| 单词 | randomization |
| 例句 | Mendelian randomization attempts to establish causal links from genetic data. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z However, contrary to our hypothesis, this Mendelian randomization analysis did not show significant effects of gut microbiota on metabolic factors and chronic diseases. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z As in all games of this sort, the key to the playing is randomization. Video Game Review: Less Hype, More Action 2011-05-13T18:31:27Z Mendelian randomization is a method that has several advantages over observational studies. Does our gut microbiota really influence our health and life expectancy? 2023-05-03T04:00:00Z The randomization algorithms enables future patients joining the trial to have increased odds of getting the best drug for them personally. Adaptive, efficient multi-arm phase 2 clinical trial for glioblastoma 2023-09-18T04:00:00Z There’s a method in genetics called Mendelian randomization that mimics a randomized controlled trial, so we can test for causal and not correlative associations between different foods and different diseases. Your Genes May Influence What You Like to Eat 2023-08-01T04:00:00Z More evidence comes from Mendelian randomization studies, which compare the health of people who carry different gene variants to tease out cause and effect. Can ‘toxic’ bilirubin treat a variety of illnesses? 2023-06-08T04:00:00Z They turned to DNA and Mendelian randomization, a recently popularized method of using genetic variations to characterize and sort people. How exercise leads to sharper thinking and a healthier brain 2023-04-05T04:00:00Z So the researchers turned to a crafty statistical calculation known as Mendelian randomization, which can tease out the direction of an influence when the gene-disease connection is strong. The link between our food, gut microbiome and depression 2023-01-31T05:00:00Z He added that because the Nova Scotia orchard has more of a research focus, it was designed with randomization, replication and other factors in mind, “to make their data more relevant.” How About Them Apples? Research Orchards Chart a Fruit’s Future. 2022-09-27T04:00:00Z But efforts to document such bias often had weaknesses, such as a small sample size or lack of randomization. Reviewers award higher marks when a paper’s author is famous 2022-09-13T04:00:00Z But the Biobank study’s use of Mendelian randomization is more suggestive of causality, and so its results might carry more weight. Does moderate drinking protect your heart? Genetic study offers a new answer. 2022-03-29T04:00:00Z These include randomization of first-year roommate assignments, curricular changes that require broader exposure outside chosen major subjects, and other steps to move students outside their “enclaves of familiarity.” Opinion | How higher education can counter the dangerous weakening of American self-governance 2021-12-13T05:00:00Z The researchers reported this as a possible randomization failure in the 2020 paper, and also published the full data set. Fraudulent data set raise questions about superstar honesty researcher 2021-08-24T04:00:00Z This trial should be the first in an ongoing series of adaptive clinical trials, using the power of randomization to determine the optimal dosing strategy for vaccines over time. Opinion | Why the Biden administration’s recommendation on booster shots is a mistake 2021-08-18T04:00:00Z The key element of this study is the randomization. Perspective | Workplace wellness programs are big business. They might not work. 2021-06-16T04:00:00Z To do that, the researchers used a method called Mendelian randomization. Does moderate drinking protect your heart? Genetic study offers a new answer. 2022-03-29T04:00:00Z Snead said that to preserve the principle of a secret ballot, election offices should use data randomization to keep voters’ identities anonymous during ballot counting. Conservative group pushes proposals to tighten voting laws 2021-03-02T05:00:00Z While it also restores item randomization to a previous state, the primary purpose is to fix the game-breaking part of the “Down on the Street” quest. Cyberpunk 2077 gets new patch to fix old patch that introduced a game-breaking bug 2021-01-28T05:00:00Z But the University of Washington hospital system expects to receive enough doses to vaccinate everyone in that high-risk tier within two weeks, so randomization isn't necessary — for now. Hospitals scramble to prioritize which workers are first for COVID shots 2020-12-17T05:00:00Z But the lack of randomization makes it difficult to draw a firm conclusion from the study, cautions Anthony Gordon, an anaesthetist at Imperial College London. Evidence for Convalescent Plasma Coronavirus Treatment Lags Behind Excitement 2020-08-24T04:00:00Z But the lack of randomization makes it difficult to draw a firm conclusion from the study, cautions Anthony Gordon, an anaesthetist at Imperial College in London. Evidence lags behind excitement over blood plasma as a coronavirus treatment 2020-08-18T04:00:00Z "There's been a decision made by the Council that we were not going to utilize randomization because that would mean withholding treatment from kids that needed it," he said. Does science support the "wilderness" in wilderness therapy? 2020-02-02T05:00:00Z This update restores item randomization and fixes a bug which affected some users’ holocall with Takemura in Down on the Street quest. Cyberpunk 2077 gets new patch to fix old patch that introduced a game-breaking bug 2021-01-28T05:00:00Z Mendelian randomization offers a simple way to detangle correlation from causation by relying on gene variants that mimic environmental factors. The conceptual mistake that lies at the heart of economics 2019-12-09T05:00:00Z “Mendelian randomization in principle is a really, really cool idea. It attempts to solve one of the most daunting challenges in epidemiology,” says Philipp Koellinger, a social-science geneticist at the Free University of Amsterdam. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Before randomization, criminals typically purchased minors’ Social Security numbers on the black market or tracked down the numbers of dead children. Has your newborn’s identity already been stolen? 2019-10-10T04:00:00Z "And we understood that that lack of randomization would be criticized by some colleagues, but we felt that ethically we did not want to go and utilize that form of research design." Does science support the "wilderness" in wilderness therapy? 2020-02-02T05:00:00Z Then they used a genetic technique called Mendelian randomization that takes advantage of the randomized distribution of genetic variants in the population. Coffee May Lower Risk of Gallstones 2019-09-24T04:00:00Z The problem is, critics argue, that not all Mendelian randomization studies are sound. The conceptual mistake that lies at the heart of economics 2019-12-09T05:00:00Z The problem is, critics argue, that not all Mendelian randomization studies are as sound. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z “Offered a choice between three drugs with a 90 percent cure rate, and 20 or more with less chance of cure — who would consent to randomization?” Scientists Discover New Cure for the Deadliest Strain of Tuberculosis 2019-08-14T04:00:00Z One programme set up to encourage practices such as randomization and blinding in animal experiments was advised to change its name from a “research improvement project” to a “research optimization project”. Research integrity is much more than misconduct 2019-06-02T04:00:00Z With Mendelian randomization, scientists zero in on small snippets of genes that vary from person to person. Exercise can help reduce risk of depression, new study finds 2019-02-18T05:00:00Z Various options for adjusting time signature, steps, and randomization allow for creating unique irregularities and polyrhythms. 5 of our favorite synths from NAMM 2019 2019-02-01T05:00:00Z This is a big problem, she adds, because Mendelian randomization allows researchers to seek, find and publish relationships between unfamiliar data sets without any specialist knowledge of the relevant field. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Though common in medical studies, randomization is rare in health care policy, as is mandatory participation. Can Paying for a Health Problem as a Whole, Not Piece by Piece, Save Medicare Money? 2018-09-17T04:00:00Z In the Nature research journals, checks for blinding and randomization are just over six. Research integrity is much more than misconduct 2019-06-02T04:00:00Z That result is what Choi and her colleagues found when they applied Mendelian randomization to exercise and depression. Exercise can help reduce risk of depression, new study finds 2019-02-18T05:00:00Z “Without this randomization, it would just drop the object all the time because it wasn’t used to it,” says Plappert. OpenAI sets new benchmark for robot dexterity 2018-07-30T04:00:00Z Several epidemiologists say that it’s an open secret in the field that many published Mendelian randomization studies are problematic. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z But a new study used a genetic technique called Mendelian randomization to minimize the effect of several variables and provide stronger evidence of cause and effect. Highly Educated, Very Nearsighted? 2018-06-06T04:00:00Z I started developing different strategies as I found different patterns in how the randomization produced the game boards. Delete is a better, smarter Minesweeper 2018-06-10T04:00:00Z Mendelian randomization remains a mathematical exercise, of course, and in the real world, people’s lives and behaviors are shaped by more than genetics. Exercise can help reduce risk of depression, new study finds 2019-02-18T05:00:00Z The importance of some techniques I teach, such as blinding, randomization and transparent analysis, are only now being emphasized in basic research. Health tips for research groups 2018-05-15T04:00:00Z To an economist, Mendelian randomization looks a lot like something called instrumental variable analysis, in which a variable referred to as the instrument is used to help unpick hidden relationships between two other observations. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Additionally, fewer than 5% included important information on whether bias-reducing methods such as randomization of the experimental groups were used, they report today in PLoS Biology. Clinical trials may be based on flimsy animal data 2018-04-05T04:00:00Z The studies were increasingly fine-tuned and complex, with eligibility requirements and randomization plans that made them a prototype for subsequent research trials. James F. Holland, physician who helped show chemotherapy could treat cancer, dies at 92 2018-03-25T04:00:00Z Mendelian randomization is a technique developed specifically to probe causal relationships. Robust research needs many lines of evidence 2018-01-22T05:00:00Z Scientists then track the variants' sway on health, a method called Mendelian randomization because it relies on accidents of heredity to create comparison groups. Is it time to retire cholesterol tests? 2017-12-06T05:00:00Z One central assumption in Mendelian randomization is that the genetic variants must not affect the outcome in any other way. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Additionally, fewer than 5% included important information on whether bias-reducing methods such as randomization of the experimental groups were used, they report today in PLoS Biology. Clinical trials may be based on flimsy animal data 2018-04-05T04:00:00Z Is the Author implying that they should implement some kind of randomization so that limited LE resources are sent to areas where they are not needed? Opinion | ‘Intelligent’ Policing and My Innocent Children 2017-12-02T05:00:00Z “We all know the most rigorous data in clinical medicine is through randomization,” control groups and follow-through, he says. Some call this contraceptive a breakthrough for women. Others say it’s dangerous. 2017-07-26T04:00:00Z Its studies all supported the same hypothesis; its methods included randomization and standard-looking data analyses. Psychology: Science in spite of itself : Nature : Nature Research 2017-04-25T04:00:00Z “As these assumptions are crucial for the validity of Mendelian randomization studies, they should always be discussed in the specific context of the study,” the researchers argue18. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Chimaeras were verified with prostate tumour formation by MRI and assigned into preclinical studies through randomization which maximized the chance that male mice housed in the same cage received different drugs. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z With regards to randomization, for subcutaneous transplantation, animals were distributed among treatment groups when tumours reached a mean volume of approximately 200–400 mm3. A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer : Nature : Nature Research 2017-03-28T04:00:00Z The scientists found that relatively few applicants reported the use of methods such as sample randomization when designing their experiments. Swiss survey highlights potential flaws in animal studies 2016-12-19T05:00:00Z For instance, when trial reports fail to account for control patients or do not fully describe methods for randomization and blinding, they are also more likely to report exaggerated effects. Let’s make peer review scientific 2016-07-04T04:00:00Z Mendelian randomization is also subject to a distinct source of bias — one that’s a matter of life and death. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z Blinding was not applied, because allocation required investigators to assess mouse prostate tumour size with MRI before randomization. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z During this relaxation/randomization phase, electric fields are applied that clear the positrons and antiprotons remaining in the trap. An improved limit on the charge of antihydrogen from stochastic acceleration : Nature : Nature Publishing Group 2016-01-19T05:00:00Z Eighty-six percent said that they used randomization and 47% said they used blinding. Swiss survey highlights potential flaws in animal studies 2016-12-19T05:00:00Z A major limitation of the plasma study was a lack of randomization. Ebola Treatment Using Plasma From Survivors Is Not Effective, Study Says 2016-01-06T05:00:00Z But Mendelian randomization shows a survivor bias that must be identified and corrected for. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z It also allows the randomization proportions of the trial population or the rates at which data are accrued to be changed. Patient-centric trials for therapeutic development in precision oncology : Nature : Nature Publishing Group 2015-10-13T04:00:00Z Later studies reported randomization, blinding and COI statements at higher rates than did earlier ones, but rates never reached above 45%. Poorly-designed animal experiments in the spotlight 2015-10-12T04:00:00Z There was no randomization or blinding in selection of samples for sequencing. Temporal and spatial analysis of the 2014-2015 Ebola virus outbreak in West Africa : Nature : Nature Publishing Group 2015-06-16T04:00:00Z “Without randomization, you have no way to control for all the different variables that come into play when you’re dealing with a patient.” Chinese Ebola Drug Brings American Objections 2015-06-11T04:00:00Z And although Mendelian randomization does not always offer perfect clarity, it might, at least, point researchers in the right direction. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z In addition, patients’ perception of the cosmetic results, established by questionnaires completed before the study subjects learned of their randomization, suggest that women in the two groups felt similarly how their post-op beasts appeared. In Breast Cancer Surgery, Taking Out A Bit Extra Dramatically Reduces O.R. Revisits 2015-06-09T04:00:00Z In fact, in 2011, the median journal impact factor was generally lower for studies that reported randomization than for publications that didn't. Poorly-designed animal experiments in the spotlight 2015-10-12T04:00:00Z These are known as “marginal patients” — not marginal because they don’t matter but because they’re the margin affected by randomization. Alcoholics Anonymous and the Challenge of Evidence-Based Medicine 2015-04-06T04:00:00Z "Properly designed placebo-controlled trials can meet these conditions, and innovative designs, such as adaptive randomization, ought to be considered as a means of addressing these research goals." Results from encouraging Ebola trial scrutinized 2015-02-26T05:00:00Z Now, epidemiologists and others are feeding these findings into more Mendelian randomization tests. The gene-based hack that is revolutionizing epidemiology 2019-12-09T05:00:00Z No animals were excluded from the study and no randomization or blinding was required. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer/'s disease : Nature : Nature Publishing Group 2015-02-17T05:00:00Z Now a new study, using a technique called Mendelian randomization, provides persuasive evidence that low serum vitamin D itself increases the risk of death. Low Vitamin D Tied to Higher Death Risk 2014-11-24T05:00:00Z Phone numbers provide a device for randomization that is impossible online. Explaining Online Panels and the 2014 Midterms 2014-07-27T04:00:00Z The changes made were often for the better; for example, a few reviewers rightly suggested that manuscripts needed to explain their processes for patient randomization more clearly. Bigfoot sighted on Twitter : Nature : Nature Publishing Group 2014-07-15T04:00:00Z Notably, each sub-study involves a randomization process, so patients will receive either an experimental drug or, for comparison, standard care with chemotherapy such as docetaxel. Ambitious 'Lung-MAP' Trial Aims to Evaluate Biomarkers and New Drugs in Squamous Cell Lung Cancer 2014-06-23T04:00:00Z When test subjects are paying for the product under investigation, establishing efficacy is hard: controls, randomization, masking and other hallmarks of clinical research break down7. Regulation: Sell help not hope 2014-06-15T04:00:00Z The randomization also helps to prevent accusations of racial or other profiling. For Your Next Flight, Hope the TSA 'Randomizer' Puts You in a Faster Lane 2014-05-08T18:48:15Z Significantly, it does away with the idea of randomization, where some patients are given a treatment and others get a "control" substance for comparison - traditionally the gold standard in drug testing. New kind of trial aims to speed cancer drug development 2014-04-16T23:04:08Z The Phase 2 trial used "adaptive randomization," meaning patients entering the study were assigned to treatment regimens that were performing better in patients with the same cancer subtype. Puma drug better than Herceptin in HER2 breast cancers: trial 2014-04-07T14:31:13Z No randomization was performed as host mice were genetically identical, and no mice were excluded from analysis of tumour onset. Tumour cell heterogeneity maintained by cooperating subclones in Wnt-driven mammary cancers 2014-04-04T18:28:38.990Z Yet randomized field experiments are in vogue among academics in social science and medicine, even though randomization is often times neither the most economical nor the most ethical way to learn how the world works. Today's Economist: The Economics of Randomized Experiments 2014-03-05T05:01:13Z Although the trial used randomization, the gold standard in clinical research, women were assigned to receive or skip mammograms after they underwent breast exams. Breast Cancer Screening Isn't Going Anywhere 2014-02-13T10:50:25Z By using the randomization provided by the lottery and emergency-department records from Portland-area hospitals, we studied the emergency department use of about 25,000 lottery participants over about 18 months after the lottery. [Research Article] Medicaid Increases Emergency-Department Use: Evidence from Oregon's Health Insurance Experiment 2014-01-16T18:56:17.126Z The usual alternative, traditional observational studies utilizing registries, “lack the rigor of randomization.” A Disruptive TASTE of the Future? 2013-09-01T06:00:00Z The paper doesn’t specifically address that question, but does report that 15 patients were randomized in the control arm and 32 in the treatment arm, suggesting a 2:1 randomization. Recent €23 Million Biotech IPO Relied Heavily On Questionable Research 2013-07-08T13:02:00Z If Professor Ziliak and others have exaggerated the costs to participants of randomization, then studies using randomization would not have to pay much extra for participants. Today's Economist: The Economics of Randomized Experiments 2014-03-05T05:01:13Z The data, however, were analyzed as a completely randomized design, which is inappropriate given these restrictions on randomization. [Technical Comment] Comment on "Stress in Puberty Unmasks Latent Neuropathological Consequences of Prenatal Immune Activation in Mice" 2013-05-16T17:55:21.913Z The randomization analysis merely shows that individual male reproductive success is repeatable across years; hence, the highly skewed distribution of reproductive success does not arise by chance alone. [Technical Comment] Comment on “Bateman in Nature: Predation on Offspring Reduces the Potential for Sexual Selection” 2013-05-02T17:55:31.350Z In the example of the Darwin's finches, the randomization is performed over 120 data points under a null hypothesis that x and y values are independent. [Technical Comment] Comment on "Evolutionary Trade-Offs, Pareto Optimality, and the Geometry of Phenotype Space" 2013-02-14T19:25:20.847Z Patients in the control arm of the study were offered renal denervation following assessment of the trial’s primary endpoint at six months following randomization. Promising One Year Results For Renal Denervation In Resistant Hypertension Spark Hype 2012-12-18T21:17:17Z That practice might appear to make drug trials more expensive, but an active market for study participants would help us quantify some of the costs of randomization and increase the knowledge generated by each study. Today's Economist: The Economics of Randomized Experiments 2014-03-05T05:01:13Z A subgroup analysis suggested the possibility that prasugrel might be more effective than clopidogrel in current or recent smokers, in patients who underwent angiography prior to randomization, and in patients taking a proton-pump inhibitor. TRILOGY At ESC: No Advantage For Prasugrel Over Clopidogrel In Medical ACS Patients 2012-08-26T05:48:45Z By doing so, they didn’t break the randomization, and shouldn’t have introduced confounding, as suggested by this commentary piece. Fascinating Debate Over Statins For Primary Prevention 2012-05-30T17:22:15Z Researchers are also finding true causes through Mendelian randomization, a genetic technique that is exciting epidemiologists. Children of the 90s: Coming of age 2012-04-11T17:20:42.063Z We therefore used the following randomization strategy: we started by counting the number of genes affected by structural variations, for every sample in our data set. Sequencing of neuroblastoma identifies chromothripsis and defects in neuritogenesis genes 2012-03-28T21:50:58.107Z However, after two months, the drug court administrator and the researchers decided to end the randomization part of the study because of ethical concerns. Consults Blog: Expert Answers on E.M.D.R. 2012-03-26T19:17:09Z In the September issue of Gibson's essay, "Life in the Meta-City," details how cities increase "the number and randomization of potential human and cultural contacts" and how they serve as "vast, multilayered engines of choice." Cities in Fact and Fiction: An Interview with William Gibson 2011-08-26T12:15:02.610Z The utility of weighting trials according to LDL reduction is not that it maintains the equivalence of randomization, it is that it helps to neutralize the heterogeneity in the overall statin meta-group. Fascinating Debate Over Statins For Primary Prevention 2012-05-30T17:22:15Z Before randomization, the science of clinical trials was imprecise. Paul Meier, Statistician Who Revolutionized Medical Trials, Dies at 87 2011-08-13T02:22:33Z Additionally, these studies often repeat the tests many times using randomization of specific aspects of the experimental design, which helps reduce the likelihood that the results were due to chance or unknown factors. Finding good information on the internet 2011-07-16T13:15:00.290Z Ruth woke me one night with a rhetorical barrage about the reasons for randomization in clinical trial research. Well: The Blind Luck of Cancer Trials 2011-03-15T14:35:38Z “That’s how I’m going to be able to live with the randomization.” Target Cancer: New Drugs Stir Debate on Basic Rules of Clinical Trials 2010-09-19T03:30:00Z Our knowledge of microeconomic policies comes from repetition and randomization. What We Don't Know, and Perhaps Can't 2010-06-01T11:11:00Z As early as the mid-1950s, Dr. Meier was one of the first and most vocal proponents of what is called “randomization.” Paul Meier, Statistician Who Revolutionized Medical Trials, Dies at 87 2011-08-13T02:22:33Z Many device studies lacked standards most scientists expect: randomization and a clear goal. 2009-12-29T21:55:00Z |
| 随便看 |
英语例句辞典收录了117811条英语例句在线翻译词条，基本涵盖了全部常用单词及词组的例句翻译及用法，是英语学习的有利工具。