and sickle, the symbols of the Communist Party. Li Keqiang: Official nerves show as BBC hears praise for dead Chinese leader 2023-11-02T04:00:00Z An estimated 100,000 people in the United States have sickle cell disease, most of whom have African ancestry. F.D.A. Experts Will Vote on Safety of a Cure for Sickle Cell Disease 2023-10-30T04:00:00Z FDA is expected to approve it for sickle cell disease by 8 December; a decision by European regulators is also pending. United Kingdom approves first-ever CRISPR treatment, a cure for sickle cell disease and beta thalassemia 2023-11-15T05:00:00Z Food and Drug Administration; the agency is expected to make a decision early next month, before considering another sickle cell gene therapy. UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia 2023-11-16T05:00:00Z Around 15,000 people in the UK have sickle cell disorder, most with an African or Caribbean family background. Casgevy: UK approves gene-editing drug for blood disorders 2023-11-16T05:00:00Z “My children no longer have a fear of losing their mom to sickle cell disease,” she said. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z A report by the Institute for Clinical and Economic Review said that for people who don’t have sickle cell disease, “it is hard to understand the physical, emotional and mental toll.” F.D.A. Experts Will Vote on Safety of a Cure for Sickle Cell Disease 2023-10-30T04:00:00Z Also clouding Casgevy’s approval is that most people with sickle cell disease live in Africa, which has few medical facilities that can offer the complex care needed to deliver the treatment. United Kingdom approves first-ever CRISPR treatment, a cure for sickle cell disease and beta thalassemia 2023-11-15T05:00:00Z Millions of people around the world, including about 100,000 in the U.S., have sickle cell disease. UK becomes 1st country to approve gene therapy treatment for sickle cell, thalassemia 2023-11-16T05:00:00Z Doctors are more likely to incorrectly associate Black patients with diagnoses of HIV, hypertension, obesity, sarcoidosis, sickle cell anemia and stroke. Doctors Do Racist Things to Patients. Here Are Seven Ways They Can Stop 2023-10-26T04:00:00Z The FDA is expected to decide on the second gene therapy for sickle cell, made by Bluebird Bio, before the end of the year. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z Other comparable treatments for sickle cell could follow. F.D.A. Experts Will Vote on Safety of a Cure for Sickle Cell Disease 2023-10-30T04:00:00Z For six months in 2003 she used a borrowed lawn mower, sickle and rake to clear weeds, which drew the notice, and help, from the county historic commission. America’s Black Cemeteries and Three Women Trying to Save Them 2023-09-27T04:00:00Z She had been held for nine days along with her family in Harlingen, Texas, and had sickle cell anemia and other conditions. DHS is separating migrant parents from their children in Border Patrol facilities 2023-09-19T04:00:00Z Researchers in Poland excavated a 17th-century woman buried with a sickle around her neck and padlock on her foot. Undying Dread: A 400-Year-Old Corpse, Locked to Its Grave 2023-09-05T04:00:00Z The only cure for painful sickle cell disease today is a bone marrow transplant. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z “Iranians love the Shah. Mossadegh is sending your country to the government of the hammer and sickle.” AP WAS THERE: A 1953 CIA-led coup in Iran topples prime minister, cements shah’s power 2023-08-24T04:00:00Z Two large fields on the island sport a star from the Chinese flag and a hammer and sickle representing the ruling Communist Party. China appears to be building an airstrip on a disputed South China Sea island 2023-08-16T04:00:00Z The shield was emblazoned with the Soviet hammer and sickle. Ukraine Replaces Soviet Emblem on Kyiv’s Motherland Monument 2023-08-07T04:00:00Z Some 85 percent of Ukrainians backed the removal of the hammer and sickle from the landmark, according to data from the country’s Culture Ministry released last year. Ukraine replaces Soviet coat of arms with trident on towering Kyiv landmark 2023-08-06T04:00:00Z The agency is expected to decide on the treatment in early December, before taking up a different sickle cell gene therapy later that month. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z Some 85 percent of Ukrainians backed the removal of the hammer and sickle from the landmark, according to data from the country’s Culture Ministry released last year. Ukraine replaces Soviet coat of arms with trident on towering Kyiv landmark 2023-08-06T04:00:00Z Alvarez, a Panamanian girl who was chronically ill with sickle cell anaemia and heart disease, was detained by border agents after crossing the US-Mexico border with her family. Migrant girl death in US custody was "preventable" 2023-07-19T04:00:00Z She had a chronic heart condition and sickle cell anemia. Border Patrol fails to assess medical needs for children with preexisting conditions, report says 2023-07-18T04:00:00Z Wise said it was not clear whether the medical providers in Harlingen were aware that she had sickle cell disease. Court monitor: 8-year-old's death in Border Patrol custody caused by 'series of failures' 2023-07-18T04:00:00Z Dr. Allison King, who cares for children and young adults with sickle cell disease, said she’s enthusiastic about the possibility of new treatments. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z Days later, an 8-year-old girl from Panama who had a history of heart problems and sickle cell anemia died while she and her family were in custody of Border Patrol in Harlingen, Texas. Unaccompanied migrant girl from Guatemala dies in US custody from underlying disease, officials say 2023-07-12T04:00:00Z “Maybe one day we’ll wake up to the hammer and sickle flying up there,” he growls, describing the flag of the former Soviet Union. They envision the world’s tallest flagpole in this Maine town. Instead of uniting, it is dividing 2023-06-29T04:00:00Z Her health condition, sickle cell disease, means she experiences acute and chronic pain, particularly in her hip and shoulder. Disabled drivers wary of Blue Badge use after thefts 2023-06-23T04:00:00Z Anadith’s mother says the girl had a history of heart problems and sickle cell anemia. Family of girl who died in Border Patrol custody holds New York funeral, says they want justice 2023-06-16T04:00:00Z Scientists believe being a carrier of the sickle cell trait helps protect against severe malaria. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z Those with sickle cell can experience episodes of severe pain sometimes lasting weeks. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z Your book illuminates the Panthers’ true legacy: the Free Breakfast for Children Program, the People’s Free Medical Clinics, sickle cell anemia testing. Elmer Dixon’s ‘Die Standing’ is a portrait of a Seattle revolutionary 2023-06-07T04:00:00Z Anadith had suffered from a heart condition since birth and had sickle cell anemia. 8-Year-Old Migrant Who Died in C.B.P. Custody Was Seen by Medical Staff 11 Times 2023-06-01T04:00:00Z The girl’s mother had previously told The Associated Press that agents had repeatedly ignored her pleas to hospitalize her medically fragile daughter, who had a history of heart problems and sickle cell anemia. 8-year-old girl sought medical help 3 times on day she died, US immigration officials say 2023-05-21T04:00:00Z By comparison, research earlier this year showed medical expenses for current sickle cell treatments, from birth to age 65, add up to about $1.6 million for women and $1.7 million for men. A new cure for sickle cell disease may be coming. Health advisers will review it next week 2023-10-27T04:00:00Z More than half of children born with sickle cell will die before the age of five, usually from an infection or severe anaemia. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z The family told agents that the girl had a history of heart problems and sickle cell anemia, CBP acknowledged in its second statement on the death. Death of 8-year-old girl in Border Patrol custody highlights challenges providing medical care 2023-05-22T04:00:00Z They knew the girl had a history of heart problems and sickle cell anemia. Mother of 8-year-old girl who died in Border Patrol custody says pleas for hospital care were denied 2023-05-20T04:00:00Z These farmers used stone tools such as sickles and made simple jars to store their grain. World History: to 1500 2023-04-19T00:00:00Z The structural difference between a normal hemoglobin molecule and a sickle cell molecule—that dramatically decreases life expectancy in the affected individuals—is a single amino acid of the 600. Concepts of Biology 2013-04-25T00:00:00Z "They say that someone with sickle cell cannot live beyond 20 years old. They only get to 15 years and most they can live is 18 years old." Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z They arrived just before midnight, carrying machetes and hoes, hammers and sickles, with plans to seize the land. If You Don’t Use Your Land, These Marxists May Take It 2023-04-30T04:00:00Z For 34 years, sickle cell disease had been hammering Jimi’s body and stealthily shredding his ambitions. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z A bright red star with gold-colored hammer and sickle adorns the pyramid’s peak. ‘Learn From Pain’: Why Germany Protects Soviet War Memorials 2023-04-28T04:00:00Z Because of this change of one amino acid in the chain, the normally biconcave, or disc-shaped, red blood cells assume a crescent or “sickle” shape, which clogs arteries. Concepts of Biology 2013-04-25T00:00:00Z Ms Bey pointed out that she was diagnosed with sickle cell at the age of six months and had survived - she is now in her 30s. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z The party, which at its height had more than 2,000 members in chapters throughout the country, created free school breakfast programs and provided sickle cell anemia testing, legal aid and adult education. A new docuseries explores the Black Panther who shaped Tupac: His mom 2023-04-21T04:00:00Z “The hope,” said Valentine, “is that if the feds and governments and society can figure this out with sickle cell, they can figure this out with other diseases.” His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z In Jakarta, the light dimmed and the sun took on the appearance of a sickle moon, according to photos shares on social media. Hybrid solar eclipse draws thousands to remote Australian town 2023-04-20T04:00:00Z In sickle cell anemia, the hemoglobin β chain has a single amino acid substitution, causing a change in both the structure and function of the protein. Concepts of Biology 2013-04-25T00:00:00Z In 2017, Ms Bey founded the Africa Sickle Cell organisation, an non-governmental organisation focused on improving the lives of people with sickle cell. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z At the front of the room was the ruling Communist Party’s hammer and sickle logo, with a sign declaring the meeting’s purpose: “Symposium of unmarried young women of the right age.” In China, Marriage Rates Are Down and ‘Bride Prices’ Are Up 2023-03-26T04:00:00Z Until recently, there weren’t many treatments for sickle cell disease. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Amarey, who has sickle cell disease, thought about friends she made at camp who were going through similar health struggles. Paul Newman’s camp for sick kids rises from the ashes 2023-03-21T04:00:00Z I’m a 32-year-old Black male also living with sickle cell disease, and I feel great. High-dose topical capsaicin requires a prescription 2023-03-15T04:00:00Z "A lot of communities attribute sickle cell to ancestral curses, witchcraft," Ms Bey told BBC Africa Eye. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z “It’s heartbreaking because I do still have family members who suffer from sickle cell disease,” says Gray, who was treated for free as part of a clinical trial. Gene-editing summit touts sickle cell success, while questions on embryo editing linger 2023-03-12T05:00:00Z A turning point occurred when sickle cell became an attractive target for companies to invest in — as new gene therapy techniques reached prime time and better understanding of the disease clarified the best therapeutic strategies. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z It also spent $5.4 billion on sickle cell disease treatment maker Global Blood Therapeutics and bought Arena Pharmaceuticals for another $6.7 billion. Pfizer will spend $43 billion to acquire Seagen 2023-03-13T04:00:00Z In the trailer, Law sports a long, frizzy gray wig and a furry mustache while wielding the villain’s signature sickle. Disney's 'Peter Pan & Wendy' trailer criticized for depictions of Hook and Tinker Bell 2023-03-02T05:00:00Z One of the main challenges for people with sickle cell in Taveta, and other towns across Kenya, is access to medicine. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z Purporting to be based in San Francisco, its profile picture shows a blond woman wearing a fur hat with a hammer and sickle badge. Russian propagandists are buying Twitter blue-check verifications 2023-02-22T05:00:00Z At the same time, a growing array of gene therapy techniques gave scientists tools to flip genetic switches or insert new genes — kicking off a flurry of competing sickle cell cures. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z “We foreshadow what the Wolf will reveal he is later in the story by having his sickle, or scythe, having that same kind of framing.” The blink-and-you-miss-them film references in 'Puss in Boots: The Last Wish' 2023-02-21T05:00:00Z "For sickle cell we need donors who are RO and that is usually found in donors with black heritage." Nearly 250,000 potential donors yet to give blood 2023-02-15T05:00:00Z Two of his children had been diagnosed with sickle cell. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z He said that under occupation he approached a 22-year-old Russian soldier operating an air-defense battery, who was wearing an arm patch with the Soviet hammer and sickle. In Rural Ukraine, Medicine and Hope Roll In on a Truck 2023-02-08T05:00:00Z After years of little progress, there wasn’t just one way to treat sickle cell — there were many. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Many in the crowd waved socialist-red flags — some adorned with a hammer and sickle. Can Germany Be a Great Military Power Again? 2023-01-24T05:00:00Z “I ask myself, ‘Who am I without sickle cell?’” Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z As a result of his campaigning, along with Ms Bey, a joint haemophilia and sickle clinic finally opened in their town, the first in Taita Taveta county. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z Sometimes light, sometimes dark, it is neither a disk nor a sickle nor a piece of cheese nor a sign of rebirth and love. Perspective | The moon and its lovely lies “I have wanted to see this succeed for 40 years,” said Francis Collins, the former NIH director whose postdoctoral research in the early 1980s was on sickle cell. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z A new gene-editing technique may be able to cure sickle cell anemia; Bill Gates argues in his annual letter that the same approach may eventually offer a cure for HIV/AIDS as well. Cheer up — the world is better off than you think 2023-01-03T05:00:00Z This year, Dr. Jackson and other people with sickle cell may have the option of finally living without the damage the disease causes. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z "Who here has sickle cell?" asked Lea Kilenga Bey, the woman at the front, who they had all been waiting to hear from. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z The soaring cost of living will lead to an increase in hospital admissions for people with sickle cell this winter, a charity has warned. Cost of living crisis: Sickle cell families staying in bed for warmth 2022-12-31T05:00:00Z “I thought we’d be lucky if in my lifetime, if we achieved even a single cure of someone for sickle cell disease.” His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Hillman’s family explained in its initial post that his form of cancer affects “young African Americans with sickle cell trait. Unfortunately treatment has not been successful.” Former Broncos RB Ronnie Hillman dies at 31 2022-12-22T05:00:00Z Do they start looking for jobs after thinking that, with frequent hospitalizations because of sickle cell, they were unemployable? Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z The red blood cells of someone with sickle cell, which are normally round, are shaped like a crescent moon or a sickle, and cannot transport enough oxygen around the body. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z People with sickle cell disease produce unusual sickle-shaped red blood cells which can block blood vessels. Cost of living crisis: Sickle cell families staying in bed for warmth 2022-12-31T05:00:00Z On his first date with Amanda, when they were in their early 20s, he put down the menu and told her he had sickle cell, and that he understood if that was a dealbreaker. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z His death, in a hospital, was caused by complications of sickle cell anemia, his brother Michael said. Lloyd Newman, Teenage Chronicler of ‘Ghetto Life,’ Dies at 43 2022-12-13T05:00:00Z One report examined what private insurance companies paid and found that the lifetime costs of sickle cell were $1.7 million, including $44,000 that patients paid out of pocket. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z Ms Bey has recorded video diaries of her sickle cell crises. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z But people with sickle cell disease belong to historically marginalized populations that face systemic inequality in accessing good medical care, Goshua noted. Sickle cell cure will be cost-effective if health disparities considered -study finds 2022-12-13T05:00:00Z To manage Jimi’s sickle cell, the couple forged a powerful partnership. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z She and another sister also died of complications of sickle cell anemia. Lloyd Newman, Teenage Chronicler of ‘Ghetto Life,’ Dies at 43 2022-12-13T05:00:00Z That, patients and advocates said, does not begin to capture what sickle cell really costs. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z Jaundice is a common of symptom of sickle cell. Kenya sickle cell: Fighting to dispel the myths around the disease 2023-06-11T04:00:00Z With that windfall, it plans to get richer, sinking the cash into developing and marketing potential blockbusters for conditions like migraines, ulcerative colitis, prostate cancer, sickle cell disease and obesity. As Pfizer triples COVID vaccine price, ‘marketing machine’ in overdrive 2022-11-13T05:00:00Z Bluebird has treated 50 sickle cell patients, six of whom have been followed for six years, and submitted its data to regulators in April. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z A women with sickle cell disease said the possibility of lab-grown blood has given her "hope" for the future. Lab-grown blood gives hope says sickle cell sufferer 2022-11-10T05:00:00Z Concerns about the high price of the treatment worry many people with sickle cell and their families. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z These are necessary for people who depend on regular blood transfusions for conditions such as sickle cell anaemia. Lab-grown blood given to people in world-first clinical trial 2022-11-06T04:00:00Z Like the previous version, they are not intended for treatment of pain from sickle cell disease and cancer, or palliative and end-of-life care, which demand special consideration from caregivers. CDC releases new, more flexible guidelines for prescribing opioids 2022-11-03T04:00:00Z The beauty of gene editing for sickle cell is that it takes a lot of the luck out of the equation. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Affecting 15,000 people in the UK, sickle cell disease is incurable and requires regular blood transfusions. Lab-grown blood gives hope says sickle cell sufferer 2022-11-10T05:00:00Z Still, sickle cell has been such a burden. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z CDC said the new guidelines do not apply to treatment for sickle cell disease and cancer or end-of-life care. CDC issues first major update to opioid prescribing advice since 2016 2022-11-03T04:00:00Z The NHS is urgently calling for black donors to give blood to help people with sickle cell disease as the demand for donations reaches record levels. Sickle cell: Black donors urged to give blood to help treat patients 2022-10-06T04:00:00Z The first gene therapies for sickle cell will be a turning point, but it will take years — and many millions of dollars — to reach even a fraction of the patients who could benefit. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z A Birmingham woman with sickle cell has written a series of children's books to help raise awareness of the condition. Sickle cell: Birmingham woman raises awareness with books 2022-10-04T04:00:00Z He has now finished high school and is interested in joining the military but has since learned that, with sickle cell, he would not be accepted. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z Two is symbolized by hands holding a hammer and sickle. 'Red-baiting' fliers mailed to Vietnamese Americans in tight California congressional race 2022-09-30T04:00:00Z One type of sickle cell disease, called sickle cell anemia, is a leading cause of stroke in children. Study: Too few kids with sickle cell get stroke screen, care 2022-09-20T04:00:00Z Already, the success of the front-runners is winnowing out competition, as some companies drop their sickle cell gene therapy programs. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z People with sickle cell disease produce unusually shaped red blood cells that can cause problems as they do not live as long as healthy cells and can block blood vessels. Sickle cell: Birmingham woman raises awareness with books 2022-10-04T04:00:00Z Many worry, she said, about “trading one familiar issue — sickle cell — with something else and overall fear of the unknown.” Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z A sharp sickle was placed across her neck, ready to decapitate her should she jolt awake after death, and a padlock was put around her big toe. ‘Vampire’ grave shows 17th-century fear of women who ‘didn’t fit in’ 2022-09-07T04:00:00Z The research involved 3,300 children with sickle cell anemia in 2019. Study: Too few kids with sickle cell get stroke screen, care 2022-09-20T04:00:00Z He recalled the early days of bone marrow transplants to treat sickle cell, when he would write appeal after appeal to insurers to try to get the novel procedure covered. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z And on Friday 28 October, she will run an online workshop all about the history of sickle cell. Sickle cell: Birmingham woman raises awareness with books 2022-10-04T04:00:00Z Dr. Jackson shared that sentiment, saying that without sickle cell, “I’m an outsider, no longer part of this community.” Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z A professor from Poland’s Nicolaus Copernicus University in Torun said burials involving a sickle are extremely unusual. ‘Vampire’ grave shows 17th-century fear of women who ‘didn’t fit in’ 2022-09-07T04:00:00Z A red hammer and sickle spray was painted on one window of the Biddy Mulligan's pub in the Grassmarket area, while the word "scab" was written on another. Edinburgh wakes up to the bin strike hangover 2022-08-30T04:00:00Z After Jimi’s treatment, he had a different kind of crisis: Who am I without sickle cell? His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Bluebird is testing a different product that uses the same method for sickle cell anemia, which is more common in the United States than thalassemia. News at a glance: New gene therapy, Europe’s drought, and a black hole’s photon ring 2022-08-24T04:00:00Z Kevin Wake, 54, who lives in Kansas City, Mo., said sickle cell forced him to retire from his job in pharmaceutical sales and management and led him to think his days might be numbered. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z The use of a sickle across the neck was “pretty tame,” he added. ‘Vampire’ grave shows 17th-century fear of women who ‘didn’t fit in’ 2022-09-07T04:00:00Z A Soviet general secretary, Leonid Brezhnev, unveiled the monument in 1981: a figure of a woman, a sword in her right hand and a shield in her left emblazoned with the Soviet hammer and sickle. Defiance is the mood of the day as Ukrainians celebrate their independence. 2022-08-24T04:00:00Z He felt guilty for not being elated that he was finally well, but he mourned the years of lost potential that he had spent as a prisoner of sickle cell. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z For example, sickle cell anemia results from just one amino acid substitution in a hemoglobin molecule consisting of 574 amino acids. Biology for AP Courses 2022-06-09T00:00:00Z He thinks he might like a job at a drug company that is developing sickle cell treatments, perhaps as a patient advocate if they are looking for such employees. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z The watered-down wheat not only slows the combine, but if farmers break a combine sickle on a rock while cutting down wheat, they may have a hard time finding a replacement, Chvatal said. Storms rain on parade of Walla Walla wheat growers 2022-08-21T04:00:00Z The acquisition of the maker of Oxbryta, one of the few treatments approved by the Food and Drug Administration for sickle cell disease, is the latest blockbuster deal for the pharmaceutical giant. Cash-rich Pfizer snaps up Global Blood Therapeutics for $5.4 billion 2022-08-08T04:00:00Z “The physical toll of the disease sickle cell itself doesn’t compare to the emotional vacuum it creates,” he said. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z If you were to look at sickle cell anemia, a disorder affecting hemoglobin produced in red blood cells, which technique would be the most useful in detecting polymorphism in a sample? Biology for AP Courses 2022-06-09T00:00:00Z Dr. Jackson said he would in part because sickle cell is so much a part of his identity that he can’t imagine life without it. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z To some, the controversial, self-taught healer was a visionary, a man who claimed that he cured HIV/AIDS, sickle cell anemia, cancer, asthma and, on occasion, blindness. Journey to the center of the sea moss universe. You'll see Dr. Sebi is alive in L.A. 2022-08-05T04:00:00Z Disorders such as sickle cell disease and CF are still common in human populations. Miller & Levine Biology 2018-01-01T00:00:00Z Three of Jimi’s children are carriers of the sickle cell trait. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Diseases like sickle cell anemia and thalassemia decrease the blood’s ability to deliver oxygen to tissues and its oxygen- carrying capacity. Biology for AP Courses 2022-06-09T00:00:00Z Terry Jackson lives a life dominated by sickle cell disease. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z Anemias caused by faulty or decreased RBC production include sickle cell anemia, iron deficiency anemia, vitamin deficiency anemia, and diseases of the bone marrow and stem cells. Anatomy and Physiology 2013-06-19T00:00:00Z Individuals with just one copy of the sickle cell allele are generally healthy and are also highly resistant to the parasite. Miller & Levine Biology 2018-01-01T00:00:00Z “I knew sickle cell would win that battle as well,” Jimi said. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z In sickle cell hemoglobin, this glutamate is replaced by a valine. Biology for AP Courses 2022-06-09T00:00:00Z Yet gene therapy cannot undo all the effects of sickle cell. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z Acquired forms include the autoimmune disease lupus, immune reactions to heparin, polycythemia vera, thrombocytosis, sickle cell disease, pregnancy, and even obesity. Anatomy and Physiology 2013-06-19T00:00:00Z On nights and weekends, he boosted his resume with a part-time job doing academic research on sickle cell anemia. He worked from home and died suddenly. Five days passed before his body was found 2022-07-12T04:00:00Z Then, midway through Amanda’s pregnancy, the couple read an article about Victoria Gray, a woman whose genes had been experimentally edited to treat her sickle cell disease. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z The structural difference between a normal hemoglobin molecule and a sickle cell molecule—which dramatically decreases life expectancy—is a single amino acid of the 600. Biology for AP Courses 2022-06-09T00:00:00Z And he did experience “an identity crisis,” when he had to make a life without sickle cell, he said. Sickle Cell Cure Brings Mix of Anxiety and Hope 2023-01-17T05:00:00Z A woman who became one of the first people to have a stem cell transplant for sickle cell disease on the NHS says she wants others to know there is hope. 'I want sickle cell patients to know there is hope' 2022-07-11T04:00:00Z On June 12, he spelled out “Live in the Past” in huge Soviet-style letters on two buildings in his city, next to another with a hammer and sickle. Art of dissent: How Russians protest the war on Ukraine After decades of neglect, stigma and underfunding, sickle cell is getting the equivalent of the red carpet treatment in science. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Figure 3.28 The beta chain of hemoglobin is 147 residues in length, yet a single amino acid substitution leads to sickle cell anemia. Biology for AP Courses 2022-06-09T00:00:00Z That was the gene-editing tool that Gang Bao, a biochemical engineer at Rice University, first used to try to treat sickle cell disease, an inherited disorder marked by misshapen red blood cells. The Many Uses of CRISPR: Scientists Tell All 2022-06-27T04:00:00Z Ms Regis-Etumnu said: "I just want sickle cell patients to know that we see you. And there is hope." 'I want sickle cell patients to know there is hope' 2022-07-11T04:00:00Z None of the 31 sickle cell patients experienced painful drops in oxygen that would have normally sent them to the hospital. CRISPR, 10 Years On: Learning to Rewrite the Code of Life 2022-06-27T04:00:00Z It’s a dramatic about-face for sickle cell patients, who have often felt abandoned by the medical system. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z The amino acid may not show any significant effect the protein structure and function or it may have a significant effect, as in the case of hemoglobin in individuals with sickle cell trait. Biology for AP Courses 2022-06-09T00:00:00Z It took Dr. Bao’s lab more than two years of development, and then zinc finger nuclease would successfully cut the sickle cell sequence only around 10 percent of the time. The Many Uses of CRISPR: Scientists Tell All 2022-06-27T04:00:00Z Why do some people grow up not knowing they have sickle cell? "I didn't know I had sickle cell anaemia" 2022-06-19T04:00:00Z Later this year, the company will test its first drug on people with sickle cell anemia. CRISPR, 10 Years On: Learning to Rewrite the Code of Life 2022-06-27T04:00:00Z Decades before Jimi was born, chemist Linus Pauling discovered the root of the problem in sickle cell disease: an atypical form of the oxygen-carrying hemoglobin protein inside red blood cells. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z In the meeting, Greene also raised the issue of sickle cell anemia — a genetic disorder related to one’s ancestry, not skin color — and suggested a genetic link to Black maternal mortality. Tension over role of racism in public health strains Va. agency under Youngkin 2022-06-15T04:00:00Z At the same time, other treatments that have not relied on gene editing have had success for sickle cell. The Many Uses of CRISPR: Scientists Tell All 2022-06-27T04:00:00Z As we say goodbye to her, she tries to give us her beloved red flag with the sickle and hammer. Babushka Z: The woman who became a Russian propaganda icon 2022-06-14T04:00:00Z Red paint was thrown over the statue and a hammer and sickle were painted nearby, police said. CCTV released after Margaret Thatcher statue damaged 2022-06-03T04:00:00Z He dubbed sickle cell the first “molecular” disease — a new paradigm that would shape biomedical research for decades. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z “I told him I would not participate in that false equivalence and his bringing up sickle cell in the conversation.” Tension over role of racism in public health strains Va. agency under Youngkin 2022-06-15T04:00:00Z His brown suede belt bore the hammer and sickle of the Soviet Union. From Ukraine’s Front Lines, Bravery and Wreckage 2022-06-01T04:00:00Z The £300,000 sculpture in Grantham was daubed with red paint and a hammer and sickle was painted on the fence protecting it. Grantham Margaret Thatcher statue vandalised weeks after egging 2022-05-29T04:00:00Z The town is now firmly under control of pro-Russian fighters, who have occupied the local government building and hung a Soviet hammer and sickle flag at the door. 'Stop playing' with Russia, end war: Zelenskiy tells West 2022-05-27T04:00:00Z Atypical hemoglobin is the result of a misspelling in one gene — a T where there should be an A. People with just one copy of the altered gene have “sickle cell trait.” His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Many of these infant deaths are now known to be caused by sickle cell anaemia, an inherited disorder common among black people. Nigeria's facial scars: The last generation 2022-05-20T04:00:00Z In contrast, 7.7 percent of Americans with African ancestry have one copy of the sickle cell variant, and 0.3 percent have two copies. Targeting the Uneven Burden of Kidney Disease on Black Americans 2022-05-17T04:00:00Z Red hammer and sickle flags hang on the wall. A Mini-Russia Gets Squeezed by War 2022-05-15T04:00:00Z The party’s flag was a black hammer and sickle in a white circle against a red background, a communist mirror image of a swastika. Perspective | The far-right mystical writer who helped shape Putin’s view of Russia 2022-05-12T04:00:00Z At a sickle cell support group, Jimi began to understand how deeply the disease infiltrated every aspect of daily life. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z The bill specifies the illnesses that could be treated, including cancer, multiple sclerosis, glaucoma, sickle cell anemia and autism. Procedural ruling kills medical marijuana bill in SC House 2022-05-04T04:00:00Z It is reminiscent of another gene variant that protects against malaria but causes sickle cell disease in those who inherit two copies. Targeting the Uneven Burden of Kidney Disease on Black Americans 2022-05-17T04:00:00Z Transnistria has its own flag, complete with a Soviet-style hammer and sickle, and a separate identity from the rest of Moldova. Rattled by Ukraine War, Moldova Strives to Dodge Russia’s Long Shadow 2022-04-23T04:00:00Z Patients with sickle cell disease can experience severe pain, are vulnerable to infections and can develop many life-threatening conditions. Giving Guide: Spring 2022 | Provided by ST Content Studio 2022-04-22T04:00:00Z Then there’s hydroxyurea, the first and only drug that was approved to treat sickle cell until 2017; three drugs have been approved since then. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z The dancers circled a group of performers who held up yellow flowers to form the symbol of the Workers’ Party of Korea -– a hammer, brush and sickle. N. Korea marks key anniversary but no word on army parade 2022-04-14T04:00:00Z That variant became prominent in parts of Africa and other areas of the world where malaria is common, but sickle cell variants are much less common than APOL1 risk variants. Targeting the Uneven Burden of Kidney Disease on Black Americans 2022-05-17T04:00:00Z Scott's press secretary, Caroline Anderegg, shared that the senator has long held an interest in sickle cell disease, which is the most commonly inherited blood disorder in the U.S. and disproportionately strikes Black people. Big Pharma pours drug industry money on Republican Senator Tim Scott 2022-04-03T04:00:00Z Ms Sonibare, now studying for a PhD researching sickle cell disease, said the Queen had thanked her for her speech and asked her about the award scheme. Relief as Queen makes it to the abbey for memorial 2022-03-29T04:00:00Z Hydroxyurea helps keep red blood cells from sickling, or deforming into a sickle shape, by increasing levels of a type of fetal hemoglobin that is switched off after birth. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z The account executive is now studying for a PhD in sickle cell research and health inequalities, and stressed the need to support the young in the wake of the pandemic. Queen thanks DofE winner Doyin Sonibare after thanksgiving speech 2022-03-29T04:00:00Z Transnistria has its own flag, complete with a Soviet-style hammer and sickle, and its own makeshift currency that partly consists of plastic coins reminiscent of a board game. On Ukraine’s Border, Moldovans Wonder: Where Will Putin Stop? 2022-03-06T05:00:00Z Since 2019, Scott has introduced 17 health-related bills or resolutions about everything from food allergens and sickle cell disease to health disparities among racial and ethnic minorities. Big Pharma pours drug industry money on Republican Senator Tim Scott 2022-04-03T04:00:00Z The invention of new tools—hoes, sickles, and plow sticks—made the task of farming easier. World History: Patterns of Interaction 2012-01-01T00:00:00Z Gary Gibbons, director of the NHLBI, pointed to data showing that federal funding for sickle cell research has doubled since 2010, and he highlighted the Cure Sickle Cell Initiative that was launched in 2018. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z If that works, sickle cell treatment could be greatly expanded in countries where the condition is widespread. Messenger RNA Therapies Are Finally Fulfilling Their Promise 2022-03-02T05:00:00Z These are called sickle cell crises and are common in people with the condition. New sickle cell treatment given to first patients in England 2022-02-24T05:00:00Z Red blood cells are normally round and squishy, but mutated haemoglobin can make them rigid and take on their characteristic sickle shape. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z The guidelines do not apply to patients suffering pain from cancer or sickle cell, or are in end-of-life or palliative care. C.D.C. Proposes New Guidelines for Treating Pain, Including Opioid Use 2022-02-10T05:00:00Z “NHLBI is committed to improving the care and long-term survival for children and adults with sickle cell disease in the U.S. as well as other parts of the world,” Gibbons said. His sickle cell disease brought agony. Gene therapy is bringing hope. 2023-04-28T04:00:00Z Sickle cell disease, which disproportionately affects Black Americans, is caused by genetic mutations that turn red blood cells from flexible discs into rigid sickles that can block blood flow and cause sudden painful crises. With CRISPR gene editing, unique treatments begin to take off for rare diseases 2022-02-05T05:00:00Z "We hope that this new treatment will bring a new lease of life to many living with sickle cell." New sickle cell treatment given to first patients in England 2022-02-24T05:00:00Z The risk of heart attack, stroke and organ damage are all higher in people with sickle cell disease. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z Special forces, police and national guard held the exercises on snowy streets near abandoned Soviet hotels and buildings, some of which display the hammer and sickle. Ukrainian soldiers drill urban warfare scenario in deserted Chernobyl town 2022-02-04T05:00:00Z The proposal specifies the illnesses that could be treated, including cancer, multiple sclerosis, glaucoma, sickle cell anemia and autism. SC senator gets 7-year wish for medical marijuana debate 2022-01-26T05:00:00Z Similarly, the seven patients with sickle cell disease had no sudden painful crises because of blocked blood flow since the treatment. With CRISPR gene editing, unique treatments begin to take off for rare diseases 2022-02-05T05:00:00Z A report from MPs last year found "serious failings" in sickle cell care with some evidence of discrimination against patients. New sickle cell treatment given to first patients in England 2022-02-24T05:00:00Z But the hallmark of sickle cell disease are the severe pain episodes called crises, which need hospital care and morphine to take the pain away. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z A Thai man was suspected of attacking the two with a rice sickle for drinking and playing music loudly, police said, according their preliminary investigation. Briton dies, another severely injured in Thailand after knife attack, police say 2022-01-24T05:00:00Z She had quit her job as a mechanic last year after the symptoms of her sickle cell disease worsened, becoming a stay-at-home parent to Francis’s two children. Low-wage workers prop up the nursing home industry. They’re quitting in droves. 2022-01-23T05:00:00Z A sickle was found at the scene, they added. Briton killed in attack in Thailand named by police 2022-01-22T05:00:00Z Ten specialist treatment centres have been set up across England which doctors hope will improve outcomes for sickle cell patients. New sickle cell treatment given to first patients in England 2022-02-24T05:00:00Z Jimi Olaghere thought he would have to wait decades to be freed from his sickle cell disease - but now scientists have engineered his blood to overcome the disease which left him in constant pain. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z Some children have been admitted for underlying conditions such as lung disease, diabetes and sickle cell disease that have worsened because of an omicron infection, doctors say. Kids’ low COVID-19 vaccination rates called a ‘gut punch’ 2022-01-12T05:00:00Z And so, while we might be inclined to put these patients in the incidental covid category, a relatively mild case of covid may have triggered their sickle pain crisis. Perspective | Is a patient hospitalized ‘with’ covid or ‘for’ covid? It can be hard to tell. 2022-01-07T05:00:00Z “So the angel swung his sickle over the earth and gathered the grapes of the earth, and threw them into the great winepress of God’s wrath.” Dust Bowl Democrats 2021-12-30T05:00:00Z But she’s haunted by a question: What if she’d known before she got pregnant that her child might be born with sickle cell? Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z His family urged Jimi to take part in other clinical trials or have a bone marrow transplant - which is an option for some people with sickle cell. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z The biotechnology company put a partial hold on a program to develop a sickle cell disease treatment. Ball, Occidental fall; Verso, Bluerock Residential rise 2021-12-20T05:00:00Z She describes herself as a sickle cell warrior who lives each day like it’s her last. 10 photo essays that capture 2021, a year of uncertainty and endurance When the sickle comes for her, will the angel find her living in Florida? Dust Bowl Democrats 2021-12-30T05:00:00Z Yet few of the couples at risk for having babies with sickle cell know it. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z He told his family: "One day in the future, probably 20 to 50 years from now, I'm going to get my DNA edited, and it's going to cure my sickle cell." Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z Decades before, No. 17 had been famous as the building with the dancer: a statue of a ballerina, holding a hammer and sickle, placed atop the cupola during Stalin’s building blitz. Three decades after the Soviet era, this Moscow street echoes what was. And hints where Russia is heading. “When I was younger,” she told me, “I thought I would live until my mid-20s because I knew other people with sickle cell that died in their 20s.” 10 photo essays that capture 2021, a year of uncertainty and endurance And in the meantime, if people don’t like it, they can always move back to California, where an angel with a sickle awaits them. Dust Bowl Democrats 2021-12-30T05:00:00Z A person who inherits the mutated gene from just one parent has what is called sickle cell trait, not the disease itself. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Crucially, it's only the adult form of haemoglobin that is affected by sickle cell disease. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z NHS England said sickle cell treatment had been overhauled, with 10 new specialist centres for the disease being set up across the country. MPs find 'serious failings' in sickle cell care 2021-11-15T05:00:00Z The Centers for Disease Control and Prevention describes sickle cell anemia as an inherited red blood cell disorder that causes those cells to become hard and sticky, and appear C-shaped. 10 photo essays that capture 2021, a year of uncertainty and endurance Sickling attacks are overwhelmingly associated with Black athletes, since approximately one in 12 African-Americans carry the sickle cell trait. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z But if both partners in a couple have the trait, there’s a one in four chance that their baby will inherit it from both of them and have sickle cell disease. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z "What we are seeing is patients are going back to their normal life, none have required admission to hospital or doctor visits because of sickle cell related complications," Dr Frangoul says. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z MPs and health campaigners are calling for major improvements in care for sickle cell patients. MPs find 'serious failings' in sickle cell care 2021-11-15T05:00:00Z Healthy red blood cells are round and move through small blood vessels to carry oxygen, whereas sickle cells die earlier and transport less oxygen. 10 photo essays that capture 2021, a year of uncertainty and endurance "I was fully aware of exertional sickling when I did the autopsy, but I had no history of sickle cell disease or trait," Beaver told Salon. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z “In my view, sickle cell represents the worst and best of health care,” said Dr. Elliott Vichinsky, a sickle cell expert at the University of California, San Francisco. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z The same genetic procedure has been performed on a total of 45 patients with either sickle cell disease or another blood disorder called beta thalassaemia, which is caused by malformed haemoglobin. Sickle cell: ‘The revolutionary gene-editing treatment that gave me new life’ 2022-02-19T05:00:00Z The report has made a number of recommendations including more funding for sickle cell research and better training for healthcare staff. MPs find 'serious failings' in sickle cell care 2021-11-15T05:00:00Z The actress also has sickle cell anaemia, so will need a full body blood exchange the week before her surgery, which is planned for early December. Ex-Coronation Street star Victoria Ekanoye has breast cancer 2021-11-08T05:00:00Z "It was not until I looked at the cardiac biopsy material that I found sickle cell in the microvasculature and could raise the issue." Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z Preventive Services Task Force, an independent panel of experts that advises the federal government on screening tests and services to prevent disease, has never considered sickle cell. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z In 2017, before the first gene-editing trial for sickle cell disease had been approved, his team interviewed more than 100 patients, families and physicians to gauge their attitudes and beliefs about the technology. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z Last month, NHS England announced the first treatment for sickle cell disease for more than 20 years, which will be rolled out to thousands of patients. MPs find 'serious failings' in sickle cell care 2021-11-15T05:00:00Z The Panthers were known, among other things, for free breakfast programs for school children and a pioneering sickle cell disease testing program. Debut of Huey Newton bust spotlights an influential figure 2021-10-22T04:00:00Z You most likely have heard of sickle cell anemia, an inherited red blood cell disorder. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z Yet, though screening for sickle cell trait “is a very important topic,” Dr. Owens said, it had never been nominated. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z “I have sickle cell. I struggle with it daily.... I don’t want the reason why I can’t get it done to be because, oh, your insurance, or you don’t have the money.” We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z The report found sub-standard care for sickle cell patients admitted both to general wards and A&E, as well as inadequate training about the condition among healthcare staff. MPs find 'serious failings' in sickle cell care 2021-11-15T05:00:00Z One early-phase clinical trial employed an ex vivo gene-editing method to treat people with sickle cell disease or with a related blood disorder called beta thalassemia. The Definition of Gene Therapy Has Changed 2021-10-19T04:00:00Z Activists for sickle cell anemia research and treatment don't necessarily want to hear evidence about exertional sickling and football deaths, fearing it could draw oxygen away from their fundraising efforts. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z Dr. Scott’s obstetrician suggested the couple see a genetic counselor well into her pregnancy, after learning they both had the sickle cell trait. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z In the U.S., only about one in four people with sickle cell disease receives the standard of care. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z The first results from a small clinical trial aimed at treating sickle cell disease and a closely related disorder, called beta thalassemia, were published this past June. Four Success Stories in Gene Therapy 2021-10-20T04:00:00Z This condition causes red blood cells to take on a sickle shape and clump together, making them unable to transport oxygen efficiently. The Quest to Overcome Gene Therapy’s Failures 2021-10-20T04:00:00Z But sickle cell trait is different; it is not a disease. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z His parents hope he will be free of sickle cell one day. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Creary herself has spent hours writhing in pain in hospital emergency rooms, misperceived by staff as drug seeking because she is Black and has sickle cell disease. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z Seven people with severe sickle cell disease received the same treatment, all of whom showed increased levels of hemoglobin and reported at least three months without severe pain. Four Success Stories in Gene Therapy 2021-10-20T04:00:00Z Bluebird Bio, a biotech company in Cambridge, Mass., reported promising results from a clinical trial of its sickle cell gene therapy in late 2020. The Quest to Overcome Gene Therapy’s Failures 2021-10-20T04:00:00Z "I was never given the history of documented sickle cell trait, or shown any documentation that I recall," he said. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z Why not just test all adults for the sickle cell trait? Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Creary has noticed scientists promoting the narrative of gene therapy as social justice—a way of repairing the damage done to those living with sickle cell disease. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z More than a year later those improvements persisted in five subjects with beta thalassemia and two with sickle cell. Four Success Stories in Gene Therapy 2021-10-20T04:00:00Z She has sickle cell disease - which affects red blood cells - and really struggled. Malaria vaccine 'will change African lives forever' 2021-10-11T04:00:00Z "The coach told my source, 'It's a sickle cell death,'" Anderson reported. Football's unknown epidemic: When Black players die suddenly, the cover-up begins 2021-11-13T05:00:00Z Even Linus Pauling, who famously discovered that sickle cell was caused by the substitution of a single amino acid in the globin protein, was part of this dismal history. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z She points to the Web site for the NIH’s Cure Sickle Cell Initiative, which opens with, “It’s time to rewrite the story of sickle cell.” We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z For example, people with one copy of the sickle cell gene are protected from malaria. The most common Alzheimer’s risk gene may also protect against memory loss 2021-10-06T04:00:00Z But Travanna has sickle cell anemia, a rare red blood cell disorder that requires her to receive monthly blood transfusions. With youth vaccine rates still low, D.C. awards first college scholarship as part of incentive program 2021-10-06T04:00:00Z The flag of the city of Los Angeles would fly alongside Greece’s blue and white and the Soviet Union’s hammer and sickle at the closing ceremonies. The story of L.A.’s oddball flag. Wait, L.A. has a flag? 2021-10-05T04:00:00Z Routine genetic tests of newborns detect not just sickle cell disease but also sickle cell trait. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Her research suggests that discussions about gene therapy, at least for sickle cell disease, must address big issues such as colonialism, slavery, racism, and “all the things that come from generations and generations of oppression.” We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z Obstetricians who fail to screen for disabling conditions can be sued for “wrongful birth” by parents whose children are born with disabilities such as sickle cell anemia, Down’s syndrome and spina bifida. ‘How did YOU get pregnant?’ How disabled mothers are neglected by modern medicine 2021-09-30T04:00:00Z The Ranger closed the case about nine months later, on learning that the medical examiner had ruled that Mr. Miller’s death was caused by a sickle cell crisis. They Investigate Police Killings. Their Record Is Wanting. 2021-09-25T04:00:00Z The Ranger closed the case about nine months later, on learning that the medical examiner had ruled that Miller’s death was caused by a sickle cell crisis. When officers kill, Texas Rangers investigate. Their record is spotty 2021-09-25T04:00:00Z Both parents should be counseled and tested to see if future children are at risk of having sickle cell disease. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z She knows gene therapy might completely erase her sickle cell disease, untethering her from its pain and complications. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z But in 2019 she became the first American teenager with sickle cell to be declared free of the disease six months after undergoing an experimental gene therapy meant to cure her. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z It is claimed that one officer failed to pass on the fact that Mr Okorogheye suffered from sickle cell anaemia to the missing persons team after being contacted by his GP. Richard Okorogheye death: Met Police officers face misconduct probe 2021-09-07T04:00:00Z “I am fully aware of the risk,” Frederick, who has sickle cell anemia and Type 1 diabetes, said in an interview. Housing issues and coronavirus concerns cloud first week at Howard 2021-09-02T04:00:00Z There was a moment in the early 1970s when the Black Panthers made sickle cell part of their drive to improve health care for Black people. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Melissa Creary was three years old when she was diagnosed with sickle cell disease. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z She assures teenagers she met at a camp for children with sickle cell: “One day they can have what I had.” Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z Texarkana College police, who initially confronted Boykin, sent a custodial death report to the Texas attorney general saying the coroner determined that Boykin died of natural causes linked to complications of sickle cell trait. Lawsuit: Texas officers ignored pleas of man before death 2021-09-02T04:00:00Z DeSantis mentioned good candidates were elderly people and those with chronic kidney disease, diabetes, morbid obesity and sickle cell. Florida launches antibody treatment effort to help hospitals 2021-08-12T04:00:00Z Testing for sickle cell trait fit their mission, along with tests for high blood pressure and elevated levels of lead in the blood. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z To dilute the sickle cells clogging her bloodstream, she had to undergo monthly blood transfusions. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z But the hope is shadowed by a legacy of underinvestment in treatments for sickle cell compared with diseases that mostly afflict white people, researchers have shown. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z When doctors diagnosed sickle cell disease in his daughter when she was an infant, they said she was probably not going to live long. Florida church reeling after six members die within 10 days amid spike in cases 2021-08-08T04:00:00Z It featured an image of the Soviet hammer and sickle imposed on a rainbow flag. Poles Tussle Over an Icon of Their Past, With an Eye on the Future 2021-07-28T04:00:00Z That focus on sickle cell disease is long gone, Dr. Vichinsky noted. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Creary studies the biology, policy and social determinants of health related to sickle cell disease in the U.S. and Brazil. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z “It’s an exciting time for sickle cell,” said Dr. Erica Esrick, a hematologist at Boston Children’s Hospital who led the clinical trail in which Helen participated. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z As you’d expect and perhaps even want from a slasher movie where Time itself is wielding the sickle, the body count escalates fast. Review: M. Night Shyamalan's 'Old' isn't so bad, except when it's terrible 2021-07-22T04:00:00Z In sickle cell disease, or SCD, a single mutation in the beta-hemoglobin gene leads to red blood cells that become crescent-shaped, or sickled. How Designer DNA Is Changing Medicine 2021-07-17T04:00:00Z She got the idea from the mother of Rickey’s best friend, who asked her: Have you ever thought about forming a sickle cell foundation? Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Her experience of severe sickle cell disease led her to talk with physicians about gene therapy in a new way—not as an academic exchanging ideas with colleagues but as a patient seeking answers. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z Researchers will follow these patients for 15 years to see if there are long-term complications, or if they remain free of sickle cell and can be considered truly cured. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z Indications of sickle cell disease, an inherited blood disorder that mainly affects African Americans, were found. Faces of the dead emerge from lost African American graveyard 2021-07-09T04:00:00Z In the case of sickle cell, the correction allows the body simply to produce normal hemoglobin. How Designer DNA Is Changing Medicine 2021-07-17T04:00:00Z She raised money to help a woman caring for her 14-year-old nephew who had sickle cell. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z A handful of gene-targeted treatments are under development for sickle cell disease, and hundreds more are being investigated for a variety of conditions, including cystic fibrosis, muscular dystrophy, hemophilia, Huntington’s disease, HIV and cancer. We Need to Ground Truth Assumptions about Gene Therapy 2021-10-22T04:00:00Z One concern is that altering genes to rid them of sickle cell could introduce mutations that cause cancer. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z A numberless crowd of faceless men marched with red banners, surrounding a locomotive engine emblazoned with hammer and sickle. The War on History Is a War on Democracy 2021-06-29T04:00:00Z In real time, the hope is that genetic editing will provide a cure for a very common and debilitating inherited disease, sickle cell. How Designer DNA Is Changing Medicine 2021-07-17T04:00:00Z He wet his bed at night because sickle cell damaged his kidneys. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z He pumped a fist into the air, standing in a Mao suit at a lectern stamped with a hammer and sickle, as 70,000 spectators in Tiananmen Square clapped and cheered. As Communist Party turns 100, China's Xi rallies his compatriots and warns his critics 2021-07-01T04:00:00Z Bluebird Bio, one of the companies testing a gene therapy for sickle cell — not Helen’s — recently paused its clinical trial after two patients developed cancer to study whether their illnesses were caused by the treatment. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z Also, a patient who requires regular transfusions for a health condition such as sickle cell disease might be asked to undergo treatments less often, Dr. Cohn added. U.S. blood centers, hospitals struggle with blood shortage 2021-06-30T04:00:00Z Colón’s case represents a point on the curve of an emerging technology that may forever alter our approach to treating diseases like sickle cell. How Designer DNA Is Changing Medicine 2021-07-17T04:00:00Z Rickey, his father’s namesake, was born with sickle cell, a blood disorder that would cause him searing pain throughout a life likely to be cut short by the disease. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z Soldiers marched in goose step under a red arch emblazoned with the hammer and sickle as cannons fired 100 rounds. As Communist Party turns 100, China's Xi rallies his compatriots and warns his critics 2021-07-01T04:00:00Z If and when a gene therapy is approved for sickle cell, it is not clear how many people would be able to get it. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z SCT is a benign genetic condition; it is not a disease and is not associated with decreased life expectancy like sickle cell disease. Some Medical Examiners Say Sickle Cell Trait Causes Sudden Death. They’re Wrong 2021-06-20T04:00:00Z It was this type of treatment, as part of the largest lentivirus ongoing gene therapy trial led by Bluebird Bio, that effectively arrested Colón’s sickle cell condition. How Designer DNA Is Changing Medicine 2021-07-17T04:00:00Z Most states’ guidelines say the baby’s pediatrician should be told if the child has sickle cell trait — but the information chain can end there. Sickle Cell Math Is Brutally Simple, but Not Widely Taught 2021-12-28T05:00:00Z She had masks made with the words “sickle cell” printed across the front. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z Like every sickle cell patient, Helen had a mutation in a gene that turned her red blood cells into rigid crescents instead of soft disks. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z But like countless other children with sickle cell, she was never screened. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z He was given an anaesthetic, but it transpired that Noel had undiagnosed sickle cell anaemia, and the anaesthetic triggered a serious reaction. Subnormal: The scandal of black children sent to 'special' schools 2021-05-19T04:00:00Z The medical examiner attributed the death of Mr. Moss, 31 and apparently in good physical condition, to natural causes, particularly sickle cell trait “following exertion.” How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z Her husband first learned that she had sickle cell when they were dating and she told him that she was having a pain crisis. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z But that gene, the adult globin gene, is the one that can carry a sickle cell mutation. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z A new study, based on a survey of the largest group of children with sickle cell to date and recently published in The Journal of Pediatric Hematology/Oncology, again documented the dire situation. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z A communist hammer and sickle, one of the few left in the Czech capital, was bolted on to the granite. Spy row revs up Czech-Russian tensions 2021-05-07T04:00:00Z After Mr. Pierce’s autopsy, the coroner’s office focused not on the drugs but on sickle cell trait, ruling that he had died a natural death caused by “widespread red blood cell sickling.” How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z And because he was white, there was a lower chance that he would carry the sickle cell mutation, meaning it was less likely that their children would have the disease — something she also found appealing. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z The treatment, of a 33-year-old woman with sickle cell, was a success. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z Some medical centers with special sickle cell clinics failed to consistently follow up with families who missed appointments. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z The Soviet Communists replaced it with a red-and-green flag, including the hammer and sickle symbol and a traditional folk motif. Why wearing the wrong socks is risky in Belarus 2021-05-06T04:00:00Z The medical examiner ruled that he had died a natural death caused by sickle cell crisis, and a grand jury declined to bring charges. How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z They have found little evidence to suggest that sickle cell patients who regularly take opioids see their quality of life improve. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z In January, his doctor, Alexis Thompson of Northwestern University, told him he no longer had sickle cell disease. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z A recent survey funded by the National Institutes of Health of 2,200 sickle cell patients from eight sites found that just 48% of patients were taking hydroxyurea regularly. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z That flag was reintroduced by President Alexander Lukashenko in 1995 - after the fall of communism - but minus the hammer and sickle. Why wearing the wrong socks is risky in Belarus 2021-05-06T04:00:00Z After he died at a hospital, the medical examiner said that the manner of his death was undetermined — and that it was caused in part by sickle cell trait. How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z Months earlier, Tennessee had enacted some of the nation’s most stringent restrictions on doctors prescribing opioids during a deadly epidemic, though there were exceptions for sickle cell patients. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z Helen, too, has been adjusting to life as a healthy person — an alteration her pediatric hematologist, Dr. Alexander Ngwube of Phoenix Children’s Hospital, has observed in sickle cell patients cured with bone-marrow transplants. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z “To have teenage patients who never heard the word hydroxyurea — that’s preposterous,” said Dr. Patrick McGann, a sickle cell specialist at Cincinnati Children’s Hospital who puts all his patients on the drug. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z He also suffered from sickle cell disease - a condition which affects red blood cells and is common among people of African and Caribbean heritage - and oxygen is routinely used to treat low blood saturation. Evan Smith inquest: Hospital 'failure' led to sepsis patient's death 2021-04-06T04:00:00Z To gain a sense of how often medical examiners have used sickle cell trait to explain in-custody deaths, The Times reviewed thousands of pages of autopsy records, court filings and police reports. How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z Her red blood cell count was stable and her iron was low — metrics that, Dr. Hanna said, suggested that her sickle cell was not that severe. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z “Remember, with sickle cell disease they are hospitalized a lot,” he said. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z Kyra, who has sickle cell, had suffered a devastating stroke — her second — a common complication of this inherited disease, which afflicts 100,000 Americans, most of them Black. These Sisters With Sickle Cell Had Devastating — and Preventable — Strokes 2021-05-23T04:00:00Z He found there was a "lack of understanding of sickle cell disease in the medical and nursing staff looking after Mr Smith". Evan Smith inquest: Hospital 'failure' led to sepsis patient's death 2021-04-06T04:00:00Z Medical experts say sickle cell trait has caused deaths in rare cases of extreme overexertion, especially among military trainees and college athletes. How a Genetic Trait in Black People Can Give the Police Cover 2021-05-15T04:00:00Z Pain crises usually came right before her period, she told him, and he said that researchers were exploring whether there was a link between sickle cell pain and menstruation. ‘On That Edge of Fear’: One Woman’s Struggle With Sickle Cell Pain 2021-05-30T04:00:00Z Lasting damage to her hip from sickle cell makes it hard for her to dance, but, she said, she should be able to teach. Pioneering gene therapy freed her of sickle cell. Is a cure at hand? 2021-09-14T04:00:00Z |
| 随便看 |
|
英语例句辞典收录了117811条英语例句在线翻译词条，基本涵盖了全部常用单词及词组的例句翻译及用法，是英语学习的有利工具。