| 单词 | plasma cell |
| 例句 | That same year, Bissell told me, after several scary bouts with pneumonia, he was diagnosed with multiple myeloma, a cancer that attacks plasma cells. The 18-Year Wait for New Wrens Music Is Over. Sort Of. 2021-09-20T04:00:00Z Mr. Scalise, Louisiana Republican, who appeared on Fox News Friday, was diagnosed with multiple myeloma in late August— a blood cancer that develops in plasma cells in the bone marrow. Rep. Scalise says cancer treatment going ‘phenomenally’ well 2023-10-06T04:00:00Z More recently, he was diagnosed in late August with multiple myeloma, a blood cancer that develops in plasma cells in the bone marrow. Scalise building backing to become next speaker 2023-10-04T04:00:00Z Patients with multiple myeloma, a blood cancer of plasma cells in the bone marrow, who also have diabetes have a reduced overall survival when compared to those without diabetes. Diabetes may accelerate blood cancer growth, yet survival outcomes differ by race 2023-09-29T04:00:00Z Multiple myeloma is a type of blood cancer that forms in plasma cells and accumulates in bone marrow, according to the Mayo Clinic. Majority Leader Scalise diagnosed with cancer, promises to continue working 2023-08-29T04:00:00Z Nearly three decades later, he was diagnosed with the cancer that attacks plasma cells in the blood and can be caused by benzene exposure, court documents said. Jury returns $63M verdict after finding Chevron covered up toxic pit on California land 2023-06-09T04:00:00Z Nearly three decades later, Wright was diagnosed with the cancer that attacks plasma cells in the blood and can be caused by benzene exposure, court documents said. California jury returns $63M verdict after finding Chevron covered up toxic pit before selling land 2023-06-08T04:00:00Z There is also a passive immune response where antibodies come from an outside source, instead of the individual’s own plasma cells, and are introduced into the host. Concepts of Biology 2013-04-25T00:00:00Z In September, he told the small crowd, he had been diagnosed with MGUS, a blood disorder that affects plasma cells in bone marrow and diminishes kidney function. New data show Houston-area communities are being flooded with chemicals 2022-12-16T05:00:00Z Most have a cell wall external to the plasma cell membrane, the composition of which can vary among groups, and many have additional structures such as flagella and pili. Biology for AP Courses 2022-06-09T00:00:00Z Macrophages, mast cells, lymphocytes, plasma cells, and phagocytic cells are found in connective tissue proper but are actually part of the immune system protecting the body. Anatomy and Physiology 2013-06-19T00:00:00Z Myeloma is a type of blood cancer that develops from cells in the bone marrow called plasma cells. GSK to buy Sierra Oncology for $1.9 bln in boost to blood cancer ops 2022-04-13T04:00:00Z Figure 17.22 On first exposure to an allergen, an antibody is synthesized by plasma cells in response to a harmless antigen. Concepts of Biology 2013-04-25T00:00:00Z It takes several months to build what’s known as immune memory — essentially protection galvanized by long-lived, antibody-secreting plasma cells that reside in niches such as the bone marrow. The best time to get a COVID booster shot: What the science tells us 2021-11-26T05:00:00Z However, the chapter is filled with illustrative examples that are applicable to concepts we’ve explored previously, including chemistry, structure of the plasma cell membrane, and movement of molecules across membranes. Biology for AP Courses 2022-06-09T00:00:00Z A plasma cell is a B cell that has differentiated in response to antigen binding, and has thereby gained the ability to secrete soluble antibodies. Anatomy and Physiology 2013-06-19T00:00:00Z The disease attacks bone marrow plasma cells, which make antibodies in response to the virus that causes COVID—and to the vaccines. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z B cells differentiate into plasma cells that secrete antibodies, whereas TC cells destroy infected or cancerous cells. Concepts of Biology 2013-04-25T00:00:00Z So-called long-lived plasma cells are one of the body’s backups. Vaccine protection may diminish need for yearly boosters 2021-06-02T04:00:00Z Despite the difficulty of the information, many concepts will seem familiar, such as the role of proteins embedded in plasma cell membranes and interactions among different types of cells and molecules. Biology for AP Courses 2022-06-09T00:00:00Z One minor difference in the way these proteins are synthesized distinguishes a naïve B cell with antibody on its surface from an antibody-secreting plasma cell with no antibodies on its surface. Anatomy and Physiology 2013-06-19T00:00:00Z Drugs prescribed to treat it kill off normal plasma cells, as well as cancerous ones, further compounding the problem. How Immunocompromised People Without Strong Vaccine Protection Are Coping with COVID 2021-11-09T05:00:00Z The production of antibodies by plasma cells in response to an antigen is called active immunity and describes the host’s active response of the immune system to an infection or to a vaccination. Concepts of Biology 2013-04-25T00:00:00Z She is undergoing chemotherapy for multiple myeloma, a cancer of the plasma cells in her bone marrow. Beer Here, Bouquets Next Door: How a Bar Defied the Pandemic 2021-03-16T04:00:00Z A plasma cell is an immune cell that secrets antibodies; these cells arise from B cells that were stimulated by antigens. Biology for AP Courses 2022-06-09T00:00:00Z After B cells are activated by their binding to antigen, they differentiate into plasma cells. Anatomy and Physiology 2013-06-19T00:00:00Z Her husband, Alfred Branch, 88, died from multiple myeloma, a cancer of plasma cells, a few days earlier. Grit, gratitude evident in lives of Mississippi residents 2020-11-28T05:00:00Z Figure 17.18 In the primary response to infection, antibodies are secreted first from plasma cells. Concepts of Biology 2013-04-25T00:00:00Z Memory B cells linger in the bone marrow until a virus returns, when they take on a new identity as antibody-producing plasma cells. How strong is the immune response to COVID-19 infection? 2020-08-16T04:00:00Z Other antigen-loaded dendritic cells migrate through the lymphatic system where they activate B cells, T cells, and plasma cells in the lymph nodes. Biology for AP Courses 2022-06-09T00:00:00Z Th2 cells, on the other hand, are cytokine-secreting cells that act on B cells to drive their differentiation into plasma cells that make antibody. Anatomy and Physiology 2013-06-19T00:00:00Z An antibody is a protein made by plasma cells in response to infection and is a sign of the body's attempt to fight the virus. Most who recover from coronavirus carry antibodies, study finds 2020-05-07T04:00:00Z These daughter cells become either plasma cells or memory B cells. Concepts of Biology 2013-04-25T00:00:00Z Such an increase did not occur in the denervated mice, indicating that splenic-nerve activity regulates the formation of plasma cells and thus adaptive immunity. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z During the adaptive immune response to a pathogen that has not been encountered before, called a primary response, plasma cells secreting antibodies and differentiated T cells increase, then plateau over time. Biology for AP Courses 2022-06-09T00:00:00Z The antibodies of the plasma cell have the exact same antigen-binding site and specificity as their B cell precursors. Anatomy and Physiology 2013-06-19T00:00:00Z Arent disclosed last May she was being treated for multiple myeloma, a form of cancer affecting plasma cells. Long-serving Democrat plans to retire from Utah Legislature 2020-01-16T05:00:00Z The plasma cells, on the other hand, produce and secrete large quantities, up to 100 million molecules per hour, of antibody molecules. Concepts of Biology 2013-04-25T00:00:00Z The authors also report that the inhibition or ablation of corticotropin-producing neurons in either of the two brain regions impaired the formation of plasma cells after antigen injection. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z However, if the host is re-exposed to the same pathogen type, circulating memory cells will immediately differentiate into plasma cells and CTLs without input from APCs or TH cells. Biology for AP Courses 2022-06-09T00:00:00Z Thus, plasma cells are said to be terminally differentiated. Anatomy and Physiology 2013-06-19T00:00:00Z This dampening suggests the measles virus kills the long-lived plasma cells that inhabit the bone marrow and provide disease memory, Elledge says. Measles Infection Could Leave Kids Vulnerable to Other Diseases 2019-10-31T04:00:00Z During the adaptive immune response to a pathogen that has not been encountered before, known as the primary immune response, plasma cells secreting antibodies and differentiated T cells increase, then plateau over time. Concepts of Biology 2013-04-25T00:00:00Z This molecule binds to a nicotinic receptor on an immune cell called a B cell, causing it to differentiate into a plasma cell. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z Figure 33.17 In the primary response to infection, antibodies are secreted first from plasma cells. Biology for AP Courses 2022-06-09T00:00:00Z These memory cells lead to the differentiation of more plasma cells and memory B cells during secondary responses. Anatomy and Physiology 2013-06-19T00:00:00Z A friend was recently diagnosed with multiple myeloma, a cancer of a type of white blood cell called plasma cells. Can a Doctor Refuse to Treat a Patient Who Takes Cannabis? 2019-02-05T05:00:00Z However, if the host is re- exposed to the same pathogen type, circulating memory cells will immediately differentiate into plasma cells and TC cells without input from APCs or TH cells. Concepts of Biology 2013-04-25T00:00:00Z The plasma cell boosts immune defences by making antibodies that recognize the specific antigen that activated the T cell. Brain–spleen connection aids antibody production 2020-04-28T04:00:00Z Upon re-exposure to the same pathogen, memory cells differentiate into antibody-secreting plasma cells that output a greater amount of antibody for a longer period of time. Biology for AP Courses 2022-06-09T00:00:00Z This is the time it takes for the B cell clones to expand and differentiate into plasma cells. Anatomy and Physiology 2013-06-19T00:00:00Z Multiple myeloma is a cancer of plasma cells, which are found in bone marrow and are an important part of the immune system. Recent editorials published in Indiana newspapers 2018-08-08T04:00:00Z The motion of the bubbling plasma cells excites waves of magnetic energy that course outward. NASA’s Parker Probe will venture closer than ever to the sun to explore its mysterious atmosphere 2018-08-01T04:00:00Z The latest, also published Thursday in JAMA, focuses on multiple myeloma, a cancer of the blood, specifically affecting plasma cells, integral to the functioning of the immune system. Cancer burden among 9/11 firefighters and first responders larger than previously thought: Study 2018-04-26T04:00:00Z Antibodies are synthesized and secreted by activated plasma cells in the spleen, and the spleen filters foreign substances and antibody-complexed pathogens from the blood. Biology for AP Courses 2022-06-09T00:00:00Z Although other plasma proteins are produced by the liver, immunoglobulins are produced by specialized leukocytes known as plasma cells. Anatomy and Physiology 2013-06-19T00:00:00Z PD-1 regulates germinal center B cell survival and the formation and affinity of long-lived plasma cells. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity 2017-11-07T05:00:00Z Daniel Swift, a lawyer who worked in Mr. Bassiouni’s legal practice, said the cause was complications from multiple myeloma, a cancer that forms in plasma cells. M. Cherif Bassiouni, ‘father of international criminal law,’ dies at 79 2017-09-26T04:00:00Z Multiple myeloma causes plasma cells in the blood to become cancerous — these cells are integral to the functioning of the immune system and proper blood flow throughout the body. Cancer burden among 9/11 firefighters and first responders larger than previously thought: Study 2018-04-26T04:00:00Z After an adaptive defense is produced against a pathogen, typically plasma cells first secrete IgM into the blood. Biology for AP Courses 2022-06-09T00:00:00Z Eventually, the plasma cells secrete antibodies with antigenic specificity identical to those that were on the surfaces of the selected B cells. Anatomy and Physiology 2013-06-19T00:00:00Z Don is undergoing treatment for multiple myeloma, which affects plasma cells in the bone and is sometimes called bone marrow cancer. Salem couple finds room in hearts for 72 exchange students 2017-08-13T04:00:00Z Multiple myeloma, also known as bone marrow cancer, begins in the blood’s plasma cells. Alabama: AD Bill Battle to undergo cancer treatments 2016-06-21T04:00:00Z Bard, 54, started driving for Uber in November, after his wife was diagnosed with multiple myeloma, a cancer of the plasma cells. Uber drivers have mixed reactions to $100 million settlement 2016-04-22T04:00:00Z This class supports antigen recognition and maturation of B cells to plasma cells. Biology for AP Courses 2022-06-09T00:00:00Z Notice in the figure that both plasma cells and memory B cells are generated simultaneously. Anatomy and Physiology 2013-06-19T00:00:00Z A few months later in Europe, Sninsky was diagnosed with multiple myeloma, a cancer formed by malignant plasma cells. Cyclist returns to Thibodaux with message of hope 2016-04-02T04:00:00Z Multiple myeloma is caused by malignant plasma cells in the bloodstream and bone marrow, according to the U.S. New Drug Shows Potential for Blood Cancer 2015-06-02T04:00:00Z In 2013, Beth was diagnosed with multiple myeloma, a cancer that attacks the bone marrow’s plasma cells. Ordained priest recalls early career as female sports writer 2015-05-17T04:00:00Z Antibodies circulate freely and act independently of plasma cells. Biology for AP Courses 2022-06-09T00:00:00Z It is produced by specialized leukocytes called plasma cells. Anatomy and Physiology 2013-06-19T00:00:00Z Suddenly, he was experiencing severe back pain and taking serious medication to combat the cancer that was attacking his plasma cells, while still working on documentaries and reports for NBC News. The Most Heartbreaking Moments in Tom Brokaw's Cancer Memoir 2015-05-12T04:00:00Z Determined to cover the stories that mattered to him, he went to Africa after having been declared to be in remission from multiple myeloma, a cancer of the plasma cells. Michel du Cille: A Photographer With Compassion and Respect 2014-12-12T05:00:00Z Multiple myeloma may also present with an infection or bruising, since it affects infection-fighting plasma cells in the bone marrow. Understanding Blood Cancers 2014-11-13T05:00:00Z Figure 33.27 On first exposure to an allergen, an IgE antibody is synthesized by plasma cells in response to a harmless antigen. Biology for AP Courses 2022-06-09T00:00:00Z These activated B cells are known as plasma cells. Anatomy and Physiology 2013-06-19T00:00:00Z Goldman, which announced the change late Thursday, said Mr. Schiro had received a diagnosis of multiple myeloma, a cancer of the plasma cells. Goldman Sachs Names Ogunlesi New Lead Director 2014-07-25T04:00:00Z In 1996, Neal was found to have multiple myeloma, a rare cancer of the plasma cells that inhibits the production of healthy blood cells. End of the Ride for Lance Armstrong 2014-03-01T18:42:43Z Multiple myeloma is a cancer that starts in plasma cells in bone marrow and disrupts the production of normal blood cells. Novartis bone marrow cancer drug meets goal in late-stage study 2013-12-06T10:04:40Z How is a naïve B cell stimulated to mature into a plasma cell that secretes antibodies? Biology for AP Courses 2022-06-09T00:00:00Z Immunological memory is the residuum of a successful immune response that in the B cell lineage comprises long-lived plasma cells and long-lived memory B cells. [Special Issue Review] Diversity Among Memory B Cells: Origin, Consequences, and Utility 2013-09-12T17:56:44.660Z He finally ended up in severe pain at a large teaching hospital where a correct diagnosis was made: multiple myeloma, cancer of the plasma cells. Ask an Expert: Answers About Rheumatoid Arthritis, Part 2 2013-07-24T12:00:01Z The cause was multiple myeloma, a cancer of the plasma cells, said Kevin McKinney, a senior associate athletic director at the University of Wyoming, where Robinson starred in the 1960s. Flynn Robinson, Sharpshooting N.B.A. Guard, Dies at 72 2013-05-25T04:25:29Z The drug is being studied to treat multiple myeloma, a cancer that starts in plasma cells in bone marrow and disrupts the production of normal blood cells. Aeterna Zentaris to stop late-stage cancer drug trial, shares fall 2013-03-11T18:25:56Z T cells secrete cytokines, which help the B cell to multiply and mature into an antibody- producing plasma cell. Biology for AP Courses 2022-06-09T00:00:00Z Depletion of T cells also caused a rapid loss of IgA plasma cells and sIgA production in the intestine, indicating that T cells participate both in the development and maintenance of intestinal IgA B cells. Reciprocal interactions of the intestinal microbiota and immune system 2012-09-13T11:20:55.227Z Multiple myeloma, a type of cancer that affects the plasma cells in bone marrow, is relatively rare in the United States but often deadly. FDA OKs Onyx's Kyprolis for multiple myeloma 2012-07-20T16:19:42Z Multiple myeloma is a type of cancer that affects the plasma cells in bone marrow. Onyx soars to life high on favorable FDA panel vote 2012-06-21T15:24:45Z Multiple myeloma affects plasma cells in bone marrow. FDA focuses on toxic side effects with Onyx drug 2012-06-18T13:29:10Z Natural killer cells secrete cytokines, which help the B cell to multiply and mature into an antibody-producing plasma cell. Biology for AP Courses 2022-06-09T00:00:00Z In multiple myeloma, however, these same monoclonal plasma cells explode in numbers and become malignant, causing anaemia, bone destruction and kidney failure. Aetiology: The path to disease 2011-12-14T18:21:15.300Z In the chain of events leading to multiple myeloma, two factors seem to dictate the disease process: the internal genetic alterations within cancerous plasma cells, and their external environment in the bone marrow. Genetics: Profiling a shape-shifter 2011-12-14T18:21:12.203Z When one particular long-lived blood cell, a plasma cell, acquires a certain combination of genetic mutations, it leads to the unchecked growth of myeloma. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z By all objective measures of the disease — malignant plasma cells in the bone marrow and aberrant M protein in the bloodstream — the cancer is eradicated. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z T cells secrete interferons, which help the B cell to multiply and mature into an antibody- producing plasma cell. Biology for AP Courses 2022-06-09T00:00:00Z For instance, the precancerous cells are no longer normal plasma cells, so the antibodies they create are not the same as those produced by a normal cell. Aetiology: The path to disease 2011-12-14T18:21:15.300Z In multiple myeloma, plasma cells reproduce furiously, creating piles of damaged proteins that must be cleared from the cell. Drugs: More shots on target 2011-12-14T18:21:03.017Z Intriguingly, it seems that these interactions with the microenvironment are the same in myeloma's healthy counterparts, the plasma cells. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z It states that the drugs kill the malignant plasma cells but leave a reservoir of cancer stem cells that continue growing and can produce more plasma cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Natural killer cells secrete interferons, which help the B cell to multiply and mature into an antibody-producing plasma cell. Biology for AP Courses 2022-06-09T00:00:00Z Red staining in the plasma cells shows that myeloma has developed. Aetiology: The path to disease 2011-12-14T18:21:15.300Z They are more like cells from the most advanced, aggressive stage of the disease, called plasma cell leukaemia. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z His group was investigating the drug resistance that inevitably occurred in patients with multiple myeloma, a cancer affecting blood plasma cells. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z These ideas can be tested, Wicha and others believe, in patients with multiple myeloma who have used existing drugs to achieve clinical remission, with all their cancerous plasma cells eradicated. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z According to the fluid mosaic model of the plasma cell membrane, what is the primary function of carbohydrates attached to the exterior of cell membranes? Biology for AP Courses 2022-06-09T00:00:00Z “We don't know whether it's a change in the plasma cell or a change in the microenvironment” that triggers these adaptations, says Roodman. Aetiology: The path to disease 2011-12-14T18:21:15.300Z Hybridomas produced by fusing plasma cells with myeloma cells and used to test for antibodies. Animal models: Towards a myeloma mouse 2011-12-14T18:21:00.887Z The second is the ratio of the number of genetically diverse plasma cells to the number of identical, clonal plasma cells in a bone-marrow biopsy. Diagnostics: The early bird 2011-12-14T18:20:59.480Z The central question in multiple myeloma is whether the cells with these properties — the ability to recapitulate the disease and to self-renew — are plasma cells or the B cells that give rise to plasma cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Because both gases are small, nonpolar molecules, they freely travel across the phospholipid bilayer of the plasma cell membrane. Biology for AP Courses 2022-06-09T00:00:00Z Several different genetic mutations can lead to the same result: mutated, proliferating plasma cells. Aetiology: The path to disease 2011-12-14T18:21:15.300Z Potential buyers are studying Onyx’s business and its carfilzomib drug, which treats a cancer of plasma cells known as multiple myeloma, one of the people said. Onyx Spurs Pfizer Talk With Cancer Drug as Patent Cure: Real M&A 2011-12-01T05:57:02Z One of the more straightforward methods is to measure the tumour burden, or the percentage of clonal plasma cells in the bone marrow. Diagnostics: The early bird 2011-12-14T18:20:59.480Z The debate has important clinical implications because it may take different kinds of drug to target plasma cells and B cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Evidence for on-target toxicity included B cell aplasia as well as decreased numbers of plasma cells and hypogammaglobulinemia. [Research Articles] T Cells with Chimeric Antigen Receptors Have Potent Antitumor Effects and Can Establish Memory in Patients with Advanced Leukemia 2011-08-10T20:25:07.373Z As Reuters reported: This team developed a method using X-ray crystallography to test very large numbers of human plasma cells, to increase their odds of finding an antibody even if it was extremely rare. One Shot Wonder? Progress on a Universal Flu Vaccine 2011-07-23T05:25:00Z This team developed a method using X-ray crystallography to test very large numbers of human plasma cells, to increase their odds of finding an antibody even if it was extremely rare. Flu "super antibody" may bring universal shot closer 2011-07-28T18:17:14Z Antibodies, or immunoglobulins, are composed of two heavy and two light protein chains that are made separately and then built up into antibodies inside plasma cells. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Some of the first transplant experiments refuted the notion of a subpopulation of myeloma cancer stem cells that is distinct from the plasma cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z In 1991, Mr. Brady learned he had multiple myeloma, a disease of the plasma cells. In the Garden: On City Rooftops, Scrappy Green Spaces in Bloom 2011-06-23T04:20:02Z According to documents presented in Brooklyn federal court, Hogan was prescribed Zometa in 2003 after being diagnosed with multiple myeloma, a type of cancer that affects blood plasma cells. U.S. jury finds Novartis not liable for jaw disease 2011-05-26T21:46:07Z Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z A skewed ratio of free kappa to free lambda light chains indicates a proliferation of clonal plasma cells and thus a higher risk of progression. Diagnostics: The early bird 2011-12-14T18:20:59.480Z “All myeloma plasma cells have the potential to proliferate under certain conditions,” Epstein says, “and when they do proliferate they change their phenotype to something that other people consider a stem cell.” Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z For Davis — who was diagnosed in late 2009 with myeloma, a malignancy of plasma cells — a transplant will not be curative. Pioneering 'bloodless' therapy 2011-01-22T01:43:23Z Symptoms and Diagnosis Multiple myeloma is a cancer of the plasma cells in the bone marrow, a vital part of the immune system. Personal Health: Cancer Survival Demands Steady Scientific Progress 2010-04-12T20:54:00Z The induration is due not only to the dense packing of the connective-tissue spaces with lymphocytes and plasma cells, but also to the formation of new connective-tissue elements. Manual of Surgery Volume First: General Surgery. Sixth Edition. By contrast, he explains, in a person with symptomatic myeloma, nearly all the plasma cells are phenotypically aberrant or clonal. Diagnostics: The early bird 2011-12-14T18:20:59.480Z Instead, he thinks they can maintain the disease and cause relapse because of the capacity of different plasma cells to temporarily acquire the ability to divide. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z There was an acute parenchymatous nephritis with focal plasma cell infiltrations suggesting acute interstitial nephritis. The Journal of Abnormal Psychology, Volume 10 “The problem is, when you look in the bone marrow, plasma cells do not divide, so the cancer growth must come from an earlier cell that does divide,” she says. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z The local lesions are to be regarded as being of the nature of reactions against accumulations of the parasite, lymphocytes and plasma cells being the elements chiefly concerned in the reactive process. Manual of Surgery Volume First: General Surgery. Sixth Edition. He tested a combination of two drugs, lenalidomide and dexamethasone, on patients with smouldering myeloma and high counts of abnormal plasma cells. Diagnostics: The early bird 2011-12-14T18:20:59.480Z It does so by continuing to give rise to new plasma cells that keep churning out the antibody to that antigen. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z There were no plasma cells in any area examined. The Journal of Abnormal Psychology, Volume 10 That earlier cell must come from a B-cell progenitor that gives rise to the plasma cells. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Pilarski says that this 'clonotypic' relationship between myeloma plasma cells and the precursor memory B cell could reveal the derivation of all the bulk tumour cells from a putative cancer stem cell. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Also, because of the clonotypic relationship between myeloma plasma cells and earlier memory B cells, there can be no doubt that whatever the myeloma stem cell is, memory B cells are involved somehow. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z The plasma cells derived from these memory B cells inherit the sequence and make antibodies specific to the antigen. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z Killing myeloma stem cells will not be a replacement for therapies that target malignant plasma cells, which could kill the patient before the cancer stem-cell therapy has time to work. Tumorigenesis: Testing ground for cancer stem cells 2011-12-14T18:21:04.423Z |
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