| 单词 | senescence |
| 例句 | “It should be perfectly obvious. I engineered a way to reverse senescence through cellular regeneration.” The Fourteenth Goldfish 2014-08-26T00:00:00Z “I have more important things to worry about than hair. I need to get my T. melvinus out of the lab. It’s what helped me sort out the mechanism for reversing senescence.” The Fourteenth Goldfish 2014-08-26T00:00:00Z In “Up” the handkerchief moment came early on, as the long, loving marriage of Carl and Ellie Fredricksen was chronicled in a montage that located the film’s emotional heart simultaneously in boyhood and senescence. Film: They Grow Up So Quickly, Don?t They? 2010-07-09T04:31:00Z In this effort he relies heavily on examples from the animal kingdom, such as the Galápagos tortoise, which dwells for the many decades of its life in an enviable state known as “negligible senescence.” Looking Forward to Your 170th Birthday 2021-04-02T04:00:00Z Mr. Johnson worked on six more episodes of the original “Twilight Zone,” many of them poignant takes on senescence. George Clayton Johnson, Science Fiction Writer Known for ‘Logan’s Run,’ Dies at 86 2015-12-27T05:00:00Z Devotees who use the age of their idol to calculate their own dismaying senescence may be shocked that he is so old, but to many more of us he has always been around. Critic?s Notebook: His Back Pages, Captured on Film 2011-05-17T19:00:20Z In contrast to the respect often accorded to the generation that fought World War II, their progeny are facing relative hostility in their senescence. Baby boomers are taking on ageism — and losing 2016-08-03T04:00:00Z The senescence of the remaining population earned the city the nickname “God’s waiting room.” Palm Springs Is in Demand, With Help From Coachella 2014-05-30T04:00:00Z For that, it’s worth tasting wines at all levels of aging, from young through adolescence and middle age to doughty senescence. Rioja Gran Reserva, a Wine Beginning to Be Shaped by Time 2020-02-13T05:00:00Z Mr. Sorrentino’s concentration on the pathos of male senescence is an aspect of the film’s nostalgia. Review: Sorrentino’s ‘Youth’: A Euro Buddy Film 2015-12-03T05:00:00Z In the age of Viagra and testosterone supplements, grumpy old men shuffling into senescence are a vanishing species. Review: Al Pacino in ‘Danny Collins’ Plays a Dissolute Pop Star 2015-03-19T04:00:00Z What abides is a giddy awareness of history as a tale told by unreliable narrators, as well as the oddly comforting impression that senescence has its own poetic license. Review: Screwball Eggheads Tear Up the Library in ‘Travesties’ 2018-04-24T04:00:00Z They showed that cancer stem cells induce senescence in macrophages -- the immune cells which are responsible for the first step of the destruction of cancer cells. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z "There is likely a treasure trove of aging, longevity and negligible senescence information within the genus Ictiobus," said Lackmann. Study uncovers hundred-year lifespans for three freshwater fish species in the Arizona desert 2023-10-30T04:00:00Z These “pillars of aging” include DNA damage, the aging or senescence of individual cells, inflammation, and stress responses. Ways to Extend Your Healthy Years, Not Just Your Life 2023-10-17T04:00:00Z As cancer has become less of a death sentence in some cases, perhaps AD might also one day be a treatable chronic illness – rather than a sentence of senescence and death. What are the biomarkers of Alzheimer's really telling us? 2023-09-30T04:00:00Z The process leading up to shedding is known as leaf senescence. How climate change disrupts fall foliage 2023-09-29T04:00:00Z In mice models, the cancer stem cells suppressed the proliferation of macrophages; further investigation showed that macrophages cultured with cancer stem cells exhibit senescence or cellular aging. Cancer stem cells trigger macrophage aging 2023-11-14T05:00:00Z The scientific report suggests taurine plays a role in reducing cellular senescence - where cells in the body stop dividing - a hallmark of ageing. Taurine may extend life and health, scientists find 2023-06-08T04:00:00Z Annual herbs complete their life cycles – from seed to senescence, or death – in a single growing season. Tips for growing culinary herbs (you don’t even need a garden) 2023-05-23T04:00:00Z The aging of a plant and all the associated processes is known as senescence, which is marked by several complex biochemical changes. Fundamentals of Biology 2015-01-01T00:00:00Z After all, American politics is possibly the only arena where senescence is not an impediment to success. Column: I almost wrote off Joe Biden in 2020. Boy, was I wrong then. What about now? 2023-02-12T05:00:00Z The work our bodies do changes as we age, the activities of our cells waxing and waning in a choreographed dance from growth to adulthood to senescence. New Human Metabolism Research Upends Conventional Wisdom about How We Burn Calories 2022-12-13T05:00:00Z According to an Associated Press analysis of an NIH research database, there have been about 11,500 projects involving cellular senescence since 1985, far more in recent years. ‘Zombie’ cells may hold clues to improving old age 2022-09-09T04:00:00Z With the number of people 65 or older expected to double globally by 2050, cellular senescence is “a very hot topic,” says Viviana Perez Montes of the National Institutes of Health. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z One of the characteristics of senescence is the breakdown of chloroplasts, which is characterized by the yellowing of leaves. Fundamentals of Biology 2015-01-01T00:00:00Z Cytokinins are known to delay senescence in leaf tissues, promote mitosis, and stimulate differentiation of the meristem in shoots and roots. Biology for AP Courses 2022-06-09T00:00:00Z They can be beneficial to health by promoting senescence in nearby cells at risk of becoming cancerous and attracting immune cells to clear out cancer cells. Cells become zombies when the ends of their chromosomes are damaged 2022-07-23T04:00:00Z But scientists are trying to change that — and tackle one of humanity’s biggest challenges — through a little-known but flourishing field of aging research called cellular senescence. ‘Zombie’ cells may hold clues to improving old age 2022-09-09T04:00:00Z According to an Associated Press analysis of an NIH research database, there have been around 11,500 total projects involving cellular senescence since 1985, far more in recent years. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Hormones are known to play a role in senescence. Fundamentals of Biology 2015-01-01T00:00:00Z Other effects of GAs include gender expression, seedless fruit development, and the delay of senescence in leaves and fruit. Biology for AP Courses 2022-06-09T00:00:00Z We wanted to know if direct damage to telomeres can be sufficient to trigger senescence and make zombie cells. Cells become zombies when the ends of their chromosomes are damaged 2022-07-23T04:00:00Z But as it aged into stellar senescence, it ejected much of its outer layers of gas into space, creating the nebula. Behold, Some Hidden Gems from JWST’s First Images 2022-07-21T04:00:00Z And research offers tantalizing clues that people may be able to help tame senescence themselves using the strategy favored by Soller: exercise. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z All the cells, tissues, and organs are affected by senescence, with noticeable variability between individuals owing to different genetic makeup and lifestyles. Anatomy and Physiology 2013-06-19T00:00:00Z This physical deterioration, or senescence, often causes an uptick in mortality risk as older animals become susceptible to predators or disease. Centenarian Tortoises May Set the Standard for Anti-Aging 2022-06-23T04:00:00Z This can prematurely trigger senescence and contribute to age-related diseases, including immunodeficiency, cardiovascular disease, metabolic disease and cancer. Cells become zombies when the ends of their chromosomes are damaged 2022-07-23T04:00:00Z That has given researchers hope of an eventual cure, as well as critical insights into ordinary human senescence. Living With Gusto Despite a Rare, Fatal Disease, and Hunting for Answers 2022-04-01T04:00:00Z He discovered cellular senescence by accident, cultivating human fetal cells for a project on cancer biology and noticing they stopped dividing after about 50 population doublings. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z They believe that learning more about how to help dogs with the condition can, in the process, provide research data that helps fight human diseases related to senescence. Dogs can get a canine form of dementia — and it is very similar to the human version 2022-03-05T05:00:00Z They found that 75 percent of the species, including Aldabra giant tortoises and pancake tortoises, exhibited low or negligible senescence. Centenarian Tortoises May Set the Standard for Anti-Aging 2022-06-23T04:00:00Z Age-related shortening of telomeres isn't the only thing that triggers senescence; telomere damage is also sufficient to turn a cell into a zombie. Cells become zombies when the ends of their chromosomes are damaged 2022-07-23T04:00:00Z Stars, much like humans, go through different stages of life, from birth through middle age through senescence. Astronomers observe a distant solar system that looks a lot like ours will after the sun explodes 2021-10-20T04:00:00Z Scientists are careful to note that cell senescence can be useful. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z But we never out-evolved the eventual senescence that is part of being a complex animal with all manner of metabolically costly adaptations and embellishments. How Long Can We Live? 2021-04-28T04:00:00Z A few, like Greek tortoises and black marsh turtles, even displayed negative rates of senescence, meaning their mortality risk decreased as they aged. Centenarian Tortoises May Set the Standard for Anti-Aging 2022-06-23T04:00:00Z Aging, or senescence, is a progressive loss of function and performance with time. What can ants, bees, and other social insects teach us about aging? 2021-03-25T04:00:00Z These attack senescence, a condition that results when certain cells in the body become damaged over time, and stop dividing, which impairs the body’s ability to replace old and injured tissue. Can some drugs delay aging? Scientists focus on those that target frailty and age-related disease. 2021-03-05T05:00:00Z Research suggests it counters the buildup of senescent ones, helping the immune system clear them and counteracting the molecular damage that can spark the senescence process. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Or is the timing of so-called “leaf senescence” linked to when spring happens? Keeping coronavirus from spreading in schools, why leaves fall when they do, and a book on how nature deals with crisis 2020-11-26T05:00:00Z “For humans, our environment continues to get better and better, but we are still not able to switch off senescence.” Centenarian Tortoises May Set the Standard for Anti-Aging 2022-06-23T04:00:00Z Autumn’s longer nights and cooler days kick-start the seasonal color change, known as leaf senescence. Human-driven climate change is changing the colors of fall foliage, scientists say 2020-10-16T04:00:00Z I worried that maybe I was too eager to embrace my senescence. Perspective | Take a load off: My search for the perfect living room lounge chair 2020-08-09T04:00:00Z After a 12-week aerobics, resistance and balance training program, researchers found that older adults had lowered indicators of senescence and better muscle strength, physical function and reported health. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z In some populations, this can result in “negative senescence” — a phenomenon where the durability of older trees means they actually have a greater chance of survival than younger ones, Dr. Munné-Bosch said. Can Trees Live Forever? New Kindling for an Immortal Debate 2020-07-27T04:00:00Z Part of the attraction of using senolytic CAR T cells is their potential for treating the many diseases in which senescence is involved. T cells engineered to target senescence 2020-06-16T04:00:00Z Moderate heat and drought extend the growing season and delay leaf senescence. Human-driven climate change is changing the colors of fall foliage, scientists say 2020-10-16T04:00:00Z Now, interest in the role of senescence in chronic lung disease is growing, potentially leading to new treatments. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z But scientists are trying to change that — and tackle one of humanity’s biggest challenges — through a little known but flourishing field of aging research called cellular senescence. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z Genetic analysis of the trees’ vascular cambium — a thin layer of cells that lies just underneath the bark, and creates new living tissue — showed “no evidence of senescence,” or cell death, the authors wrote. Can Trees Live Forever? New Kindling for an Immortal Debate 2020-07-27T04:00:00Z Entry into senescence imposes a stable arrest of the cell cycle, preventing old, damaged or precancerous cells from dividing. T cells engineered to target senescence 2020-06-16T04:00:00Z Over a life span, DNA accumulates damage that eventually results in cancer or broad-scale deficits to gene function that cause senescence, disease and eventual death. A Quest for the Genetic Fountain of Youth 2020-03-26T04:00:00Z “You can find a predominance of senescent cells at the site of a lung disease, but in those individuals, you find senescence cells elsewhere too.” Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z “I got tired of prescribing better wheelchairs and incontinence devices,” says Kirkland, a professor of medicine at Mayo considered a pioneer of the senescence renaissance. Zombie cells central to the quest for active, vital old age 2022-08-30T04:00:00Z For these reasons, Dr. Munné-Bosch thinks “we will never prove” whether long-lived trees experience senescence, he said. Can Trees Live Forever? New Kindling for an Immortal Debate 2020-07-27T04:00:00Z Now the reader will probably have an obvious objection to this portrait of senescence and stagnation: What about politics? Opinion | The Age of Decadence 2020-02-07T05:00:00Z That’s because the genes in the cambium contain no program for senescence, or death, they say, but continue their program for making defenses even after hundreds of years. The Secret That Helps Some Trees Live More Than 1,000 Years 2020-01-13T05:00:00Z “There’s recognition now of the importance of senescence and lung ageing in COPD,” says Lee. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z As expected, the expression of genes associated with senescence, the final and fatal stage of life, increased predictably in dying leaves. How the Ginkgo biloba achieves near-immortality 2020-01-13T05:00:00Z Oxford professor Lynne Cox is an expert in the biological mechanisms of ageing and one of the world leaders in developing new ways of stopping cell ageing, otherwise known as cellular senescence. Scientists harness AI to reverse ageing in billion-dollar industry 2019-12-21T05:00:00Z Tonnessen-Murray and colleagues investigated the effects of chemotherapy-driven senescence in breast cancer cells in mice treated with the chemotherapeutic drug doxorubicin. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z He expects the ideal treatment age will differ from person to person, and that ultimately scientists will develop a blood or urine test that can assess the level of senescence present. The science of senolytics: how a new pill could spell the end of ageing 2019-09-02T04:00:00Z Senescent cells have the ability to convert other cells to senescence — even at a distance. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z The mere presence of factors associated with triggering this cell fate is not in itself sufficient to provide an ���on switch��� for senescence. A dynamic view of chemotherapy effectiveness 2019-08-04T04:00:00Z “As organisms – and people – age, changes build up in their cells that eventually trigger cellular senescence,” she said. Scientists harness AI to reverse ageing in billion-dollar industry 2019-12-21T05:00:00Z Ingestion peaked at 4–6 days after drug treatment, a time that correlated with the induction of senescence. Senescent cells feed on their neighbours 2019-10-27T04:00:00Z After we studied the grim MRI results—Kevin Durant’s ruptured Achilles, Klay Thompson’s torn A.C.L.—it dawned on us that the era defined by the Golden State Warriors could be facing its senescence. Zion Williamson and the N.B.A. Draftees Usher in a New Era of Basketball 2019-06-21T04:00:00Z Some researchers think that this senescence might spread to other tissues. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z The authors found that if cells were treated with a small molecule that triggers DNA replication, senescence occurred more commonly than cell division after chemotherapy. A dynamic view of chemotherapy effectiveness 2019-08-04T04:00:00Z In a Nature Cell Biology study in February scientists reported a newly discovered role for NAD+ metabolism at the intersection of cellular aging and cancer—specifically, in a process called cellular senescence. Cancer Research Points to Key Unknowns about Popular "Antiaging" Supplements 2019-05-30T04:00:00Z Neurons may be the high-wire act of cell types, and the senescence of aging inexorably wears on them. There won’t be a cure for Alzheimer’s disease in our lifetime 2019-05-19T04:00:00Z One of the hallmarks of aging is called cellular senescence. Can a Pill Really Help You Live Longer? 2019-04-20T04:00:00Z The first approach to tackling senescence is a class of drugs called senostatics, which block the molecular pathways that lead to senescence. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Understanding the factors that drive the senescence of tumour cells might thus aid the development of new anticancer treatments. A dynamic view of chemotherapy effectiveness 2019-08-04T04:00:00Z Damaged cells often enter senescence—cellular old age—as a protective mechanism that allows them to expend less energy. Treatments for childhood cancer can devastate lives years later. Scientists are trying to change that 2019-03-14T04:00:00Z The authors confirmed that abnormally low levels of TREX1 permit LINE-1-derived DNA to accumulate in the cytoplasm in late senescence. Inhibition of ‘jumping genes’ promotes healthy ageing 2019-02-05T05:00:00Z Another famed ancient, Lucretius, thought sleep is caused by the spirit being attacked and weakened into a state of senescence by mysterious air particles. Why Do We Sleep? 2019-01-25T05:00:00Z When insults to DNA threaten to push a cell into a cancerous state, senescence can come to the rescue. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z A growing body of evidence indicates that the regulation of commitment to enter senescence is complex. A dynamic view of chemotherapy effectiveness 2019-08-04T04:00:00Z Our bodies naturally produce collagen, but that slows down with age — hence, wrinkles and cartilage breakdown being associated with senescence. As collagen supplements become popular, experts debate their efficacy 2019-01-06T05:00:00Z If they blocked LINE-1 transcription using inhibitory RNA molecules, or blocked reverse transcription using the drug lamivudine, the interferon response was not triggered in late senescence. Inhibition of ‘jumping genes’ promotes healthy ageing 2019-02-05T05:00:00Z Until we’re all brain patterns on computers, there are still forces that do not bend to our wants, including senescence and death. Judge John Hodgman on Choosing Your Age 2018-12-21T05:00:00Z The association has led some to suspect that senescence plays a part in triggering the symptoms of COPD. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Stars are still being born, but the universe seems to be approaching senescence. All the Light There Is to See? 4 x 10⁸⁴ Photons 2018-12-03T05:00:00Z They find that neuronal expression of mutant tau triggers senescence in glia, the support cells of the brain. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z Baker's postdoc studies had focused on cellular senescence, the cellular version of aging, which had not yet been linked to Alzheimer's. The Alzheimer’s gamble: NIH tries to turn billions in new funding into treatment for deadly brain disease 2018-08-30T04:00:00Z They discovered severe injuries rapidly triggered a process called senescence throughout the liver. Drug 'may cut need for liver transplants' 2018-08-15T04:00:00Z But not everyone is on board with linking senescence to both the symptoms and the causes of COPD. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Cytoplasmic chromatin triggers inflammation in senescence and cancer. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z This, too, provided evidence of senescence in astrocytes and microglia, but not in neurons. Elimination of senescent cells prevents neurodegeneration in mice 2018-09-18T04:00:00Z “There’s nothing more disgusting than a publication entering senescence,” said Sicha over email. Influential publication The Awl shuts down amid a downturn in web publishing 2018-01-16T05:00:00Z Because October is around the time that they finish laying eggs, it's possible they were showing the cognitive decline associated with senescence. Unsolved Science Mysteries From 2017 2017-12-18T05:00:00Z Cellular senescence has not yet been proved to be the prime driver of COPD. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z PAI-1 may help drive cellular senescence, a potential key contributor to aging in which cells lose the ability to divide. Mutation in blood clotting gene may extend human life span 2017-11-15T05:00:00Z But it wasn't long before researchers discovered what molecular biologist Judith Campisi calls the “dark side” of senescence. To stay young, kill zombie cells 2017-10-23T04:00:00Z There are ways in which we have passed from eros to thanatos — from the chaos of unrestrained desire to the stability of senescence. Opinion | The ’70s and Us 2017-10-14T04:00:00Z However, premature loss of telomeres sends cells into senescence — when it no longer divides and grows, and this milestone hastens aging. 2 top female scientists sue Salk Institute for gender discrimination 2017-07-13T04:00:00Z Other researchers, however, think that cellular senescence will turn out to be a crucial driver of COPD. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z At this point, cells can either turn cancerous, self-destruct, or enter a semi-dormant state, called senescence. Purging the body of 'retired' cells could reverse ageing, study shows 2017-03-23T04:00:00Z By the mid-2000s, senescence was chiefly understood as a way of arresting the growth of damaged cells to suppress tumours. To stay young, kill zombie cells 2017-10-23T04:00:00Z The infirm cells the scientists targeted had undergone a partial shutdown known as senescence, in which they lose the ability to divide. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z The process prevents cancer by shutting down abnormal cells, but senescence also triggers inflammation that drives ageing. Breakthrough prize awards $25m to researchers at 'Oscars of science' 2016-12-04T05:00:00Z Some researchers think that senescence might spread between cells and tissues. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z The scientific term for the color change is leaf senescence, when deciduous trees pack up their summer clothes and prepare to sleep naked through the long frigid winter. How a Changing Climate Is Shaping a Leaf Peeper’s Paradise 2016-11-02T04:00:00Z Today, researchers continue to study how senescence arises in development and disease. To stay young, kill zombie cells 2017-10-23T04:00:00Z Researchers think senescence may prevent worn-out, cancer-prone cells from initiating tumors, but it may also promote aging. From AI to protein folding: Our breakthrough runners-up 2016-12-22T05:00:00Z The sources of it aren’t well known, but scientists are investigating possible contributors, including a state called cellular senescence. The Future of Aging 2016-08-09T04:00:00Z But Barnes argues that there is good reason to pay attention to senescence. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z But Howard Neufeld, a professor of biology at Appalachian State University in North Carolina, said climate change could eventually affect the complex processes in leaf senescence and lower anthocyanin production, dulling the autumn reds. How a Changing Climate Is Shaping a Leaf Peeper’s Paradise 2016-11-02T04:00:00Z DNA damage, telomere shortening and cell senescence also change methylation patterns. Scientists can make mice live longer. Now they want to do the same for you. 2016-04-18T04:00:00Z You must seize the biochemical processes in your body in order to vanquish, by and by, illness and senescence. The Doomsday Invention 2015-11-23T05:00:00Z I can’t help but see in my reaction to Charlie’s senescence a preview of how I may act with my parents, or how my children will act with me. An old dog teaches you more than you’d like to know about mortality 2015-10-18T04:00:00Z Both of the major risk factors for the disease — ageing and smoking — are known to bring about senescence in lung cells. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Few let their flowers enter into senescence with grace. A Bouquet Inspired by a Morris Louis Canvas 2015-10-05T04:00:00Z I wasn't wild about the toilet two-step towards senescence, but perhaps what made it all the more galling was that my wife slumbered on… and on. A Point of View: 'How I learned to embrace my insomnia' - BBC News 2015-09-19T04:00:00Z The nurse’s face became wrinkled, catapulted into senescence by Calahan’s superpowers. Memory loss: what makes people forget who they are? 2015-07-29T04:00:00Z Meditation can supposedly treat anything that ails you, including anxiety, depression, addiction, insomnia, stress, heart disease, eating disorders, chronic pain, cancer, AIDS--even senescence! Meta-Meditation: A Skeptic Meditates on Meditation 2015-07-08T04:00:00Z “With exosomes, you can tell which cell type shed them, and then you can look at their cargo for markers of senescence,” says Kirkland. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Leaves may be programmed to drop once they reach a certain age, causing their senescence to shift earlier in the year if spring arrives sooner. May Flowers Bring Leaf Showers 2015-05-02T04:00:00Z Though she’s been assisted by field researchers, and some biologists are deeply interested in senescence, the broad nature of her question precludes a narrowly scientific response. Want To Live Forever? The Oldest Creatures In The World Are Converging On Brooklyn For This Pioneer Works Exhibit 2014-09-25T04:00:00Z Nonetheless on July 28, Austria, in the manner of an empire in an advance stage of senescence, declared war on Serbia anyway. The Wrong Turn That Changed a Century -- and Still Haunts Us Today 2014-06-27T04:00:00Z Using that gene’s activity as a signal of such cellular senescence, Sharpless and his team started to test how different factors affected this gene. You're older than you think you are 2014-05-28T04:00:00Z Others, such as Lee, think advances in imaging will make it possible to see inside cells in the lung to detect and quantify their senescence. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Error bars represent s.d. of triplicate independent experiments. , suppression induces senescence. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z A yeast peptide appears to reverse senescence—when follicle cells linger in a dormant state and cease to replicate. Hair Follicles in a Dish Make for Cruelty-Free Testing 2014-03-11T11:30:00Z For health insurers, age equals risk — senescence brings sickness. Retiring: The Dream of Retiring Abroad, With Good Health Care 2014-02-21T20:26:38Z He’s also aware that cellular senescence isn’t the only marker of a person’s physiologic age. You're older than you think you are 2014-05-28T04:00:00Z The habit is also known to promote cellular senescence. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Error bars represent s.d. of triplicate independent experiments. , suppression induces senescence. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z He did this at 37, which is the cusp of senescence in his merciless sport. Op-Ed Columnist: Maturity’s Victories 2014-02-01T17:58:55Z But trees seem free from this growth limit, called senescence. Older Trees Grow Faster as They Age 2014-01-16T01:15:05.743Z "Bread and circuses is not the policy of a republic," William Galston wrote recently in the Wall Street Journal, "but rather of an empire entering moral senescence." Klein: Blame the Baby Boomers 2013-10-10T22:05:24Z Older people seem to be more susceptible to chronic illness caused by cellular senescence. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Error bars represent s.d. of triplicate independent experiments. , suppression induces senescence. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z Over time, with each successive round of DNA replication, the telomeric DNA shortens until finally there is no more disposable buffer, at which point the cell stops dividing and enters senescence. The Hallmarks of Cancer: 4 - Limitless Replicative Potential 2013-10-10T19:45:47.683Z The great scar from the impact gradually froze over and healed, and Mars settled into senescence. Solved: The Mystery of the Martian Meteorites 2013-07-26T18:45:00.760Z Surprisingly, the brightness levels weren’t closely tied to longevity in the animals, suggesting that cellular senescence is just part of the larger aging puzzle. Searching for Meaningful Markers of Aging 2013-07-22T21:04:32Z Constant stimulation by toxins from cigarette smoke and pollution accelerates senescence and might exhaust the immune system, resulting in a slowing down of the body’s ability to deal with it. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Although the results showed that cell senescence was involved in obesity-linked cancer in the mice, Hara and his colleagues did not initially understand why the liver became a hotbed for tumors. Gut Microbes Spur Liver Cancer in Obese Mice 2013-06-27T19:15:05.723Z The DNA damage response is activated, leading to growth arrest; senescence. The Hallmarks of Cancer: 4 - Limitless Replicative Potential 2013-10-10T19:45:47.683Z In the 1990s, for instance, WI-38 was used to discover the most widely used marker of cellular senescence. Medical research: Cell division 2013-06-26T17:20:24.203Z But it could mean that increased telomerase activity is one way for cells to deal with the difficulties of stress, increasing telomerase activity to protect the DNA from excessive destruction, and protect cells from senescence. Increasing telomerase to save you from stress 2013-03-25T12:45:05.043Z Eventually, a threshold might be crossed “beyond which the lung is incapable of clearing senescence cells”, says Thannickal. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z “What would you say about the evolution of senescence if instead of working with insects, you worked with modular organisms, which is what lichen are?” Studying Seemingly Immortal Lichens, in a Place for the Dead 2012-12-31T19:13:21Z Blue-green areas indicate expression of marker associated with senescence. The Hallmarks of Cancer: 4 - Limitless Replicative Potential 2013-10-10T19:45:47.683Z For example, when dividing cells are damaged or stressed, cell senescence keeps them from becoming cancerous. Stem cells: Repeat to fade 2012-12-06T12:21:18.613Z The attenuation of light cued plants to prepare for senescence. City Room: Looking Down to See Nature's Early-Autumn Change in Hues 2012-10-06T00:40:30Z Forager honeybees undergo rapid physiological senescence and thereby age quickly. Bee Brain Plasticity: Turning Back the Clock on Aging 2012-07-11T12:45:00.393Z Biologists call it senescence: the grim reality of decline with age. Studying Seemingly Immortal Lichens, in a Place for the Dead 2012-12-31T19:13:21Z This state is known as senescence, and it is irreversible; although the cell does not grow or divide, it remains alive. The Hallmarks of Cancer: 4 - Limitless Replicative Potential 2013-10-10T19:45:47.683Z And it's not just senescence research that is stoking excitement. The Hunt for an Anti-Aging Pill Is on 2012-05-14T13:20:00Z But with his passing, the tentacles of hierarchical bureaucracy, which are already becoming noticeable at Google, will re-emerge and Apple is destined to resume its inexorable path to senescence and death. Inside Apple: Can It Thrive Without Steve? 2012-02-02T19:15:30Z We decided to see if these senescence effects are actually occurring in farmers' fields, and if so whether they are big enough to matter. Extreme Heat Hurts Wheat Yields as World Warms 2012-01-30T18:45:15.333Z Research like Dr. Pringle’s — along with other studies of species including the bristlecone pine tree and the wandering albatross, a bird, both of which may avoid senescence — suggests another possible path. Studying Seemingly Immortal Lichens, in a Place for the Dead 2012-12-31T19:13:21Z Yet it is also true that there is no preordained march toward senescence. Education Life Preview: A Sharper Mind, Middle Age and Beyond 2012-01-19T15:24:34Z He found that human cells cultured in glassware do not multiply indefinitely, as was then assumed, but can divide only 50 or so times before lapsing into senescence. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z In other words, senescence and death are inevitable results of traditional management and and hierarchical bureaucracy, but not necessarily of the radical management principles that Steve Jobs introduced at Apple. Inside Apple: Can It Thrive Without Steve? 2012-02-02T19:15:30Z Naked mole rats show negligible senescence, no age-related increase in mortality, and high fecundity until death. Genome sequencing reveals insights into physiology and longevity of the naked mole rat 2011-11-15T17:21:47.017Z The “deadbeat” cells, in a state known as senescence, accumulate over time and produce chemicals that damage tissue and trigger inflammation. Removing Deadbeat Cells Slows Aging in Mice and May Spare Humans 2011-11-03T12:50:14Z Greider and others have shown that senescence induced by telomere shortening might offer protection against tumour formation. Telomeres: All's well that ends well 2011-10-12T17:21:06.837Z The body has therefore evolved two major systems to curb the risk of cancer — cell senescence and cell death. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Of course, judging by today's prevailing image of senescence, it's easy to see why pessimism rules. Let's dispel this gloom about living longer and make life better for the old 2011-08-06T23:09:00Z Progerin is also produced in normal cells, increasing in abundance as senescence approaches. [Research Articles] Rapamycin Reverses Cellular Phenotypes and Enhances Mutant Protein Clearance in Hutchinson-Gilford Progeria Syndrome Cells 2011-07-05T19:27:22.357Z It enters a state of senescence or dies. A Blood Test Offers Clues to Longevity 2011-05-19T01:00:21Z Inhibiting telomerase is expected to halt tumour growth either by forcing the cells to enter senescence or through excessive genomic damage, although this has not been demonstrated in humans. Telomeres: All's well that ends well 2011-10-12T17:21:06.837Z This route to senescence, discovered in the 1990s, underlies the process observed by Dr. Hayflick. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z It is usually an expression of premature senescence. Degeneracy Its Causes, Signs and Results 2011-05-02T02:00:17.657Z There is a case to be made for the shift of our reproductive energies to raising our grandchildren, which follows the tenets of the 'grandmother hypothesis' and the senescence hypothesis. Reflections on Biology and Motherhood: Where do Homo sapiens Fit In? 2011-02-25T14:45:00.237Z It may be possible, for example, to use acetylcholine boosters to increase the effectiveness of brain training programs for staving off senescence and cognitive decline with age. Understanding the Brain's Brake Pedal in Neural Plasticity 2011-02-22T13:15:08.463Z The decline in immune function over a lifetime, called immune senescence, is the reason the elderly are so much more vulnerable to illnesses such as influenza, Fuldner said. Scientists examine testing of immune system health 2011-02-14T19:59:04Z Cells thrown into senescence do not divide again but hang about in tissues until they are cleared by the immune system. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Youthful obesity is sometimes, as Féré remarks, associated with precocious maturity and resultant early senescence, but more often with extended infantilism, as in the case of Dickens’s “fat boy.” Degeneracy Its Causes, Signs and Results 2011-05-02T02:00:17.657Z The study also found support for the 'senescence' hypothesis, which suggests that females have a reduced reproductive output towards the end of their lifespan due to age-related declines in body condition. Reflections on Biology and Motherhood: Where do Homo sapiens Fit In? 2011-02-25T14:45:00.237Z You may be older than I in actual years, but you've got to hand it to me on the score of temperamental senescence! In the Onyx Lobby 2011-02-14T03:00:31.897Z Terms such as "senescence," "debility" and "old age" are already in the ICD catalog, and physicians sometimes enter them on death certificates. Agency to weigh if 'old age' causes death 2010-09-19T06:01:00Z Researchers do not yet understand why there are two systems, or how the body chooses whether to assign a damaged cell to senescence or to death. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z In fact, terms such as "senescence", "debility" and "old age" are already in the ICD catalogue, and physicians sometimes enter them on death certificates. Is it time to bring back 'old age' as a cause of death? 2010-09-17T17:19:00Z Human females are unique in the animal kingdom in that we reach reproductive senescence in the middle of our lifespans. Reflections on Biology and Motherhood: Where do Homo sapiens Fit In? 2011-02-25T14:45:00.237Z “Cultural artifacts: a comparison of senescence in natural, laboratory-adapted and artificially selected lines of Drosophila melanogaster.” Laboratory Life 2010-04-13T23:00:00Z Each living thing has its span, which consists of a cycle from birth through maturation and senescence to dissolution, and the latter half of the process is as "fateful" and "inevitable" as the former! Creative Intelligence Essays in the Pragmatic Attitude When they detect any damage in the cell’s controls, they force it into either senescence or death. In Body?s Shield Against Cancer, a Culprit in Aging May Lurk 2011-11-21T19:46:51Z Sober brownstone houses, their front steps rising steeply to stain-glass paneled doors; heavily curtained bay windows; weather-stained and rotting gingerbread; an atmosphere of reluctant decay and genteel senescence. The Prophetic Camera Even in his extreme senescence there was an April mood somewhere in his nature "that put a spirit of youth in everything." The Atlantic Monthly, Volume 20, No. 121, November, 1867 He was abreast of the important scientific discoveries of his day and was not at all astonished that the problem of senescence should be solved. Black Oxen It is no mere analogy to suppose that human senescence is the result of a slow but chronic poisoning of the organism. The World's Greatest Books — Volume 15 — Science There are various processes of rejuvenescence, e.g. rest, repair, change, reorganisation, which work against the inevitable processes of senescence, but sooner or later the victory is with ageing. The Outline of Science, Vol. 1 (of 4) A Plain Story Simply Told The Pacific Standard Tribe always seemed a little bovine to him, their facial muscles long conditioned to relax into a kind of spacey, gullible senescence. Eastern Standard Tribe Many of the hypotheses have been interesting, that of Metschnikoff, for example, who finds as a dominating influence in causing senescence the absorption of toxic substances formed in the large intestine by certain bacteria. Disease and Its Causes How it may be some years hence, when this cure for senescence has become a commonplace, I do not pretend to say. Black Oxen But we must make further studies before we can answer the question whether our senescence can be ameliorated. The World's Greatest Books — Volume 15 — Science Not that there is any other mark of senescence than the ripened sweetness of a life both publicly and privately well spent. The Function of the Poet and Other Essays "The first signs of a very dissolute and wabbly senescence—you have spent the afternoon talking about tan and a lady's legs." The Beautiful and Damned In rare cases in the very old a condition is found in which no change is present to which death can be attributed, all organs seem to share alike in the senescence. Disease and Its Causes It is entirely logical, and no more marvellous, that science should be able to arrest senescence, put back the clock. Black Oxen For youth this embroidery of details is the precocious senescence that Nordau has so copiously illustrated as literary decadence. Youth: Its Education, Regimen, and Hygiene Previous artists had imitated Nature too carelessly,—not deeply perceiving that wisdom and virtue, striving in man to resist senescence and decay, must in a goddess accomplish their purpose, and preserve her in perpetual bloom. The Atlantic Monthly, Volume 02, No. 11, September, 1858 What two phenomena of senescence were more frequent? Ulysses Whether there is, entirely apart from all conditions affecting nutrition and the effect of injuries which disturb the usual cell activities, an actual senescence of the cells of the body is uncertain. Disease and Its Causes |
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