| 单词 | senescent |
| 例句 | In one thin arm, threaded with veins in a kind of senescent bas-relief, was a basket. The Great Santini 1976-01-01T00:00:00Z That talk of "younger years" may make her sound prematurely senescent – Aguilera is, after all, still just 29 – but she's famously been performing since she was six years old. Christina Aguilera: 'I'm a very sexual person by nature' 2010-06-12T23:12:00Z This causes inflammation around the body, as does the natural accumulation of old “zombie” cells, called senescent cells, and inflammation compromises the immune response. How to boost your immune system to avoid colds and coronavirus 2020-03-08T05:00:00Z No one goes less gentle or more magnificently into the mortal, senescent twilight than Lear. | 'King Lear' : ?King Lear? at the Public Theater - Review 2011-11-09T03:01:30Z His book proved an apt fable for a nation cresting toward maturity and eager to seize preeminence from senescent Europe. Oz Revisited – Part 2: How They Made It Wonderful 2013-09-17T15:44:25Z As the headmistress in “Riddance” says, recalling her girlhood, “My style was scarcely juvenile. If anything, it was senescent, with the gaseous orotundity of an earlier era.” Shelley Jackson, Author and Advocate of the Monstrous 2018-10-24T04:00:00Z An existing drug that targets senescent, or sleeping cells could provide the answer to treating lower back pain, according to a new study. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z "Our results indicate that drugs targeting senescent macrophages could be a treatment for cancer -- an unprecedented development," concluded Wada. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z For example, senolytic drugs target senescent cells, which no longer divide but linger in the body instead of being cleared by the immune system. Ways to Extend Your Healthy Years, Not Just Your Life 2023-10-17T04:00:00Z Aging cells, known as senescent cells, contribute to various inflammatory conditions and age-related ailments as humans age. Selective removal of aging cells opens new possibilities for treating age-related diseases 2023-10-04T04:00:00Z "We are exploring the technology for the treatment of more challenging senescent cancer cells and other diseases." Researchers develop new way to target cancer cells 2023-09-25T04:00:00Z When these cells become senescent, they no longer function properly, which can lead to problems with bone maintenance and repair. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Macrophages were not the only immune cells affected; while the proliferation of T cells was unchanged, their antitumor activity was suppressed due to the immunosuppressive factors produced by senescent macrophages. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z Another area of research involves senescent, or “zombie,” cells that scientists are targeting for treatment with drugs. Lawmakers believe scientists are closer to discovering ‘fountain of youth’ 2022-09-15T04:00:00Z About 100 companies, plus academic teams, are exploring drugs to target senescent cells. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Because they are resistant to death, senescent – or "zombie" – cells accumulate with age. Cells become zombies when the ends of their chromosomes are damaged 2022-07-23T04:00:00Z Finally, because porous endplates allow new nerves to grow into the endplate bone, causing sensitivity, the authors looked at whether senescent osteoclasts play a role in this process. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Scientists also are studying a class of compounds known as senolytics, which attack “senescent” cells in the body that tend to proliferate with age. Can some drugs delay aging? Scientists focus on those that target frailty and age-related disease. 2021-03-05T05:00:00Z These senescent cells are typically cleared by the immune system, but as the body ages, they begin to accumulate, ramping up inflammation. How anti-ageing drugs could boost COVID vaccines in older people 2020-10-13T04:00:00Z “When you’re young, your immune system is able to recognize these senescent cells and eliminate them,” says Perez, who studies cell biology and aging. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Fetal cells are less likely to be senescent, he explains, and so increase the odds of success. A menagerie of stem-cell models 2020-09-21T04:00:00Z This suggests there is an ongoing dysfunctional production of new bone tissue within the spinal endplate in the ageing or injured spine, and that treatment to remove the senescent osteoclasts could halt this process. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z “It takes 10 days to six weeks for a cell to become senescent, but only a brief exposure to these drugs to get the cells to kill themselves,” Kirkland says. Can some drugs delay aging? Scientists focus on those that target frailty and age-related disease. 2021-03-05T05:00:00Z However, Amor and colleagues found that uPAR is highly expressed in senescent cells both in vitro and in vivo. T cells engineered to target senescence 2020-06-16T04:00:00Z Another pilot study found the same combination reduced the burden of senescent cells in the fat tissue of people with diabetic kidney disease. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z This helps to clear up cellular debris and any toxins that might have pushed the cells to become senescent in the first place. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z "Our findings suggest that depletion of these senescent osteoclasts, perhaps by use of existing drugs, could represent a new strategy in the treatment of lower back pain." Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z They are working to improve their understanding of the disease, including the role of senescent cells — sometimes referred to as zombie cells owing to the ‘undead’ state in which they persist. Chronic obstructive pulmonary disease 2020-05-12T04:00:00Z They report that treatment with CAR T cells that target uPAR eliminated senescent premalignant and malignant cells in mouse models of liver and lung cancer. T cells engineered to target senescence 2020-06-16T04:00:00Z Some teams are trying to develop “senomorphics” that can suppress detrimental effects of molecules emitted by senescent cells. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z “You can find a predominance of senescent cells at the site of a lung disease, but in those individuals, you find senescence cells elsewhere too.” Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z They tested for the simultaneous presence of two markers within the bone -- 'TRAP' which is a hallmark of osteoclasts, and p16, used to identify senescent cells. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Another consequence of aging is the accumulation of so-called senescent cells, normal cells that stop dividing, contribute to tissue aging and secrete substances like cytokines that induce inflammation. Tackling Inflammation to Fight Age-Related Ailments 2019-12-23T05:00:00Z The recognition process drives the T cells to kill the senescent cells. T cells engineered to target senescence 2020-06-16T04:00:00Z And a Japanese team has tested a vaccine on mice specific to a protein found in senescent cells, allowing for their targeted elimination. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z The lungs are well-vascularized organs that are regularly exposed to pollutants in air and can become overwhelmed by repeated toxic insults, which can lead to the development of numerous senescent cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z In both types of spinal degeneration, they saw a strong association between the presence of senescent osteoclasts and the degree of degeneration and spine hypersensitivity. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z A combination of two drugs, dasatinib and quercetin, was shown in a Mayo Clinic study in obese mice to remove senescent cells and permit cell growth to resume in the brain. Tackling Inflammation to Fight Age-Related Ailments 2019-12-23T05:00:00Z This issue might not be of concern when targeting senescent cells, because they do not proliferate. T cells engineered to target senescence 2020-06-16T04:00:00Z Research suggests it counters the buildup of senescent ones, helping the immune system clear them and counteracting the molecular damage that can spark the senescence process. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Removing every senescent cell in the lungs might have damaging side effects. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Next, they explored whether a drug called Navitoclax, which targets senescent cells, could eliminate senescent osteoclasts and reduce spinal hypersensitivity. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z There are now cutting-edge clinical trials in senolytics: the use of molecules to selectively destroy senescent cells in people. Scientists harness AI to reverse ageing in billion-dollar industry 2019-12-21T05:00:00Z Merging two promising therapeutic strategies by using CAR T cells to target senescent cells might be a powerful combination for tackling certain diseases. T cells engineered to target senescence 2020-06-16T04:00:00Z A study LeBrasseur led last year provided the first evidence in humans that exercise can significantly reduce indicators, found in the bloodstream, of the burden of senescent cells in the body. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z As well as certain secretory factors, the researchers want to monitor exosomes — small vesicles that senescent cells secrete in large quantities. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z As hoped, the treatment caused a significant reduction in senescent osteoclasts compared to untreated mice, as well as reduced pain and increased activity in mice with both types of spine degeneration. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z This might account for a portion of the numerous lysosomes that are a hallmark of senescent cells. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z Writing in Nature, Amor et al.1 describe a method that selectively removes senescent cells in mice. T cells engineered to target senescence 2020-06-16T04:00:00Z It’s built upon the idea that cells eventually stop dividing and enter a “senescent” state in response to various forms of damage. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z The compounds — a cancer drug called dasatinib, and a compound found in many fruits and vegetables called quercetin — triggered the death of senescent cells and improved the participants’ physical function. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Not nearly as inactive as the name suggests, senescent cells contribute to chronic inflammation and interfere with protective collagens. Why We Can’t Tell the Truth About Aging 2019-10-28T04:00:00Z The cells that were engulfed by the senescent cells were neighbouring senescent or non-senescent cancer cells. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z This recruits T cells and NK cells of the immune system, promoting removal of the senescent cells. T cells engineered to target senescence 2020-06-16T04:00:00Z Scientists link some disorders to buildups of senescent cells in certain spots. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z When Kirkland’s group transplanted a relatively small number of senescent cells into young mice, this was enough to cause persistent physical problems for the animals. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Basically, most cells divide and replicate some fifty-plus times before becoming senescent. Why We Can’t Tell the Truth About Aging 2019-10-28T04:00:00Z Crucially, senescent cells that ate their neighbours survived longer in vitro than those that did not. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z One possible way to target senescent cells is with drugs that kill them selectively, called senolytic drugs. T cells engineered to target senescence 2020-06-16T04:00:00Z For example, research suggests certain senescent cells that accumulate in lungs exposed to cigarette smoke may contribute substantially to airway inflammation in COPD. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Rapamycin, a natural compound that inhibits mTOR, has been shown to increase lifespan in mice, possibly by putting a dampener on senescent secretions. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z They predict the emergence of drugs that will modulate these and other molecules known to be involved in longevity pathways, or destroy harmful senescent cells that accumulate as we age and help to fuel disease. The enlightenment of age 2019-09-09T04:00:00Z This finding suggests that metabolic building blocks retrieved from the lysosomal digestion of neighbouring cells were being used by senescent cells to promote their survival. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z To find antigens that are specific to senescent cells, Amor and colleagues analysed the expression of transmembrane proteins found in senescent human and mouse cells. T cells engineered to target senescence 2020-06-16T04:00:00Z Experimental drugs designed to selectively clear senescent cells have been dubbed “senolytics,” and Mayo holds patents on some. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z “Senolytics work by transiently disabling those pathways, for just a few minutes, and allow the senescent cells to commit suicide,” Kirkland explains. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Xu has found that obesity can cause senescent cells to develop prematurely. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z This surprising finding that cell death supports the survival of senescent cells highlights the complexity of cell-death regulation in multicellular animals. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z As we age there’s an increase in the number of senescent cells … these are sometimes called zombie cells because they haven’t been repaired into functional cells but haven’t been eliminated either. Can a Pill Really Help You Live Longer? 2019-04-20T04:00:00Z From the results of cell aging studies, Ness speculates that in childhood cancer survivors, senescent cells "communicate with other cells around them," telling those cells to senesce as well. Treatments for childhood cancer can devastate lives years later. Scientists are trying to change that 2019-03-14T04:00:00Z A senescent cell is like a classic movie monster — it exists in an ‘undead’ state. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z “We also found that clearing senescent cells improves insulin sensitivity. So senolytic drugs not only work on ageing but also on obesity … Senescence is a connection between these two very common conditions.” The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z The authors tested chemotherapy-induced senescent cells of other types of cancer, including lung cancer and a bone cancer called osteosarcoma, and found that these cells also cannibalize neighbouring cells. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z De Cecco et al. showed that the cytoplasmic DNA in senescent cells is produced, at least in part, by reactivated LINE-1 elements. Inhibition of ‘jumping genes’ promotes healthy ageing 2019-02-05T05:00:00Z In turn, senescent glia affect the ability of neurons to regulate tau phosphorylation and aggregation, ultimately promoting neuronal degeneration. 2018: Choice cuts from this year’s News & Views articles 2018-12-13T05:00:00Z “Normally, these senescent cells get cleared, and this allows tissue architecture to be maintained,” says Victor Thannickal, a respiratory scientist at the University of Alabama at Birmingham. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Grönke says that senescent cells “play a big role after cancer treatment”, developing as a result of chemotherapy and radiation therapy. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z It would be interesting to investigate whether senescent cells choose particular target cells to cannibalize in a competitive fashion. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z Because the process of getting from sentencing to execution is so protracted, averaging 15 years, senescent people on the nation’s death rows are going to be problems as long as there is capital punishment. Opinion | Abolish the death penalty 2018-09-28T04:00:00Z The research in mice is the first to show that so-called senescent cells, which enter a state of suspended animation as the body ages, contribute to neurodegeneration. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z “When they don’t get cleared, then the accumulation of senescent cells can cause harm,” he says. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z “It’s also well known that these animals have less senescent cells at comparable ages.” The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z And if normal cells are found to be removed by senescent cells in aged tissues, this depletion might contribute directly to tissue degeneration. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z Similarly, the mechanisms by which senescent astrocytes and microglia signal back to neurons remain to be determined. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z Initially senescent cells were thought to be inert bystanders – useless, but harmless. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z One reason for researchers’ uncertainty is that senescent cells in the body can be difficult to distinguish from healthy cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Just as obesity has been shown to increase the burden of senescent cells in tissue, exercise can reduce it, says Xu. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z When given to younger mice in which the aging process was jump-started with a transfer of senescent cells, the anti-aging cocktail forestalled the onset of age-related diseases. Live longer in fine fettle? Mouse study shows drug cocktail keeps aging at bay 2018-07-10T04:00:00Z In a paper in Nature, Bussian et al.3 examine the role of senescent cells in a mouse model of a type of neurodegeneration that involves aggregation of the protein tau. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z Writing in the journal Nature, the researchers describe how mice with a genetic form of dementia accumulated senescent cells in regions of the brain that are involved in memory and cognition, such as the hippocampus. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z Kirkland’s group is working on blood, urine and epigenetic tests so that researchers can get a handle on the burden of senescent cells in each patient. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z These so-called “zombie” cells linger and proliferate as we age, emitting substances that cause inflammation and turn other healthy cells senescent, ultimately leading to tissue damage throughout the body. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z With advancing age, senescent cells take the wheel, and the human body careens into disease states ranging from cancer and diabetes to arthritis, vision loss and dementia. [BC-MCT-NEWS-BJT] 2018-07-10T04:00:00Z But despite intense study, the exact effect of senescent cells in different contexts — including in neurodegeneration — remains unclear. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z However, when the mice were treated by administering a genetically modified enzyme to sweep away senescent cells as they appeared, the outward symptoms of dementia vanished. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z Some fear that research on the potential clinical relevance of senescent cells could be overwhelmed by hype. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Xu is at work on senolytics, a branch of medicine that targets senescent cells; the various faulty cells that have been identified as instrumental in our eventual demise. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z In a new study, scientists reveal aging to be a process set in motion by the rise of malign forces called senescent cells, which progressively hijack the body and take it on a nightmarish joyride. [BC-MCT-NEWS-BJT] 2018-07-10T04:00:00Z Moreover, the authors found similar effects when they treated tauP301S mice with a ‘senolytic’ compound, which triggers pharmacological removal of senescent cells. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z “We anticipate finding that senescent cells negatively impact brain health in humans, but those experiments will be difficult to design and perform,” said Baker. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z “We now have maybe a dozen different biomarkers of senescent cells, but the problem is that no single biomarker is exclusive to senescent cells.” Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Xu says that, in theory at least, it should prove impossible to build up a resistance to the drugs, “because senescent cells cannot proliferate”. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z PAI-1 is one of the inflammatory agents that senescent cells typically secrete, and it’s possible that the Amish mutation disrupts that process. Amish Mutation Protects Against Diabetes and May Extend Life 2017-11-15T05:00:00Z If eliminating senescent cells in humans does improve age-related illnesses, researchers will aim to create broader anti-ageing therapies, says David. To stay young, kill zombie cells 2017-10-23T04:00:00Z The team also revealed the brain cells that became senescent were two forms of immune cell in the brain, called microglia and astrocytes, rather than neurons. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z But disappointing results led to speculation that it might be better to deal with the source of inflammation — senescent cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Rather than indulging mobs of senescent villagers, another suggests, the government should give the authority to resolve petty disputes to nazims, the lowliest of elected officials. Pakistan is “mainstreaming” misogynist tribal justice 2017-10-12T04:00:00Z America’s nuclear arsenal is in the hands of a senescent Twitter troll, but those with political power have refused to treat this fact as a national emergency. Opinion | Corker Told the Truth About Trump. Now He Should Act on It. 2017-10-10T04:00:00Z In fact, even the defining feature of a senescent cell — that it does not divide — is not written in stone. To stay young, kill zombie cells 2017-10-23T04:00:00Z Scientists are also uncertain what happens when senescent cells are removed from the brain – whether new brain cells would be generated or whether over time the brain’s cell content would gradually shrink. Removing faulty brain cells staves off dementia in mice 2018-09-19T04:00:00Z A second potential approach is to destroy senescent cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z It is well known that, as we age, more of our cells become senescent — they stop dividing and lose function. Osteoporosis: Staying strong : Nature : Nature Research 2017-10-03T04:00:00Z Canada and the United States face some of the same problems, and one of the most pressing is senescent infrastructure that is failing to keep pace with each country’s growing economy and expanding population. Canada’s infrastructure projects take off while Trump’s plans sputter 2017-08-04T04:00:00Z In young mice, no more than 1% of cells in any given organ were senescent. To stay young, kill zombie cells 2017-10-23T04:00:00Z Damaged cells that stop dividing, called senescent cells, accumulate with age, and are thought to contribute to inflammation, tissue damage and age-related diseases. Ageing: Senescent cells cleared out : Nature : Nature Research 2017-03-28T04:00:00Z In the lab, senescent cells survive conditions that easily kill normal cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z “It was found that these senescent cells secrete a whole load of junk and they’re not just bystanders but have a negative effect,” said De Keizer. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z The approach works by flushing out retired or "senescent" cells in the body that have stopped dividing. Drug 'reverses' ageing in animal tests - BBC News 2017-03-23T04:00:00Z In two-year-old mice, however, up to 20% of cells were senescent in some organs. To stay young, kill zombie cells 2017-10-23T04:00:00Z Now, researchers have developed a molecule that selectively destroys these so-called senescent cells. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z Unlike the zombie armies of Hollywood films, senescent cells can be useful. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z The latest paper is the first to show that ageing can not only be delayed by removing senescent cells – but potentially reversed. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z But while they appear to just sit there, senescent cells release chemicals that cause inflammation and have been implicated in ageing. Drug 'reverses' ageing in animal tests - BBC News 2017-03-23T04:00:00Z Now biotechnology and pharmaceutical companies are keen to test drugs — known as senolytics — that kill senescent cells in the hope of rolling back, or at least forestalling, the ravages of age. To stay young, kill zombie cells 2017-10-23T04:00:00Z “This is the first time that somebody has shown that you can get rid of senescent cells without having any obvious side effects.” Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z “We know that senescent cells can produce a low-grade inflammatory response, which is identical to what we see in COPD,” says Barnes. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z The findings raise the possibility that a future therapy that rids the body of senescent cells might protect against the ravages of old age. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z The group of scientists created a drug that selectively killed senescent cells by disrupting the chemical balance within them. Drug 'reverses' ageing in animal tests - BBC News 2017-03-23T04:00:00Z A senescent cell is in its twilight: not quite dead, but not dividing as it did at its peak. To stay young, kill zombie cells 2017-10-23T04:00:00Z As we get older, senescent cells build up in our tissues, where researchers think they contribute to illnesses such as heart disease, arthritis, and diabetes. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z A build-up of senescent cells in the lungs also seems to limit the potential for tissue renewal. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z In the study, published in the journal Cell, scientists used a compound designed to knock senescent cells out of their state of suspended animation, towards cell death. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z They exposed animals to four commonly used cancer drugs and found that the drugs caused senescent cells to persist in non-cancerous tissue, and that those cells boosted inflammation. Cancer: 'Old' cells linked to drug side effects : Nature : Nature Research 2017-01-10T05:00:00Z Yet at some point, senescent cells begin to accumulate — a process linked to problems such as osteoarthritis, a chronic inflammation of the joints, and atherosclerosis, a hardening of the arteries. To stay young, kill zombie cells 2017-10-23T04:00:00Z In the past, scientists have genetically modified mice to dispatch their senescent cells, allowing the rodents to live longer and reducing plaque buildup in their arteries. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z This could be because the immune system deteriorates with age, which might impede the removal of senescent cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Initially senescent cells were thought to be neutral bystanders that no longer make a useful biological contribution but that are harmless. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z Chemotherapy drugs cause some healthy cells to stop dividing and become senescent, and such cells are thought to promote ageing. Cancer: 'Old' cells linked to drug side effects : Nature : Nature Research 2017-01-10T05:00:00Z “There is nothing definitive about a senescent cell. Nothing. Period,” says Campisi. To stay young, kill zombie cells 2017-10-23T04:00:00Z Such genetic alterations aren’t practical for people, but researchers have reported at least seven compounds, known as senolytics, that kill senescent cells. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z The first study showing that eliminating senescent cells can produce health and longevity benefits, at least in middle-aged mice, came out in February. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z There is now growing evidence for the role of senescent cells in age-related diseases, with higher concentrations of the cells being seen in arthritic joints, cataracts and the plaque-lined arteries. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z But the molecular markers the scientists used to recognize and remove senescent cells are not exclusive to those cells, he notes. Are old cells breaking our hearts? 2016-10-27T04:00:00Z So far, each senolytic kills a particular flavour of senescent cell. To stay young, kill zombie cells 2017-10-23T04:00:00Z “The paper adds a potentially new way to target senescent cells,” says diabetes researcher James Kirkland of the Mayo Clinic in Rochester, Minnesota. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z In October, the same research team took aim at senescent cells from the immune system that amass in artery-clogging plaques and may drive their formation. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z “I think approaches aiming at the elimination of senescent cells will probably be in clinical trial in the next few years. Peptides such as this one are almost ready to go into clinical trials.” Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z In the rodents that received the drug, however, the telltale streaks were much smaller, and harbored few senescent cells. Are old cells breaking our hearts? 2016-10-27T04:00:00Z Despite self-disabling the ability to replicate, senescent cells stay metabolically active, often continuing to perform basic cellular functions. To stay young, kill zombie cells 2017-10-23T04:00:00Z Although the molecule did not reduce the number of platelets in either mouse group, killing off large numbers of senescent cells could still trigger a potentially fatal complication sometimes suffered by cancer patients. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z The multibillion-dollar question: Will taking out senescent cells help humans stay young longer? From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z Kirkland and his colleagues wondered what would happen if senescent cells were removed. The Future of Aging 2016-08-09T04:00:00Z For one thing, Van Deursen says, researchers first need to show that targeting senescent cells works in animals whose arterial blockages more closely mimic human atherosclerosis, such as pigs. Are old cells breaking our hearts? 2016-10-27T04:00:00Z They identified six signalling pathways that prevent cell death, which senescent cells activate to survive12, 13. To stay young, kill zombie cells 2017-10-23T04:00:00Z Moreover, senescent cells foster wound healing, and destroying the cells could impair this ability. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z Both studies used genetically modified mice that clear away their senescent cells in response to a particular compound—a technique that isn’t feasible in humans. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z The study investigators used a drug to eliminate senescent cells in normal mice and found that their life spans were extended by 17 percent to 35 percent. Cell Treatment Boosted Mice's Life Span by a Third 2016-02-03T05:00:00Z In their new study, Van Deursen and colleagues tried to determine the role of senescent cells in atherosclerosis. Are old cells breaking our hearts? 2016-10-27T04:00:00Z Mice whose senescent cells were killed off over six months were healthier, in several ways, than a control group of transgenic mice in which these cells were allowed to build up. Destroying worn-out cells makes mice live longer 2016-02-02T05:00:00Z Instead, he says, they want to determine whether the molecule kills cancer cells, which share some similarities with senescent cells, starting with the brain tumor glioblastoma. Molecule kills elderly cells, reduces signs of aging in mice 2017-03-23T04:00:00Z But researchers have created several so-called senolytic drugs that slay senescent cells without genetic tinkering. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z Usually, age takes precedence, no matter the ailments of the senescent first generation of princes sired by the Kingdom’s founder, the warrior Abdulaziz Al-Saud. The Saudi Royal Family Shakeup 2015-04-30T04:00:00Z Atherosclerosis developed rapidly in the animals that retained senescent cells. Are old cells breaking our hearts? 2016-10-27T04:00:00Z The scientists who conducted the study, led by James Kirkland, Laura Niedernhofer, and Paul Robbins, screened 46 different compounds to find ones that would interfere with the ability of senescent cells to survive. A True Fountain-Of-Youth Drug Combo? 2015-03-16T04:00:00Z When telomeres are too short, the cell will either stop replicating and become senescent or it will die. Gerontology: Will you still need me, will you still feed me? : Nature : Nature Publishing Group 2014-10-14T04:00:00Z To examine whether senescent cells are involved in obesity-induced cancers, Hara and his colleagues worked with genetically engineered mice whose cells emit light upon becoming senescent. Gut Microbes Spur Liver Cancer in Obese Mice 2013-06-27T19:15:05.723Z The researchers suspected that these cells were being made senescent by something produced by gut bacteria. Cancer and the microbiome: A punch in the gut 2013-06-27T15:06:40Z When the scientists measured the amount of fatty buildup in one of the animals’ major arteries, they found that mice purged of senescent cells carried 60% less plaque than did the other mice. Are old cells breaking our hearts? 2016-10-27T04:00:00Z They call these drugs “senolytic” for their ability to kill senescent cells. A True Fountain-Of-Youth Drug Combo? 2015-03-16T04:00:00Z Transplanting young stem cells into a neighbourhood full of older cells, some of which are senescent, is probably not going to work very well, she says. Stem cells: Repeat to fade 2012-12-06T12:21:18.613Z Cells that are irreparably damaged or pre-cancerous can become senescent — meaning that they stop dividing for overall health of the organism. Gut Microbes Spur Liver Cancer in Obese Mice 2013-06-27T19:15:05.723Z "This is a fungus very well-adapted to colonizing senescent or dead leaf tissue once conditions are right," Leonard says. Fungal Meningitis Pathogen Discovers New Appetite for Human Brains 2012-11-12T11:45:00.180Z In the mice that eliminated their senescent cells, Van Deursen and colleagues found, plaques carried thicker protective caps and thus were less likely to break. Are old cells breaking our hearts? 2016-10-27T04:00:00Z The researchers also measured the length of participants' telomeres, which typically shorten every time a cell divides until they reach a point that triggers the cell to enter a senescent state. Largest U.S. Genetic Biobank Reveals Early Findings 2012-11-09T20:04:24Z “There's mounting evidence that senescent cells in the niche are going to be an important part of the stem-cell transplant story.” Stem cells: Repeat to fade 2012-12-06T12:21:18.613Z But before senescent cells die, they can spew out chemicals that may cause inflammation and promote cancer development. Gut Microbes Spur Liver Cancer in Obese Mice 2013-06-27T19:15:05.723Z They also contained genes that would prevent them from suffering harm once their senescent cells were removed with drug therapy. New fronts in the battle against age-related diseases 2011-12-12T20:55:04Z Early on, senescent foam cells may promote the growth of lesions by inciting inflammation. Are old cells breaking our hearts? 2016-10-27T04:00:00Z The genetic method used to purge mice of senescent cells cannot be used in people. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z But once cells are senescent, they secrete cytokines and other molecules that might tip their neighbours — and possibly more distal cells — into a proliferative, cancerous state. Stem cells: Repeat to fade 2012-12-06T12:21:18.613Z The process in which we now find James engaged is mental rather than senescent, but you would hardly guess it to look at him. The Whirligig of Time 2011-11-04T02:00:23.063Z These "senescent" cells, which are no longer dividing or producing new cells, are normally removed from the body by natural processes, but they build up with age. New fronts in the battle against age-related diseases 2011-12-12T20:55:04Z The story starts with an observation, made a few years ago, that senescent cells often produce a molecule called P16INK4A. Ageing: Forever young? 2011-11-02T18:18:01Z “If you remove the senescent cells you improve things considerably, but you can’t reverse the process or completely stop the aging because it has other causes,” Dr. van Deursen said. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z So researchers at the Mayo Clinic used a drug to target only senescent cells and force them to self-destruct, in a group of mice that were genetically engineered to age rapidly. Eternal Youth? Science Shows That Clearing Old Cells Delays Aging 2011-10-18T10:25:00Z Their senescent cells were also made sensitive to a normally harmless drug, enabling the researchers to destroy the cells with a medicine that did no damage elsewhere in the animal’s body. Removing Deadbeat Cells Slows Aging in Mice and May Spare Humans 2011-11-03T12:50:14Z Rid of the senescent cells, the Mayo Clinic researchers reported online Wednesday in the journal Nature, the mice’s tissues showed a major improvement in the usual burden of age-related disorders. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z But he cautions that further research is needed to understand the effects of removing senescent cells. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z Until recently, few people gave much thought to senescent cells. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z When cells become senescent, they produce harmful compounds such as those that cause inflammation. Eternal Youth? Science Shows That Clearing Old Cells Delays Aging 2011-10-18T10:25:00Z The study used genetically engineered mice with senescent cells that carry a molecule called caspase 8. Removing Deadbeat Cells Slows Aging in Mice and May Spare Humans 2011-11-03T12:50:14Z It may be that senescent cells are beneficial in youth but harmful in old age, when the immune system seems to clear them less rapidly from the body. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z First, the researchers cleared senescent cells from the mice throughout their lives—giving the drug every 3 days beginning as soon as the animals were weaned. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z But the startling result is plausible because it ties together an emerging body of knowledge about senescent cells. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Human T17 cells phenotypically resembled terminally differentiated memory T cells but were distinct from central memory, exhausted, and senescent T cells. [Research Articles] Human TH17 Cells Are Long-Lived Effector Memory Cells 2011-10-12T19:25:05.093Z In the young, senescent cells are flushed by a strong immune system. Removing Deadbeat Cells Slows Aging in Mice and May Spare Humans 2011-11-03T12:50:14Z Dr. van Deursen said he thought it worth trying to eliminate senescent cells after the finding that they reliably switch on a gene known as p16-Ink4a. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z The mouse on the right was treated with drugs that remove senescent cells from its body, keeping it more youthful. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z Only in the last few years have researchers come to realize that senescent cells do occur naturally and that they play central roles in both cancer and aging. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z And spring's pied garland, worn for Beauty's sake, And summer's crown of pride, less fair appear Than the subdued, enchanted tints that make The aureole of the senescent year. Sonnets and Other Verse 2011-09-11T02:00:08.503Z By the time Pacific salmon close in on their spawning grounds, they are senescent and naturally immunosuppressed. Upstream Battle: What Is Killing Off the Fraser River's Sockeye Salmon? [Slide Show] 2011-05-05T10:15:00.237Z Drugs already exist to combat some of the inflammatory hormones secreted by senescent cells. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z In elderly humans, at least 5% of the total cells in the body are thought to be senescent. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z Moles, for instance, are collections of senescent cells that continue to produce melanin and defend the skin from ultraviolet rays. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Its senescent glamour lingered upon the towering plinth and fluted pillars of the temple of the Sacred Bo-tree, seven miles south of Gaya-town. Caravans By Night A Romance of India 2011-01-03T03:01:02.370Z They are one of a handful of organisms known as negligibly senescent — they defy aging. Thriving in Harsh Settings, Old Trees May Soon Meet Their Match 2010-09-27T22:47:00Z Thus whenever a cell became senescent, it also armed a self-destruct mechanism. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z A cell that's no longer dividing is known as senescent; it continues to live but no longer functions as it once did. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z And despite being termed senescent, the cells are very active: They convert themselves into factories that churn out 100 different kinds of growth factors, along with cytokines, the inflammatory agents that stimulate the immune system. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z When the Florentines established a chair for the explanation of the Divina Commedia in their university, and offered it to Boccaccio, the senescent poet at once undertook the arduous duty. Encyclopaedia Britannica, 11th Edition, Volume 4, Slice 1 "Bisharin" to "Bohea" That senescent October moon which a year ago marked the end of love's halcyon would have been a suitable light for such a party. Carnival Their findings indicate that any therapy that rids the body of senescent cells would delay age-related changes. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z Van Deursen and colleagues developed a way to kill senescent cells in mice, clearing them from the body. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z The Mayo team genetically engineered a strain of mice in which whenever a cell became senescent by switching on its p16-INK4a gene, it also primed a cell suicide device. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z They did not see the poignant beauty of the seemingly senescent hills covered with wisps of green and bathed in blazing sunshine. For Every Man A Reason Thrones rose and fell; and still the crescent, Unsanative and now senescent, A plastered skeleton of lath, Looked forward to a day of wrath. The Works of Robert Louis Stevenson - Swanston Edition Vol. XXII (of 25) Juvenilia and Other Papers Dr. van Deursen’s work is the first to show that removing senescent cells is beneficial. Senescent Cells Drive Aging, but Can Be Purged, Mouse Study Suggests 2011-11-02T19:24:30Z "Our method allowed us to look at the consequences of removing senescent cells at different stages of the mouse life cycle," van Deursen says. Cellular Spring Cleaning Slows Aging 2011-11-02T19:04:00Z The Mayo team used a special drug to activate this device and clear the mice of all their senescent cells. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Whatever her charm, she was no longer in her first youth, and only unripe fruit could sting that senescent palate. Black Oxen Clarence, who immediately dominated the scene, rendering Nancy's greeting to Annie vain and perfunctory, was a three-year-old with a frivolity of manner that ill became his senescent phiz. Tutors' Lane The gardener slammed the door of the senescent truck with vehement lack of affection. Greener Than You Think On this theme she chanted long and lovingly and a hundred coloured, senescent imageries leaped from the song. Nights in London The researchers showed that mice purged of senescent cells could run much longer on a treadmill, had larger fat deposits — fat disappears from the skin as people age, causing wrinkles — and developed cataracts much later. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Tito, in his epigram, described himself as senescent, and consequently not likely to be wounded by Cupid's darts, but he, nevertheless, was ensnared by Lucretia's charms. Lucretia Borgia According to Original Documents and Correspondence of Her Day The experiences which voice themselves in theology have cooled and hardened down; the philosophy which is implicit in theology is past philosophy; the science implicit in theology is senescent science. Modern Religious Cults and Movements In the jewelled light of a senescent moon, his wife and little daughter gazed at them curiously, without semblance of pity or fear. Visionaries "No doubt a sudden impulse of senescent kleptomania," said the superintendent, sagely, when he had noted down for transference to headquarters Madame Dépine's verbose and vociferous description of the traits and garments of the runagate. The Grey Wig: Stories and Novelettes So despite their healthier tissues, the mice purged of senescent cells died at the usual age of heart problems. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z By that sort of piety to which senescent female sinners everywhere and at all times devote themselves she secured new friends. Lucretia Borgia According to Original Documents and Correspondence of Her Day They know that your glory is crescent, And, though each uplifteth her horn, Each feels that her glory's senescent, In spite of their duplicate scorn. Punch, Or The London Charivari, Volume 102, April 2, 1892 He had noted with disgust, however, the stooped shoulders and white imperial of the silk-hatted man beside her, and the senescent line of his back. Youth and the Bright Medusa If I, with too senescent air, Invade your elder memory's pale, You snub me with a pitying 'Where Were you in the September Gale?' The Complete Poetical Works of James Russell Lowell Dr. van Deursen’s team is now testing to see whether normal mice will live longer when purged of senescent cells. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z If the senescent old British lion attempts any funny business with the Russian bear it is liable to lose its umbilicus, and the surgical operation will be performed without the use of anaesthetics. Brann the Iconoclast — Volume 10 The book never was published; it was merely printed to satisfy the senescent vanity of a property-worshiping, cliche-parroting reactionary who made money ranching before he became governor of Wyoming. Guide to Life and Literature of the Southwest, with a Few Observations A senescent city; mostly antiquated Spanish architecture,—ponderous archways and earthquake-proof walls. Two Years in the French West Indies Unless other factors intervene, this reduction in speed is progressive until senescent death. Origin and Nature of Emotions But Dr. van Deursen thinks it would be better to go after the senescent cells themselves. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z In his view it should be easy enough by trial and error to find chemicals that selectively destroy senescent cells, just like the targeted chemicals now used to treat certain kinds of cancer. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z And unlike the cancer cells, which proliferate so fast that they soon develop resistance, the senescent cells cannot replicate, so they should be easy targets. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z “So I can guarantee that there will be initiatives to find drugs that kill senescent cells and mimic the system that we have developed in the mouse.” In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z But the senescent cells make the situation much worse with their inflammatory hormones. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z |
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