| 单词 | plasmid |
| 例句 | Others returned to a practice of smuggling plasmids, circular molecules of DNA used to manipulate genes, from abroad after Addgene, the U.S. nonprofit plasmid repository and distributor, stopped shipping to Russia. Scientists in Russia struggle in a world transformed by its war with Ukraine 2023-11-09T05:00:00Z The ETH researchers have become the first to show that the cell nucleus weeds out such DNA rings and deposits them, together with the plasmids coming from outside the cell, in the cell plasma. A hygiene program for chromosomes 2023-10-02T04:00:00Z They identified the presence of a new plasmid -- a small, circular DNA molecule -- in all epidemic V. cholerae samples tested since November 2018. Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered 2023-09-29T04:00:00Z The DNA transferred can be in the form of a plasmid, a small circular piece of extrachromosomal DNA, or as a hybrid, containing both plasmid and chromosomal DNA. Fundamentals of Biology 2015-01-01T00:00:00Z In cloning, the plasmid molecules can be used to provide a "vehicle" in which to insert a desired DNA fragment. Concepts of Biology 2013-04-25T00:00:00Z And even when all systems function as intended, disinfection does not destroy DNA in a way that renders antibiotic resistance genes benign because they can exist outside cells, as in plasmids, Smith said. Discovery of antibiotic-resistant superbugs in L.A. wastewater sparks worry 2023-04-10T04:00:00Z The ETH cell biologist and her team now plan to unravel the mysteries of the exclusome by examining cellular changes at the plasmid DNA as well as the "licence" for depositing plasmids into the exclusome. A hygiene program for chromosomes 2023-10-02T04:00:00Z This plasmid introduced genes encoding resistance to multiple clinically used antibiotics, including macrolides. Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered 2023-09-29T04:00:00Z Alternatively, many genes responsible for drug resistance are found on plasmids or in transposons that can be transferred easily between microbes of different species through horizontal gene transfer. Fundamentals of Biology 2015-01-01T00:00:00Z A valuable characteristic of plasmid vectors is the ease with which a foreign DNA fragment can be introduced. Concepts of Biology 2013-04-25T00:00:00Z Bacteria are also vulnerable to rogue DNA strands known as plasmids that coerce the cells into copying them. CRISPR is so popular even viruses may use it 2022-11-23T05:00:00Z It is made up of DNA rings known as plasmids. A hygiene program for chromosomes 2023-10-02T04:00:00Z The researchers also found the multidrug-resistant plasmid in local, endemic V. cholerae strains not associated with the cholera disease itself, suggesting these different strains were able to exchange plasmids with antibiotic-resistance capabilities. Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered 2023-09-29T04:00:00Z A similar process occurs in bacteria that have plasmids. Fundamentals of Biology 2015-01-01T00:00:00Z These plasmid vectors contain many short DNA sequences that can be cut with different commonly available restriction enzymes. Concepts of Biology 2013-04-25T00:00:00Z The scientists found that chromosomes and plasmids, which carry genetic information, in the microbe’s cells are linked together, which keeps these structures aligned and prevents irradiated cells from breaking down until they can be repaired. Earthly Microbes Might Survive on Mars for Hundreds of Millions of Years 2022-10-27T04:00:00Z Some of the plasmids that end up in the exclusome originate from outside the cell, while others -- known as telomeric rings -- come from the capped ends of chromosomes, the telomeres. A hygiene program for chromosomes 2023-10-02T04:00:00Z The plasmid's stability in V. cholerae defies usual mechanisms that would have eliminated it. Genes fuelling antibiotic resistance in Yemen cholera outbreak uncovered 2023-09-29T04:00:00Z Transposons also have the ability to move resistance genes between plasmids and chromosomes to further promote the spread of resistance. Fundamentals of Biology 2015-01-01T00:00:00Z In molecular cloning with bacteria, a desired DNA fragment is inserted into a bacterial plasmid using restriction enzymes and the plasmid is taken up by a bacterium, which will then express the foreign DNA. Concepts of Biology 2013-04-25T00:00:00Z But a universal genetic code leaves cells vulnerable to interlopers such as viruses and plasmids, DNA snippets that reproduce inside bacteria and can ferry genes among them. Rewritten genetic code allows bacteria to fend off viral attacks 2022-10-19T04:00:00Z Why plasmids get wrapped up in an incomplete membrane envelope remains unclear. A hygiene program for chromosomes 2023-10-02T04:00:00Z Not all recombinant plasmids are capable of expressing genes. Biology for AP Courses 2022-06-09T00:00:00Z They don’t do this by changing the phage genome itself, but by adding to the soup DNA loops called plasmids that are independently translated to create modified phage proteins. There’s now a cleaner, better way to create viruses that kill antibiotic-resistant bacteria 2022-07-19T04:00:00Z To get the DNA fragment into a bacterial cell in a form that will be copied or expressed, the fragment is first inserted into a plasmid. Concepts of Biology 2013-04-25T00:00:00Z They also showed that although the improved Syn61Δ3 cells could exchange a plasmid engineered to use their modified genetic code, they could not share the plasmid with other bacteria. Rewritten genetic code allows bacteria to fend off viral attacks 2022-10-19T04:00:00Z Ring-shaped DNA from outside and self-made plasmids with the sequence from chromosome ends appear to lack the required characteristic. A hygiene program for chromosomes 2023-10-02T04:00:00Z DNA from the Ti plasmid integrates into the infected plant cell’s genome. Biology for AP Courses 2022-06-09T00:00:00Z Some bacteria contain small circular DNA molecules known as plasmids, which are widely used in recombinant DNA studies. Miller & Levine Biology 2018-01-01T00:00:00Z Modified plasmids are usually reintroduced into a bacterial host for replication. Concepts of Biology 2013-04-25T00:00:00Z The modified microbe could safely synthesize its own proteins but was resistant to several kinds of viruses and plasmids. Rewritten genetic code allows bacteria to fend off viral attacks 2022-10-19T04:00:00Z For mRNA vaccine makers planning variant-ready vaccines, development begins with simply changing the sequence of plasmid DNA present in bacteria. These Vaccines May Be Ready to Take On New COVID Variants 2022-02-25T05:00:00Z Researchers manipulate the Ti plasmids to remove the tumor-causing genes and insert the desired DNA fragment for transfer into the plant genome. Biology for AP Courses 2022-06-09T00:00:00Z Plasmid DNA contains a signal for replication, but it also has a genetic marker that makes it possible to distinguish bacteria that carry the plasmid from those that don’t. Miller & Levine Biology 2018-01-01T00:00:00Z Genes are inserted into plants, using plasmids in the bacterium Agrobacterium tumefaciens, which infects plants. Concepts of Biology 2013-04-25T00:00:00Z They sequenced the genes for 30 of these enzymes and inserted combinations of them into C. auto via gene-delivery vehicles called plasmids. Microbes convert industrial waste gases into commodity chemicals 2022-02-21T05:00:00Z The in vitro transcription step from the plasmid DNA encoding the antigen into mRNA molecules remains unchanged. These Vaccines May Be Ready to Take On New COVID Variants 2022-02-25T05:00:00Z The Ti plasmids carry antibiotic resistance genes to aid selection and can be propagated in E. coli cells as well. Biology for AP Courses 2022-06-09T00:00:00Z Using plasmids, recombinant DNA technology has been used to transform a bacterial cell so that it can manufacture human growth hormones. Miller & Levine Biology 2018-01-01T00:00:00Z In nature, the disease-causing A. tumefaciens have a set of plasmids that contain genes that integrate into the infected plant cell’s genome. Concepts of Biology 2013-04-25T00:00:00Z In a new study detailed in Nature Communications, the researchers spurred E. coli to manufacture titin by introducing a circular strand of engineered DNA instructions called a plasmid. Bacterial Builders Churn Out Lengthy Muscle Proteins 2021-12-31T05:00:00Z The company’s novel synthetic "doggybone" vector has potential advantages over plasmid DNA manufacturing because, unlike plasmids, it can contain and transfer long stretches of DNA containing the gene of interest. These Vaccines May Be Ready to Take On New COVID Variants 2022-02-25T05:00:00Z On the other hand, transformation is often assayed by incorporating an antibiotic-resistance gene in the plasmid to be transferred into the host organism. Biology for AP Courses 2022-06-09T00:00:00Z Plant cells can be transformed using different methods: inserting a bacterium that contains a small DNA tumor-producing plasmid, removing plant cell walls, or injecting DNA directly into the cell. Miller & Levine Biology 2018-01-01T00:00:00Z Researchers manipulate the plasmids to carry the desired DNA fragment and insert it into the plant genome. Concepts of Biology 2013-04-25T00:00:00Z If a plasmid instructs E. coli to build the whole protein at once, the bacterium will avoid the production burden by removing or truncating the plasmid. Bacterial Builders Churn Out Lengthy Muscle Proteins 2021-12-31T05:00:00Z “The ambition for Touchlight, as a company and a technology, is to supplant plasmid DNA as the predominant source of DNA for advanced therapy manufacture,” says chief business officer Tommy Duncan. These Vaccines May Be Ready to Take On New COVID Variants 2022-02-25T05:00:00Z In cloning, the plasmid molecules can be used to provide a "folder" in which to insert a desired DNA fragment. Biology for AP Courses 2022-06-09T00:00:00Z Small loops called plasmids, for example, exist inside microbes and ferry genes for thwarting antibiotics among different kinds of bacteria. Mysterious DNA sequences, known as ‘Borgs,’ recovered from California mud 2021-07-15T04:00:00Z The DNA transferred is usually a plasmid, but parts of the chromosome can also be moved. Concepts of Biology 2013-04-25T00:00:00Z So the team instead engineered a plasmid that makes E. coli construct shorter protein fragments that are structured to spontaneously link together inside the bacterium. Bacterial Builders Churn Out Lengthy Muscle Proteins 2021-12-31T05:00:00Z But this variant had acquired two circles of DNA, called plasmids, that had turned it into a formidable killer. This wildlife vet tracks deadly microbes in the African jungle. Now, he’s on the trail of COVID-19 2021-01-28T05:00:00Z The foreign DNA and plasmid are cut with the same restriction enzyme and DNA is inserted within the lacZ gene, whose product metabolizes lactose. Biology for AP Courses 2022-06-09T00:00:00Z When researchers added fructose to Escherichia coli cells, gene expression increased in bits of ring-shaped DNA called plasmids. Scientists ‘program’ living bacteria to store data 2021-01-11T05:00:00Z Jerica Pitts, director of Global Media Relations at Pfizer, told Salon by email that the the plasmid DNA for the vaccine antigen is manufactured in the St. Louis site. What does a vaccine factory actually look like? 2020-12-30T05:00:00Z In hindsight, Sonstegard says his team's only mistake was not properly screening for the plasmid to begin with. Biotechnology could change the cattle industry. Will it succeed? 2020-09-06T04:00:00Z But when she and her team returned to work in March, they found that they couldn’t order plasmids and other supplies because companies in the United States were still shut down. Frozen cells and empty cages: researchers struggle to revive stalled experiments after the lockdown 2020-06-04T04:00:00Z The foreign DNA and plasmid are cut with the same restriction enzyme and DNA is inserted within the lacZ gene, whose product metabolizes lactose. Biology for AP Courses 2022-06-09T00:00:00Z They inserted a series of genes into E. coli that enabled the cells to increase plasmid expression in response to an electric voltage. Scientists ‘program’ living bacteria to store data 2021-01-11T05:00:00Z The first is a DNA plasmid, typically a small, hoop-shaped molecule. Genetic Engineering Could Make a COVID-19 Vaccine in Months Rather Than Years 2020-04-29T04:00:00Z The FDA eventually clarified its results, insisting that the study was meant only to publicize the presence of the plasmid, not to suggest the bacterial DNA was necessarily dangerous. Biotechnology could change the cattle industry. Will it succeed? 2020-09-06T04:00:00Z Starting work on a different, but known, virus requires access to key reagents including expression plasmids, antibodies and other tools of the trade. Our Knowledge of Viruses Is Badly Inadequate 2020-04-08T04:00:00Z The DNA transferred can be in the form of a plasmid or as a hybrid, containing both plasmid and chromosomal DNA. Biology for AP Courses 2022-06-09T00:00:00Z To the plasmid the scientists added the encoded instructions for Crispr enzymes that would target Salmonella DNA. Is Crispr the Next Antibiotic? 2019-10-28T04:00:00Z Research shows that RNA vaccines may be better than DNA plasmids at mobilizing the immune system to create antibodies. Genetic Engineering Could Make a COVID-19 Vaccine in Months Rather Than Years 2020-04-29T04:00:00Z First, they codify the cancer-specific mutations into a ring-shaped DNA molecule called a plasmid. Unlocking the potential of vaccines built on messenger RNA 2019-10-15T04:00:00Z In addition, when bacteria were engineered so that Cas13 targeted a messenger RNA encoded by a circular DNA sequence called a plasmid, bacterial growth was impaired2,6. Bacterial dormancy curbs phage epidemics 2019-05-28T04:00:00Z The DNA may remain separate as plasmid DNA or be incorporated into the host genome. Biology for AP Courses 2022-06-09T00:00:00Z The plasmid was then tucked inside E. coli bacteria. Is Crispr the Next Antibiotic? 2019-10-28T04:00:00Z Viruses depend on host cells to replicate, as do other ‘selfish’ genetic elements, such as viroids and plasmids. Classify viruses — the gain is worth the pain 2019-02-19T05:00:00Z The researchers add circles of DNA called plasmids that they have designed to perform a particular function, along with all the machinery needed to make proteins from DNA. How biologists are creating life-like cells from scratch 2018-11-06T05:00:00Z Another study6 used chemical cues from the environment to drive expression of a gene controlling the abundance of a form of circular DNA called a plasmid. CRISPR tool puts RNA on the record 2018-10-02T04:00:00Z Bacteria can exchange these plasmids with other bacteria, sometimes receiving beneficial new genes that the recipient can add to their chromosomal DNA. Biology for AP Courses 2022-06-09T00:00:00Z First, they cut the plasmid using restriction enzymes. What is genetic modification? 2018-08-05T04:00:00Z Landsberger and colleagues infected a bacterial population with phages encoding anti-CRISPR proteins and then introduced a type of circular DNA called a plasmid into the bacteria. Viruses cooperate to defeat bacteria 2018-07-22T04:00:00Z The scientists also took care to edit the bacterium's chromosome, rather than its plasmids. Genetically modified bacteria enlisted in fight against disease 2018-06-20T04:00:00Z His most influential work centered on plasmids, circular DNA molecules inside bacterial cells. Stanley Falkow, microbiologist who studied bacteria and the diseases they cause, dies at 84 2018-05-12T04:00:00Z In addition, prokaryotes often have abundant plasmids, which are shorter circular DNA molecules that may only contain one or a few genes. Biology for AP Courses 2022-06-09T00:00:00Z Similarities in DNA sequences between this plasmid and those of other bacteria suggest that the culprit was probably Escherichia coli, which is commonly found in the human gut. A strain of typhoid could become virtually untreatable 2018-04-26T04:00:00Z Plasmid DNA would normally be targeted by the bacterial immune system, but the earlier phage infection limited this targeting of plasmid DNA, demonstrating that the bacterial cells were in an immunosuppressed state. Viruses cooperate to defeat bacteria 2018-07-22T04:00:00Z “One is that this strain spreads to other regions through migration. But the other is that it pops up elsewhere on its own — plasmids with drug resistance are everywhere.” ‘We’re Out of Options’: Doctors Battle Drug-Resistant Typhoid Outbreak 2018-04-13T04:00:00Z In an experiment testing the efficiency of plasmid introduction into B. subtilis, they found that the presence of one of the defence systems substantially reduced the level of plasmid introduction. A stockpile of antiviral defences 2018-04-15T04:00:00Z The foreign DNA and plasmid are denatured using high heat, and DNA is inserted within the lacZ gene, whose product metabolizes glucose. Biology for AP Courses 2022-06-09T00:00:00Z The genes comprising a potential circuit are then assembled into circular DNA molecules called plasmids. Robotic labs for high-speed genetic research are on the rise 2018-03-01T05:00:00Z Liu and Tang altered three DNA letters in one such plasmid, so that it contained a sequence targeted by a guide RNA. CRISPR hack transforms cells into data recorders 2018-02-14T05:00:00Z The genes conferring AMR are often carried in plasmids: small, circular pieces of DNA that bacteria exchange easily3 through a process called horizontal gene transfer. Deploy vaccines to fight superbugs This file contains Supplementary Figure 1, the uncropped source images of the blots and Supplementary Tables 1 and 2, a description of the plasmids and primers used in this study. A semi-synthetic organism that stores and retrieves increased genetic information 2017-11-28T05:00:00Z Some prokaryotes also have smaller loops of DNA called plasmids that are not essential for normal growth. Biology for AP Courses 2022-06-09T00:00:00Z To obtain appropriate plasmids the foundry’s customers may simply order parts from the library. Robotic labs for high-speed genetic research are on the rise 2018-03-01T05:00:00Z Liu and Tang put both the altered and normal plasmids into cells and measured the relative ratio of the two. CRISPR hack transforms cells into data recorders 2018-02-14T05:00:00Z Bacterial plasmids, Escherichia coli sequences, and phage ΦX174 sequences were also removed. Genome sequence of the progenitor of the wheat D genome Aegilops tauschii 2017-11-14T05:00:00Z This file contains annotated sequences of plasmids denoted in Supplementary Table 1 suitable for direct import into sequence analysis software. A semi-synthetic organism that stores and retrieves increased genetic information 2017-11-28T05:00:00Z Antibiotic resistance is one trait that often spreads through a bacterial colony through plasmid exchange. Biology for AP Courses 2022-06-09T00:00:00Z True to its name, the foundry is set up to build and test DNA plasmids only. Robotic labs for high-speed genetic research are on the rise 2018-03-01T05:00:00Z Liu and Tang also developed methods for resetting the ratio of altered to unaltered plasmid, erasing the first recording and readying the cell to document the next event using the same set of plasmids. CRISPR hack transforms cells into data recorders 2018-02-14T05:00:00Z The tiny amount of liquid Roberts injected into the fat cells under his skin contained trillions of plasmids, hoop-shaped pieces of DNA containing a section that should trigger production of the antibody N6. Why I injected myself with an untested gene therapy 2017-11-21T05:00:00Z To counter this, Porteus' research group is taking inspiration from gene therapy: they use a virus to deliver the repair guide in the form of a circle of DNA called a plasmid. Gene therapy: Erasing sickle-cell disease : Nature : Nature Research 2017-09-26T04:00:00Z In our studies with human oocytes and zygotes, we used purified recombinant Cas9 protein instead of plasmid, which may enhance the specificity while shortening enzymatic exposure time, thereby diminishing off-site targeting. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z This process relies on plasmids, small circular DNA molecules that contain the bacterium’s genetic material but are separate from chromosomes. A Dangerous, ‘Silent Reservoir’ for Gonorrhea: The Throat 2017-07-31T04:00:00Z The researchers also modified CAMERA2 to work in mammalian cells, recording changes directly in the genome rather than in plasmids. CRISPR hack transforms cells into data recorders 2018-02-14T05:00:00Z In December, Ascendance's researchers will release a second version that contains 10 to 100 times the number of plasmids; Roberts plans to inject that as well. Why I injected myself with an untested gene therapy 2017-11-21T05:00:00Z In 2015, a group at Paris Descartes University experimentally demonstrated that when bacteria exchange certain plasmids, the plasmids reprogram the recipient bacteria with genetic information that compels them to contribute to the common good. Can Microbes Encourage Altruism? 2017-07-17T04:00:00Z Although the two genes were found on separate plasmids, it’s common for one plasmid to carry resistance genes for multiple drugs, says Catherine Logue, a veterinary microbiologist at Iowa State University in Ames. Resistance to last-ditch antibiotic has spread farther than anticipated 2017-06-11T04:00:00Z All data and full plasmid sequences are available upon request from the corresponding author. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination : Nature : Nature Research 2017-02-01T05:00:00Z Three different sized libraries were used as templates for the plasmid subclone sequencing process and both ends were sequenced. Evolutionary genomics of the cold-adapted diatom Fragilariopsis cylindrus : Nature : Nature Research 2017-01-15T05:00:00Z Despite his appetite for risk, Roberts was feeling uneasy in the three weeks since injecting the plasmid treatment. Why I injected myself with an untested gene therapy 2017-11-21T05:00:00Z Prokaryotes also swap scraps of DNA called plasmids, which can be parasitic — draining resources from their host and forcing it to self-destruct if it tries to expel its molecular hitch-hiker. Five big mysteries about CRISPR’s origins 2017-01-11T05:00:00Z The vaccine uses a piece of DNA, known as a plasmid, to produce a chain reaction in the body that ends with an immune response to Zika. Zika largely spares U.S. as virus wreaks havoc worldwide 2017-01-03T05:00:00Z We then coax a cell line made from an embryonic kidney into taking up the Trojan horse plasmid. One of our reporters tried to do CRISPR. He failed miserably. 2016-11-03T04:00:00Z She and Forterre discovered no viruses, but they did find that Thermococcus strains produced a vast amount of membrane vesicles from cells containing plasmid DNA. Extremophiles: Life at the deep end : Nature : Nature Research 2016-10-25T04:00:00Z Roberts' hope, and the hope of the treatment's creators at Ascendance, was that the plasmids would successfully cross into the nuclei of Roberts' cells and coax them into producing N6 antibodies. Why I injected myself with an untested gene therapy 2017-11-21T05:00:00Z Scientists used a circular piece of DNA, called a "plasmid," to carry genes that prompt the body itself to produce certain Zika virus proteins, alerting the immune system. Zika researchers seeking volunteers willing to be infected 2016-08-19T04:00:00Z The first person was injected Aug. 3 with the vaccine, which uses a piece of DNA called a plasmid that is engineered to produce Zika proteins that prompt the body to launch an immune response. Obama shifts funds to keep work going on Zika vaccine 2016-08-11T04:00:00Z Wagner conducts the experiment in parallel with me, and his plasmid properly incorporates the oligo that will guide Cas9 to its target. One of our reporters tried to do CRISPR. He failed miserably. 2016-11-03T04:00:00Z The researchers suspect the gene is on a plasmid and are working with other labs to confirm that. Superbug gene detected in a second person in the U.S. 2016-07-11T04:00:00Z Similarly, the effectiveness of digoxin depends on whether the gut of an individual contains specific strains of Eggerthella lenta, the plasmids of which encode an enzyme that rapidly degrades digoxin and renders it ineffective14. Microbiome-wide association studies link dynamic microbial consortia to disease : Nature : Nature Publishing Group 2016-07-05T04:00:00Z By the following day, early results confirmed that the gene was fully present and was most likely on a plasmid. Behind the scenes of a U.S. superbug discovery that made headlines around the world 2016-06-06T04:00:00Z “Was it on the plasmid? Was it in the chromosome?” Searching for superbugs: The lab looking for the next big threat 2016-05-31T04:00:00Z The second tube holds a plasmid, which is a circular piece of DNA that will act as a Trojan horse. One of our reporters tried to do CRISPR. He failed miserably. 2016-11-03T04:00:00Z Other bacteria rely on a shortcut: They get infected with something called a plasmid, a small piece of DNA, carrying a gene for antibiotic resistance. The superbug that doctors have been dreading just reached the U.S. 2016-05-26T04:00:00Z Yet other bacteria rely on a shortcut: They get infected with a plasmid carrying the resistance gene. Superbug known as ‘phantom menace’ on the rise in U.S. 2015-12-03T05:00:00Z But finding the gene on the plasmid would be much, much worse. Behind the scenes of a U.S. superbug discovery that made headlines around the world 2016-06-06T04:00:00Z It was, as expected, on the plasmid — the worst of the two places. Searching for superbugs: The lab looking for the next big threat 2016-05-31T04:00:00Z It took Dr. Valentino about two months to load all the necessary genetic elements onto a plasmid, a viruslike circle of DNA that genetic engineers use to insert genes into chromosomes. Engineering Mosquitoes’ Genes to Resist Malaria 2015-11-23T05:00:00Z However, the new gene was found on plasmids -- mobile forms of DNA that are much more easily copied and transferred between different bacteria. Scientists Spot Gene That Could Make Bacteria Resistant to All Antibiotics 2015-11-18T05:00:00Z And similar to the 'phantom menace' type of CRE, the gene is contained in a plasmid. Superbug known as ‘phantom menace’ on the rise in U.S. 2015-12-03T05:00:00Z It also was in a strain of E. coli, and also on a plasmid. Behind the scenes of a U.S. superbug discovery that made headlines around the world 2016-06-06T04:00:00Z “We are very concerned to see it in there with this particular plasmid.” Searching for superbugs: The lab looking for the next big threat 2016-05-31T04:00:00Z To help track the progress of the experiment, Dr. Gantz engineered a color marker into the plasmid’s cargo, a gene that turned the mosquitoes’ eyes red. Engineering Mosquitoes’ Genes to Resist Malaria 2015-11-23T05:00:00Z The gene is introduced on a plasmid — a circular packet of DNA — which is usually carried into a plant by the bacterial pest Agrobacterium tumefaciens. CRISPR tweak may help gene-edited crops bypass biosafety regulation 2015-10-18T04:00:00Z Unlike more common types of CRE, it carries a plasmid, or mobile piece of DNA, with an enzyme that breaks down antibiotics. Superbug known as ‘phantom menace’ on the rise in U.S. 2015-12-03T05:00:00Z Or in a much more troubling spot, on something called a plasmid, a mobile piece of DNA that exists outside the chromosome? Behind the scenes of a U.S. superbug discovery that made headlines around the world 2016-06-06T04:00:00Z Making matters worse, the plasmid was carried by E. coli, itself a highly contagious germ. Searching for superbugs: The lab looking for the next big threat 2016-05-31T04:00:00Z Within the bacterium, one of the simplest living things on earth, an array of structures—capsule, wall, membrane, cytoplasm, ribosomes, plasmid, pili, nucleoid, flagellum—work in concert to common ends. Bill Gates and Elon Musk are wrong: Artificial intelligence is not going to take over the world 2015-10-15T04:00:00Z Producing the peptides simply required ordering a plasmid and growing engineered bacteria, Komives said, but the team does need to optimize the peptide purification process. Opossum Compounds Isolated to Help Make Antivenom 2015-03-30T04:00:00Z These are made from reliable cell lines by isolating and incorporating the genes into plasmid DNA and transferring the plasmids into cells or bacteria for culture. Reproducibility: Standardize antibodies used in research 2015-02-03T05:00:00Z In this approach the target cell accepts a 'Trojan horse' plasmid of DNA from another bacteria, with the Crispr hidden inside. Novel antibiotic class created 2014-09-24T04:00:00Z In nature, plasmids transfer genes among bacteria – and that may seem trivial to you. Cooking Oils, Overcooked 2014-09-22T04:00:00Z "The plasmids we are talking about carry an antibiotic-resistant gene to a class of antibiotic called carbapenems," said the study's co-author, Dr. Tara Palmore, an infection control specialist at the U.S. Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2014-09-17T04:00:00Z These genes are found on plasmids, small rings of DNA that are separate from chromosomes. Holy sites 'may offer clues to antibiotic resistance' 2014-06-07T04:00:00Z With the diatom protein supplying a diet of foreign nucleotides, the plasmid was copied and passed on to dividing E. coli cells for nearly a week. First life with 'alien' DNA 2014-05-06T04:00:00Z With the diatom protein supplying a diet of foreign nucleotides, the plasmid was copied and passed on to dividing cells for nearly a week. First Life with "Alien" DNA Created in Lab 2014-05-07T19:02:00Z The Scripps researchers first engineered a circular piece of DNA called a plasmid containing the novel nucleotides and put it into the bacteria. Researchers Report Breakthrough in Creating Artificial Genetic Code 2014-05-07T17:04:12Z Their report, published Sept. 17 in Science Translational Medicine, showed that plasmid transfer in hospitals is likely contributing to the increase in antibiotic-resistant bacteria. Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2014-09-17T04:00:00Z Yet the genes for streptomycin resistance are carried on a plasmid that is resistant to commonly used antibiotics. Microbiology: Resistance fighters 2014-04-30T17:20:56.945Z Corresponding scrambled mutated sequences were also cloned into the same plasmid. Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity 2014-04-04T18:28:57.531Z The chromatin regulator library contains six plasmids pools. Reversible and adaptive resistance to BRAF(V600E) inhibition in melanoma 2014-04-04T18:28:46.746Z For all cases, positive wells were identified, suggesting that TSY1 carries the plasmid and produces the entire set of metabolites. An environmental bacterial taxon with a large and distinct metabolic repertoire 2014-02-05T18:21:56.312Z Tiny circles of DNA called plasmids appear to be the culprit. Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2014-09-17T04:00:00Z Only about half responded, and some plasmids took months to arrive. Repositories share key research tools 2014-01-15T18:20:54.030Z We shared our rice genetic materials and plasmid with laboratories in Korea, France and China and asked them to independently repeat the experiments. Lab Life: The Anatomy of a Retraction 2013-10-10T19:45:05.090Z Maybe we’ll learn a bit more about the connection between Fink and Fontaine, Ryan and Comstock, Jack and Booker, and between the dark harvesting of plasmids and the mysterious production of vigors. Clues From The 'BioShock Burial At Sea' DLC Reveal 2013-08-01T15:12:00Z What's more, the gene that encoded the enzyme sat on a plasmid, a piece of DNA that can move easily from one bacterium to another. Antibiotic resistance: The last resort 2013-07-24T17:20:25.367Z Using advanced DNA sequencing of samples from more than 1,000 patients, the researchers were able to see the complete genome of bacteria samples and identify the antibiotic-resistant genes -- plasmids -- located in those samples. Researchers Discover How Bacteria Resist Antibiotics in Hospitals 2014-09-17T04:00:00Z She wrote to more than a dozen labs to request certain plasmids — circular packets of DNA that scientists use to shuttle genes into cells. Repositories share key research tools 2014-01-15T18:20:54.030Z The so-called DNA vaccine is made up of a small round piece of DNA called a plasmid that is genetically engineered to tamp down the immune response to insulin and preserve insulin-producing beta cells. Type 1 diabetes vaccine shows promise in early study: researchers 2013-06-26T18:04:08Z They found that a ring of DNA, called a plasmid, in the microbe caused the gall, Agrobacterium tumefaciens. World Food Prize Honors Ag Biotech Pioneers 2013-06-19T22:45:00Z But I need salts to use vigor, harkening back to the previous Bioshock games, where you need Eve to use plasmids. A Hands-On Demo of BioShock: Infinite 2013-02-07T22:34:35Z The composition of the plasmid library was confirmed by sequencing. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets 2012-06-20T17:22:43.540Z Like viruses, however, plasmids might also enter the genome at the wrong place, accidentally activating cancer genes. Stem Cells: Flexible friends 2012-02-29T18:21:27.080Z Cohen was studying how to transfer plasmids from one cell to another. Synthetic Biology: Bits and pieces come to life 2012-02-29T18:21:16.530Z Bacteria often store them on circular pieces of DNA known as plasmids, which are not part of the microbes' primary genome. Drug Resistance Loiters on Antibiotic-Free Farms 2011-12-02T19:47:41Z For plasmids, red corresponds to coding regions, yellow to mobile elements. A draft genome of Yersinia pestis from victims of the Black Death 2011-10-26T17:21:57.317Z The plasmid library was then used to generate an influenza virus library, essentially as described. Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets 2012-06-20T17:22:43.540Z From this, they sequenced a short loop of DNA, called the pPCP1 plasmid, that is partially responsible for bubonic plague's ability to infect humans. Plague genome: The Black Death decoded 2011-10-26T17:20:52.043Z The bacterium’s genome consists of a single chromosome, about 4.6 million DNA units long, and three small rings of DNA called plasmids. Scientists Sequence Genome of Ancient Plague Bacterium 2011-10-13T19:30:12Z But many of the microbes Chénier's team studied harbored a chlortetracycline resistance gene on plasmids, even after years without the antibiotic. Drug Resistance Loiters on Antibiotic-Free Farms 2011-12-02T19:47:41Z For plasmids, red corresponds to coding regions, yellow to mobile elements. A draft genome of Yersinia pestis from victims of the Black Death 2011-10-26T17:21:57.317Z The team found enough ancient DNA in this way to reconstruct a plasmid, a small ring of DNA, that belonged to medieval . Reports of the Black Death's death have been greatly exaggerated 2011-10-16T16:15:00.250Z The plague bacterium’s genome consists of a single chromosome, some 4.6 million DNA units in length, and three small rings of DNA called plasmids. Scientists Sequence Genome of Ancient Plague Bacterium 2011-10-12T17:58:42Z Dr. Krause and others reported the DNA sequence of one of the plasmids in August. Scientists Sequence Genome of Ancient Plague Bacterium 2011-10-13T19:30:12Z One hypothesis is that the other genes on the plasmids protect the animals from high levels of copper and zinc, metals found in pig feed. Drug Resistance Loiters on Antibiotic-Free Farms 2011-12-02T19:47:41Z Genes that protect microbes against these two frequently prescribed cell killers typically sit together on plasmids, small circlets of DNA that, similar to children trading baseball cards, pass easily between bacterial species. Antibiotic Resistance May Hitchhike Along Roads 2011-09-28T00:01:00Z Targeted enrichment of ancient pathogens yielding the pPCP1 plasmid of Yersinia pestis from victims of the Black Death. Reports of the Black Death's death have been greatly exaggerated 2011-10-16T16:15:00.250Z And they lacked a miniature chromosome — a plasmid — found in anthrax bacteria that also carries toxin genes. Bacterial Genome Sequencing Offers Latest Tool Against Diseases 2011-08-29T21:33:07Z The desirable parts are then stitched together into larger plasmids by other enzymes. Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z Meanwhile, there are spine-tingling enemies, beautifully decrepit surroundings, new weapons and plasmids, shocks and revelations. The Top 20 Games of 2010: part three 2010-12-23T08:34:11Z Fluent in plasmids When all goes well, the new organisms work as their creators intend. U-Va. students are using DNA to try to make a 'new machine' 2009-10-23T04:00:00Z They do so by harvesting a gene from one cell, copying it and then putting it into a transfer vehicle, often a sub-cellular structure called a plasmid. Scientists create partially synthetic bacterial cell 2010-05-20T18:23:00Z The plasmids were then transferred into a third species, Bacillus subtilis, where the DNA was stitched together. Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z They cut the genome of the bacterium Synechocystis PCC6803 into large chunks and propagated them in specially prepared plasmids in E. coli. Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z For an extra cost, oligonucleotides can be assembled into synthetic genes up to 1,500 base pairs long, which are stitched into plasmids — circles of DNA that can be propagated in bacteria. Synthetic genomes: The next step for the synthetic genome 2011-05-18T17:21:09.763Z This year, organizers said they expect about 1,050 students, nearly all of whom are fluent in the language of plasmids and protein-coding sequences. U-Va. students are using DNA to try to make a 'new machine' 2009-10-23T04:00:00Z The plasmid is then inserted into a different cell, which recognizes and activates the gene, leading to the production of a scientifically or commercially useful protein. Scientists create partially synthetic bacterial cell 2010-05-20T18:23:00Z |
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