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单词 nuclease
例句 nuclease
But soon after fertilization, the nuclease cuts the DNA sequence on the other chromosome from the parent that did not carry the gene at the precise location of the gene drive. Gene Drives Could Fight Malaria and Other Global Killers but Might Have Unintended Consequences 2023-01-13T05:00:00Z
The mismatch repair proteins detect this base and remove it from the newly synthesized strand by nuclease action. Biology for AP Courses 2022-06-09T00:00:00Z
Two types of pancreatic nuclease are responsible for their digestion: deoxyribonuclease, which digests DNA, and ribonuclease, which digests RNA. Anatomy and Physiology 2013-06-19T00:00:00Z
In the beginning there was zinc finger nuclease. The Many Uses of CRISPR: Scientists Tell All 2022-06-27T04:00:00Z
And the nuclease approach could not be used if all copies of mtDNA carry the same mutation. Mitochondrial genome editing gets precise 2020-07-07T04:00:00Z
The nuclease produces a double-strand break, which is repaired using the host cell’s machinery. Hijack of CRISPR defences by selfish genes holds clinical promise 2019-06-11T04:00:00Z
This was used to describe just about any DNA modification by exogenous nuclease systems. Gene editing: sloppy definitions mislead 2018-12-18T05:00:00Z
Future studies will be crucial to dissect the apparently opposing nuclease processes at breaks and forks, and their effects on tumour-cell survival, as a possible nexus point for therapeutic intervention. A new road to cancer-drug resistance 2018-10-30T04:00:00Z
It took Dr. Bao’s lab more than two years of development, and then zinc finger nuclease would successfully cut the sickle cell sequence only around 10 percent of the time. The Many Uses of CRISPR: Scientists Tell All 2022-06-27T04:00:00Z
They then used a virus to shuttle DNA that encodes the nuclease, and healthy IDS gene into liver cells, where IDS is needed. First test of in-body gene editing shows promise 2018-09-04T04:00:00Z
The Fan1 nuclease protects stalled DNA replication forks and thereby prevents chromosomal damage and cancer. Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability | Science 2016-02-18T05:00:00Z
The CRISPR-Cas9 nuclease helps guide RNA to open the target DNA strands and position them for cutting. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage | Science 2016-02-18T05:00:00Z
The viral scraps serve as an infection memory bank: From them, bacteria create guide RNAs that can seek out the DNA of returning viruses before chopping up the viral genes with a nuclease. And Science’s Breakthrough of the Year is … 2015-12-17T05:00:00Z
All of these strategies entail a 'hit-and-run' mechanism that requires only transient expression of the nuclease complex and, in some cases, a repair template to modify the genome permanently. Gene therapy returns to centre stage : Nature : Nature Publishing Group 2015-10-13T04:00:00Z
In an embryo, a nuclease may not necessarily cut both copies of the target gene, or the cell may start dividing before the corrections are complete, resulting in a genetic mosaic. Don’t edit the human germ line 2015-03-11T04:00:00Z
The Fan1 nuclease protects stalled DNA replication forks and thereby prevents chromosomal damage and cancer. Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability | Science 2016-02-18T05:00:00Z
The CRISPR-Cas9 nuclease helps guide RNA to open the target DNA strands and position them for cutting. Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage | Science 2016-02-18T05:00:00Z
The rate of off-target activity varies depending on the type of cells and the nuclease used. Gene therapy: Editorial control : Nature : Nature Publishing Group 2014-11-11T05:00:00Z
The new antibiotic uses an RNA-guided nuclease called a "Crispr" to hunt down and chop up target genes inside bacterial cells. Novel antibiotic class created 2014-09-24T04:00:00Z
The RNAs act as guides, matching the nuclease to corresponding locations in the human genome. Don’t edit the human germ line 2015-03-11T04:00:00Z
Binding of transcription factors to regulatory DNA regions in place of canonical nucleosomes triggers chromatin remodelling, resulting in nuclease hypersensitivity. An expansive human regulatory lexicon encoded in transcription factor footprints 2012-09-05T17:21:56.447Z
The enzyme, called a zinc finger nuclease, clips the gene for the CCR5 receptor and disables it. Gene Therapy May Thwart HIV 2011-09-19T17:36:25Z
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