| 单词 | protease inhibitor |
| 例句 | Chee chronicles their involvement with activist organizations like Act Up/SF and Queer Nation in the long years before the advent of protease inhibitors. Writing as Drag: Alexander Chee’s Essays Consider the Novelist’s Craft 2018-06-27T04:00:00Z A breakthrough came in 1996 with the arrival of protease inhibitors, whose workings are clearly explained in a remarkable animated segment. Movie Review: ‘How to Survive a Plague,’ AIDS Documentary by David France 2012-09-20T23:56:55Z And over a few years, we developed a series of antiretroviral drugs, then we added the protease inhibitor. Fauci's warning to America: 'We're living in a progressively anti-science era and that's a very dangerous thing' 2022-12-22T05:00:00Z While drugs that initially seemed promising fell short, by the mid-90s, protease inhibitors slashed virus levels and delivered a medical miracle. F.D.A. Rushed a Drug for Preterm Births. Did It Put Speed Over Science? 2022-03-25T04:00:00Z It was just after the data on these protease inhibitors had been unveiled at a major scientific conference. Opinion | The Moral Danger of Declaring the Pandemic Over Too Soon 2022-02-17T05:00:00Z Paxlovid, known as a protease inhibitor, is designed to block an enzyme the virus needs in order to multiply. UK medicines regulator approves new Covid antiviral Paxlovid 2021-12-31T05:00:00Z The second compound is another protease inhibitor called ritonavir. FDA greenlights Pfizer’s oral COVID-19 drug 2021-12-22T05:00:00Z It is part of a class of drugs called protease inhibitors currently used to treat HIV, hepatitis C and other viruses. Pfizer says COVID-19 pill near 90% effective in final analysis 2021-12-14T05:00:00Z But, she added, “protease inhibitors have different liabilities.” New Covid Pills Offer Hope as Omicron Looms 2021-12-07T05:00:00Z Paxlovid, by contrast, is a protease inhibitor, much like those developed to combat HIV. How the New Antiviral Pills Help Thwart COVID 2021-12-01T05:00:00Z The Pfizer antiviral is a protease inhibitor, a well-studied class of drugs that revolutionized the fight against HIV and have a known safety record. Pfizer antiviral slashes COVID-19 hospitalizations 2021-11-05T04:00:00Z Pfizer's drug, part of a class known as protease inhibitors, is designed to block an enzyme the coronavirus needs in order to multiply. Pfizer says antiviral pill cuts risk of severe COVID-19 by 89% 2021-11-05T04:00:00Z The Pfizer drug, known as a protease inhibitor, is designed to block an enzyme the virus needs in order to multiply. Covid: Pfizer says antiviral pill 89% effective in high risk cases 2021-11-05T04:00:00Z The oral therapy is a protease inhibitor, meaning it prevents the virus from replicating in the cell. Pfizer testing oral pill as COVID treatment 2021-03-25T04:00:00Z One line of attack that looks particularly promising is a group of drugs called protease inhibitors. Coronavirus: Virus provides leaps in scientific understanding 2021-01-09T05:00:00Z That was because, in tablet form, the protease inhibitor was metabolized too quickly, broken down by the body before it could effectively disable the virus, says a Pfizer spokesperson. Pfizer antiviral slashes COVID-19 hospitalizations 2021-11-05T04:00:00Z The protease inhibitors and other compounds look promising in cell and animal studies. The science stories likely to make headlines in 2021 2020-12-31T05:00:00Z Other drugs currently in clinical trials, such as the HIV drug lopinavir, are known as protease inhibitors and prevent the virus from breaking its proteins down into particles that spread through the body. For COVID Drugs, Months of Frantic Development Lead to Few Outright Successes 2020-11-13T05:00:00Z The next set of drugs was protease inhibitors, one of which I helped to develop. Lessons from AIDS for the COVID-19 Pandemic 2020-09-29T04:00:00Z The drug combination is what is known as a protease inhibitor, and it works by blocking an enzyme involved in viral replication. Here’s What We Know about the Most Touted Drugs Tested for COVID-19 2020-04-16T04:00:00Z Because lopinavir is quickly broken down in the human body by our own proteases, it is given with low levels of ritonavir, another protease inhibitor, that lets lopinavir persist longer. WHO launches global megatrial of the four most promising coronavirus treatments 2020-03-22T04:00:00Z Baric explains that proteins in the human body bind 99% of these protease inhibitors, leaving little of them to fight viruses. Can an anti-HIV combination or other existing drugs outwit the new coronavirus? 2020-01-27T05:00:00Z Other researchers are using the glowing bacteria to develop a protease inhibitor to treat HIV and other diseases. 6 Medical Innovations That Moved from The Battlefield to Mainstream Medicine 2017-11-11T05:00:00Z That window is rather narrow for all polymerase and protease inhibitors. Lessons from AIDS for the COVID-19 Pandemic 2020-09-29T04:00:00Z Signals that activate resistance traits, such as anti-digestive protease inhibitors, can be wafted on the wind or transmitted through the underground mycorrhizal networks, built by fungi, that connect plants. Plant science: The plant as pugilist : Nature : Nature Research 2017-02-28T05:00:00Z As treatments advanced, including the major development of protease inhibitors in the 1990s, newer drugs attacked HIV-infected cells at a later point in their life cycle. Study explores healthy old age for those with HIV 2015-11-21T05:00:00Z For instance, a regimen involving the antiviral Ribavirin, interferon and Incivek, a protease inhibitor, costs close to $80,000, according to Express Scripts, a pharmacy benefit manager that handles prescriptions for large parties. What Obamacare means for your investment portfolio Soaking the seeds also breaks down phytic acid and protease inhibitors, which allows the nutrients to be more readily absorbed by the body. Whole-Wheat Seeded Loaves 2014-06-02T04:00:00Z Also, one class of antiretroviral drugs — protease inhibitors — tends to raise cholesterol levels. Global Health: Heart Problems Linked to Those Born With H.I.V. 2014-03-03T21:35:07Z Until late last year, the standard treatment for hepatitis C infection was a challenging 48-week regimen of weekly injections with interferon along with one or two oral antiviral drugs, ribavirin and a protease inhibitor. Well: Progress Against Hepatitis C, a Sneaky Virus 2014-02-24T05:01:20Z Current standard treatments for genotype 1 often include a protease inhibitor. FDA panel unanimously backs Gilead's hepatitis C drug sofosbuvir 2013-10-25T18:55:01Z The FDA advisory committee will also hear comment this week on Johnson & Johnson's application to sell simeprevir, an experimental protease inhibitor designed to target genotype 1 HCV. Preview - New wave of oral hepatitis C drugs near U.S. approval 2013-10-23T16:38:38Z Oramed has introduced a protease inhibitor and another tweak designed to protect and enhance absorption of its oral insulin. Pharma's David and Goliath in race to produce insulin pill 2013-10-09T05:01:05Z In all forms of shock, blockade of digestive proteases with protease inhibitor attenuated entry of digestive enzymes into the wall of the intestine and subsequent autodigestion and morphological damage to the intestine, lung, and heart. [Research Articles] Pancreatic Digestive Enzyme Blockade in the Intestine Increases Survival After Experimental Shock 2013-01-23T19:55:07.367Z A further breakthrough in treatment may come this year with the development of the experimental drug class called nucleotide polymerase inhibitors, which bind to a different part of the virus than the protease inhibitors. Boomers’ Drug Use Pushes Hepatitis Deaths Past HIV, Study Finds 2012-02-20T22:22:01Z The reduced prospects for Victrelis come even as its sales are being dwarfed by Vertex Pharmaceuticals Inc's Incivek, a rival protease inhibitor that was also approved last May. Merck says hepatitis pill hampers HIV Drugs 2012-02-09T19:37:49Z “To our knowledge, no other protease inhibitor has shown this,” he said. Merck Gains on Boosting Dividend for First Time Since 2004 2011-11-11T15:32:14Z Taken in combination with two other anti-HIV drugs, protease inhibitors work by halting the action of the protease enzyme, a protein produced by HIV that is necessary for replication of the virus. Key to HIV-Drug Resistance Found 2011-07-12T14:18:00Z Animals treated with protease inhibitors also survived in larger numbers than untreated controls over a period of 12 weeks. [Research Articles] Pancreatic Digestive Enzyme Blockade in the Intestine Increases Survival After Experimental Shock 2013-01-23T19:55:07.367Z And the conformational changes that underpin resistance to one protease inhibitor may also confer resistance to other inhibitors of that protease — a phenomenon called class resistance. Perspective: Recognizing resistance 2011-06-13T13:20:36.973Z A major caveat of the protease inhibitors, however, is that they must be used in combination with the existing standard of care. Perspective: Miles to go before we sleep 2011-06-13T13:20:34.157Z “This one would be a good partner for a protease inhibitor,” says Pockros. Therapeutics: New drugs hit the target 2011-06-13T13:20:32.767Z Currently there are nine FDA approved protease inhibitors, and 21 most common drug-resistant mutations. Key to HIV-Drug Resistance Found 2011-07-12T14:18:00Z But protease inhibitors, available since 1996, are expensive and are thus not available to most of the afflicted. 30 years after AIDS' discovery, medical and behavioral challenges remain 2011-06-05T00:44:43Z Separate clinical trials on boceprevir and telaprevir showed both drugs, so-called protease inhibitors, cured more patients when used with approved treatments. Merck Wins U.S. FDA Panel’s Backing for Hepatitis C Drug 2011-04-27T20:23:04Z Eventually, these were joined by a new generation of drugs known as protease inhibitors. W. H. Prusoff, Who Developed AIDS Drug, Is Dead at 90 2011-04-07T02:55:44Z Both compounds are protease inhibitors and are expected to hit the market at about the same time. New Drugs for Hepatitis C On the Horizon 2011-03-30T21:45:00.247Z However, almost half of HIV patients who initially respond to treatment with protease inhibitors develop drug-resistance strains and stop responding to treatment within eight to 10 months. Key to HIV-Drug Resistance Found 2011-07-12T14:18:00Z But there could be some overlap between the action of the protease inhibitors and that of interferon. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z The research, published this month in the Journal of Biological Chemistry, shows HIV protease inhibitor drugs directly interfere with the way blood sugar levels are controlled in the body. Researchers say uncover HIV, insulin resistance link 2010-11-23T23:19:00Z Munching caterpillars produce oral secretions that “activate a whole series of defense responses,” Dr. Baldwin said, including the production of toxins and protease inhibitors that decrease the caterpillars’ digestive ability. 2010-01-22T07:22:00Z Early studies showed that although a protease inhibitor given on its own was very effective initially, it often led to resistant strains of the virus in a matter of days, Gordon says. New Drugs for Hepatitis C On the Horizon 2011-03-30T21:45:00.247Z As is the problem with any drug that targets an HCV protein, viruses have emerged that are resistant to protease inhibitors. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z And, if a protease inhibitor were added in the treatment mix, it could prevent some of the destruction of the host's immune response. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z Because patients harbor a heterogeneous mix of HCV species, there could easily be a few in the population that are able to grow despite protease inhibitors, causing a so-called "viral breakthrough". Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z The protease inhibitors could be just the beginning of anti-HCV drugs that are added to the treatment regime. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z Compounds that inhibit the HCV polymerase are currently in phase II trials and, if all goes well, could get to market about a year after protease inhibitors. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z |
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