| 单词 | oncogene |
| 例句 | They were attacking the cancer with a new cocktail: two chemo drugs and a protein receptor that they hoped would turn off the oncogene in Gus’s cancer. The Fault in Our Stars 2012-01-10T00:00:00Z While most cancers are caused by genetic mutations in DNA that trigger genes in normal cell growth to become oncogenes, skin cancer is caused by excessive sun exposure. Yes, some sunscreens contain cancer-causing chemicals — but the sun is still far more dangerous 2023-07-13T04:00:00Z Proto-oncogenes are normal genes that, when mutated, become oncogenes—genes that cause a cell to become cancerous. Concepts of Biology 2013-04-25T00:00:00Z Cells such as these daughter cells quickly accumulate both oncogenes and non-functional tumor suppressor genes. Biology for AP Courses 2022-06-09T00:00:00Z And although developers of targeted therapies focus mainly on mutations to a subset of genes called oncogenes, there is more to malignancy. The RNA and protein landscape that could bring precision medicine to more people 2020-09-22T04:00:00Z After a postdoctoral fellowship at the University of California at San Diego, she joined Gallo’s lab, where, in addition to her work on HIV/AIDS, she contributed to research on cancer-causing oncogenes. Flossie Wong-Staal, pioneering HIV/AIDS researcher, dies at 73 2020-07-13T04:00:00Z For example, HER2-positive breast cancers involve a mutated HER2 oncogene, which produces a protein that increases the growth of cancer cells. How cancer genomics is transforming diagnosis and treatment 2020-03-24T04:00:00Z Once a proto-oncogene has been altered such that there is an increase in the rate of the cell cycle, it is then called an oncogene. Concepts of Biology 2013-04-25T00:00:00Z This is because oncogenes can alter transcriptional activity, stability, or protein translation of another gene that directly or indirectly controls cell growth. Biology for AP Courses 2022-06-09T00:00:00Z The cancer genes, called oncogenes, were not malignant in themselves, Dr. Leder and his research team concluded. Philip Leder, medical researcher who explored genetic links to cancer, dies at 85 2020-02-15T05:00:00Z These fibres also form in lung cells engineered to express cancer-promoting oncogenes, regardless of the stiffness of the ECM. Tension in tumour cells keeps metabolism high 2020-02-11T05:00:00Z Dong and colleagues show that two key clock genes, BMAL1 and CLOCK, are co-opted to act as oncogenes in glioblastoma. Alterations to the circadian clock make brain tumours vulnerable 2019-10-13T04:00:00Z These include mutations in types of gene known as oncogenes and tumour suppressors that, respectively, are associated with promoting or blocking cancer formation. Lethal clues to cancer-cell vulnerability 2019-04-09T04:00:00Z An example of an oncogene involved in cancer is a protein called myc. Biology for AP Courses 2022-06-09T00:00:00Z “This gives you a lot of power to study oncogenes and kinases and proteins that have very rapid activity.” Protein-slaying drugs could be the next blockbuster therapies 2019-03-19T04:00:00Z As a result, the chance of hitting tumor suppressors and oncogenes, and genes that favor metastasis or drug resistance, becomes much higher, accelerating cancer development. A New Idea about How Cancer Begins 2019-03-01T05:00:00Z Other mutations, typically in well known oncogenes, were always present. The unexpected role of histones in childhood brain cancer 2018-09-25T04:00:00Z Verma had assembled a small, talented group of scientists who uncovered the structure of certain retroviruses and revealed how they co-opted oncogenes to cause cancer. Famed cancer biologist allegedly sexually harassed women for decades 2018-04-26T04:00:00Z Proto-oncogenes are normal genes that, when mutated in certain ways, become oncogenes, genes that cause a cell to become cancerous. Biology for AP Courses 2022-06-09T00:00:00Z At first, the cancer-research community mistook it for an oncogene — one that, when mutated, drives the development of cancer. The most popular genes in the human genome Early on it was thought to be an oncogene capable of turning a cell cancerous under some circumstances. This protein is mutated in half of all cancers. New drugs aim to fix it before it’s too late 2016-10-05T04:00:00Z In mice, introducing the K27M mutation into embryonic neural progenitor cells together with a mutation in the common oncogene Trp53 — a frequent partner mutation in childhood HGG — induces a tumour to form. The unexpected role of histones in childhood brain cancer 2018-09-25T04:00:00Z Until this point, cancer was thought to be caused by the activation of oncogenes. Alfred G. Knudson (1922-2016) : Nature : Nature Research 2016-08-23T04:00:00Z Consider what might happen to the cell cycle in a cell with a recently acquired oncogene. Biology for AP Courses 2022-06-09T00:00:00Z Lead author on the study Brook Chernet injected frog embryos with two types of genes, an oncogene to predispose them to cancer and another gene to produce light sensitive "ion channels" in tumor-type cells. Battling cancer with light 2016-04-26T04:00:00Z The genes in question are known as oncogenes, for when they go wrong they can lead to the growth of cancers. The slopes of enlightenment 2015-10-15T04:00:00Z Leukaemia related to vector insertion near oncogenes also occurred in a fraction of patients during their long-term follow-up. Gene therapy returns to centre stage : Nature : Nature Publishing Group 2015-10-13T04:00:00Z It also prompted hopes of finding drugs that would target oncogenes and cure some cancers. Cancer: The Ras renaissance 2015-04-14T04:00:00Z An oncogene is any gene that, when altered, leads to an increase in the rate of cell cycle progression. Biology for AP Courses 2022-06-09T00:00:00Z Take the example of the oncogene KRAS, which encodes a signalling protein involved in cell proliferation. Personalized medicine: Special treatment : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Working in culture, they have infected cells from the creatures with a genetically engineered virus that contains a pair of oncogenes, or cancer-promoting genes, that reliably turns mouse cells malignant2,3. Comparative Biology: Naked Ambition 2014-07-03T04:00:00Z Working in culture, they have infected cells from the creatures with a genetically engineered virus that contains a pair of oncogenes, or cancer-promoting genes, that reliably turns mouse cells malignant2, 3. Comparative biology: Naked ambition : Nature : Nature Publishing Group 2014-05-27T04:00:00Z “It is not to be underestimated. But it's also one of the most important oncogenes in cancer.” Cancer: The Ras renaissance 2015-04-14T04:00:00Z Only 35 of these regions contained either genes known to suppress tumours or those, known as oncogenes, which when mutated encourage cancers to form. Genetic oncology: Cancer cartography 2013-09-26T15:05:58Z In June, the Memorial Sloan Kettering Cancer Center forged a partnership with Quest Diagnostics of Madison, New Jersey, to broaden clinician access to the centre's in-house genetic test, which also surveys numerous oncogenes in parallel. Personalized medicine: Special treatment : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Mutational frequencies of oncogenes and tumour suppressors vary between tumours of different tissues, probably reflecting the importance of distinct signalling pathways within specific tissues or cellular contexts. The causes and consequences of genetic heterogeneity in cancer evolution 2013-09-18T17:22:16.487Z In contrast to ©-retroviral gene therapy, our LV-based therapy did not induce in vivo selection of clones carrying integrations near oncogenes. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z The HPV activated the "oncogene," perhaps accounting for the aggressiveness of the cancer that killed Lacks as well as HeLa cells' ability to reproduce every 24 hours and never stop. For Henrietta Lacks' famous cells, new and unique protection 2013-08-07T17:23:32Z Tumor progression, oncogenes and the evolution of metastatic phenotypic diversity. Scicurious Guest Writer! Beyond the code: addressing complexity in cancer genetics 2013-05-29T13:45:05.300Z Drugs that target mutant oncogenes might halt or reverse tumour growth. Personalized medicine: Special treatment : Nature : Nature Publishing Group 2014-09-09T04:00:00Z Most of the new drugs block the action of genes called oncogenes that, when mutated, send unchecked growth signals to cancer cells. New Cancer Drugs Are Showing Great Promise 2012-09-11T19:40:00Z This strategy provided clinical benefit but resulted in expansion and malignant transformation of hematopoietic clones carrying vector insertions near oncogenes, thus increasing leukemia risk. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z Chen and her group hoped to induce the cancer by activating oncogenes, genes that trigger cancer, in a group of liver cells called hepatocytes. Cells Get a Makeover, Cancer Follows: A Path to New Therapies or Warning to Stem Cell Alchemists? 2012-07-18T11:08:25Z Figure 2: Hubs of rearrangement breakpoints affect known and putative oncogenes. a, Circos plots representing four melanoma genomes with notable structural alterations. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z In their normal states, oncogenes help cell division occur, and tumour-suppressor genes tell it when to stop. Cancer: Solving an age-old problem 2012-02-29T18:21:13.613Z We identified several known oncogenes and tumour suppressor genes with histone modifications and altered DNA methylation that correlated with changes in gene expression. A novel retinoblastoma therapy from genomic and epigenetic analyses 2012-01-18T18:21:09.930Z Lentiviral gene therapy did not induce selection of integrations near oncogenes, and no aberrant clonal expansion was observed after 20 to 32 months. [Research Article] Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome 2013-08-22T18:25:57.537Z The ability to predict when a tumor will exhibit oncogene addiction would be useful in the development of targeted therapeutics. [Research Articles] Survival and Death Signals Can Predict Tumor Response to Therapy After Oncogene Inactivation 2011-10-05T18:55:14.357Z Figure 2: Hubs of rearrangement breakpoints affect known and putative oncogenes. a, Circos plots representing four melanoma genomes with notable structural alterations. Melanoma genome sequencing reveals frequent PREX2 mutations 2012-05-23T17:22:14.467Z Some genes, called oncogenes and tumour-suppressor genes, serve to encourage or repress cancer, respectively. Cancer: Solving an age-old problem 2012-02-29T18:21:13.613Z In this week’s issue of Science Translational Medicine, Tran et al. present a simple framework for the quantitative modeling of oncogene addiction that provides mechanistic insights into tumor biology. [Perspectives] Striking a Balance Between Feasible and Realistic Biological Models 2011-10-05T18:55:08.630Z It appears the oncogenes were added to preexistent retrovirus genomes at some time in the not too distant past. Nobel Laureates Speak in Scientific American 2011-06-08T13:15:07.613Z Retroviruses integrate into a host cell's DNA and can therefore potentially disrupt gene expression and lead to cancer; and one of the reprogramming factors, Myc, is itself an oncogene that could cause cancer. Stem cells: The growing pains of pluripotency 2011-05-18T17:20:32.423Z But the ministry did not change its position on the private funding for the oncogene drug programme. 'Soap opera' sours cancer chief hunt 2011-05-18T17:20:25.717Z Mutations that deregulate Ras signaling play a central pathogenic role in both disorders, and Mx1-Cre, KrasLSL-G12D mice that express the oncogene develop a fatal disease that closely mimics these two leukemias in humans. [Research Articles] A MEK Inhibitor Abrogates Myeloproliferative Disease in Kras Mutant Mice 2011-03-30T18:55:17.813Z Another way to recognize biologically significant mutations is to search for recurrence of identical mutations indicative of gain-of-function alterations in oncogenes. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z The oncogenes would be innocuous as long as they remained quiescent. Nobel Laureates Speak in Scientific American 2011-06-08T13:15:07.613Z ZNF703 is the first "oncogene" to be discovered in five years. Key breast cancer 'driver' found 2011-02-18T12:31:24Z "It's surprising that activating oncogenes in a stem-cell population doesn't cause tumours," he says. Mutant Stem Cells Can Cause Skin Cancer at Cuts 2011-02-15T01:15:05.443Z An oncogene is one which would normally help instruct healthy cells to divide but if it becomes overactive, it upsets the normal checks and balances that control that process. Key breast cancer 'driver' found 2011-02-18T12:31:24Z Interestingly, a recent RNA interference screen in multiple myeloma showed that IRF4 was required for multiple myeloma survival, consistent with its role as a putative oncogene. Initial genome sequencing and analysis of multiple myeloma 2011-03-23T18:52:33.100Z However the saga of oncogenes concludes, it presents some lessons for everyone concerned with cancer research. Nobel Laureates Speak in Scientific American 2011-06-08T13:15:07.613Z |
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