| 单词 | preclinical |
| 例句 | They then used this information to enhance anticancer activity in preclinical models by promoting or blocking T-cell differentiation. Scientists identify T-cell differentiation nodes to improve cancer-killing 2023-11-15T05:00:00Z "From the idea to the development of the new nanoparticles to preclinical testing, chemists, biologists, pharmacists, and physicians have worked hand in hand." Nanoparticles for optimized cancer therapy 2023-11-15T05:00:00Z Given what Smith calls possible “scientific fraud” in the preclinical research supporting 3K3A-APC’s supposed protective effects, he thinks the trial should not go forward until NIH, USC, and other organizations can address the whistleblowers’ allegations. Misconduct concerns, possible drug risks should stop major stroke trial, whistleblowers say 2023-11-12T05:00:00Z The preclinical discovery, reported Nov. 9 in Nature Chemical Biology, provides a new chemical tool for probing the biology of diabetes, and could point the way toward better treatments for the disease. Drug screen points toward novel diabetes treatments 2023-11-09T05:00:00Z Shapiro and colleagues are collaborating with Andrew Owen, PhD, a professor at the University of Liverpool, and his team to complete preclinical studies and launch a Phase I trial. Potential for injectable 'chemical vaccine' for malaria using atovaquone 2023-10-20T04:00:00Z The FDA has signaled that it is open to starting phase I clinical trials of xenotransplants once it has enough preclinical data. No One Should Die Waiting for an Organ Transplant. These Doctors Want to Ensure That Doesn’t Happen 2023-10-19T04:00:00Z By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model's capabilities as an advanced, human-relevant, preclinical, drug discovery platform. Human Lung Chip leveraged to faithfully model radiation-induced lung injury 2023-10-17T04:00:00Z "For now, we're interested in exploring how we can use the Regeneration Classifier in preclinical contexts to predict the effectiveness of new regenerative therapies and help move those treatments closer to clinical trials." New biomarker predicts whether neurons will regenerate 2023-10-16T04:00:00Z A single dose of ADC therapy combined with lovastatin was found to reduce tumor volume at rates similar to those resulting from multiple doses of ADC in a preclinical setting. PET imaging validates use of common cholesterol drug to enhance HER2-targeted cancer therapy 2023-10-13T04:00:00Z Although these studies provide valuable information, the FDA does not consider them a substitute for clinical trials, for which it requires preclinical data in nonhuman primates. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z "It provides preclinical information about which of the thousands of different protein sites are most likely to impact cancer cell growth." New cancer drug targets uncovered using base editing and chemical proteomics 2023-10-05T04:00:00Z Small animal preclinical models fail to produce key hallmarks of the human pathophysiology and do not mimic the dose sensitivities observed in humans. Human Lung Chip leveraged to faithfully model radiation-induced lung injury 2023-10-17T04:00:00Z It opens up exciting possibilities for designing preclinical and clinical trials in the future. Selective removal of aging cells opens new possibilities for treating age-related diseases 2023-10-04T04:00:00Z The researchers found that targeting ACSS2 in this preclinical study not only hampered this aggressive cancer's ability to metabolize acetate and grow -- it also triggered the immune system to recognize and attack the cancer. Possible new treatment for triple-negative breast cancer 2023-09-18T04:00:00Z Soumyanath said that the loss of pleasure has been anecdotally documented, but it hasn't been noted in any clinical or preclinical studies. For some, ashwagandha is a godsend. For others, it's a nightmare. What gives? 2023-07-15T04:00:00Z "Back in '55 we weren't doing preclinical testing for reproductive safety," said Chambers. Can in-utero exposure to acetaminophen cause autism and ADHD? 2023-07-13T04:00:00Z By also evaluating the potential of two drugs to suppress the effects of acute RILI, the researchers demonstrated their model's capabilities as an advanced, human-relevant, preclinical, drug discovery platform. Human Lung Chip leveraged to faithfully model radiation-induced lung injury 2023-10-17T04:00:00Z “The rigor of the preclinical evidence here, I think, is unique,” said Jeffrey Moscow of NCI’s Division of Cancer Treatment and Diagnosis at a press briefing. U.S. study will test whether drug combinations can wipe out tumors 2023-06-01T04:00:00Z The agency had consulted clinical data, preclinical data and the manufacturing process, among other criteria, she said. Unpacking the flawed science cited in the Texas abortion pill ruling 2023-04-13T04:00:00Z Clinical and preclinical data looked good—the vaccine was just as safe and effective as mOPV2 and much more genetically stable, Bandyopadhyay says. First polio cases linked to new oral vaccine detected in Africa 2023-03-19T04:00:00Z In preclinical studies, they also found evidence that ingestion of erythritol increased blood clot formation. Artificial sweetener linked to higher heart attack risk, study says 2023-02-28T05:00:00Z Mind-bogglingly, it wasn't until 2015 that the NIH mandated the inclusion of female laboratory animals in preclinical safety studies of new medical treatments. Here’s What Scientists Are Learning about Women’s Health from Other Female Animals 2023-02-19T05:00:00Z The experimental vaccine hasn’t been tested in people, but the concept “has shown great promise in advanced preclinical studies,” according to the NIH. NIH: research team develops promising universal flu vaccine 2022-12-06T05:00:00Z He returned to Dartmouth after World War II, graduating in 1948 and entering a two-year preclinical program at Dartmouth’s medical school. Samuel L. Katz, doctor who helped develop measles vaccine, dies at 95 2022-11-03T04:00:00Z Nonhormonal drugs show efficacy in animal models, but preclinical toxicology results are needed before clinical studies to demonstrate safety, tolerability and efficacy in people can begin. Male Birth Control Is in Development, but Barriers Still Stand in the Way 2022-10-13T04:00:00Z Companies hope the products will be authorized solely on basis of preclinical data showing adequate levels of neutralizing antibodies. Omicron-Specific COVID Boosters Are Coming 2022-07-07T04:00:00Z About 2,000 people have used the product in preclinical trials, with all-important clinical trials expected to begin at a number of U.K. medical institutions in the coming months. Can a video game tell if you’re depressed? 2022-04-28T04:00:00Z For each of the candidates that have made it into clinical trials, there are several more in preclinical development. Nose Spray Vaccines Could Quash COVID Virus Variants 2022-05-03T04:00:00Z On April 13 the stock sank by as much as 16% on reports the drug could pose risks to pregnancies, based on preclinical data. Japan's Shionogi says COVID-19 pill shows rapid clearance of virus 2022-04-24T04:00:00Z “But biosynthetic oxygen carriers are still in advanced preclinical development due to the complexities of imitating, rather than just freeze drying, human cells.” Synthetic blood substitute research advances rapidly 2022-04-16T04:00:00Z Once they’ve found a good candidate, they will typically spend several years in the “preclinical” phase, studying it to determine whether it is safe and triggers the desired response. Opinion | Bill Gates: How to Develop Life-Saving Drugs Much Faster 2022-04-15T04:00:00Z “People should do as much preclinical research as they can, and let's find out whether it's feasible,” he says. As creator of ‘CRISPR babies’ nears release from prison, where does embryo editing stand? 2022-03-21T04:00:00Z “We just don’t want to do the wrong thing,” she says, adding that solid preclinical data are crucial before testing a therapy on pregnant people. Which medicines can you take when pregnant? New efforts aim to crack a scientific black box 2022-03-16T04:00:00Z With the exception of Bennett’s surgery, for which the FDA granted emergency authorization through its compassionate use provision, the recent kidney transplants have been preclinical trials, performed on brain-dead humans. Patient who received a genetically modified pig’s heart has died, hospital says 2022-03-09T05:00:00Z Several preclinical studies for HBOCs are rounding up, and clinical trials are on the horizon. Synthetic blood substitute research advances rapidly 2022-04-16T04:00:00Z If all goes well in the preclinical phase, the drug will move into the riskiest and most expensive part of the process: clinical trials in humans. Opinion | Bill Gates: How to Develop Life-Saving Drugs Much Faster 2022-04-15T04:00:00Z “So many preclinical experiments do not end up telling you anything useful in the clinic,” says Merlino, a co-author on commentary on the issue today in Cancer Cell. Glowing tumor marker may interfere with cancer studies in mice, creating reproducibility problems 2022-02-17T05:00:00Z A 2015 paper posted on the website of the National Center for Biotechnology Information referred to them as the most widely used primate in preclinical toxicology studies. All 100 lab monkeys accounted for after several escape crash 2022-01-22T05:00:00Z UAB plans to call the preclinical human model the Parsons Model. Researchers implant genetically altered pig kidneys into a brain-dead man 2022-01-20T05:00:00Z “These data add to the growing body of preclinical evidence demonstrating that sotrovimab retains activity against all tested variants of concern,” the company said Tuesday. Results expected next week from U.S. labs testing vaccines’ strength against omicron 2021-12-07T05:00:00Z A statement from AstraZeneca, whose scientists joined the research, said the “preclinical research further advances our knowledge about the potential mechanisms underlying the extremely rare condition … which is treatable for the majority of people.” Scientists find clues to what triggers rare blood clots in AstraZeneca coronavirus vaccine 2021-12-02T05:00:00Z We have encouraging preclinical data for a flu vaccine we are developing with Pfizer. News at a glance: An abolished marine preserve, a cloud of space debris, and a psychedelic clinical trial success 2021-11-17T05:00:00Z These start with a preclinical trial, and then three phases of testing before being approved. A "T-cell priming" vaccine could provide better COVID-19 immunity than mRNA vaccines 2021-11-17T05:00:00Z The use of a brain-dead human allows surgeons to test a preclinical model without harming a living person, rather than relying on other primates as substitutes. Researchers implant genetically altered pig kidneys into a brain-dead man 2022-01-20T05:00:00Z “We have therapies that manage symptoms, but no disease-modifying treatment. In preclinical work, we’ve been able to show that PRP can delay disease progression, laying the foundation for a pilot clinical study in patients.” Could platelet-rich plasma injections help avoid knee surgery? More studies may give answer. 2021-11-05T04:00:00Z Pfizer said in a preclinical study, the drug showed no evidence of “mutagenic DNA interactions.” Opinion | The promise of a pill: New vistas appear in the fight against covid-19 2021-11-06T04:00:00Z Chamberlain said that with all the preclinical work Tabebordbar has done, the new viruses could move into clinical trials soon, within six months to a year. He can’t cure his dad. But a scientist’s research may help everyone else 2021-11-07T04:00:00Z “The field up to now has been stuck in the preclinical primate stage, because going from primate to living human is perceived as a big jump,” Montgomery said. In a first, U.S. surgeons attached a pig kidney to a human — and it worked 2021-10-20T04:00:00Z This extract is created by bubbling cigarette smoke through a solution and is often used in preclinical studies as an analogy for the smoke itself. Cigarette Smoke Kills Eye Cells 2021-10-18T04:00:00Z “But there is compelling preclinical evidence that they work ... via psychological mechanisms … but also may have some direct effects on descending pain pathways.” Can Psychedelic Drugs Treat Physical Pain? 2021-09-30T04:00:00Z “We are really the template for all these other autoimmune diseases that are now also discovering these long preclinical periods,” she says. Targeted Treatments for Autoimmune Disease Make Progress 2021-09-20T04:00:00Z In addition to these approved drugs, many other snake venom components are now involved in preclinical or clinical trials for a variety of therapeutic applications. The false promise of snake wine in Southeast Asia 2021-08-01T04:00:00Z She adds that participants in the study with preclinical Alzheimer's would, in some cases, drive less at night, restrict their driving to slightly smaller areas around their home or travel more slowly than expected. How your driving might reveal early signs of Alzheimer's 2021-07-12T04:00:00Z This raises the possibility of eventually creating diagnostics to catch preclinical melanoma in humans. Cancer Clues Found in Gene behind ‘Lemon Frost’ Gecko Color 2021-06-24T04:00:00Z “There were no antifungals anywhere in the world in clinical or even preclinical development.” Deadly Fungi Are the Newest Emerging Microbe Threat All Over the World 2021-05-18T04:00:00Z A vaccine may show promise in a preclinical or Phase I trial, but if any of those factors are working against a research team, a sudden paradigm shift will fail to move the candidate forward. How Human Challenge Trials Can Accelerate Vaccine Development 2021-05-05T04:00:00Z In a January 25 press release, the company announced that it was advancing the booster into preclinical studies and an early-stage clinical trial in the United States. Booster Shots Against Scary COVID Virus Variants Are In the Works 2021-02-18T05:00:00Z One found that when Medicare created a new drug benefit in 2006, preclinical testing and clinical trials increased for drugs for older patients — those most likely affected by the policy. Drug Prices by Committee: One Way Biden Could Lower Costs 2021-02-11T05:00:00Z As such, the only pregnancy-related data available are from preclinical studies in laboratory animals and a handful of clinical trial participants who later discovered they were pregnant. Should you get the COVID-19 vaccine while pregnant? Here's what experts say. 2021-02-05T05:00:00Z The company, which did not disclose its valuation in the fundraising, said the proceeds will be used to accelerate the progress of its clinical programmes and further expand its preclinical pipeline. Chinese biotech firm Abbisko raises $123 million from Carlyle, Warburg 2021-01-08T05:00:00Z There are currently 56 candidate vaccines undergoing clinical testing, and another 166 candidates are at preclinical stages, data from the WHO shows. One fifth of global population won’t have access to vaccine until 2022: study 2020-12-17T05:00:00Z “Following these results and the latest encouraging new preclinical data, we will now work to further optimize our candidate to achieve this goal.” GSK, Sanofi say COVID-19 shot won’t be ready until late 2021 2020-12-11T05:00:00Z “It’s probably going to move fast,” he told Hanne Bak, senior vice president of preclinical manufacturing, who develops the initial recipes to turn science experiments into a repeatable process. These laboratory-made antibodies are a best bet for a coronavirus treatment, but there won’t be enough 2020-09-30T04:00:00Z Additionally, there are at least 92 preclinical vaccine trials happening on animals, which means the vaccine is being administered to animals like mice or monkeys to see if it produces an immune response. A coronavirus vaccine may only work for one year. Here’s what that means for society 2020-09-23T04:00:00Z Most of these are in the early stages of preclinical development; several dozen are in clinical trials, and only a handful have begun final-phase tests for efficacy. The underdog coronavirus vaccines the world will need if front runners stumble 2020-09-08T04:00:00Z And when, as used to happen, big companies bought smaller ones whose new drugs showed preclinical promise, the purchase price covered any debt the small companies had incurred. Why creating life-saving drugs is a lousy bet 2020-08-18T04:00:00Z It can take a decade or longer to go from preclinical research to production. Coronavirus vaccines get a biotech boost 2020-07-20T04:00:00Z As of July, there are over 135 vaccines in preclinical tests, and another 30 in clinical trials on people. Inside Johnson & Johnson’s Nonstop Hunt for a Coronavirus Vaccine 2020-07-17T04:00:00Z More than 130 others are in preclinical studies. Oxford coronavirus vaccine safe and promising, according to early human trial results published in the Lancet 2020-07-20T04:00:00Z The World Health Organization reports that there are currently 23 potential vaccines being tested in human trials, with more than 130 others in preclinical studies. The most promising coronavirus vaccine candidate shows yet more positive results 2020-07-20T04:00:00Z The F.D.A. told her and the researchers at Massachusetts General what preclinical data would be required before testing in patients would be allowed. ‘It Will Consume Your Life’: 4 Families Take On Rare Diseases 2020-07-07T04:00:00Z The fact that these insidious diseases and their impact are rarely discussed in preclinical medical education demonstrates how immigrant health issues are devalued and underemphasized. Medical Students Should Be Taught How to Care for Immigrant Patients 2020-07-13T04:00:00Z These start with a preclinical trial, and then moves through three phases of testing before being approved. How to differentiate coronavirus vaccine news from hype 2020-07-12T04:00:00Z Multiple vaccine trials are in a preclinical stage in India, and several other candidates are being tested around the world. Asia Today: India’s virus cases, deaths surge again 2020-06-30T04:00:00Z And the steady trickle of exciting progress in preclinical research provides ready fodder for marketing. Inside the stem-cell pharmaceutical factory 2020-06-16T04:00:00Z As of May 27, 10 vaccines were in the clinical stages of evaluation, with 115 vaccines racing through the preclinical stages. Bad Medicine Is Worse than No Medicine 2020-06-12T04:00:00Z Another 115 are considered by the World Health Organization to be in the “preclinical” stage of development. Can Operation Warp Speed deliver a COVID-19 vaccine by the end of the year? 2020-06-02T04:00:00Z Such models would be valuable for drug development and preclinical testing. Take lessons from cancer evolution to the clinic 2020-05-26T04:00:00Z Great Lakes Discoveries will support all preclinical stages of drug discovery and development of selected projects. U of Michigan, Deerfield partner on drug discovery projects 2020-05-27T04:00:00Z These and other exosome-based therapies for a variety of conditions, including cancer and Alzheimer’s disease, are still in preclinical development — numerous experimental and regulatory hurdles remain. The therapeutic potential of exosomes 2020-05-12T04:00:00Z Belgian researchers are only now starting preclinical trials on hamsters. The urgent quest for a coronavirus treatment involves door-to-door blood collection and a llama named Winter 2020-05-06T04:00:00Z In some cases, these preclinical vaccine candidates are scarcely off the drawing board. Can Operation Warp Speed deliver a COVID-19 vaccine by the end of the year? 2020-06-02T04:00:00Z Some scientists say the preclinical evidence is strong enough to support chloroquine’s use, however. Here’s What We Know about the Most Touted Drugs Tested for COVID-19 2020-04-16T04:00:00Z Of the 69 drugs, 27 are already approved, 14 are in clinical trials, and 28 are in preclinical tests. These drugs don’t target the coronavirus—they target us 2020-04-02T04:00:00Z They should also demand strong preclinical evidence that the experimental vaccines prevent infection, even though that will probably mean waiting weeks or even months for the models to become available. Don’t rush to deploy COVID-19 vaccines and drugs without sufficient safety guarantees 2020-03-15T04:00:00Z Some ideas include significantly reducing the “preclinical” curriculum, now that professors do not have to “teach to the test.” A Major Medical Licensing Exam Is Going Pass/Fail, and it's About Time 2020-03-12T04:00:00Z In 2021, it would link existing childhood cancer databases, create a data commons for preclinical studies and clinical data, and fund research on rare pediatric cancers. National Institutes of Health would see 7% cut in 2021 under White House plan 2020-02-10T05:00:00Z Following extensive preclinical characterization of these microbes in mice and pigs, the researchers ran a randomized, double-blind controlled feeding study that provides preliminary support for efficacy in people. Diet should be a tool for researchers, not a treatment 2020-01-28T05:00:00Z “It is very encouraging to see a wide variety of new innovative approaches in the preclinical pipeline,” the study said. W.H.O. Warns That Pipeline for New Antibiotics Is Running Dry 2020-01-17T05:00:00Z That said, preclinical trials in mice will be necessary to ascertain that the benefit is sustained and robust over the course of long-term therapy. Strategy to selectively remove mutant proteins could combat neurodegeneration 2019-10-29T04:00:00Z A recent paper from the University of North Carolina at Chapel Hill showed that $495,000 was spent aligning the preclinical curriculum to test preparation, for example through subscriptions to popular study resources. A Major Medical Licensing Exam Is Going Pass/Fail, and it's About Time 2020-03-12T04:00:00Z The company is doing preclinical work on hybrid drugs aimed at α1-antitrypsin deficiency, an inherited lung and liver disease, and hereditary amyotrophic lateral sclerosis, a degenerative neurological condition. RNA therapies explained 2019-10-15T04:00:00Z Alnylam’s preclinical work on eye delivery suggests that doses as small as three micrograms can be effective and have a long-lasting effect. The challenge of delivering RNA-interference therapeutics to their target cells 2019-10-15T04:00:00Z Now, around 100 years after the ‘Spanish flu’ pandemic of 1918 that killed about 50 million people, multiple universal-vaccine programmes are demonstrating promise in both preclinical and clinical testing. Towards a universal flu vaccine 2019-09-17T04:00:00Z The researchers found a clue to the real mechanism for a drug, now in preclinical testing, that supposedly blocks a protein called PBK, which aids cell division. Some cancer drugs miss their target. CRISPR could improve their aim 2019-09-11T04:00:00Z Pain researchers are usually cautious about touting preclinical results. Analgesia without opioids 2019-09-10T04:00:00Z He specializes in developing gene therapies for rare diseases for families and foundations and helps move them from preclinical testing into clinical trials. His daughter Annabel has a rare disorder. He’s developing a novel gene therapy. 2019-08-30T04:00:00Z A 2018 study found this was a result of “serious male biases in basic, preclinical, and clinical research”. Why don’t doctors trust women? Because they don’t know much about us | Gabrielle Jackson 2019-09-01T04:00:00Z Mice are often used for early studies of vaccine preclinical development but Palese points out that they are not a natural reservoir for the influenza virus. Towards a universal flu vaccine 2019-09-17T04:00:00Z These experiments suggest the wildling mice could be a more accurate model of human immune responses in preclinical trials. Could lab mice born to wild parents improve the search for human cures? 2019-08-01T04:00:00Z In 2015 it was estimated that the amount spent on irreproducible preclinical research in the U.S. for the year. To Fix the Reproducibility Crisis, Rethink How We Do Experiments 2019-07-18T04:00:00Z But one of the biggest areas holding back progress is inefficiency in the preclinical, animal testing phase of the drug-discovery process. How to Fight "Eroom's Law" 2019-07-09T04:00:00Z Even in preclinical trials with cell lines and rodents, males have been favoured over females. Why don’t doctors trust women? Because they don’t know much about us | Gabrielle Jackson 2019-09-01T04:00:00Z “For example, no one knew CBD was potentially toxic to the liver until we conducted clinical and preclinical studies. To answer such questions, we’ve spent the past 20 years researching this plant.” At First-Ever Public Hearing on CBD, FDA and Advocates Try to Blaze Trail to Regulatory Compromise 2019-05-31T04:00:00Z The male bias is seen across all fields of preclinical research, but one of the starkest areas is neuroscience, in which male animals outnumber females by nearly six to one. 'Sexist' research means drugs more tailored to men, says scientist 2019-05-31T04:00:00Z But she says that other institutes are expanding their mouse research — mouse models are increasingly used by scientists in preclinical research, for instance. Genomics institute to close world-leading animal facility 2019-05-28T04:00:00Z Only one in 10 drugs that enter human clinical trials reach the market after preclinical success. How to Fight "Eroom's Law" 2019-07-09T04:00:00Z The work is only at the preclinical stage, but Yusoff is already aware of a catch when working with such a virus. The biotechnologists making their mark on the international stage 2019-05-28T04:00:00Z Statistical significance is just one of several criteria — including replication, cost–benefit analysis and synthesis of information from different sources — that need to be met before deciding whether a preclinical lead is worth pursuing. Stats: a trillion P values and counting 2019-05-13T04:00:00Z None of these compounds has made it through preclinical toxicology studies to get into a human trial yet. Why Women—and Men—Need Better Birth Control 2019-04-25T04:00:00Z We are developing a flexible quality-management framework that aims to improve conduct and reporting of preclinical research in both the public and the private sectors. A European initiative to unclog pipeline for new medicines 2019-04-22T04:00:00Z AstraZeneca uses female rodents in most of its preclinical pain research because they’re less aggressive and easier to house and handle than males. Why the sexes don’t feel pain the same way 2019-03-26T04:00:00Z The regulations will not apply to preclinical and basic research, including gene editing of human embryos not being used for reproduction. China to tighten rules on gene editing in humans 2019-03-05T05:00:00Z Usually, researchers have to test their innovation in the lab and then on animals in preclinical research. 'I might have had her for a bit longer' 2019-02-26T05:00:00Z In the end, our preclinical trials failed last summer. Here’s what happened when I tried to develop a new drug for a deadly cancer. 2019-01-11T05:00:00Z Cooper encouraged me to continue talking with my doctor because “these powerful stories, as well as evidence from preclinical or animal studies, help drive the basis for rigorous studies.” Perspective | Is the hype about CBD, or cannabidiol, real? 2019-01-04T05:00:00Z The government clarified its position and regulatory procedures, specifying that embryo gene editing is permitted in China for basic and preclinical research, but prohibited for clinical or reproductive use. Engineering a biomedical revolution 2018-12-11T05:00:00Z A starting point would be a global registry to record preclinical research that involves gene editing in human embryos. Daily briefing: Jurassic blubber 2018-12-05T05:00:00Z At best, some research leading to negative results in clinical trials will appear on clinical-trial registries or, perhaps, in publications, but without the context of how these compounds performed in preclinical or early-stage programmes. Be open about drug failures to speed up research 2018-11-12T05:00:00Z Fortunately, the development of a host of fresh treatment approaches is advancing, with some already entering the clinic, and others showing promise in clinical or preclinical trials. Ulcerative colitis: towards remission 2018-11-06T05:00:00Z “The notion that a company that is preclinical is inferior is not correct,” he says. Biotechs With No Drugs in Trial Are Raising Millions in IPOs 2018-10-31T04:00:00Z Here, patient-support groups are again likely to be crucial, this time in lobbying pharmaceutical companies to get involved in tackling childhood HGG — for example, by supplying drugs for preclinical and clinical research. The unexpected role of histones in childhood brain cancer 2018-09-25T04:00:00Z The researchers are planning to conduct additional preclinical studies in animals to confirm their findings before applying to the FDA for human trials. Nonaddictive pain reliever shows promise in animal trials: Report 2018-08-30T04:00:00Z Details on data generated before phase III trials — including preclinical and early clinical research — were crucial to frame the failure’s significance in terms of which hypotheses it falsified. Be open about drug failures to speed up research 2018-11-12T05:00:00Z In my experience, close to half of preclinical content was redundant. Opinion | Our doctors are too educated 2018-08-13T04:00:00Z Another important impetus for amyloid-β testing was the push to treat people earlier in the course of the condition, often before they show symptoms — a stage known as preclinical Alzheimer’s disease. Alzheimer’s disease is getting easier to spot 2018-07-24T04:00:00Z The models also served as crucial preclinical test beds for drugs. The search for better animal models of Alzheimer’s disease 2018-07-24T04:00:00Z Before testing any compounds with potential therapeutic value in humans, the pharmaceutical product candidate enters the preclinical testing stage. HOVERINK BIOTECHNOLOGIES APPOINTS VSTOCK TRANSFER, LLC AS ITS TRANSFER AGENT AND REGISTRAR 2018-07-11T04:00:00Z That day, panel members heard presentations on the drug's preclinical and clinical data from agency staff and AstraZeneca in Cambridge, U.K., its maker and one of the world's largest pharmaceutical companies. Hidden conflicts? Pharma payments to FDA advisers after drug approvals spark ethical concerns 2018-07-05T04:00:00Z There is growing evidence, however, that Alzheimer’s disease begins its attack on the brain many years before such symptoms appear, leading researchers to suggest that there is a syndrome called preclinical Alzheimer’s disease. Perspective | Five myths about Alzheimer’s disease 2018-06-15T04:00:00Z "Their brain is constantly reminding them of how good it felt," says Brett Abrahams, Ovid's director of preclinical biology. Chemists seek antiaddiction drugs to save hijacked brains 2018-04-12T04:00:00Z That was the case for Nikita Patel, who started a job at a local preclinical CRO after graduating from the University of San Diego in California. Outsourcing is in 2018-04-10T04:00:00Z The sponsor must submit the results of the preclinical tests, together with manufacturing information, analytical data, any available clinical data or literature and a proposed clinical protocol, to the FDA as part of the IND. HOVERINK BIOTECHNOLOGIES APPOINTS VSTOCK TRANSFER, LLC AS ITS TRANSFER AGENT AND REGISTRAR 2018-07-11T04:00:00Z “Improving the design, conduct and reporting of preclinical research is of the utmost priority if we are to move ahead, with all due haste, in the development of novel treatments across a range of diseases.” Clinical trials may be based on flimsy animal data 2018-04-05T04:00:00Z It didn't examine the preclinical evidence underlying the studies in detail, however. Two controversial stem cell trials could harm patients, critics say 2018-03-29T04:00:00Z “There are about a dozen candidates that range from preclinical animal studies up through and including phase-two clinical trials,” he says. The Chase for a Permanent Flu Vaccine 2018-02-05T05:00:00Z “As these designs enter advanced stages of preclinical testing and early clinical trials, we will learn a lot more about the best way to further advance genome editing as therapies.” Resistance to Common Germs Poses a Hurdle to New Gene Therapies 2018-01-12T05:00:00Z Equally intriguing is a recent finding suggesting that loneliness may be a preclinical sign for Alzheimer’s disease. How Loneliness Affects Our Health 2017-12-11T05:00:00Z “Improving the design, conduct and reporting of preclinical research is of the utmost priority if we are to move ahead, with all due haste, in the development of novel treatments across a range of diseases.” Clinical trials may be based on flimsy animal data 2018-04-05T04:00:00Z Loss of IL-11 reduced fibrosis in three preclinical models of cardiovascular fibrosis, leading the authors to propose IL-11 as a therapeutic target. IL-11 is a crucial determinant of cardiovascular fibrosis 2017-11-12T05:00:00Z Shoddy preclinical research is not just bad science — it is unethical. Preclinical research: Meet patients to sharpen up research All of this work is preclinical—in cells and animal models—thus far. Could the "Alzheimer's Gene" Finally Become a Drug Target? 2017-10-11T04:00:00Z The process helped to validate the genetic basis for some drugs in humans in a way that mouse studies and other preclinical research often can't. The rise and fall and rise again of 23andMe 2017-10-10T04:00:00Z Arrowhead Pharmaceuticals and Wave Life Sciences have a number of preclinical programs in play, though none have advanced nearly as far as Alnylam. Experimental Drug That Mutes Defective Genes Raises New Hopes 2017-10-05T04:00:00Z Females are neglected long before drug trials enlist their human subjects, however, because preclinical animal tests are also biased towards males. Clinical research: Inequality in medicine : Nature : Nature Research 2017-10-03T04:00:00Z In the United Kingdom, NPL is leading the way on services specifically aimed at preclinical studies. Metrology is key to reproducing results 2017-07-24T04:00:00Z “They all said the same thing: you shouldn’t combine preclinical research and clinical work in the same application,” she recalls. The best-kept secrets to winning grants 2017-05-23T04:00:00Z Synlogic scientists presented the preclinical data in March at the annual meeting of the American College of Medical Genetics and Genomics in Phoenix, Arizona. Therapeutic developments: Masters of medicine : Nature : Nature Research 2017-05-16T04:00:00Z CARB-X aims to invest $450 million over five years with the goal of speeding up preclinical discovery and development of at least 20 antibacterial products and moving at least two of them into human trials. Quest for new antibiotics gets first major funding from global partnership 2017-03-30T04:00:00Z Nevertheless, the imbalanced history continues to disadvantage researchers who conduct preclinical studies using female animals. Clinical research: Inequality in medicine : Nature : Nature Research 2017-10-03T04:00:00Z This creates a barrier to the translation of preclinical studies into clinical practice, and unnecessarily increases the number of animals used in studies. Metrology is key to reproducing results 2017-07-24T04:00:00Z As with all preclinical model systems and human clinical pathological correlations, prospective clinical trials will be needed to substantiate the hypotheses of our work. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z “If this particular approach is as effective as the preclinical data suggest, then you could see a lot of other people saying maybe we should adopt the same strategy,” says Lazo. Therapeutic developments: Masters of medicine : Nature : Nature Research 2017-05-16T04:00:00Z We propose a three-tier principle of transparency, replication and triangulation that should be achieved before publication, to ensure that the results warrant further study in preclinical and clinical trials. Preclinical data: Three-point plan for reproducibility : Nature : Nature Research 2017-02-28T05:00:00Z Last year also saw the launch of CARB-X, a public–private partnership funded by the United States and the United Kingdom that aims to stimulate preclinical development of new antibiotics. The drug-resistant bacteria that pose the greatest health threats 2017-02-27T05:00:00Z We call this large confirmatory study a preclinical trial. No publication without confirmation 2017-02-21T05:00:00Z Chimaeras were verified with prostate tumour formation by MRI and assigned into preclinical studies through randomization which maximized the chance that male mice housed in the same cage received different drugs. Effective combinatorial immunotherapy for castration-resistant prostate cancer : Nature : Nature Research 2017-03-19T04:00:00Z In its news release, the company said it conducted 17 preclinical and clinical studies. An old drug gets a new price to fight a rare disease: $89,000 a year 2017-02-10T05:00:00Z A missed milestone, particularly in preclinical studies, hardly signals a catastrophe, says Eric Schmidt, a biotech analyst at Cowen Group in New York City. This mysterious $2 billion biotech is revealing the secrets behind its new drugs and vaccines 2017-02-01T05:00:00Z It should encourage reviewers to consider a broader evidence base, as well as whether positive effects in preclinical studies might reflect chance or bias8. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z Because investigators would be required to 'put up or shut up' and formally submit to a preclinical trial, they would be more comprehensive and careful with their exploratory work. No publication without confirmation 2017-02-21T05:00:00Z Building on similar research designs moving through preclinical development, this version uses an array of actuators that function as artificial muscles to squeeze and twist simultaneously. Heart-hugging device could help keep the beat 2017-01-18T05:00:00Z The agency is supporting phase-one trials of a separate vaccine at three research centers across the country, plus three approaches that are in the preclinical stage. Zika largely spares U.S. as virus wreaks havoc worldwide 2017-01-03T05:00:00Z Indeed, preclinical research shows that the cells do not integrate into the brain — most die after 12 months. Neuroscience: New nerves for old : Nature : Nature Research 2016-12-06T05:00:00Z What is the likelihood of observing the preclinical results? Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z The efficiencies gained by this change should more than overcome the resources needed to conduct a preclinical trial. No publication without confirmation 2017-02-21T05:00:00Z Cellular PrP has been validated as a therapeutic target and passive immunization with anti-PrP monoclonal antibodies has provided a preclinical proof of principle, although it will be challenging to achieve therapeutic concentrations in the brain. Mammalian prions and their wider relevance in neurodegenerative diseases : Nature : Nature Research 2016-11-08T05:00:00Z “Yet despite the available preclinical and clinical evidence, creatine failed to slow the clinical progression of Parkinson disease as measured ... in the long-term clinical trial.” Two hundred steps : Nature : Nature Research 2016-10-25T04:00:00Z Institutes can strike much better deals if they hold onto the intellectual property throughout the preclinical development stage so they can ensure investors that their compound has already passed numerous hurdles. Two major California research institutes will merge 2016-10-21T04:00:00Z Both preclinical studies showed only “moderate” positive effects. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z If they cut corners, cherry-pick data or eschew blinding in their experiments, they harm their chances of their hypothesis surviving the rigorous testing proposed in a preclinical trial. No publication without confirmation 2017-02-21T05:00:00Z Such studies are fast and can quickly reveal promising treatments, but the conditions are so dissimilar from those in the human body that most of the preclinical successes don't work in people. How Treating Cancer in Canines Is Advancing Human Medicine 2016-10-06T04:00:00Z The changes follow on other new NIH review standards to improve the rigor and reproducibility of NIH-funded preclinical research. NIH aims to beef up clinical trial design as part of new data sharing rules 2016-09-16T04:00:00Z The startup will then carry out additional preclinical work to come up with an actual drug candidate. Two major California research institutes will merge 2016-10-21T04:00:00Z What is the likelihood of observing the preclinical results? Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z In this example, it is assumed that 250 potential therapies went through preclinical testing. No publication without confirmation 2017-02-21T05:00:00Z A few years ago, two pharmaceutical companies reported that they could not replicate the vast majority of academic findings in preclinical experiments. Mouse microbes may make scientific studies harder to replicate 2016-08-16T04:00:00Z “But additionally, there are anecdotal patient reports, increasing numbers of legitimate clinical case studies, and large amounts of preclinical studies that all indicate tumor-fighting activities of cannabinoids, and with great mechanistic detail.” 7 Scientific Effects of Marijuana That Experts Want to Study 2016-08-11T04:00:00Z CARB-X aims to provide necessary funding for research and development and technical assistance to move products from proof of concept through preclinical development. Major global partnership to speed antibiotic development launched 2016-07-28T04:00:00Z One would be to convene a National Academy of Sciences panel to advise on how best to harness preclinical evidence to evaluate clinical potential. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z Our proposed paper would be accepted by journals only if it included a ‘preclinical trial’ following best clinical-research practices. No publication without confirmation 2017-02-21T05:00:00Z The goal is to coach nascent companies through preclinical lab research and up to the point of registering their products with the Food and Drug Administration so that clinical trials can begin. Millions Injected Into Push for New Antibiotics It will support preclinical research projects around the world. Antibiotics funding hike gets mixed reception 2016-07-27T04:00:00Z Pain researchers' arguments for using only male rodents in preclinical pain research don't hold up to scrutiny, says Jeffrey S. Mogil. Perspective: Equality need not be painful : Nature : Nature Publishing Group 2016-07-12T04:00:00Z Second, FIH trials should proceed only after careful vetting of the preclinical evidence by people with the appropriate expertise who are independent of the drug sponsor. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z Unlike clinical studies, most preclinical research papers describe a long chain of experiments, all incrementally building support for the same hypothesis. No publication without confirmation 2017-02-21T05:00:00Z Representative preclinical models are needed for testing whether causal relationships exist between these and other environmental factors and community states. A microbial perspective of human developmental biology : Nature : Nature Publishing Group 2016-07-05T04:00:00Z The Paris-based company is also conducting preclinical studies on a vaccine that is based on a technology it used to develop treatments against dengue and Japanese encephalitis. Sanofi Teams Up With U.S. Army on Zika Vaccine 2016-07-06T04:00:00Z Critics point to decades of preclinical and clinical work with stem cells and the pipelines of stem-cell treatments. FDA should stand firm on stem-cell treatments 2016-07-04T04:00:00Z However, we are not arguing that the preclinical evidence must be strong, rather that it be examined critically to inform ethical judgement. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z These would be more formal and rigorous than the typical preclinical testing conducted in academic labs, and would adopt many practices of a clinical trial. No publication without confirmation 2017-02-21T05:00:00Z That is, that it supports an expectation, for example that ‘reproducible’ preclinical results are those worth taking forward to clinical trials. Muddled meanings hamper efforts to fix reproducibility crisis 2016-06-13T04:00:00Z Irreproducible results and the incomplete reporting of findings from preclinical studies are of particular concern for emerging interventions involving the transfer of living human cells. Policy: Global standards for stem-cell research 2016-05-11T04:00:00Z Cells, not bodies, entered this preclinical trial, and the results will guide her future treatment. The Improvisational Oncologist 2016-05-12T04:00:00Z Today, the evaluation of preclinical evidence is especially important. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z However, the participants with preclinical Alzheimer's eventually overcame this map-learning deficit, and performed nearly as well as the control group in later testing. Trouble With Sense of Direction May Be Linked to Early Alzheimer's: Study 2016-04-26T04:00:00Z The muddle is hampering communication about the problem and efforts to address it, a meeting last week on improving the reproducibility of preclinical research was told. Muddled meanings hamper efforts to fix reproducibility crisis 2016-06-13T04:00:00Z But extracting the most from these combinations will require more well-designed preclinical studies to support the human ones. Cocktails for cancer with a measure of immunotherapy 2016-04-12T04:00:00Z “Speculative trading in preclinical biotechs is nothing new, but Editas’ extreme volatility is further fueled by a deceptively low float.” U.S. stocks are finally back in the black. Here’s why investors aren’t in the clear. 2016-03-18T04:00:00Z Across medical science, preclinical studies are plagued by poor design, implementation and reporting2. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z Recognizing the problem, the US National Institutes of Health said in 2014 that it would require researchers to report their plans for the balance of male and female animals in preclinical studies. Scientists still fail to record age and sex of lab mice 2016-03-02T05:00:00Z Scientists who are concerned about the irreproducibility of preclinical research say that they welcome the initiative — but are not sure whether it will gain traction. Biotech giant publishes failures to confirm high-profile science 2016-02-03T05:00:00Z In its statement, released on 22 January, the RSS called for the publication of the ‘investigator brochure’, which details the preclinical studies that led up to the trial. Researchers question design of fatal French clinical trial 2016-01-21T05:00:00Z In most countries, medical students receive their medical degree — and ‘Dr’ title — after successfully completing both preclinical undergraduate studies and clinical training, and then passing a state examination. Ills of the system 2015-11-03T05:00:00Z Several investigations suggest that the magnitude of effects seen in many preclinical studies are not reproducible3, or do not reflect intended clinical scenarios4. Consider drug efficacy before first-in-human trials 2017-01-29T05:00:00Z Additionally, data can be gathered from in vivo pharmacokinetic or other functional studies, in vitro functional studies, and preclinical and clinical studies that link pharmacological effects or drug concentrations to genetic variation. Pharmacogenomics in the clinic : Nature : Nature Publishing Group 2015-10-13T04:00:00Z The company said on Tuesday its decision to release preclinical data from more than 50 of its medicines was unprecedented in scale and would help accelerate the hunt for synergistic tumor-fighting drug combinations. AstraZeneca taps crowd sourcing to find cancer drug cocktails 2015-09-22T04:00:00Z On average, only one in every 5,000 compounds that drug companies discover and put through preclinical testing becomes an approved drug. The Solution to Drug Prices 2015-09-09T04:00:00Z The same is true of preclinical animal work. Remote Control Biology 2015-07-29T04:00:00Z It is now generating grams of the drug using a fermenter, doing extensive preclinical testing of this and other drug candidates, and seeking more leads from uncultivated microbes in soil and marine samples. Mining the microbial dark matter 2015-06-15T04:00:00Z It is no wonder that many preclinical studies performed using mice are not reproducible1. Reproducibility: Use mouse biobanks or lose them 2015-06-09T04:00:00Z Microbiologist Ferric Fang of the University of Washington, Seattle, questions whether it is possible to extrapolate from a few previous studies on reproducibility and conclude that 50% of preclinical research can’t be reproduced. Study claims $28 billion a year spent on irreproducible biomedical research 2015-06-09T04:00:00Z There is also uncertainty around what kinds of experiment count as preclinical research. US societies push back against NIH reproducibility guidelines 2015-04-16T04:00:00Z The effects that researchers are looking for in these preclinical studies are often subtle, and ‘power calculations’ are needed to reveal the number of animals needed to show an effect. UK funders demand strong statistics for animal studies 2015-04-14T04:00:00Z However, turning such compounds into usable drugs will require a lot of preclinical work, says Wright. Mining the microbial dark matter 2015-06-15T04:00:00Z The company had exciting preclinical data on head and neck tumours and was eager to move the drug forward. Biotech boot camp 2015-03-24T04:00:00Z “This preclinical data is extremely exciting,” he says. Banned weight-loss drug could combat liver disease, diabetes 2015-02-26T05:00:00Z That is why drug trials are looking to recruit seniors with preclinical Alzheimer’s who are on the verge of decline but otherwise look healthy. Catching Alzheimer’s before Memory Slips 2015-02-12T05:00:00Z The fund also sees the challenge program as extending its current efforts, which support preclinical and clinical work on promising drugs for neglected diseases using Japanese resources and capabilities. Japanese foundation joins the public health Grand Challenge bandwagon 2015-02-04T05:00:00Z Additional studies in the U.S. will evaluate the tool alongside PET and other measures for preclinical Alzheimer's. Eye-Tracking Test Enters into the Running for an Alzheimer’s Screen 2015-01-31T05:00:00Z There will be two years of preclinical and three years of clinical trials. Antibiotics Gain Resistance, Researchers Fight Back 2015-01-26T05:00:00Z In 2013, preclinical trials of the drug on heroin-addicted rats showed those vaccinated didn’t relapse into addiction and were not hooked by high amounts of heroin in their system. Why You've Never Heard of the Vaccine for Heroin Addiction 2015-01-09T05:00:00Z This step of the medical licensing exam is often taken by students after completing their preclinical years. Navigate Transferring From One Medical School to Another 2015-01-08T05:00:00Z The first two years of medical school, the preclinical years, teach students about disease in the abstract, as testable material. A medical student develops an illness she has been studying 2014-12-12T05:00:00Z "The preclinical data on progesterone's neuroprotective effects are compelling, but we were not able to translate them to a multi-center clinical trial with human traumatic brain injury," he added. Hormone Treatment for Brain Injury Fails to Meet Expectations 2014-12-10T05:00:00Z The CRO industry started in the early 1980s in the United States with an initial focus on preclinical and clinical development. MedidataVoice: The Rise Of R&D Capability And Technology Platforms In China 2014-12-02T05:00:00Z We opened Innovation Centers in London, California and Boston and we entered into many exciting collaborations to advance early stage, preclinical proof-of-concept programs. MedidataVoice: J&J Is On The Hunt For Chinese Innovation 2014-11-18T05:00:00Z For women with preclinical rheumatoid arthritis, the odds of a premature delivery were 1.3 times higher. Rheumatoid Arthritis in Moms-to-Be Linked to Premature Births 2014-11-13T05:00:00Z But preclinical research into different Ebola vaccines, in part funded by NIAID, continued apace. Fauci and Collins agree to agree on Ebola vaccine development and NIH funding 2014-10-20T04:00:00Z This represents an important step to remove existing gender bias in both preclinical and clinical trials. The Reality of Heart Disease: A Wake-Up Call For Women 2014-09-29T04:00:00Z National Institutes of Health is investing $10 million in additional funding in scientific trials to encourage researchers to consider gender in their preclinical and clinical studies. NIH Adds $10M to Encourage Gender Balance in Clinical Trials 2014-09-23T04:00:00Z Other projects are focused on preclinical studies of nerve degeneration. Global initiative targets progressive multiple sclerosis 2014-09-16T04:00:00Z The researchers also linked slightly lower birth weights to infants born to mothers with either diagnosed or preclinical disease than those born to mothers without the illness. Rheumatoid Arthritis in Moms-to-Be Linked to Premature Births 2014-11-13T05:00:00Z The Journal described Krieg as “heavily involved in helping prepare preclinical data for submission to the FDA in support of approval for eteplirsen.” Stop Squabbling, Mom Tells Troubled Biotech: 'Just Get My Kid the Drug' 2014-07-28T04:00:00Z Together, preclinical and clinical researchers must develop meaningful endpoints for human trials. Medical research: Treat ageing 2014-07-22T04:00:00Z The therapy needs more preclinical work before it would be even close to ready for human trials. Efforts aimed at slowing the aging process have produced some promising results The project is planning to start preclinical testing in 2015 and reach the market in 2018, but there are still many questions to be answered, including security issues. The Gates Foundation is developing a remote-control contraceptive 2014-07-07T04:00:00Z If the prevention trials fail, it will be up to academics to persuade companies back to the table with solid preclinical and early clinical data, says Mucke. Alzheimer's disease: The forgetting gene 2014-06-03T04:00:00Z But preclinical research continues to include a majority of male animals and tissues. New federal rules will force scientists to use more female lab animals 2014-05-14T04:00:00Z In April 2013, a $50-million donation quintupled the size of Harvard’s preclinical programme, which aims to turn a profit and invest that in more grants. Universities seek to boost industry partnerships 2014-05-07T17:20:19.738Z The present study showed similarities in the remodeling characteristics of xenogeneic ECM scaffolds when used as a surgical treatment for volumetric muscle loss in both a preclinical rodent model and five male patients. [Research Articles] An Acellular Biologic Scaffold Promotes Skeletal Muscle Formation in Mice and Humans with Volumetric Muscle Loss 2014-04-30T18:55:14.141Z Human embryos created for research by nuclear transfer might aid preclinical assessment. Policy: Regulate embryos made for research 2014-04-30T17:20:33.448Z Researchers and industry representatives will discuss preclinical research and emerging therapeutic targets, as well as partnerships, funding and licensing issues. Seven days: 4–10 April 2014 2014-04-09T17:20:15.453Z Despite this, there exist numerous pitfalls when translating preclinical data into the clinic. [Research Articles] Integrative Biology Approach Identifies Cytokine Targeting Strategies for Psoriasis 2014-02-12T19:25:12.939Z Instead, in 2012, he turned to a Harvard programme that supports preclinical research. Universities seek to boost industry partnerships 2014-05-07T17:20:19.738Z If the antecedent work is questionable and the trial is particularly important, key preclinical studies may first need to be validated independently. Policy: NIH plans to enhance reproducibility 2014-01-29T18:51:22.011Z Recently, the scientific community was shaken by reports that a troubling proportion of peer-reviewed preclinical studies are not reproducible. [Editorial] Reproducibility 2014-01-16T18:55:01.337Z The foundation also sponsors $10,000 prizes for scientists who develop useful preclinical models. Disease research: Rare insights 2014-01-15T18:21:24.574Z These reports highlight the need to distinguish between different classes of therapeutic that target the same pathway and emphasize the importance of accurate preclinical modelling of clinical dosing regimens. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z These trials might only be necessary when warranted by clinical or preclinical problems. Cardiovascular Outcome Studies in Diabetes Drugs Finally Arrive 2013-09-02T06:02:00Z Agency officials are also considering a requirement that independent labs validate the results of important preclinical studies as a condition of receiving grant funding. NIH mulls rules for validating key results 2013-07-31T17:20:16.890Z These companies consist of as few as one full-time employee who oversees a drug from preclinical development to tests in patients, all in the hands of outside contractors. Biotechnology: Virtual reality 2013-06-05T17:20:36.817Z If I had unlimited resources, however, I would quickly complete the last preclinical studies necessary to enter phase I clinical trials with our most promising compounds. 30 under 30: Fighting Cancer with Metal-Based Drugs 2013-06-01T11:45:00.160Z As is the case for the Hedgehog signalling pathway in which extensive preclinical data showed increased expression of Hedgehog ligands in many tumour types. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z The authors suggest that low LDL cholesterol may be a marker for preclinical cancer. Mouthwash as an acne treatment 2013-05-23T00:38:07Z The potential “off-label” use of this drug for AD treatment needs to be tempered by compelling and reproducible preclinical data. [Technical Comment] Comment on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” 2013-05-23T18:25:20.267Z Same with a “Series B” into a drug discovery platform company whose lead asset is in preclinical – most observers would call that an early stage company. Debunking Myths About Biotech Venture Capital 2013-05-22T13:50:21Z Nearly 80 of those are still in drug discovery and preclinical testing. Immunokinase Drug Candidates: $12B in Value Creation and Counting 2013-03-13T20:18:16Z This highlights the impact of preclinical model choice on experimental outcome. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Even once they find that lead compound, he added, “all the safety trials, in vitro trials and small animal trials, all that preclinical work, usually takes eight to ten years.” Researchers Home in on Biological Ways to Restore Hearing [Excerpt] 2013-02-15T11:15:03.257Z Although many human cancers are located in mucosal sites, most cancer vaccines are tested against subcutaneous tumors in preclinical models. [Research Articles] Mucosal Imprinting of Vaccine-Induced CD8+ T Cells Is Crucial to Inhibit the Growth of Mucosal Tumors 2013-02-13T19:25:06.490Z For example, the first preclinical compounds developed from structure-based drug design have recently been described for A2AR as candidates for the treatment of Parkinson’s disease. Molecular signatures of G-protein-coupled receptors 2013-02-13T18:21:29.900Z We think there are plenty of targets to get excited about in the field of immunokinase modulation, many with strong preclinical rationale and compelling human genetic linkages despite lacking clinical-stage pharmacologic validation. Immunokinase Drug Candidates: $12B in Value Creation and Counting 2013-03-13T20:18:16Z Looking ahead, the preclinical evaluation of combination therapies that target multiple tumour components will require the incorporation of several types of preclinical system and most likely the development of complex genetically engineered models. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z It is one of 16 vaccines being studied in human clinical trials and the study results will inform the design of more than 50 vaccines being tested in preclinical trials in animals. Insight: Revived search for a TB vaccine may be about to pay off 2013-02-01T10:32:10Z After preclinical testing in a caprine model, a pilot clinical study was initiated where the biomaterials system was combined with standard microfracture surgery in 15 patients with focal cartilage defects on the medial femoral condyle. [Research Articles] Human Cartilage Repair with a Photoreactive Adhesive-Hydrogel Composite 2013-01-09T19:55:10.827Z The earliest stage is preclinical Alzheimer’s - asymptomatic people who have silent build-up of plaques or brain shrinkage or have genetic mutations. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z Five active programs exist, according to Thomson Pharma, and they are all in drug discovery or preclinical studies. Immunokinase Drug Candidates: $12B in Value Creation and Counting 2013-03-13T20:18:16Z Moreover, assessing efficacy preclinically when targeting multiple compartments of the tumour is further complicated by the absence of distinct tumour compartments in some preclinical model systems. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z This raised concerns about the predictive validity of preclinical studies in animals for outcomes in human stroke trials. [Research Articles] A Translational Paradigm for the Preclinical Evaluation of the Stroke Neuroprotectant Tat-NR2B9c in Gyrencephalic Nonhuman Primates 2012-10-03T19:25:05.300Z The winners, to be announced in June 2013, will have to provide preclinical evidence of the biological rationale for the compound’s new use. New cures sought from old drugs 2012-10-03T18:21:20.430Z If some 30 percent of cognitively normal elderly show silent plaque buildup, that would imply that more than 100 million people worldwide may meet criteria for preclinical Azheimer’s. Ask an Expert: Answers About Alzheimer’s, Part 2 2012-11-16T11:00:00Z A. Most often, it is the earliest, preclinical stage of dementia. The New Old Age Blog: Coping With Mild Cognitive Impairment 2012-09-10T10:50:30Z Such limitations mean that no single model will be sufficient for comprehensive preclinical evaluation. Influence of tumour micro-environment heterogeneity on therapeutic response 2013-09-18T17:22:26.223Z Success of the recombinant subunit vaccine in nonhuman primates provides crucial data in supporting its further preclinical development for potential human use. [Research Articles] A Hendra Virus G Glycoprotein Subunit Vaccine Protects African Green Monkeys from Nipah Virus Challenge 2012-08-08T18:55:10.530Z All were taken through preclinical testing and into early human trials at a cost of millions of dollars, and all were found to be safe. New cures sought from old drugs 2012-10-03T18:21:20.430Z Here, we discuss preclinical DBS research that provides insight into the mechanisms underlying cognitive and psychiatric applications of this technique, emphasizing the predictive validity of animal models and their potential use in translational research. [Reviews] Deep Brain Stimulation for Psychiatric Disease: Contributions and Validity of Animal Models 2012-07-11T18:55:01.370Z These findings suggest new preclinical and clinical scheduling and treatment combination strategies to enhance in vivo immune evasion and effective intravenous delivery of oncolytic viruses to patients in vivo. [Research Articles] Cell Carriage, Delivery, and Selective Replication of an Oncolytic Virus in Tumor in Patients 2012-06-13T18:55:08.080Z But drug development is hard, and it has taken years for companies to find promising compounds and take them through the phases of preclinical testing. An Alzheimer’s Gene: One Family’s Saga 2012-06-07T13:48:08Z Drug development is hampered by the lack of preclinical models with therapeutic predictive value. [Research Articles] A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma 2012-06-06T19:25:13.100Z In addition, E4 significantly reduced existing fibrosis in these preclinical models. [Research Articles] A Peptide Derived from Endostatin Ameliorates Organ Fibrosis 2012-05-30T18:55:09.437Z This design must incorporate preclinical and clinical data in a rational manner and measure end points that are appropriate for metastasis prevention. Perspective: The right trials 2012-05-30T17:51:10.087Z Finally, there is preclinical evidence that IL-1 blockade is more effective at preserving insulin secretion when the glucose drive is high. Perspective: Testing failures 2012-05-22T15:21:18.330Z Simultaneously, the country’s biggest biomedical charity, the Wellcome Trust, said that it would fund preclinical experiments to gauge the safety of the techniques. UK sets sights on gene therapy in eggs 2012-01-25T18:50:18.833Z The division of preclinical innovation is largely intramural. Acting Director Thomas Insel Explains New NIH Translational Center's Aims and Structure 2012-01-10T15:53:30Z Klumpp says the Roche is supporting research into new therapies targeting viral replication as well as other mechanisms, but notes that these efforts are preclinical. Drugs: Lines of defence 2011-12-07T18:21:00.377Z The foundation also is collaborating with Novartis, based in Basel, Switzerland, on a separate program to develop drugs for SMA, also at the preclinical stage. Roche Enters Race to Cure Genetic Disease With $490 Million Deal 2011-11-30T10:44:47Z "Certainly there is substantial preclinical and clinical literature arguing that early life stress negatively impacts brain development and future social and cognitive interactions," she says. Surety Bond: Breast-Feeding May Increase Children's IQ 2011-11-16T20:45:00.300Z Here, we optimized these compounds for oral bioavailability and demonstrated their fast-acting efficacy in treating chronic urinary tract infections in a preclinical murine model. [Research Articles] Treatment and Prevention of Urinary Tract Infection with Orally Active FimH Inhibitors 2011-11-16T19:55:21.817Z A division of preclinical innovation will house a $44 million set of mostly intramural programs, including small-molecule screening and drug development for rare diseases. Acting Director Thomas Insel Explains New NIH Translational Center's Aims and Structure 2012-01-10T15:53:30Z Our preclinical studies suggest that several agents are candidates for intraductal therapy. [Research Articles] Preclinical and Clinical Evaluation of Intraductally Administered Agents in Early Breast Cancer 2011-10-26T19:55:10.567Z These preclinical findings provide proof of concept that Forteo may be useful for decelerating cartilage degeneration and inducing matrix regeneration in patients with osteoarthritis. [Research Articles] Teriparatide as a Chondroregenerative Therapy for Injury-Induced Osteoarthritis 2011-09-21T18:55:07.393Z Caliper products include DNA sequencing equipment, reagents and microfluids used gene and protein detection, preclinical imaging instruments and automated laboratory equipment. UPDATE 2-PerkinElmer to buy Caliper for $600 mln 2011-09-08T11:38:20Z Thus, HAC-mediated gene transfer shows efficacy in a preclinical model of DMD and offers potential for future clinical translation. [Research Articles] Stem Cell-Mediated Transfer of a Human Artificial Chromosome Ameliorates Muscular Dystrophy 2011-08-17T20:55:11.047Z This Commentary explores the need for standards in evaluating therapeutic efficacy in preclinical models of T1D. [Commentary] Evaluating Preclinical Efficacy 2011-08-17T20:55:02.090Z They also added a new research category called preclinical Alzheimer's, the earliest stage of the disease when clumps of amyloid start to form in the brains of people who are otherwise healthy. Special report: With Alzheimer's in the genes, when do you test? 2011-07-20T08:39:01Z "This is really the first study that tests for falls in the preclinical phases of Alzheimer's disease," Stark said. Falls, eye tests may detect early Alzheimer's 2011-07-17T15:01:13Z I believe that cooperation between public and private organizations in the preclinical arena — equivalent to ADNI's clinical role — will ease the transition from preclinical to clinical work. Perspective: In search of biomarkers 2011-07-13T17:20:53.713Z Because the controls were age-matched, the two with high antibody levels might have preclinical disease, Kodadek says, in much the same way that amyloid plaques emerge well before cognitive symptoms. Biomarkers: Warning signs 2011-07-13T17:20:51.947Z When he was at Pfizer, only about 15 percent of the research budget went to the preclinical work of discovering new medicines. Research cuts may haunt Pfizer, ex-R&D chief says 2011-07-05T18:56:29Z In preclinical studies, significantly fewer vaccinated animals exhibited chronic infection relative to unvaccinated controls after exposure to HCV. Vaccines: A moving target 2011-06-13T13:20:41.413Z Their preclinical studies on pigs suggest that it causes far less damage. Turning to Biomechanics to Build a Kinder, Gentler Rib Spreader 2011-05-16T22:14:23Z This preclinical stage about 10 years before dementia sets in is seen as the best place to intervene in the disease. New Alzheimer's guidelines view disease in stages 2011-04-19T04:35:02Z Differences between animal and human liver activity often result in under-reported human toxicities in preclinical animal testing of drug compounds. 2011 Lemelson M.I.T. Student Inventor Prizes Offer a Glimpse of the Future in Medical and Security Screening Tech [Slide Show] 2011-03-10T01:45:00.530Z There's an argument for drinking to loosen up social behaviors, said Selena Bartlett, director of the preclinical development group at the Ernest Gallo Clinic and Research Center at the University of California at San Francisco. More health reports support moderate drinking 2010-12-29T21:07:04Z The company said it would undertake several studies, which mostly do not involve humans, to confirm that cancer signs in preclinical rat data do not translate into risks for humans. Arena eyes obesity drug refiling by end of 2011 2010-12-22T22:49:46Z The clinical hold was not due to issues related to the planned trial design or its clinical and preclinical findings, the company said in a statement. Helix says FDA puts its cancer drug on clinical hold 2010-11-19T23:28:00Z Lower down the market drug discovery group Summit rose 15% to 2.875p after positive half year results and upbeat preclinical trial results. Standard Chartered adds 2% on bid talk, but FTSE dips on economic worries 2010-10-12T16:06:00Z LifeServe's prototype, developed from the founders' university research and now in preclinical testing, is a medical device meant to help minimally trained care providers open patients' airways in emergency situations. America's Best Young Entrepreneurs 2010 2010-09-23T20:05:00Z "I'm not interested in a gleam in someone's eye, in early preclinical stage assets," he said. Amgen eyes deals, international expansion 2010-09-22T17:10:00Z Contract research organizations that focus on preclinical and early-stage development are yet to see a recovery as smaller firms, which are most active in early drug development, stay cautious on spending. UPDATE 2-Charles River Q2 below Wall Street, shares fall 2010-08-02T17:52:00Z Higher cash flow and increased earnings do appear to be on the horizon, if there is a cyclical upturn in preclinical services, a key business to Charles River. Lessons from the End of the Charles River Deal 2010-07-30T19:40:00Z The new guidelines include criteria for three stages of the disease: preclinical disease, mild cognitive impairment due to Alzheimer’s disease and, lastly, Alzheimer’s dementia. Rules Seek to Expand Diagnosis of Alzheimer?s 2010-07-14T01:39:00Z Carmat, a medical start-up backed by the European Aeronautic Defense and Space company, is in the final stages of preclinical testing of its total artificial heart for patients with end-stage heart failure. French Company Promotes Its Artificial Heart Technology 2010-07-13T23:41:00Z The Gates Foundation is providing a $1.5 million grant to DNDi for preclinical assessments of compounds specifically for use against visceral leishmaniasis, a deadly parasitic infection spread by the bite of a sandfly. Anti-TB compounds could fight neglected diseases 2010-07-07T10:20:00Z Sales of the preclinical segment fell 12 percent to $125 million. UPDATE 2-Charles River Q2 below Wall Street, shares fall 2010-08-02T17:52:00Z Sanofi and Regulus will collaborate on microRNA drug discovery and preclinical development for an initial four targets, including the lead fibrosis programme. UPDATE 1-Sanofi signs up to $750 mln drug deal with Regulus 2010-06-22T06:30:00Z Osorio runs a laboratory in Madison for preclinical animal trials of all the company's vaccines. Case Study: Attempting a Global Merger 2010-05-01T16:00:00Z In total, the alliance could be valued at over $750 million when taking into account upfront payments, equity investment, research funding, and potential preclinical, clinical and commercial milestone payments for multiple products. UPDATE 1-Sanofi signs up to $750 mln drug deal with Regulus 2010-06-22T06:30:00Z |
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