| 单词 | phase III |
| 例句 | The FDA only pulled its approval of Avastin for breast cancer after that blinded phase III trial was finished, a trial that showed that patients on Avastin didn’t live longer than those not on it. FDA Did the Right Thing in Pulling Avastin for Breast Cancer 2011-11-21T18:30:26Z If confirmatory phase III studies didn’t reproduce that benefit, the FDA could revoke its approval, as with the Avastin case. How Big Pharma Undermined Medical Innovation for Financial Gain 2012-02-16T00:22:16Z Two phase III trials for aducanumab were halted in March 2019 following a "futility analysis," meaning it didn't seem likely that continuing the trials would find it worked any better than placebo. Navigating new Alzheimer's drugs can be confusing and expensive. So do they really help patients? 2023-09-13T04:00:00Z But in early 2021, scientists were wowed by a phase III clinical trial investigating a new drug of the same type: semaglutide. ‘Breakthrough’ Obesity Drugs Are Effective but Raise Questions 2023-01-10T05:00:00Z The Japanese unit of Britain's Jazz Pharmaceuticals PLC said on Thursday it had started a phase III trial of a cannabis-based drug for epilepsy. VIEW Bank of England raises rates to 3.5%, says inflation has peaked 2022-12-15T05:00:00Z The Japanese unit of Britain's Jazz Pharmaceuticals PLC said on Thursday it had started a phase III trial of a cannabis-based drug for epilepsy. With ropes and hands, trawler crew save dozens of migrants from freezing waters after dinghy sinks 2022-12-15T05:00:00Z Forty per cent of people receiving that antibody in phase III clinical trials showed brain swelling in scans. Heralded Alzheimer’s Drug Works, but Safety Concerns Loom 2022-12-01T05:00:00Z The drug furthest along is nirsevimab, which was 75 percent effective in healthy infants in a phase III trial and has been shown to be safe in premature infants as well. RSV Is Surging: What We Know about This Common and Surprisingly Dangerous Virus 2022-11-04T04:00:00Z The company plans to apply for the drug to be approved, pending results from a second phase III trial wrapping up in April 2023. ‘Breakthrough’ Obesity Drugs Are Effective but Raise Questions 2023-01-10T05:00:00Z Two incomplete phase III trials demonstrated that the drug could clear amyloid from the brain, but only one subset of participants showed a slowing in cognitive decline. Alzheimer’s Drug Slows Mental Decline in Trial—But Is It a Breakthrough? 2022-09-30T04:00:00Z Novartis said on Monday its canakinumab drug to help treat non-small cell lung cancer failed a phase III trial, the latest blow for the treatment which also fell short in a study last year. European shares edge higher; weak China data stokes worries 2022-08-15T04:00:00Z CLAIM: A Japanese study “says ivermectin is effective against Omicron in phase III trial.” NOT REAL NEWS: A look at what didn’t happen this week 2022-02-04T05:00:00Z At the end of last month, a large phase III trial was abruptly halted because the benefit of the drug to patients did not outweigh the risks. Genetic Therapies for Brain Diseases 2022-01-01T05:00:00Z Asked in the online briefing when he could give more details, he said: “The emergence of phase III data tends to accelerate all processes of this type, but I couldn’t give you a specific date.” Britain's antiviral chief hints at interest in Merck COVID-19 pill 2021-10-01T04:00:00Z By contrast, lecanemab’s phase III trial, called Clarity AD, ran uninterrupted for a full 18 months and slowed decline to a statistically significant extent. Alzheimer’s Drug Slows Mental Decline in Trial—But Is It a Breakthrough? 2022-09-30T04:00:00Z It is currently being evaluated in a phase III clinical trial in the United States. How to Reduce Racial Disparities in Smoking Deaths 2021-08-26T04:00:00Z THE FACTS: While scientists continue to conduct research into the drug’s use against COVID-19, the finding being cited refers to pre-clinical research — not a “phase III trial,” which involves testing the drug on humans. NOT REAL NEWS: A look at what didn’t happen this week 2022-02-04T05:00:00Z A phase III trial of tominersen involving 791 participants from 18 countries was terminated early on the advice of an independent committee of experts, who had conducted a planned review of the data. Genetic Therapies for Brain Diseases 2022-01-01T05:00:00Z In 2019, Aducanumab failed in a futility analysis of two pooled phase III randomized controlled trials, but was later claimed to have yielded a small benefit for a subset of patients in a high-dosage group. Alzheimer's Inc: When a Hypothesis Becomes Too Big to Fail 2021-08-25T04:00:00Z The new phase III results could tip the scales in favour of approval, although they are not formally part of the review. Alzheimer’s Drug Slows Mental Decline in Trial—But Is It a Breakthrough? 2022-09-30T04:00:00Z The FDA’s approval is based on data from two phase III trials. Landmark Alzheimer's Drug Approval Confounds Research Community 2021-06-08T04:00:00Z At the time, a phase III clinical trial was under way to test the vaccine at two universities in Peru; Vizcarra was not part of the trial. Scandal Over COVID Vaccine Trial at Peruvian Universities Prompts Outrage 2021-03-29T04:00:00Z Scientists do not yet know the long-term effects on the diseases concerned, and it’s not clear if this was the issue in the phase III trial of tominersen. Genetic Therapies for Brain Diseases 2022-01-01T05:00:00Z In the end, the phase III clinical trial used multiple approaches. How a debate over two competing vaccines gripped the medical community — in 1961 2021-02-21T05:00:00Z And the situation in India is not bad enough to skip phase III trials, some argue. Scientists criticize ‘rushed’ approval of Indian COVID-19 vaccine without efficacy data 2021-01-05T05:00:00Z Around 40% of treated patients in the two phase III trials developed brain swelling. Landmark Alzheimer's Drug Approval Confounds Research Community 2021-06-08T04:00:00Z Nov 16 - Bharat Biotech says it is starting phase III trials. India's coronavirus vaccine approved by drugs experts 2021-01-02T05:00:00Z For now, researchers are eagerly awaiting the results of the tofersen phase III trials in ALS, and for more information about exactly why the tominersen trial for Huntington’s was halted. Genetic Therapies for Brain Diseases 2022-01-01T05:00:00Z Interim results from its phase III trial are expected to be delivered to Indonesia’s Food and Drug Agency next month. Indonesia to ink Pfizer, AstraZeneca vaccine deals as awaits Sinovac clearance 2020-12-29T05:00:00Z The approval of a vaccine without phase III data is “unconscionable,” says Vineeta Bal, an immunologist at India’s National Institute of Immunology. Scientists criticize ‘rushed’ approval of Indian COVID-19 vaccine without efficacy data 2021-01-05T05:00:00Z “When you do the phase III in different countries, it’s more transparent, it’s more trustworthy,” he says. With global push for COVID-19 vaccines, China aims to win friends and cut deals 2020-11-25T05:00:00Z A phase III clinical trial for that intervention is currently underway. Pfizer’s Early Results Bode Well for a COVID Vaccine Approval This Year 2020-11-12T05:00:00Z The Sputnik V vaccine, developed at the National Research Centre for Epidemiology and Microbiology in Moscow, is currently going through phase III clinical trials in Belarus, UAE, Venezuela and India. Russian Covid vaccine shows encouraging results 2020-11-11T05:00:00Z Even if Novavax’s phase III trials succeed, vaccine watchers say the company’s biggest vulnerability will remain: the manufacturing process. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z Bharat Biotech first applied for regulatory approval in the first week of December, less than a month after it began enrolling participants for its phase III trial. Scientists criticize ‘rushed’ approval of Indian COVID-19 vaccine without efficacy data 2021-01-05T05:00:00Z But China is not waiting for the phase III results before widely using the vaccines at home. With global push for COVID-19 vaccines, China aims to win friends and cut deals 2020-11-25T05:00:00Z In São Paulo, the Sinovac vaccine is being tested as part of phase III clinical trials with support from the Doria government. Brazilians protest mandatory COVID-19 immunization, Chinese vaccine 2020-11-01T04:00:00Z With phase III trials of numerous COVID-19 vaccines in the works, she thinks it unlikely that challenge trials will speed the development of the first vaccines. Human Challenge Trials Will Deliberately Infect Dozens in the UK 2020-10-21T04:00:00Z The phase III clinical trial of Novavax’s flu vaccine in older adults, also made using the moth cell system, returned excellent results. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z Obtaining an EUA hinges on how independent reviewers judge a vaccine’s performance during periodic readouts of phase III clinical trial data. Don’t Expect a COVID Vaccine before the Election 2020-10-16T04:00:00Z In March, Biohaven Pharmaceuticals in New Haven, Connecticut, revealed promising results of a phase III trial for migraine prevention with rimegepant, a gepant that was already approved to treat acute migraine. A new generation of headache drugs 2020-10-13T04:00:00Z The current phase III trials are each enrolling several tens of thousands of participants. COVID-vaccine trial results are imminent — and scientists’ concerns are growing 2020-09-24T04:00:00Z Phase III trials in the UK, which began in June, aim to recruit 10,000 people, while a phase III trial in Brazil hopes to recruit 5000 participants. Relief as coronavirus vaccine trial restarts — but transparency concerns remain 2020-09-13T04:00:00Z Novavax is the only one to have launched a phase III trial. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z Pfizer, which began a phase III trial for its vaccine on July 27, plans to conduct its first readout when the number of symptomatic cases reaches 32. Don’t Expect a COVID Vaccine before the Election 2020-10-16T04:00:00Z Konkle said the phase III trial of the drug is now underway. New fusion protein treatment holds promise for people with ‘royal’ clotting disorder 2020-09-09T04:00:00Z Researchers at the University of Oxford in collaboration with the pharmaceutical company AstraZeneca are developing the vaccine, which is one of nine coronavirus vaccines in the final, 'phase III' stage of being tested. A leading coronavirus vaccine trial is on hold: scientists react 2020-09-08T04:00:00Z The following sites were picked to participate in the phase III trials: Phase III trials of coronavirus vaccine to take place at 5 US military sites, Pentagon confirms 2020-09-03T04:00:00Z And in early July, Operation Warp Speed granted the company up to $1.6 billion, with $800 million available immediately, for a phase III clinical trial and for manufacturing 100 million doses of vaccine. Will a small, long-shot U.S. company end up producing the best coronavirus vaccine? 2020-11-03T05:00:00Z The vaccine is currently undergoing phase III clinical trials in Brazil, the United Kingdom and the United States to test its effectiveness. India will supply coronavirus vaccines to the world — will its people benefit? 2020-09-02T04:00:00Z Both vaccines are still in phase III efficacy trials. Here’s how the U.S. could release a COVID-19 vaccine before the election—and why that scares some 2020-08-28T04:00:00Z Yet only phase III clinical trials can show which vaccines—if any—will actually provide protection. ‘Warp Speed’ COVID-19 Vaccine Efforts Aim for Diverse Volunteers and Long-Lasting Protection 2020-08-25T04:00:00Z More than 200 COVID-19 vaccines are in development worldwide and several are already in phase III trials, with more front runners slated to begin theirs soon. Russia’s fast-track coronavirus vaccine draws outrage over safety 2020-08-10T04:00:00Z This month, Sinovac launched a phase III trial of its vaccine in Brazil. China’s coronavirus vaccines are leaping ahead – but face challenges as virus wanes 2020-07-30T04:00:00Z Next comes the all-important large phase III trials that will show whether these vaccines actually protect people from the new coronavirus. Daily briefing: Three vaccines show early promise for COVID-19 2020-07-20T04:00:00Z Oxford’s vaccine is being tested for efficacy in the United Kingdom, Brazil and South Africa, and the Moderna-NIAID vaccine is set to begin its phase III trial in the United States this month. What trial results reveal about the coronavirus vaccine frontrunners 2020-07-20T04:00:00Z The company plans to launch its phase III clinical trial in September. ‘Warp Speed’ COVID-19 Vaccine Efforts Aim for Diverse Volunteers and Long-Lasting Protection 2020-08-25T04:00:00Z But little is known about phase III trial plans for the Gamaleya vaccine. Russia’s fast-track coronavirus vaccine draws outrage over safety 2020-08-10T04:00:00Z And the fact that China was willing to approve CanSino’s vaccine for use in the military before phase III trials were complete raised eyebrows. China’s coronavirus vaccines are leaping ahead – but face challenges as virus wanes 2020-07-30T04:00:00Z A phase III trial, designed to assess the vaccine’s efficacy is scheduled to start this month. Coronavirus vaccines get a biotech boost 2020-07-20T04:00:00Z Harris is leading a promising study of inhibitors of JAK enzymes for vitiligo; the research is now moving into phase III clinical trials. Temprian Therapeutics: developing a gene-based treatment for vitiligo 2020-06-29T04:00:00Z “But overall, I’m optimistic about the vaccine candidates going into phase III. We have a lot more to learn, but the immune responses so far look promising.” ‘Warp Speed’ COVID-19 Vaccine Efforts Aim for Diverse Volunteers and Long-Lasting Protection 2020-08-25T04:00:00Z Only one, from pharmaceutical firm AstraZeneca and the University of Oxford, is starting phase III clinical trials that will test whether it actually works. Daily briefing: Coronavirus vaccine — where we are now 2020-06-10T04:00:00Z It hopes to begin a phase III efficacy trial in July, to test whether the vaccine can prevent disease in high-risk groups, such as health-care workers and people with underlying medical problems. Coronavirus Vaccine Trials Have Delivered Their First Results—But Their Promise is Still Unclear 2020-05-21T04:00:00Z Reis has already developed a candidate leishmaniasis vaccine, based on broken-up parasite cells, that is going into phase III trials. Coronavirus vaccines get a biotech boost 2020-07-20T04:00:00Z They also modelled how it binds to the antiviral drug remdesivir, originally developed to treat Ebola and now in phase III trials for coronavirus. The sprint to solve coronavirus protein structures — and disarm them with drugs 2020-05-14T04:00:00Z Each of the phase III clinical trials in the U.S. aims to enroll 30,000 individuals. ‘Warp Speed’ COVID-19 Vaccine Efforts Aim for Diverse Volunteers and Long-Lasting Protection 2020-08-25T04:00:00Z Outcomes, such as patient-reported symptoms, were not significantly different — but a phase III trial, aiming to enrol 520 people, is now under way and might prove more sensitive. Research round-up: COPD 2020-05-12T04:00:00Z “Doing a phase III trial to show efficacy is meaningless if it's not coupled to a plan to actually licence and deliver under some regulatory authority,” he says. Coronavirus vaccines: how to choose the best 2020-04-29T04:00:00Z The field of Alzheimer’s disease is littered with drugs that looked really promising in phase II clinical trials but that turned out to be ineffective when they were put into phase III clinical trials. Shortcuts in COVID-19 Drug Research Could Do Long-Term Harm, Bioethicists Worry 2020-04-24T04:00:00Z If all goes well, Meng says, Sinovac will seek to launch traditional phase III efficacy trials that compare the vaccine with a placebo in thousands of people. COVID-19 vaccine protects monkeys from new coronavirus, Chinese biotech reports 2020-04-23T04:00:00Z “But we’re hoping to significantly change that for the phase III,” Jansen says. ‘Warp Speed’ COVID-19 Vaccine Efforts Aim for Diverse Volunteers and Long-Lasting Protection 2020-08-25T04:00:00Z In September 2019, Sunovion launched a larger, phase III trial that will include more than 1000 people, designed to prove the drug’s efficacy and win regulatory approval. Experimental schizophrenia drug could reduce long-neglected symptoms 2020-04-15T04:00:00Z A new vaccine might also be made available to health care workers and others at high risk even before phase III efficacy trials are completed. With record-setting speed, vaccine makers take their first shots at the new coronavirus 2020-03-31T04:00:00Z And this month Gilead launched two phase III trials of the drug in medical centers in Asia. Could Chloroquine Treat Coronavirus? 2020-03-27T04:00:00Z The thing that takes the longest time in testing vaccines is phase III efficacy testing. Should scientists infect healthy people with the coronavirus to test vaccines? 2020-03-25T04:00:00Z Johns Hopkins Center for Psychedelic and Consciousness Research is in phase III clinical trials to approve psilocybin for market as a prescription medication. Psychedelics in Palliative Care 2020-03-20T04:00:00Z The results of the phase III trial, announced late last year, revealed that the drug was about 20% more likely to produce remissions after 1 year than steroids were. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z And even if these trials are successful, even bigger phase III trials will be needed a few years down the line before the treatment can be used in the clinic. Could the gut microbiome be linked to autism? 2020-01-28T05:00:00Z MDMA, she says, is a relatively safe drug with relatively low abuse potential, and it is currently in a phase III trial that is close to Food and Drug Administration approval. MDMA Could Be Tailored to Make It More Suitable for Treating Mental Illness 2019-12-11T05:00:00Z But the vaccine offers only a partial shield against the shape-shifting parasitic disease: over the four years of the vaccine’s phase III trial, it prevented around 30% of serious cases. The conceptual mistake that lies at the heart of economics 2019-12-05T05:00:00Z It is also in phase III of its clinical trials, the last phase before going to market as a prescription. Psychedelics in Palliative Care 2020-03-20T04:00:00Z In a phase III trial, the vaccine proved about 40% effective at preventing RSV infection in the first 90 days of life. Tailoring vaccines for older people and the very young 2019-11-26T05:00:00Z A ‘mosaic’ vaccine, which includes snippets of variants of HIV from around the world, now entering a phase III trial could change that. Research round-up: Vaccines 2019-11-26T05:00:00Z The drug's backers also claim a phase III clinical trial of about 800 people "demonstrated solid and consistent cognition improvement" among those treated versus a control group. Alzheimer’s experts greet China’s surprise approval of a drug for brain disease with hope and caution 2019-11-05T05:00:00Z There are more than ten ongoing phase III clinical trials of such therapies for liver-related diseases. Why rare genetic diseases are a logical focus for RNA therapies 2019-10-15T04:00:00Z In the subsequent phase III trial, two-thirds of participants received patisiran and one-third received a placebo. Patisiran’s path to approval as an RNA therapy 2019-10-15T04:00:00Z The results of phase II trials were positive and Medicago expects to complete its third phase III trial for flu this year. Accelerating flu protection 2019-09-17T04:00:00Z These outcomes have raised hopes that this vaccine — set to be the fifth tested for efficacy in humans — will perform well in a phase III trial. Research round-up: Vaccines 2019-11-26T05:00:00Z Cummings says GV-971 would not yet meet the criteria for approval in the United States, which requires significant results on two measures of cognitive ability and usually requires two positive phase III clinical trials. Alzheimer’s experts greet China’s surprise approval of a drug for brain disease with hope and caution 2019-11-05T05:00:00Z A phase III trial of the drug in people who had experienced a heart attack or stroke showed a roughly 50% decrease in LDL cholesterol levels. Why rare genetic diseases are a logical focus for RNA therapies 2019-10-15T04:00:00Z The company is, however, conducting two phase III clinical trials on pimodivir — one using hospitalized patients and one involving outpatients at high risk of complications. The push for better flu therapies 2019-09-17T04:00:00Z The phase III trial did not include the extensive neurological exams required to detect them, he notes. A new sickle cell drug could soon get U.S. approval. But does it work? 2019-09-17T04:00:00Z Twenty percent of participants dropped out of the phase III study because of side effects. First peanut allergy treatment gains backing from FDA advisory panel 2019-09-13T04:00:00Z A phase III clinical trial is under way. Analgesia without opioids 2019-09-10T04:00:00Z A 2019 report from Pew found that there are 42 new antibiotics in development, with just 13 in phase III trials. Rapid progress transforms ideals of health 2019-05-14T04:00:00Z Currently, there are multiple trials using metformin, including a large phase III clinical trial in breast cancer. A New Way to Fight Cancer 2019-03-29T04:00:00Z The company recently published results from two phase III studies on depression, and will conclude a suicidal ideation trial next year. Party-Drug-Turned-Antidepressant Approaches Approval 2019-02-22T05:00:00Z In the company’s phase III clinical trial, participants gradually ramped up their dose, beginning at under one-500th of a peanut and flattening out at a maintenance dose equivalent to about one peanut. First peanut allergy treatment gains backing from FDA advisory panel 2019-09-13T04:00:00Z Cara Therapeutics, a biotechnology company in Stamford, Connecticut, is conducting phase III trials of a molecule that targets κ-opioid receptors, which has also been designed to minimize its entry into the brain. Analgesia without opioids 2019-09-10T04:00:00Z At the FDA advisory committee meeting, J&J presented results from five phase III trials and several smaller trials of the drug, which together included more than 1,700 people. Antidepressant based on party drug gets backing from FDA advisory group 2019-02-12T05:00:00Z Cenicriviroc, a small molecule that blocks two types of cytokine receptor, is now in phase III clinical trials. Tipping the balance 2018-12-18T05:00:00Z One of the first clinical trials of StrataGraft, published in 2011, showed that it did not induce an acute immune response8, and the substitute is now being tested in a phase III trial. Unlocking the secrets of scar-free skin healing 2018-11-20T05:00:00Z Details on data generated before phase III trials — including preclinical and early clinical research — were crucial to frame the failure’s significance in terms of which hypotheses it falsified. Be open about drug failures to speed up research 2018-11-12T05:00:00Z Although phase III clinical trials failed to show efficacy in treating brain tumours, the strategy is being tested further using other drugs in at least ten early-phase trials. Getting cancer drugs into the brain 2018-09-25T04:00:00Z Only two of the five phase III trials showed positive results, and the people who received esketamine improved only slightly more than those who took a placebo. Antidepressant based on party drug gets backing from FDA advisory group 2019-02-12T05:00:00Z But in 2017, the results of a second phase III trial in patients with newly diagnosed glioblastoma made a much bigger splash. The innovative therapies that could break the brain-cancer stalemate 2018-09-25T04:00:00Z Researchers who are collaborating with the company on a phase III trial reported that 100 of the 331 people who were treated are still alive 40 months later3. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z There is also optimism surrounding aducanumab, an antibody currently in phase III trials. The amyloid hypothesis on trial 2018-07-24T04:00:00Z Cases became so rare in Liberia that it had to downgrade a phase III trial of both vaccines to phase II after enrolling a mere 1500 of an anticipated 27,000 participants. Updated: Past failures shadow current hopes of testing drugs during an Ebola outbreak 2018-06-04T04:00:00Z The results from smaller, phase II trials don't always predict how a cancer drug will do in a randomized phase III trial. A promising new cancer drug has hit a major setback, raising questions about whether the field is moving too fast 2018-05-09T04:00:00Z In 2009, for example, a phase III study1 of the most promising vaccine identified so far found that it reduced a person’s risk of contracting HIV by only one-third. Promising HIV vaccines could stall without coordinated research 2018-02-26T05:00:00Z This heterogeneity was probably a factor in the failure of the rindopepimut phase III trial. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z Results from a phase III trial are expected by 2020; if it succeeds, it will be the first treatment targeted at amyloid-β to pass this hurdle. The amyloid hypothesis on trial 2018-07-24T04:00:00Z A trial of the Merck and GSK vaccines in Liberia wasn't abandoned, as this story previously said, but converted from a phase III to a phase II study. Updated: Past failures shadow current hopes of testing drugs during an Ebola outbreak 2018-06-04T04:00:00Z In phase III trials in postsurgical patients reported in February, oliceridine proved to be as effective a painkiller as morphine, and quicker to act. New painkillers could thwart opioids' fatal flaw 2017-11-16T05:00:00Z Pembrolizumab is the only one with a published randomized phase III comparison with chemotherapy. Therapeutics: Spoilt for choice : Nature : Nature Research 2017-11-07T05:00:00Z The agency will work closely with MAPS—a privately funded research institute founded 31 years ago in Santa Cruz, California—to design and conduct phase III trials starting next spring. MDMA's Journey from Molly to Medicine 2017-11-03T04:00:00Z Because of this, and despite the failure in 2016 of a phase III trial of a drug aimed at tau, attacking both amyloid-β and tau is seen as a potentially effective approach. The amyloid hypothesis on trial 2018-07-24T04:00:00Z The researchers are planning a phase III trial to determine how long the treatment effects last and whether Nuedexta affects disease progression. Research round-up : Nature : Nature Research 2017-10-17T04:00:00Z But in the phase III trial of elderly patients, it did little to protect against infection. Why can’t we cure the common cold? 2017-10-06T04:00:00Z A larger, phase III trial is under way, and the early data are promising, says Petrylak, who led both studies. Therapeutics: Spoilt for choice : Nature : Nature Research 2017-11-07T05:00:00Z This marks the first time psychedelic-assisted psychotherapy will be monitored in phase III trials for possible prescription use. MDMA's Journey from Molly to Medicine 2017-11-03T04:00:00Z The drug is now in phase III trials for Alzheimer’s disease, and other groups are pursuing a similar approach. The amyloid hypothesis on trial 2018-07-24T04:00:00Z If women are represented, they are most likely to appear in phase III clinical trials, which enrol large numbers of participants. Clinical research: Inequality in medicine : Nature : Nature Research 2017-10-03T04:00:00Z “I am not seeing any other drugs that are in phase III trials.” Osteoporosis: Staying strong : Nature : Nature Research 2017-10-03T04:00:00Z Success in phase III trials was based on increased desire and a decrease in distress. Sexual arousal: Sex matters : Nature : Nature Research 2017-10-03T04:00:00Z The first phase III trial will start no matter what, he says. All clear for the decisive trial of ecstasy in PTSD patients 2017-08-26T04:00:00Z The game is currently in phase III clinical trials, which means this isn’t a done deal yet. Prescription video games may be the future of medicine 2017-07-25T04:00:00Z The results of the final phase III trials of Ocrevus — which were used in the FDA determination — were published in the New England Journal of Medicine in January. MS patient’s brain infection cools enthusiasm for new medication 2017-05-30T04:00:00Z Researchers leading those trials are now training a cadre of therapists to deliver a form of psychotherapy tailored for use with MDMA, in preparation for the phase III trials. Psychedelic compound in ecstasy moves closer to approval to treat PTSD 2017-04-27T04:00:00Z In this design, a drug that performs well in the multi-armed comparison study will seamlessly move to a "phase III" portion of the trial. Congress and FDA nominee heap love on ‘adaptive trials’ 2017-04-07T04:00:00Z The biggest hurdle now is raising the money for the two phase III trials, which together will include between 200 and 300 participants. All clear for the decisive trial of ecstasy in PTSD patients 2017-08-26T04:00:00Z Clinical trials of vaccine therapy targeting lymphoma Ig variable regions showed early promise, but three independent phase III trials of idiotype vaccine found either modest or no overall clinical benefit29, 30, 31. Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens : Nature : Nature Research 2017-03-21T04:00:00Z The Butantan-produced vaccine is now being tested at 14 institutions across the country, in a $100 million, phase III randomized trial sponsored by Brazil’s federal government. Brazil’s dengue vaccine in jeopardy 2017-02-28T05:00:00Z The agency recommended that the researchers move forward with phase III trials, the final stage before potential approval of the drug. Psychedelic compound in ecstasy moves closer to approval to treat PTSD 2017-04-27T04:00:00Z The Food and Drug Administration is currently reviewing an application for a phase III trial of psilocybin, the last step before the therapy could be approved. Hallucinogenic drugs help cancer patients deal with their fear of death 2016-12-01T05:00:00Z At some point, the prohibitive cost of screening MS drugs in de facto phase III trials will force us to adopt other, more creative solutions. Perspective: Who dares, wins : Nature : Nature Research 2016-11-29T05:00:00Z In phase III trials, ocrelizumab proved superior to an existing drug that is commonly used to reduce the frequency of relapses for people who experience them. Therapies: Progressive steps : Nature : Nature Research 2016-11-29T05:00:00Z Along with larger, phase III trials, he added, “the combination of hormones needs to be studied more to consider a good balance between efficacy and safety.” Male Birth Control Shots are 96% Effective, Study Finds 2016-10-31T04:00:00Z Hans missed the window for a landmark phase III randomized clinical trial of immunotherapy. What the Cancer Moonshot Might Mean for Kids 2016-09-16T04:00:00Z On Tuesday, the regulatory body gave the green light for a phase III trial of another contentious drug: using ecstasy to treat post-traumatic stress disorder. Hallucinogenic drugs help cancer patients deal with their fear of death 2016-12-01T05:00:00Z Most of these treatments, as the history of phase III trials shows, will probably fail. FDA should stand firm on stem-cell treatments 2016-07-04T04:00:00Z "I think this, in combination with the phase III data, means that a three-dose regimen couldn't be recommended, but a four-dose regimen is still worth further evaluation," he said. Malaria Vaccine Protection Short-Lived in Young Children 2016-06-30T04:00:00Z The biggest drivers of this increase are higher clinical trial costs, especially phase III efficacy trials, along with a lower probability that the new drug will be approved by the FDA. How the FDA Drives Up Drug Prices 2016-06-06T04:00:00Z The drug galeterone, for example, the subject of a phase III trial, works in three different ways. Metastasis: Resistance fighters : Nature : Nature Publishing Group 2015-12-14T05:00:00Z Otsuka, a Japanese drug developer, also took some hits for offering the compassionate use of delaminid to just 200 patients while completing its own phase III trial, which is projected to end in 2017. TB community borrowing a page from HIV/AIDS 2015-12-08T05:00:00Z The data assessed by the EMA was primarily from a phase III clinical trial of the vaccine in about 16,000 kids in multiple African countries. The First-Ever Malaria Vaccine Just Got A Big Break 2015-07-24T04:00:00Z In hopes of seeing clearer benefits, the company is currently running a much larger, phase III trial, slated to end in October 2016, only in people with mild Alzheimer’s disease. Antibody drugs for Alzheimer's stir hope and doubts 2015-07-22T04:00:00Z In December, Biogen said that it would launch a phase III trial with 2,700 participants that would run for 18 months. Antibody drugs for Alzheimer’s show glimmers of promise 2015-07-21T04:00:00Z Initial results of a phase III trial, which focuses specifically on men with AR-V7, are expected by the end of 2016. Metastasis: Resistance fighters : Nature : Nature Publishing Group 2015-12-14T05:00:00Z But the most serious cases did show improvement, and Ratziu says the company plans to launch a phase III trial in 2500 patients with advanced NASH. How what we eat is destroying our livers 2015-07-02T04:00:00Z A vaccine for nicotine reached a phase III clinical trial in 2009, but ultimately flopped. Pharmacotherapy: Quest for the quitting pill : Nature : Nature Publishing Group 2015-06-23T04:00:00Z A randomized phase II trial of the ICT-107 vaccine showed benefit in a select group of patients with glioblastoma, and a phase III trial is planned. Harnessing the Immune System to Combat Aggressive Brain Tumors 2015-06-02T04:00:00Z The global phase III trial included 436 patients with aggressive, stage III or IV malignant melanoma. How the Herpes Virus Can Kill Cancer 2015-05-27T04:00:00Z Conventional phase III trials involve thousands of people. Personalized medicine: Time for one-person trials 2015-04-28T04:00:00Z After several hundred vaccinations, the scientists are ready to start phase III, in which efficacy is tested. Scientists argue over access to remaining Ebola hotspots 2015-03-26T04:00:00Z If TKM-Ebola does seem to work, the team wants to go straight to a bigger phase III clinical trial. New Ebola drug trial starts in Sierra Leone 2015-03-11T04:00:00Z The drug is scheduled to enter phase III trials later this year. No, The New Cholesterol Drugs From Sanofi And Amgen Aren't Going To Cost $150 Billion A Year 2015-02-18T05:00:00Z The vaccine has an acceptable safety profile, according to scientists, and will now move into phase III trials in West Africa, led by the U.S. Liberia to Receive First Batch of Experimental Ebola Vaccine That analysis should take no more than 4 weeks, and phase III trials could begin soon after. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z The team is planning a larger, phase III trial. Clotting factors: Stretching time : Nature : Nature Publishing Group 2014-11-25T05:00:00Z The trial may expand to other sites; the study team hopes to have an answer fast so that it can either move on to another drug or start a phase III study of TKM-Ebola. New Ebola drug trial starts in Sierra Leone 2015-03-11T04:00:00Z The researchers hope to move on to a phase II and phase III trial to look at how the drug impacts overall survival. Scientists Develop New Way to Treat HPV-Related Cancer 2014-11-20T05:00:00Z Mast is now recruiting patients at medical centres around the world for a phase III trial, in which it aims to test MST-188 as a treatment for vaso-occlusion. Drug development: A complicated path : Nature : Nature Publishing Group 2014-11-11T05:00:00Z Last year, a WHO panel decided that given the huge threat, it would be ethical to jump straight from these small studies to phase III trials, which test for efficacy. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z “It would be the most challenging place to do a phase III study.” Leaked documents reveal behind-the-scenes Ebola vaccine issues 2014-10-23T04:00:00Z That's why there’s a push to ramp up production to millions of doses as soon as the phase III trials launch. Push to gamble big on mass production of Ebola vaccines 2014-10-08T04:00:00Z An earlier WHO consultation made the startling announcement on 5 September that this crisis required compressing the timeline, which effectively does away with traditional phase III studies. Tough choices ahead in Ebola vaccine trials 2014-10-07T04:00:00Z The company is now collaborating with Pfizer on a phase III trial. Drug development: A complicated path : Nature : Nature Publishing Group 2014-11-11T05:00:00Z The company has begun scouting for phase III test sites in the affected countries, Kieny said. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z Spark's phase III LCA2 trial was open to children as young as three years old. Curing blindness: Vision quest 2014-09-09T04:00:00Z Funding for the phase III trials does not yet exist, Ballou says, let alone for churning out millions of shots. Push to gamble big on mass production of Ebola vaccines 2014-10-08T04:00:00Z If everything goes according to plan, Kieny says, a phase III trial could reveal as soon as April whether the GSK vaccine works. Tough choices ahead in Ebola vaccine trials 2014-10-07T04:00:00Z More than 5,000 African women are testing the ring in two phase III clinical trials that will end in 2016. The Next Generation of HIV Prevention 2014-07-07T04:00:00Z First results for the phase III studies can be expected after 6 months or so. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z Along with the Japanese pharmaceutical company Takeda, based in Osaka, Zinfandel is currently funding a phase III trial, called TOMMORROW, that will put his ideas to the test. Alzheimer's disease: The forgetting gene 2014-06-03T04:00:00Z Doctors and scientists are so excited about the potential of MEDI4736 that it has been fast-tracked to phase III hospital trials before the results of the first clinical results have even be published. AstraZeneca cancer drug hailed as 'great white hope' in fight against illness 2014-05-14T04:00:00Z Patrick Vallance, GSK’s President of Pharmaceuticals R&D, said he was disappointed that the outcome of the second phase III study did not support a regulatory submission. GSK says heart drug darapladib fails in second late-stage trial 2014-05-13T06:47:16Z TB drug trial The first regimen designed to treat both drug-sensitive and resistant strains of tuberculosis will be tested in a phase III clinical trial. Seven days: 25 April –1 May 2014 2014-04-30T17:20:24.656Z In both phase III studies, adding bitopertin to antipsychotic therapy for 24 weeks did not significantly reduce negative symptoms compared with placebo. Therapeutics: Negative feedback 2014-04-02T17:21:04.367Z There is no valid excuse to delay publication of phase III results based on commercial or marketing concerns. Why Is Actelion Suppressing Phase III Data? 2013-12-06T21:59:00Z Amgen of Thousand Oaks, California, has also launched several phase III trials of its own monoclonal antibody after it reported similarly promising results. Genetics: A gene of rare effect 2013-04-10T17:20:29.100Z Last year a large-scale phase III trial showed that the vaccine saved only a third of babies aged six to 12 weeks old from falling ill. Malaria vaccine test results disappoint 2013-03-20T23:11:28Z Conversely, the company that brought Prozac to the world has 13 drug candidates in phase III trials, the most in its history. Lilly confident on keeping dividend through patent cliff 2013-03-06T13:48:13Z A revised drug law, expected to be put before the Japanese parliament by late June, would fast-track therapies that seem to be effective in phase II or phase III trials. Stem cells cruise to clinic 2013-02-27T18:20:30.823Z FDA requires two successful phase III trials to approve a drug. In Defense Of The FDA 2012-12-19T13:04:58Z Last November, Regeneron and Sanofi began to recruit 18,000 patients for phase III trials that will test the ability of their therapy to cut cardiovascular events, including heart attacks and stroke. Genetics: A gene of rare effect 2013-04-10T17:20:29.100Z Nonetheless, phase II trials are designed to provide direction for the phase III programme and to that end we are making no changes to forecasts nor do we expect consensus to change dramatically. AstraZeneca slips on another drug disappointment, as FTSE edges lower 2012-12-13T10:03:53Z The study, the first ever phase III trial of a malaria vaccine, is still ongoing, and full data and analysis of the results won't be published until late 2014. A Setback for Malaria Vaccines 2012-11-09T17:08:38Z Their black widow treatment is currently in phase III trials run by Lavonas in—among other places—Spano's hospital, where she is also an assistant professor. Poison Nil: Snake and Scorpion Antivenoms Set for First Update in 60 Years 2012-10-11T12:15:00.187Z Exhibit 2 shows that only half of phase III studies are successful, and only 60% of drugs submitted to regulators actually get approved. In Defense Of The FDA 2012-12-19T13:04:58Z “Everything hinges on the phase III side effects,” says Steinberg. Genetics: A gene of rare effect 2013-04-10T17:20:29.100Z But in two phase III trials — one reported on 23 July and one on 6 August — the drug did not prevent cognitive decline. Seven days: 3–9 August 2012 2012-08-08T17:20:20.547Z Despite encouraging evidence from animal studies that it clears amyloid from the brain, when it came to clinical improvements in human patients the drug proved no better than placebo in two phase III clinical trials. Hopes Dashed for Yet Another Alzheimer's Therapy 2012-08-07T21:30:54Z A third treatment, for rattlesnake bites, is beginning phase III trials. Poison Nil: Snake and Scorpion Antivenoms Set for First Update in 60 Years 2012-10-11T12:15:00.187Z This puts the combined failure rate for phase III and submission to a worrisome 70%, higher than for phase II. In Defense Of The FDA 2012-12-19T13:04:58Z Yes, there are several drugs being investigated in phase II and phase III trials. What Is Acute Myelogenous Leukemia, the Cancer That Struck Nora Ephron? 2012-06-28T11:15:06.867Z Analysts at Daniel Stewart said: The product successfully completed two phase III pivotal trials and has been tested on over 600 patients with a total of approximately 26,000 doses delivered. BP boosted by US and Russia hopes but FTSE loses early gains as Spanish euphoria peters out 2012-06-11T16:40:13Z The development of certain diabetes drugs keep hitting a snag — phase III clinical trials. Perspective: Testing failures 2012-05-22T15:21:18.330Z Ardea is a biotechnology company based in San Diego, California; its main asset is lesinurad, a potential treatment for gout that is in phase III clinical trials. Seven days: 20-26 April 2012 2012-04-25T17:20:20.507Z When the company tested it in 1998–99 in a phase III trial, the recipients made antibodies, but then developed infections in their blood at the same rate as those who received placebo. Vaccine development: Man vs MRSA 2012-02-01T18:20:36.980Z We plan on starting a phase III program in the first half of 2012. Isis CEO Predicts Success For His Cholesterol Medicine -- And Substantial Delays For Regeneron, Pfizer And Amgen 2012-01-11T16:11:29Z In October, interim results from a huge phase III clinical trial of the showed disappointing efficacy and no effect on mortality. 365 days: 2011 in review 2011-12-21T18:20:27.080Z Developed by Onyx Pharmaceuticals of South San Francisco, California, carfilzomib is now in phase III trials. Drugs: More shots on target 2011-12-14T18:21:03.017Z The FDA only pulled its approval of Avastin for breast cancer after that blinded phase III trial was finished, a trial that showed that patients on Avastin lived less long than those not on it. FDA Did the Right Thing in Pulling Avastin for Breast Cancer 2011-11-21T18:30:26Z Food and Drug Administration may not provide funding and clearance for a phase III trial to proceed. Heart Failure May Be Cut by Stem Cells, Study Shows 2011-11-15T03:16:01Z The phase III trial of RTS,S resulted in groundbreaking cooperation with African scientists, who led the 11 trials in 7 countries, says Hoffman. Malaria vaccine results face scrutiny 2011-10-26T17:20:44.570Z Malaria vaccine The world's leading candidate for a malaria vaccine has claimed promising results in a phase III trial, from which the first findings were published on 18 October. Seven days: 21?27 October 2011 2011-10-26T17:20:39.310Z But he expects this effect to show up in another ongoing phase III trial: CARE-MS II, the preliminary results of which should be available later this year. Antibody Offers Hope for Multiple Sclerosis Treatment 2011-10-24T18:45:03.460Z "Demonstration of long-term efficacy is crucial to treat a chronic disease such as MS and enhances the likelihood of success of the ongoing phase III trial program," Voegtli said. Roche MS drug results boost late-stage chances 2011-10-20T09:35:38Z We are posting it as background for today's announcement of good success in a phase III trial using a traditional vaccine by GlaxoSmithKline. Three Promising Vaccine Strategies against Malaria 2011-10-18T22:15:00.373Z The phase III trial—the final test—enrolled more than 15,000 babies aged 6 to 12 weeks and toddlers between 5 and 17 months across sub-Saharan Africa. Malaria Vaccine Meets (Modest) Expectations 2011-10-18T18:33:46Z And of those that survive through to phase III, generally the last step before regulatory approval, only half will actually be approved. Translational research: 4 ways to fix the clinical trial 2011-09-28T17:21:04.080Z Results from wider, or “phase III,” trials are expected as early as September. New Help For Smokers 2011-09-06T11:15:06.590Z But they're not going to move them on to a phase III study until they see the results of the ongoing trials. Drugs: A tangled web of targets 2011-07-13T17:20:55.130Z Novartis has filed for approval in Europe and other countries, such as Canada, and is working with U.S. authorities to design a U.S.-specific phase III trial. Novartis vaccine shields against meningitis cause 2011-06-09T08:19:22Z Only then, in phase III, some time around 2018, will Poland host a missile interceptor site. Mending ties 2011-05-27T15:10:01Z It was expensive, but it paid off: the phase III trials revealed Paxpharma to be just as effective as existing antidepressants, but with a faster onset of action and milder side-effect profile. A perfect drug 2011-03-30T17:21:28.960Z Provenge needed 20 years and three phase III clinical trials to reach FDA approval. Cancer research: Promise of protection 2011-03-23T18:51:54.540Z Despite these contradictory interpretations, the company is seeking patents in both Europe and the United States, and announced in December that it plans to press ahead with a large-scale phase III trial. Drugs: A tangled web of targets 2011-07-13T17:20:55.130Z How long patients like McHutchison's and others will have to wait for new HCV medication depends on the success of the drug candidates that are currently in large-scale phase III clinical trials. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z In the phase III study, a high percentage of the 4,500 infants as young as 2 months showed the immune response when given Menveo, Novartis said. Novartis to file meningitis vaccine for infants 2010-10-25T06:27:00Z The molecule is a nightmare to synthesize, and the size of the phase III trials necessitated a complete reworking of the manufacturing process. A perfect drug 2011-03-30T17:21:28.960Z Those studies, pivotal phase III trials, can cost hundreds of millions of dollars and take years to complete. Cancer-Drug Makers Turn to Cocktails 2010-08-26T21:00:00Z But despite the wide variety of potential approaches, three of the four drugs in phase III trials share one main target: an improperly folded peptide called amyloid-β. Drugs: A tangled web of targets 2011-07-13T17:20:55.130Z Both drugs are currently in their last, or phase III, trials. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z The drug is heading for phase III trials. Get Ready for More Weight Loss Drugs. But Will They Work? 2010-03-19T19:36:00Z "The phase III trial of Avastin in prostate cancer is expected to read out later this year." Roche's Avastin helps in ovarian cancer 2010-02-25T10:04:00Z |
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