| 单词 | phase I |
| 例句 | After my grunge phase I started opening my horizons and listening to more electronic stuff. Kevin Parker: soundtrack of my life 2013-04-27T23:04:04Z It was a phase I went through, I don't like that way of dressing now, but at the time it was me. Kevin Rowland: 'My motto is "never not shopping"' 2012-07-10T15:23:00Z I used to say “heat sideways” for melting ice or boiling water, but that was just a phase I was going through. Style Invitational: We beg you to differ — it’s our compare/contrast contest 2017-04-20T04:00:00Z The groom, 36, is an oncologist at the University of Pittsburgh Medical Center, and an assistant professor there, specializing in melanoma and phase I drug development. Something Clicked and a Long-Distance Romance Blossoms 2017-12-16T05:00:00Z The FDA has signaled that it is open to starting phase I clinical trials of xenotransplants once it has enough preclinical data. No One Should Die Waiting for an Organ Transplant. These Doctors Want to Ensure That Doesn’t Happen 2023-10-19T04:00:00Z These data will be used by eGenesis to apply for regulatory approval to run phase I clinical trials, which the company hopes to start in 2025. Monkeys with Transplanted Pig Kidneys Live for Up to Two Years or More 2023-10-11T04:00:00Z Locke and colleagues designed a dendritic cell vaccine targeting a protein called survivin and tested this vaccine in a phase I clinical trial involving 13 patients with multiple myeloma. A dendritic cell vaccine was safe and induced immune responses in patients with multiple myeloma 2023-09-22T04:00:00Z I went through different phases of trying to figure out who Cootie was, and in that phase I realized, well, Cootie has never been outside. Jharrel Jerome of 'I'm a Virgo' is a Libra, but he can channel another star sign 2023-06-23T04:00:00Z The results of a phase I/II clinical trial, which were published in 2019, revealed that tominersen lowered concentrations of the mutant version of huntingtin in the cerebrospinal fluid, without causing any serious side effects. Genetic Therapies for Brain Diseases 2022-01-01T05:00:00Z That seemed to play out in the first phase I Moderna trial of 45 people; 40 were white, and two were Black. We Learned the Wrong Lessons from the Tuskegee ‘Experiment’ 2021-12-28T05:00:00Z A week later, Wave Life Sciences said that it would discontinue the development of two of its HD ASOs that were in phase I/II clinical trials. Failure of Genetic Therapies for Huntington’s Devastates Community 2021-05-07T04:00:00Z Most drugs do fail, but they fail early on in phase I trials, and much of that early research is funded with public money. COVID-19 has shown how Big Pharma is broken 2021-02-20T05:00:00Z The vaccine is currently being tested in early-stage, or phase I, trials with human volunteers. The Second-Generation COVID Vaccines Are Coming 2021-01-20T05:00:00Z He described the phase I results as "really encouraging" and said that "with further work the Molecular Clamp technology will be a robust platform for future vaccine development." Development of unique Australian COVID-19 vaccine halted 2020-12-11T05:00:00Z Biological E. Ltd - The firm started phase I and phase II trials of its vaccine candidate in November. Factbox-Indian pharma industry's COVID-19 vaccine plans 2020-12-10T05:00:00Z But two such compounds failed to significantly lower levels of mutant huntingtin in early phase I/II trials, leading the company to abandon their development. Failure of Genetic Therapies for Huntington’s Devastates Community 2021-05-07T04:00:00Z In its phase I study of 40 people aged 56 and over, Moderna in Cambridge, Massachusetts, reported that its candidate mRNA-1273 elicited similar antibody levels as those elicited in a younger age group1. How anti-ageing drugs could boost COVID vaccines in older people 2020-10-13T04:00:00Z Phase II studies are larger versions of phase I trials. Here’s how the U.S. could release a COVID-19 vaccine before the election—and why that scares some 2020-08-28T04:00:00Z By 2012, when Loh was recruited, Paratek had accomplished phase I and II clinical trials of its compound, and had amassed abundant data on its safety — but it was running out of money. Why creating life-saving drugs is a lousy bet 2020-08-18T04:00:00Z A leading COVID-19 vaccine candidate generates an immune response against the virus and causes few side effects, according to preliminary data from a phase I safety study with 45 participants. Coronavirus research updates: Dogs’ and cats’ infection rates mirror those of people 2020-07-23T04:00:00Z The results come from phase I and II trials of four promising vaccine candidates and detail how people respond to the jabs. What trial results reveal about the coronavirus vaccine frontrunners 2020-07-20T04:00:00Z Even when expedited, phase I and phase II trials will take a minimum of 5 months, he says. Scientists scoff at Indian agency's plan to have COVID-19 vaccine ready for use next month 2020-07-06T04:00:00Z After initial laboratory and animal tests, vaccines enter phase I human trials that typically have about 20 to 100 people and primarily analyze safety and immune responses. Here’s how the U.S. could release a COVID-19 vaccine before the election—and why that scares some 2020-08-28T04:00:00Z Only about 14% of antibiotics and biologicals in phase I trials are likely to win approval, according to the World Health Organization. Why creating life-saving drugs is a lousy bet 2020-08-18T04:00:00Z Assuming all goes well, the company will proceed to a phase I clinical trial, probably involving healthy volunteers and people with type 1 diabetes. Forkhead BioTherapeutics: developing a diabetes pill 2020-06-29T04:00:00Z “This phase I think is up to the players,” MacLellan said. Capitals prepare to open MedStar Iceplex when NHL allows training to restart 2020-05-29T04:00:00Z Unity Biotechnology, a start-up company in Brisbane, California, has had promising results from an initial phase I trial to treat osteoarthritis of the knee with its senolytic, UBX0101. Zombie cells hold clues to COPD progression 2020-05-12T04:00:00Z Q: If you start phase I trials in September, what’s your plan for moving forward? The $1 billion bet: Pharma giant and U.S. government team up in all-out coronavirus vaccine push 2020-03-31T04:00:00Z But although it is an important milestone, the phase I trial is just the beginning of a long process to test the drug’s safety and efficacy. Coronavirus latest: Italy death toll overtakes China’s 2020-03-19T04:00:00Z Britain leads Europe in early-stage - phase I and II - trials, with particular strength in cancer research. On eve of Brexit, Britain faces critical test to defend drug trial crown 2020-01-30T05:00:00Z “The phase I trade deal takes China as a headwind and sets it up as a potential tailwind,” Fritz said. Union Pacific 4Q delivery volume falls, so does its profit 2020-01-23T05:00:00Z It has just been tested in a phase I clinical trial, which typically establishes safety, not efficacy. Scientists find way to make diphtheria treatment without injecting horses with toxin 2020-01-17T05:00:00Z SNAs are already showing potency and safety in phase I clinical trials in humans, and other spheres targeting a deadly skin cancer are being tested in a separate set of safety trials. The Power of Spheres 2019-12-03T05:00:00Z In a phase I trial, the researchers gave 35 women aged 19 to 45 either a version of the vaccine that included aluminium hydroxide, or one that included lipid molecules or a placebo. Research round-up: Vaccines 2019-11-26T05:00:00Z Then a second carrier for siRNA was tried and seemed to work well — in vitro in a transgenic mouse model and in a phase I human study. Patisiran’s path to approval as an RNA therapy 2019-10-15T04:00:00Z The first use of RNAi-mediated gene silencing in humans is reported in a phase I trial in people with the skin cancer melanoma8. RNA therapies explained 2019-10-15T04:00:00Z And last month, the company disclosed that participants in a phase I human trial experienced dose-dependent increases in antibody levels as well. Unlocking the potential of vaccines built on messenger RNA 2019-10-15T04:00:00Z On the basis of promising evidence of cross-protection against diverse influenza A subtypes in animals, the Mount Sinai team is now conducting phase I trials to explore the vaccine’s safety and effectiveness in humans. Towards a universal flu vaccine 2019-09-17T04:00:00Z In a phase I trial, 40 adults who were given the vaccine churned out 7–15 times more RSV-fighting antibodies than were present before vaccination — an increase that persisted for months. Research round-up: Vaccines 2019-11-26T05:00:00Z “I never needed to work, the whole cable news thing was just a total pose, it was just like a phase I was going through.” Fox News host Tucker Carlson pushes zany conspiracy theory about why he has been accused of racism 2019-08-08T04:00:00Z “During the landing phase I was an 11-year-old dialed into the kitchen AM radio. I distinctly recall Mission Control exclaiming “60 seconds,” referring to the fuel remaining, then “30 seconds” with more urgency. Where were you on July 20, 1969? Readers share their memories of the moon landing 2019-07-20T04:00:00Z Human trials are underway for this approach, but the phase I study, which uses a different gene-editing technique to disrupt the CCR5 receptor gene, is yet to report outcomes. Stem-cell and genetic therapies make a healthy marriage 2019-05-14T04:00:00Z This vaccine design is now undergoing a phase I clinical trial and could in principle confer protection against many of the most prominent pandemic virus subtypes. Towards a universal flu vaccine 2019-09-17T04:00:00Z Unlike the phase I/II trial, this trial will show whether the vaccine prevents people from getting the virus. Research round-up: Vaccines 2019-11-26T05:00:00Z The following month, a team led by Humayun reported similar phase I results in five people with dry AMD, the more common form of the condition13. Four technologies that could transform the treatment of blindness 2019-04-09T04:00:00Z There are multiple phase I and II trials testing the efficacy of hydroxychloroquine. A New Way to Fight Cancer 2019-03-29T04:00:00Z In phase I trials, surgeons will then almost certainly remove the focus. Gene therapy targets epilepsy 2018-12-11T05:00:00Z But while trying to get a phase I trial started with an extract from the divi-divi tree, Caesalpinia spinosa, she hit a snag. Science in Colombia on the cusp of change 2018-10-23T04:00:00Z During a phase I trial, the scientists collected the blood of people who’d received the vaccine, sequenced the genes that produced their antibodies, and used the genes to make more antibodies. Research round-up: Vaccines 2019-11-26T05:00:00Z Chiocca’s group has begun a phase I trial of the virus, with encouraging results. Immunotherapy offers a promising bet against brain cancer 2018-09-25T04:00:00Z During my cocktail waitressing phase I dated a nearly pathological vegan with an unsettling commitment to Thelonious Monk. Would I rather be set up by an app, or by my mom? 2018-08-17T04:00:00Z "There's always a lot of focus on the start-up phase of a business, but it's the growth phase I think is really difficult," says Henrietta. How a poorly puppy inspired a pet food success story 2018-03-25T04:00:00Z Ionis Pharmaceuticals recently announced that an RNA approach called antisense reduced toxic brain proteins in a phase I trial to treat Huntington disease. Here are the stories that will make science headlines in 2018 2018-01-04T05:00:00Z The Mayo Clinic researchers have completed a phase I clinical trial to confirm safety and acceptably low side effects. Drug therapy: On the treatment trail for ALS : Nature : Nature Research 2017-10-17T04:00:00Z The first results of the phase I study of Juno’s JCAR017 drug are promising, and seem to meet Bishop’s best-in-class expectations. Juno Therapeutics ready for another round in war on cancer 2017-09-15T04:00:00Z “There was this phase I was in where my hair was actually pinned back. I was so aerodynamic,” Moolchan said. The mysterious, magnetic, mundane, magical minimalism of Sneaks 2017-03-16T04:00:00Z And it launched its first two phase I trials without announcing what diseases they targeted—a decision Bancel attributes to fears that financial markets would prematurely pigeonhole the company into a particular field. This mysterious $2 billion biotech is revealing the secrets behind its new drugs and vaccines 2017-02-01T05:00:00Z The NIH rules apply only to work done through agency grants, and include stricter reporting requirements for phase I trials. US toughens rules for clinical-trial transparency 2016-09-15T04:00:00Z A medical oncologist at the Memorial Sloan Kettering Cancer Center in New York City, Motzer was recruiting patients for a phase I clinical trial for an especially promising treatment. Immunotherapy: Controlled attack : Nature : Nature Research 2016-09-13T04:00:00Z PreScience Labs, a U.S. company founded by Geschwind, received approval for a phase I study from the U.S. Candidate cancer drug suspected after death of three patients at an alternative medicine clinic 2016-08-12T04:00:00Z Now, the companies are the first to win approval for phase I testing on humans. First Zika vaccine trials to begin within weeks 2016-06-20T04:00:00Z The researchers are able to skip the phase I safety trials because the drug had already passed them, and are going straight to phase II: testing the drug's efficacy against bipolar disorder. Can you teach old drugs new tricks? 2016-06-13T04:00:00Z In 2006, another phase I trial went seriously awry when six healthy young men suffered organ failure after being given an immune system drug at Northwick Park hospital in northwest London. French Drug Trial Leaves One Person Brain Dead, Four With Serious Disorders 2016-01-15T05:00:00Z Early in the outbreak, it had a great advantage over other drug candidates: It was plentiful and had proved safe when given to healthy volunteers in phase I trials. Special report: Ebola's thin harvest 2015-12-31T05:00:00Z Essa Pharma of Vancouver, Canada, is taking a different approach to the problem of resistance with its drug EPI-506, currently being prepared for phase I/II testing. Metastasis: Resistance fighters : Nature : Nature Publishing Group 2015-12-14T05:00:00Z The phase I study will primarily assess whether treatment for 24 weeks can lower HERV-K gene expression to undetectable levels, but Nath will also monitor the disease’s progression. Is an ancient virus responsible for some cases of Lou Gehrig’s disease? 2015-09-30T04:00:00Z If the new disease requires a significantly higher dose, the drug will have to go through phase I trials again. Can you teach old drugs new tricks? 2016-06-13T04:00:00Z Abide began enrolling participants in a phase I safety study in Belgium in July 2015. Drug development: The treasure chest : Nature : Nature Publishing Group 2015-09-22T04:00:00Z The study, led by the University of Pennsylvania, pooled the results of 394 phase I clinical drug trials from 2004 to 2011 involving mostly men between the ages of 24 and 43. Beach Bugs: Illnesses Often Follow Offshore Swims 2015-08-03T04:00:00Z Both companies need to demonstrate that the compound is safe before they can move forward, and phase I studies, which assess safety in disease-free participants, are similar regardless of the intended use. Pharmacotherapy: Quest for the quitting pill : Nature : Nature Publishing Group 2015-06-23T04:00:00Z But the new formulation hadn’t been through phase I safety trials in humans so couldn’t be used in Ebola patients. In setback for potential Ebola drug, company halts trial 2015-06-19T04:00:00Z Most of them pass phase I trials, but do not get past phase II because they don't have the same effect in humans that they had in animals. Can you teach old drugs new tricks? 2016-06-13T04:00:00Z Currently, phase I and II clinical trials usually involve giving different amounts of a drug to a small group of healthy volunteers. Personalized medicine: Time for one-person trials 2015-04-28T04:00:00Z The products hadn’t moved through phase I safety studies, and the outbreaks were much smaller and always ended within a few months. Scientists argue over access to remaining Ebola hotspots 2015-03-26T04:00:00Z “Then if something interesting — good or bad — happens during phase I, you can wheel these devices back out to figure out what's happening.” Artificial organs: Honey, I shrunk the lungs : Nature : Nature Publishing Group 2015-03-24T04:00:00Z “I said it wouldn't work for life sciences because it takes 10 to 15 years to get to a phase I clinical trial,” he says. Biotech boot camp 2015-03-24T04:00:00Z A phase I trial in patients with β-thalassaemia — a genetic blood disorder caused by insufficient haemoglobin production — is scheduled to begin this year. Don’t edit the human germ line 2015-03-11T04:00:00Z The GSK vaccine is currently in phase I trials in the U.S., the U.K., Liberia to Receive First Batch of Experimental Ebola Vaccine A vaccine initially made by NewLink Genetics but now manufactured by Merck still needs to enroll more volunteers in its phase I studies. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z Two other phase I trials for the vaccine are ongoing in the United Kingdom and Mali, with results expected by year-end, the NIH said. Early Trial Promising for Ebola Vaccine 2014-11-26T05:00:00Z Still, she and Jones say that they wish that studies sponsored by industry and private sources were also required to report results of phase I trials. Clinical-trial rules to improve access to results 2014-11-24T05:00:00Z And for the first time, federally funded researchers will be required to post the results of their phase I clinical trials. US government cracks down on clinical-trials reporting 2014-11-18T05:00:00Z And results still won’t be required for early trials, known as phase I, which test a product’s safety. Proposed rules will vastly expand trove of clinical trial data reported in U.S. database 2014-11-19T05:00:00Z So far, so-called phase I tests have given experimental Ebola vaccines to healthy volunteers not at risk for Ebola, assessing safety and immune responses. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z The NewLink vaccine trails a little; its phase I trials started later. Improved Ebola Situation in Liberia May Complicate Vaccine Trials 2014-11-17T05:00:00Z His phase I trial of this drug, in partnership with Wilkie and others, halved the pain levels in 8 of the 18 study participants, without any need for extra opioid pain relief. Neurobiology: Life beyond the pain : Nature : Nature Publishing Group 2014-11-11T05:00:00Z Industry and privately funded studies are not required to post phase I results. US government cracks down on clinical-trials reporting 2014-11-18T05:00:00Z In the new study, a so-called phase I trial, researchers tested parts of the vaccine in 15 people. Vaccine for Hepatitis C Inches Closer to Reality 2014-11-05T05:00:00Z The phase I trial, conducted by the University of Oxford in the United Kingdom, tests two shots in what’s called a prime-boost strategy. Ebola vaccines move closer to ultimate test 2015-01-09T05:00:00Z And a few are close to being ready to start phase I trials. Improved Ebola Situation in Liberia May Complicate Vaccine Trials 2014-11-17T05:00:00Z These phase I trials will assess the vaccines’ safety and whether they elicit levels of immune response that have been shown to confer protection in non-human primates. WHO plans for millions of doses of Ebola vaccine by 2015 : Nature News Blog 2014-10-23T04:00:00Z Provectus is also in phase I and II trials with its drug PH-10 for patients with atopic dermatitis and psoriasis. A New Cancer Drug Worked In Over 50% Of Patients In A Phase II Trial 2014-10-29T04:00:00Z In a few weeks, meeting participants learned, enough data may be available from small phase I trials of a vaccine jointly made by the U.S. Ebola vaccines racing forward faster than predicted, but high hurdles remain 2014-10-24T04:00:00Z The company expects to have preliminary data in November from phase I studies that analyze safety and immune response in small numbers of people not at risk of contracting Ebola. Leaked documents reveal behind-the-scenes Ebola vaccine issues 2014-10-23T04:00:00Z The GSK vaccine only went into a human for the first time on 2 September, in a phase I trial that will involve a few hundred volunteers not at risk of infection. Tough choices ahead in Ebola vaccine trials 2014-10-07T04:00:00Z It will begin phase I testing in the United States and Europe in January. WHO plans for millions of doses of Ebola vaccine by 2015 : Nature News Blog 2014-10-23T04:00:00Z Scientists say WHO's vials could have already been shipped to the research centers planning to do phase I trials. Ebola vaccine tests needlessly delayed, researchers claim 2014-09-29T04:00:00Z A second vaccine, initially developed by the Public Health Agency of Canada and now made by NewLink Genetics of Ames, Iowa, that started phase I trials in October might have similar data available by December. Ebola vaccines racing forward faster than predicted, but high hurdles remain 2014-10-24T04:00:00Z So when medical oncologist Naiyer Rizvi became involved with the phase I trial of a tumour antibody a few years ago, he was prepared for failure. Immunotherapy: Chemical tricks : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Within the next six months he hopes to begin a phase I breast cancer trial in humans. Nanoparticles could help deliver a killer blow to cancer 2014-08-13T04:00:00Z But while the biotech product, called ZMapp™, is indeed still experimental – it’s not yet approved for human use, and not yet even in phase I clinical trials – it’s far from secret. Ebola 'Secret Serum': Small Biopharma, The Army, And Big Tobacco 2014-08-05T04:00:00Z At the WHO meeting today and tomorrow, experts are discussing the many thorny issues that will arise if one or both of the vaccines successfully pass their phase I trials. Ebola vaccine tests needlessly delayed, researchers claim 2014-09-29T04:00:00Z Even the idea of putting products up for sale and into consumers' bodies on the basis of phase I data is disturbing. Regulation: Sell help not hope 2014-06-15T04:00:00Z Miller, meanwhile, is planning a phase I trial of a variation on his original approach that uses biodegradable nanoparticles instead of blood cells as antigen carriers. Immunology: A tolerant approach 2014-03-26T18:20:25.689Z The favorable data was seen in a phase I, or early-stage, trial involving 67 patients with chronic lymphocytic leukemia who had not been helped by chemotherapy or relapsed from such treatment. AbbVie leukemia drug impresses in early-stage trial 2013-12-08T15:30:56Z "They're not very high anymore - it was a phase I went through," the media mogul said. X Factor musical launches in London 2013-09-02T20:32:49Z If I had unlimited resources, however, I would quickly complete the last preclinical studies necessary to enter phase I clinical trials with our most promising compounds. 30 under 30: Fighting Cancer with Metal-Based Drugs 2013-06-01T11:45:00.160Z It is this formulation of the drug that is employed in phase I and II clinical trials that are currently under way. [Technical Response] Response to Comments on “ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models” 2013-05-23T18:26:03.153Z Last year, the company reported promising results from a phase I clinical trial testing neural stem-cell transplants for treating this disease. Bendable Needles Developed to Deliver Stem-Cells into Brains 2013-03-05T18:15:01.027Z In a small phase I trial, the drug more than doubled survival time from five months to more than twelve. Nanotechnology: Carrying drugs 2012-11-23T15:20:59.170Z Novartis will also present data on two pipeline compounds to treat metastatic breast cancer as well as a phase I study of LDK378 in patients with a certain type of non-small cell lung cancer. Novartis to show diverse oncology franchise at ASCO 2012-05-31T05:32:40Z In this context the research group where I work is founding a new spin-off company in order to enter phase I clinical trials. 30 under 30: Fighting Cancer with Metal-Based Drugs 2013-06-01T11:45:00.160Z There was one phase I went through — I was 6 at the time, maybe 7 — when I would get home from school, race upstairs and close my door. | Townies: For One More Day at the Office 2012-04-26T22:16:32Z I presented the latter's case in the best phase I knew how, but while I drew but little from him, I left feeling that he hadn't been entirely won over. Abraham Lincoln, Volume 2 (of 2) The True Story of a Great Life 2012-01-05T03:00:32.877Z With the latest analytical technologies available to him, Cheng has made good progress: he has completed phase I clinical trials of the herb and is soon to start phase II. Regulations: Herbal medicine rule book 2011-12-21T18:21:07.133Z Anderson's lab is also working with NPI-0052, which was developed by Nereus Pharmaceuticals in San Diego, California, and is now in phase I trials. Drugs: More shots on target 2011-12-14T18:21:03.017Z Only four of a planned eight patients in Geron’s phase I trial have received injections of specialized cells derived from human ES cells. Stem-cell pioneer bows out 2011-11-23T18:20:32.647Z Only four of a planned eight patients in Geron's phase I trial have received injections of specialized cells derived from human ES cells. Pioneering Stem-Cell Therapy Research Halted 2011-11-22T21:15:02.293Z "We see the donation of eggs for research purposes as really quite comparable to people who volunteer for phase I medical trials," says Albert Weale, chair of the Nuffield Council. U.K. Panel Says Women Egg Donors Should Be Paid 2011-10-11T16:37:33Z Arlen's group is testing, in a phase I trial, a monoclonal antibody to treat patients with the more common form of pancreatic cancer. The Puzzle of Pancreatic Cancer: How Steve Jobs Did Not Beat the Odds--but Nobel Winner Ralph Steinman Did 2011-10-07T11:15:00.213Z By a year after the treatment, she and the five other patients in the phase I trial showed an improvement in motor ability of 48%, and those gains largely held 4 years later. Experimental Parkinson's disease therapies: Why fake it? 2011-08-10T17:20:31.227Z In phase I trials, human volunteers responded to vaccination with a strong helper T-cell response while producing detectable levels of antibodies with the capacity to neutralize diverse viral subtypes. Vaccines: A moving target 2011-06-13T13:20:41.413Z On average, fewer than 5% of participants in phase I trials respond successfully to the treatment. Cancer therapy: Taking aim sooner 2011-06-09T11:07:17Z Another report featured results from an initiative at MD Anderson Cancer Center involving several experimental drugs in initial, or phase I, testing. A major shift in cancer drugs 2011-06-06T11:28:00Z Along with recent phase I clinical trial results, these new data provide a platform for clinical use of T cells as personalized therapeutic agents for the treatment of autoimmune diseases, graft-versus-host disease, and transplant rejection. [Perspectives] Regulatory T Cells: Customizing for the Clinic 2011-05-18T19:25:09.563Z The study, a phase I safety trial, tested a zinc finger enzyme developed by Sangamo BioSciences in Richmond, California. Targeted gene editing enters clinic 2011-03-02T18:20:33.200Z The results that the Santaris group saw in HCV-infected chimpanzees, which were published November 30 in Science, encouraged the scientists to conduct phase I trials of SPC3649 that are currently ongoing. Triple-Drug Cocktail in the Works for Hepatitis C Therapy 2011-01-05T22:16:21.493Z The same is true of medical researchers recruiting volunteers for clinical trials, especially those known as phase I trials, in which a new drug is tested on people for the first time. Cancer therapy: Taking aim sooner 2011-06-09T11:07:17Z Typically, phase I studies of cancer drugs test a single agent in patients to determine a maximum tolerable dose with the hope that a treatment effect might be seen in a couple of patients. A major shift in cancer drugs 2011-06-06T11:28:00Z The update of the phase I clinical trial was based on four months of post-treatment data. Stem cell treatment for heart attack promising: study 2010-09-23T20:12:00Z These patients were part of phase I trials, an early step in the approval phase for a new drug and often the first time that drug is tested in humans. Can cancer patients benefit from new drug trials? 2010-08-13T14:54:00Z Through Anderson's company, Nexpep, based in Ivanhoe, Australia, the researchers are also conducting phase I clinical trials on a drug based on the three gluten protein fragments they identified. Study Points to Molecular Origins of Celiac Disease 2010-07-21T18:00:00Z It must have been that even through this phase I fought on, arms and legs thrashing in what was practically an involuntary effort to fight on to the open sea. Kastle Krags A Story of Mystery The MD Anderson program pooled 1,144 patients in a phase I study after profiling their tumors for mutations that might be targets of the tested drugs. A major shift in cancer drugs 2011-06-06T11:28:00Z Of this phase I was cured, mainly through the agency of the abominable Trask, whose horse banter and innuendo at such times rendered it difficult to keep my hands off him. A Veldt Vendetta Then they made the same calculation of how well patients did on the experimental phase I drugs. Can cancer patients benefit from new drug trials? 2010-08-13T14:54:00Z During this phase I overcame my fear of exposing my thoughts, I took the risk, and my courage had the upper hand. Humanistic Nursing Over and over I asked myself the question, and when I touched its every phase I found that Henry Holmes or Isaac Bolum, some one of the store worthies, had met defeat there before me. The Soldier of the Valley Other researchers said such a high response rate in a phase I study was highly unusual and could help prompt other academic and corporate researchers to change their protocols to help speed the early-phase trials. A major shift in cancer drugs 2011-06-06T11:28:00Z When Wilde was in Paris during his last phase I made a point of sending him inscribed copies of all my books as they came out; and he did the same to me. Oscar Wilde, His Life and Confessions Volume 2 But Miller thinks that the desire to join a phase I trial is a natural one for people who are dying of cancer. Can cancer patients benefit from new drug trials? 2010-08-13T14:54:00Z The phase I would impress is that any question that has a great moral principle involved is never settled until it is settled right. Wit, Humor, Reason, Rhetoric, Prose, Poetry and Story Woven into Eight Popular Lectures The next phase I remember only too vividly. Jaffery I did not yet know what angel was whispering to me out of the physical phase I was passing through, when suddenly I became possessed by a passion for children. The Woman Thou Gavest Me Being the Story of Mary O'Neill She won't be able to believe, easily, that my old vagabond ways have lost their importance for me; that they're a phase I can afford to outgrow. Mary Wollaston This phase I could not get rid of so easily as the last; the fibres of my being remained quiet. The Jewel of Seven Stars Thought them all over in every way and phase I can imagine.’ The Man I had stagnant waking intervals, and sleep tormented by dreams, and at one phase I was, I remember, so weak as to be earth-sick and almost hysterical. The First Men in the Moon |
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