| 单词 | osteoclast |
| 例句 | Over a period of months, special cells called osteoclasts “eat” the extra bone so you end up with a bone that looks the way it did before it was broken. Ever wondered about broken bones? 2016-03-25T04:00:00Z Finally, because porous endplates allow new nerves to grow into the endplate bone, causing sensitivity, the authors looked at whether senescent osteoclasts play a role in this process. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Significantly, bone related diseases like osteoporosis, rheumatism and periodontitis are associated hyper activation of bone resorption by osteoclast. Bone density is kept up by the same process with hair color 2023-10-26T04:00:00Z Cutting-edge imaging sheds new light on cells that break down bone Imaging technology developed at Garvan shows that bone-resorbing osteoclasts gather in distinct pockets, leading to new insights for osteoporosis and cancer treatment. Cutting-edge imaging sheds new light on cells that break down bone 2023-10-26T04:00:00Z In healthy people, there is a balance between the osteoblasts that build new bone and osteoclasts that break it down. AI identifies antimalarial drug as possible osteoporosis treatment 2023-10-18T04:00:00Z The release of parathyroid hormone from the endocrine system triggers osteoclasts of the skeletal system to resorb bone and release calcium into the blood. Fundamentals of Biology 2015-01-01T00:00:00Z This suggests there is an ongoing dysfunctional production of new bone tissue within the spinal endplate in the ageing or injured spine, and that treatment to remove the senescent osteoclasts could halt this process. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z "To better understand the molecular mechanisms of osteoclast function, we first screened Rab proteins especially induced during osteoclast formation in mouse." Bone density is kept up by the same process with hair color 2023-10-26T04:00:00Z With a new level of visual detail, the researchers discovered that osteoclasts, cells that break down bone tissue, are more active in some parts of the bone compared to others. Cutting-edge imaging sheds new light on cells that break down bone 2023-10-26T04:00:00Z Current treatments for osteoporosis primarily focus on slowing the activity of osteoclasts. AI identifies antimalarial drug as possible osteoporosis treatment 2023-10-18T04:00:00Z Illustration C shows small osteoclasts surrounding the outside of bone. Fundamentals of Biology 2015-01-01T00:00:00Z "Our findings suggest that depletion of these senescent osteoclasts, perhaps by use of existing drugs, could represent a new strategy in the treatment of lower back pain." Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Blood vessels invade the cavities, and osteoblasts and osteoclasts modify the calcified cartilage matrix into spongy bone. Biology for AP Courses 2022-06-09T00:00:00Z The researchers tracked down distinct pockets of bone resorption activity as the cells 'morph' between actively resorbing osteoclasts and an intermediate cell state called osteomorphs, in real time. Cutting-edge imaging sheds new light on cells that break down bone 2023-10-26T04:00:00Z Vitamin D plays a synergistic role with PTH in stimulating the osteoclasts. Anatomy and Physiology 2013-06-19T00:00:00Z Larger osteoclasts are also on the outer surface, forming a hollow in the bone. Fundamentals of Biology 2015-01-01T00:00:00Z They tested for the simultaneous presence of two markers within the bone -- 'TRAP' which is a hallmark of osteoclasts, and p16, used to identify senescent cells. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Osteoblasts at the bone surface secrete bone matrix, and osteoclasts on the inner surface break down bone. Biology for AP Courses 2022-06-09T00:00:00Z This knowledge could be used to develop new treatments for osteoporosis, and for dormant cancer cells, which can stay hidden in bone for years until they are reactivated by osteoclasts. Cutting-edge imaging sheds new light on cells that break down bone 2023-10-26T04:00:00Z PTH secretion causes the release of calcium from the bones by stimulating osteoclasts, which secrete enzymes that degrade bone and release calcium into the interstitial fluid. Anatomy and Physiology 2013-06-19T00:00:00Z Finally, and perhaps most importantly, the study provides a mechanism by which osteoclasts in the process of resorbing bone communicate with nearby osteoblasts to regulate the extent to which new bone is formed. Receptor becomes a ligand to control bone remodelling 2018-09-04T04:00:00Z In both types of spinal degeneration, they saw a strong association between the presence of senescent osteoclasts and the degree of degeneration and spine hypersensitivity. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z The bony callus is then remodelled by osteoclasts and osteoblasts, with excess material on the exterior of the bone and within the medullary cavity being removed. Biology for AP Courses 2022-06-09T00:00:00Z Cells called osteoclasts break down bone cells that attach the antler to the skull, while osteoblasts will start building them up in the spring. Why Do Moose Shed Their Antlers? 2018-01-20T05:00:00Z It is a disorder of the bone remodeling process that begins with overactive osteoclasts. Anatomy and Physiology 2013-06-19T00:00:00Z But it is less clear how osteoclasts signal to osteoblasts to modify bone formation. Receptor becomes a ligand to control bone remodelling 2018-09-04T04:00:00Z Next, they explored whether a drug called Navitoclax, which targets senescent cells, could eliminate senescent osteoclasts and reduce spinal hypersensitivity. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z Bone remodeling involves the processes of bone deposition by osteoblasts and bone resorption by osteoclasts. Biology for AP Courses 2022-06-09T00:00:00Z Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation. Chromosomal instability drives metastasis through a cytosolic DNA response 2018-01-16T05:00:00Z Bisphosphonates, drugs that decrease the activity of osteoclasts, are often used in the treatment of Paget’s disease. Anatomy and Physiology 2013-06-19T00:00:00Z They help to direct osteoclasts to break down old bone and guide the mineralization of the new bone matrix. Osteoporosis: Staying strong : Nature : Nature Research 2017-10-03T04:00:00Z As hoped, the treatment caused a significant reduction in senescent osteoclasts compared to untreated mice, as well as reduced pain and increased activity in mice with both types of spine degeneration. Drug that kills off sleeping bone cells could treat lower back pain 2023-11-14T05:00:00Z There are three types of cells in bone: osteoblasts, osteocytes, and osteoclasts. Biology for AP Courses 2022-06-09T00:00:00Z The parasites might trigger these problems, the scientists hypothesized, by upsetting the normal balance between cells known as osteoclasts, which dissolve bone, and cells called osteoblasts, which build it back up. Malaria may weaken the skeleton 2017-06-02T04:00:00Z In Paget’s disease, new bone is formed in an attempt to keep up with the resorption by the overactive osteoclasts, but that new bone is produced haphazardly. Anatomy and Physiology 2013-06-19T00:00:00Z First, a type of bone cell called an osteoclast breaks down or resorbs the existing bone. Osteoporosis: Staying strong : Nature : Nature Research 2017-10-03T04:00:00Z Denosumab is a monoclonal antibody that blocks the action of osteoclasts, which are cells that break down bone. Breast Cancer Drugs Battle Disease's Return 2015-12-09T05:00:00Z Calcitonin decreases blood calcium levels by inhibiting osteoclasts, stimulating osteoblasts, and stimulating calcium excretion by the kidneys. Biology for AP Courses 2022-06-09T00:00:00Z But bone breakdown outpaced bone restoration, suggesting that osteoclasts were working harder. Malaria may weaken the skeleton 2017-06-02T04:00:00Z The cell responsible for bone resorption, or breakdown, is the osteoclast. Anatomy and Physiology 2013-06-19T00:00:00Z "The authors speculate that the mechanism of action involves the activation of osteoclasts, cells which break down bone, by the SSRIs," explained Dr. Caroline Messer, an endocrinologist at Lenox Hill Hospital in New York City. Common Antidepressants Linked to Higher Fracture Odds in Menopausal Women 2015-06-26T04:00:00Z However, over time, the osteoclasts tend to overtake the bone-building processes, which leads to lower bone density and a higher risk for fractures. Combining Bone-Building Drugs Makes Bones Stronger 2013-05-16T11:05:25Z It acts in the bones to inhibit osteoclast activity and in the kidneys to stimulate excretion of calcium. Biology for AP Courses 2022-06-09T00:00:00Z The mixture spurred the cells to release inflammation-promoting molecules known to spur osteoclast production. Malaria may weaken the skeleton 2017-06-02T04:00:00Z The ongoing balance between osteoblasts and osteoclasts is responsible for the constant but subtle reshaping of bone. Anatomy and Physiology 2013-06-19T00:00:00Z Bisphosphonates restore the balance by suppressing osteoclast activity, thereby discouraging bone resorption and suppressing tumour growth. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z Myeloma promotes the activity of osteoclasts, which cause bone degradation. Aetiology: The path to disease 2011-12-14T18:21:15.300Z It involves the processes of bone deposition by osteoblasts and bone resorption by osteoclasts. Biology for AP Courses 2022-06-09T00:00:00Z Normally, cells called osteoclasts clear away old bone tissue while others called osteoblasts lay down new bone. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z Over the next several weeks, osteoclasts resorb the dead bone; osteogenic cells become active, divide, and differentiate into osteoblasts. Anatomy and Physiology 2013-06-19T00:00:00Z In healthy bone, there is a balance between the activity of cells that build up new bone tissue, called osteoblasts, and those that break it down, called osteoclasts. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z So as well as weakening the bone, the osteoclasts help the tumour cells multiply. Aetiology: The path to disease 2011-12-14T18:21:15.300Z This is similar to the endochondral formation of bone, as cartilage becomes ossified; osteoblasts, osteoclasts, and bone matrix are present. Biology for AP Courses 2022-06-09T00:00:00Z Epstein's group decided to investigate osteoclast activity in SCID-hu mouse models of myeloma. Microenvironment: Neighbourhood watch 2011-12-14T18:21:10.780Z Pharmaceutical preparations of calcitonin are sometimes prescribed to reduce osteoclast activity in people with osteoporosis and to reduce the degradation of cartilage in people with osteoarthritis. Anatomy and Physiology 2013-06-19T00:00:00Z Myeloma cells upset this balance by promoting the activity of the destructive osteoclasts and inhibiting the work of osteoblasts, resulting in increased bone resorption. Orthopaedics: Structural support 2011-12-14T18:21:16.733Z In addition, the DKK1 gene may aid the destruction of osteoblasts and the proliferation of osteoclasts, although the mechanism for the activation of the gene is unknown. Aetiology: The path to disease 2011-12-14T18:21:15.300Z A drug that enhances the bone formation activity of osteoclasts may also be a good strategy. Biology for AP Courses 2022-06-09T00:00:00Z Patients randomly allocated receive standard chemotherapy and/or hormone therapy, either with or without the addition of Zometa, a drug that works by inhibiting the cells that break down bone, called osteoclasts. Novartis drug may help older breast cancer patients 2011-09-25T12:06:13Z The hormone activates osteoclasts to break down bone matrix and release inorganic calcium-phosphate salts. Anatomy and Physiology 2013-06-19T00:00:00Z They prevent bone loss by inhibiting the activity of cells that break down bone, called osteoclasts. Roche bone drug eases pain in prostate cancer trial 2011-09-25T10:29:12Z Prolia is the first approved therapy that specifically targets an essential regulator of osteoclasts, the cells that break down the cells that break down bone. Amgen osteoporosis drug effective in study 2011-09-18T15:20:16Z A therapeutic drug that inhibits osteoclast activity would be useful. Biology for AP Courses 2022-06-09T00:00:00Z Serotonin from the gut, on the other hand, keeps bone-making in check: it suppresses the osteoblasts from making fresh bone, but to the caustic osteoclasts is says neither yea nor nay. Basics: Job Description Grows for Our Utility Hormone 2011-05-02T22:05:21Z Prolia is the first in a new class of medicines that work by blocking a protein that activates bone-destroying cells called osteoclasts. Amgen says Prolia increases bone density over time 2011-03-23T21:10:42Z Denosumab is the first in a new class of medicines that work by blocking a protein which activates bone-destroying cells called osteoclasts. FDA OKs Amgen's bone drug in certain cancers 2010-11-19T02:43:00Z The drug inhibits a receptor that activates cells called osteoclasts that break down bone. 2010-01-08T18:11:00Z A therapeutic drug that inhibits osteoclast activity would be useful. Biology for AP Courses 2022-06-09T00:00:00Z An osteoblast engaged in the absorption instead of the formation of bone is called an osteoclast. Text Book of Biology, Part 1: Vertebrata |
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