| 单词 | niacin |
| 例句 | Maize lacks digestible niacin, the amino acids lysine and tryptophan, necessary to make proteins and diets with too much maize can lead to protein deficiency and pellagra, a disease caused by lack of niacin. 1491 2005-10-10T00:00:00Z The way to unlock the niacin in corn is to cook it with an alkali like lime. The Omnivore's Dilemma 2006-04-11T00:00:00Z For example, low dietary levels of vitamin B3/niacin – typically found in meat and fish – cause pellagra, a disease in which people develop dementia. Diet can influence mood, behavior and more — a neuroscientist explains 2022-09-09T04:00:00Z In animal models, decreasing or blocking the production of niacin in the brain promotes neuronal damage and cell death. Diet can influence mood, behavior and more — a neuroscientist explains 2022-09-09T04:00:00Z The B vitamins in whole grains, including thiamine, niacin and riboflavin, are crucial metabolism aids. A primer on whole grains: What they are, why they’re important and how to find them 2019-08-16T04:00:00Z If you’ve got a favorite — niacin? garlic? — you could try to make the case. Perspective | Most dietary supplements don’t do anything. Why do we spend $35 billion a year on them? 2020-01-24T05:00:00Z Observational studies in humans suggest that sufficient levels of niacin may protect against these diseases, but the results are still inconclusive. Diet can influence mood, behavior and more — a neuroscientist explains 2022-09-09T04:00:00Z Another example of how a nutrient deficiency affects brain function can be found in the element iodine, which, like niacin, must be acquired from one's diet. Diet can influence mood, behavior and more — a neuroscientist explains 2022-09-09T04:00:00Z Interestingly, niacin deficiency caused by consumption of excessive amounts of alcohol can lead to similar effects as those found with pellagra. Diet can influence mood, behavior and more — a neuroscientist explains 2022-09-09T04:00:00Z It’s a diet that’s low in niacin, or at least the kind that our bodies can readily absorb. How the Daughter of Sharecroppers Revolutionized Preschoolers' Health 2023-10-26T04:00:00Z I have been taking niacin for years along with vitamin C and the amino acids lysine and proline. Lowering a little-known cardiac risk factor 2023-06-14T04:00:00Z The researchers extracted uracil, niacin and some other organic compounds in the Ryugu samples by soaking the material in hot water and then performing analyses called liquid chromatography and high-resolution mass spectrometry. Asteroid discovery suggests ingredients for life on Earth came from space 2023-03-21T04:00:00Z A baby aspirin about half an hour before taking niacin helps keep the side effects of flushing and itchiness to tolerable levels. Is cocoa good for maintaining memory? 2023-03-01T05:00:00Z To address these serious risk factors for heart disease, I started taking niacin 30 years ago. Athlete’s foot bleach treatment is controversial 2022-11-02T04:00:00Z The trial will also use a different placebo, the vitamin niacin. Psilocybin Therapy Sharply Reduces Excessive Drinking, Small Study Shows 2022-08-25T04:00:00Z My husband has taken niacin for years under medical supervision. What happened to the flu this year? 2022-02-23T05:00:00Z That missing vitamin was nicotinic acid, later known as niacin, and it helps us evade pellagra. Book review: decoding brain diseases, molecule by molecule 2022-02-13T05:00:00Z But after reviewing the article and doing some additional research, he prescribed slow-release niacin. Is cocoa good for maintaining memory? 2023-03-01T05:00:00Z Taking niacin after meals also minimizes the flush. Athlete’s foot bleach treatment is controversial 2022-11-02T04:00:00Z Since World War Two, the UK's non-wholemeal flour has been fortified with iron, calcium and two other B vitamins - thiamin and niacin. Folic acid to be added to UK flour to help prevent birth defects 2021-09-19T04:00:00Z It’s higher in other nutrients, such as riboflavin, niacin, magnesium and zinc, found in the grain’s bran and germ. Tips for making pasta meals healthy 2020-10-09T04:00:00Z “Bone, muscle and other tissues contain iron, niacin and other metals,” said Dopp, with the Meat Institute. Processed meat recalls rise dramatically as consumers bite down on metal, plastic and glass 2019-12-20T05:00:00Z There are relatively few drugs that lower this risk factor, but niacin is among them. Is cocoa good for maintaining memory? 2023-03-01T05:00:00Z Readers can learn more about niacin and other approaches to lipid management in our eGuide to Cholesterol Control & Heart Health. Athlete’s foot bleach treatment is controversial 2022-11-02T04:00:00Z But some is converted to a compound called kynurenine, which in turn is a building block for niacin, a vitamin, and is involved with diabetes, inflammation, depression, and even cancer. This shark glows using a process previously unknown to science 2019-08-08T04:00:00Z The fact that older niacin equivalents ... niacin, niacinamide and tryptophan ... also boost NAD+ seems to be getting overlooked or forgotten. Can a Pill Really Help You Live Longer? 2019-04-20T04:00:00Z “There’s little downside to adding a bit of niacin” to people’s diets, he says. Vitamin B3 could help prevent birth defects 2017-08-09T04:00:00Z Maybe her wine-only diet isn’t high in niacin or pantothenic acid. The Game of Game of Thrones: season 7, episode 4, The Spoils of War 2017-08-07T04:00:00Z The disease was caused by a vitamin deficiency, which Dr. Kummerow solved by adding niacin to grits and other foods. Fred A. Kummerow, scientist who raised early warnings about trans fats, dies at 102 2017-06-03T04:00:00Z The drugs they tested — niacin and cholesteryl ester transfer protein inhibitors — boosted HDL in the blood but failed to reduce cardiovascular-disease risks. Does ‘good’ cholesterol still matter? 2017-05-26T04:00:00Z And we don’t think boosting NAD+ by giving large amounts of niacin equivalents as an isolated strategy is likely to produce the results that are being promoted. Can a Pill Really Help You Live Longer? 2019-04-20T04:00:00Z At NYU, patients were given niacin, which mimics some effects of psilocybin. ‘Magic mushroom’ psychedelic may ease anxiety, depression 2016-12-01T05:00:00Z Only 14% of those who received niacin reported less anxiety and less depression. Hallucinogenic drugs help cancer patients deal with their fear of death 2016-12-01T05:00:00Z Two tablespoons of the nutty stuff contains 188 calories, 16 grams of fat, eight grams of protein, two grams of fiber and is an excellent source of niacin. 8 Healthy Foods You Actually Need to Measure Out 2016-10-17T04:00:00Z Q: My husband’s doctor prescribed niacin for cholesterol control. Settling a family argument on the best mosquito repellent 2016-06-19T04:00:00Z Most refined grains are enriched with B vitamins such as thiamine, riboflavin, niacin and folate, critical for cellular growth and metabolism, and minerals like iron, which is important for cardiovascular health. The Top 5 Things You Need in Your Food 2016-04-28T04:00:00Z Efforts are made to counter this by using "active" placebos such as large doses of niacin to induce a tingling feeling. Will LSD ever be accepted as mainstream treatment? - BBC News 2016-04-13T04:00:00Z The 2015-2020 Dietary Guidelines state that "whole grains are a source of nutrients, such as dietary fiber, iron, zinc, manganese, folate, magnesium, copper, thiamin, niacin, vitamin B6, phosphorus, selenium, riboflavin and vitamin A." The Carb Controversy: Examining the Science Behind This Nutrient 2016-03-10T05:00:00Z Spelt includes complex carbohydrates, and is rich in both soluble and insoluble fiber, vitamin B2, niacin, manganese, thiamin, copper and magnesium. The 50 (New) Healthiest Foods of All Time—With Recipes 2015-11-23T05:00:00Z His HDL was too low, and the doctor said niacin would improve that. Settling a family argument on the best mosquito repellent 2016-06-19T04:00:00Z Many cheeses offer a wide array of vitamins, including riboflavin, thiamin, niacin, vitamin B6, biotin and vitamin A. As an added bonus, cheese is also a good source of calcium. Must-Try Options for Packing Protein in School Lunches 2015-09-23T04:00:00Z A check of one major drugstore chain found only other forms of B3, such as niacin, or combination B vitamins. Study: Vitamin B3 may help prevent certain skin cancers 2015-05-13T04:00:00Z The other mandated nutrients that are added into enriched refined grains are iron and three B vitamins: riboflavin, niacin and thiamin. The Carb Controversy: Examining the Science Behind This Nutrient 2016-03-10T05:00:00Z Unlike niacin, another form of B3, the supplement did not cause headaches, flushing, or low blood pressure. Vitamin B3 Prevents New Skin Cancers In Study 2015-05-13T04:00:00Z After taking the niacin, he had terrible tingling, itching and flushing. Settling a family argument on the best mosquito repellent 2016-06-19T04:00:00Z Packed with nine essential nutrients – calcium, potassium, phosphorus, protein, vitamin A, vitamin D, vitamin B-12, riboflavin and niacin – milk is a nutrient powerhouse. Which Type of Milk Is Healthiest? 2015-03-18T04:00:00Z The drug niacin did not protect against heart attacks and strokes even though it raised so-called good cholesterol and modestly lowered bad cholesterol. Tests of Cholesterol Drugs Offer Hope of Reducing Heart Attacks and Strokes 2015-03-15T04:00:00Z Though technically a legume, peanuts contain monounsaturated fats, fiber and nutrients similar to those in nuts that grow on trees, including vitamin E, niacin and folate. Peanuts are good for your health 2015-03-09T04:00:00Z Peanuts are also high in niacin, a B vitamin that helps boost energy, and the antioxidant vitamin E. It also contains the antioxidant resveratrol, which is also found in red wine. 5 Fatty Foods You Can Still Enjoy 2015-02-20T05:00:00Z Another option to control the niacin flush is apple pectin. Settling a family argument on the best mosquito repellent 2016-06-19T04:00:00Z It found that many of these drinks contained vitamins B6, B12, niacin and vitamin C in quantities “well in excess” of the average daily requirements for young adults. Are Vitamin Drinks a Bad Idea? 2015-01-30T05:00:00Z In many bean varieties, you’ll find thiamin, niacin, riboflavin, B6, and folate—B vitamins that help you convert food to energy, boost good cholesterol, and reduce inflammation, among other things. 9 Reasons You Should Eat More Beans 2015-01-09T05:00:00Z He then sold her a package of supplements containing fish oil, niacin, and vitamin B3, which cost Mary about $60 for a month’s supply. Doctor: You're Going To Have A Heart Attack! Patient: Your Tests Results Are Giving Me A Heart Attack! 2014-10-17T04:00:00Z In mushrooms, you’ll find riboflavin, niacin, and pantothenic acid–all B vitamins essential for your nervous system. 5 Fascinating Things You Didn't Know About Mushrooms 2014-10-11T04:00:00Z He later worked as a nutrition scientist at Clemson University, where he developed a method to add niacin to grits to combat a disease known as pellagra, caused by a niacin deficiency. EXCHANGE: At age 99, professor continues research 2014-09-25T04:00:00Z And a half dozen had more than three times the requirement for niacin or riboflavin. Are Vitamin Drinks a Bad Idea? 2015-01-30T05:00:00Z It’s been thought in the past that niacin, a type of B vitamin, are a viable alternative or complement to statins. Studies Question The Safety of Niacin 2014-07-17T04:00:00Z The new study confirms results of an earlier clinical trial of niacin in the United States that was stopped prematurely after three years due to a lack of benefit for patients. Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds 2014-07-16T04:00:00Z According to the National Institutes of Health, riboflavin aids red blood cell production, niacin helps the digestive system and skin, and pantothenic acid is key for growth. 5 Fascinating Things You Didn't Know About Mushrooms 2014-10-11T04:00:00Z The two studies were testing prescription versions of niacin, and the bottom line - that it didn’t help prevent heart problems any more than statins alone do - has already been announced. AP News in Brief at 8:58 p.m. EDT 2014-07-16T04:00:00Z It is hard to ingest too much niacin, for example, by eating whole foods like mushrooms, fish or avocados, which are natural sources of niacin that come bundled with fiber, protein and fat. Are Vitamin Drinks a Bad Idea? 2015-01-30T05:00:00Z Two new studies suggest significant dangers from the common cholesterol drug niacin, and some doctors say the risks are not worth it. Studies Question The Safety of Niacin 2014-07-17T04:00:00Z Laropiprant is a medication that treats flushed skin, which is a common side effect of niacin. Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds 2014-07-16T04:00:00Z Other great sources of niacin and riboflavin include peanuts and fortified cereals. 5 Fascinating Things You Didn't Know About Mushrooms 2014-10-11T04:00:00Z More diabetics on the drug lost control of their blood sugar, and there were more new cases of diabetes among niacin users. Studies see new risks for cholesterol drug niacin 2014-07-16T04:00:00Z Other foods were enriched with additional nutrients – niacin and iron were added to flour, for example – in the decades that followed. Are Vitamin Drinks a Bad Idea? 2015-01-30T05:00:00Z Though many people will likely remain on niacin, members of the medical community caution people on the drugs, warning they should talk to their doctors about whether or not they should continue. Studies Question The Safety of Niacin 2014-07-17T04:00:00Z The clinical trial also associated niacin with a 9 percent increase in death among patients, which was not a statistically significant finding but nevertheless raises concern, according to Lloyd-Jones. Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds 2014-07-16T04:00:00Z The studies previously found that niacin did not prevent heart problems better than statins alone and carried more side effects. Studies see new risks for cholesterol drug niacin 2014-07-16T04:00:00Z Prompted by that study, leaders of an earlier one that tested a different niacin drug, Niaspan, re-examined side effects among their 3,414 participants and detailed them in a letter in the medical journal. Studies see new risks for cholesterol drug niacin 2014-07-16T04:00:00Z Bread, milk and other foods are often fortified with folic acid, niacin and vitamins A and D. Are Vitamin Drinks a Bad Idea? 2015-01-30T05:00:00Z Therefore, scientists designed these two new studies to determine whether niacin helped patients avoid heart disease and stroke in the statin era. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z To test the effectiveness of niacin, Oxford researchers led a clinical trial involving heart patients in the United Kingdom, Scandinavia and China. Niacin Doesn't Reduce Heart Problems, May Create Some, Research Finds 2014-07-16T04:00:00Z Details in this week’s New England Journal of Medicine suggest that deaths, bleeding, infections, gastrointestinal and other problems were more common among niacin users. Studies see new risks for cholesterol drug niacin 2014-07-16T04:00:00Z The string of failures– for HDL therapies in general and for niacin in particular– continues unabated. New Evidence Fuels Concerns About The Safety Of Niacin 2014-07-16T04:00:00Z And to avoid overdosing their kids on certain vitamins, parents should stay away from products that contain more than 20% to 25% of daily values for vitamin A, niacin and zinc. Too Much of a Good Thing: 13 Million US Kids Get Too Many Vitamins and Minerals 2014-06-24T04:00:00Z If you are not taking niacin, then realize that there is little reason to start. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z The group said that "millions of children are ingesting potentially unhealthy amounts" of vitamin A, zinc and niacin, and that fortified breakfast cereals are the main source of this high intake. Health Highlights: June 24, 2014 2014-06-24T04:00:00Z The organization found that nearly half of kids 8 or younger consume potentially dangerous levels of vitamin A, zinc and niacin due to over-fortification. Fortified Foods May Be Dangerous 2014-06-24T04:00:00Z In light of the consistency of the results with those from previous trials of niacin alone, we believe that the findings from HPS2-THRIVE are likely to be generalizable to all high-dose niacin formulations. New Evidence Fuels Concerns About The Safety Of Niacin 2014-07-16T04:00:00Z “There is no confirmation at this time that the Texas incident was caused by excess niacin,” spokeswoman Theresa Eisenman said. FDA warns against eating Uncle Ben’s infused rice products served at schools, restaurants 2014-02-10T18:16:17Z Like many large trials, the study was designed to determine if patients would tolerate the drug before they were randomly assigned to receive niacin with laropiprant or a placebo. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z In addition, a 3-ounce cooked portion of lean meat contributes many important nutrients like iron, zinc, niacin, riboflavin, vitamin B6 and vitamin B12. How Often Should You Eat Red Meat? 2013-12-02T15:07:00Z In the current review, the members considered additional data on other vitamins and nutrients, including vitamins B and D, as well as zinc, iron, magnesium, niacin and calcium. Vitamins Won't Keep You Healthy 2013-11-12T01:20:25Z In an accompanying editorial, Donald-Lloyd Jones writes that ”the consistency of the overall findings with earlier trials of niacin alone suggest that niacin is the major problem.” New Evidence Fuels Concerns About The Safety Of Niacin 2014-07-16T04:00:00Z “It appears that the reaction may be related to an excessive amount of niacin enrichment of the product,” spokeswoman Angela Ju said. FDA warns against eating Uncle Ben’s infused rice products served at schools, restaurants 2014-02-10T18:16:17Z He then launched into a defense of treatments like niacin. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z Ask your doctor about drugs such as cholestyramine, niacin and aspirin. Be wary of liver damage from pain reliever 2013-08-24T15:12:39Z Late last year a second study, of a new Merck niacin, also failed to show any benefit and failed to show significant benefits. As Statins Soar, Use Of Other Cholesterol Medicines Declines 2013-05-29T12:05:44Z Much of the initial discussion about HPS2-THRIVE revolved around the relative importance of the niacin and laropiprant components of the drug. New Evidence Fuels Concerns About The Safety Of Niacin 2014-07-16T04:00:00Z Enrichment of rice with niacin is required under federal and state standards, she said. FDA warns against eating Uncle Ben’s infused rice products served at schools, restaurants 2014-02-10T18:16:17Z First, these new studies failed to show that niacin reduced the risk of heart disease and stroke. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z Unexpected serious side effects arose in a huge study of a Merck & Co long-acting niacin drug aimed at raising good HDL cholesterol, according to data released at the conference on Saturday. Too many drug types are compromising heart health: doctors 2013-03-13T07:53:07Z Significantly higher numbers of patients taking Tredaptive also experienced serious health problems that researchers called known side effects of niacin. Serious side effects seen with failed Merck niacin drug: study 2013-03-09T19:47:58Z The failure of the niacin trials, as well as other HDL-related trials, “lends further credence to the notion that HDL cholesterol is unlikely to be causal.” New Evidence Fuels Concerns About The Safety Of Niacin 2014-07-16T04:00:00Z A Mars Foodservices spokeswoman said the illnesses may be related to high levels of niacin, or Vitamin B3, in the rice. FDA warns against eating Uncle Ben’s infused rice products served at schools, restaurants 2014-02-10T18:16:17Z Second, niacin causes multiple side effects, many of which are serious. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z "Unfortunately I think there's a growing body of evidence that's going to put the nail in the coffin for niacin," Michos, who wasn't involved in the new research, told Reuters Health. Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z The trial was not designed to show whether the adverse side effects were caused by the niacin or the anti-flushing drug. Serious side effects seen with failed Merck niacin drug: study 2013-03-09T19:47:58Z The trial was designed to assess whether adding the niacin/laropiprant combination to standard statin therapy in high risk individuals would further reduce vascular events. Coming Attraction: First Look At What Went Wrong With Niacin 2013-02-27T05:38:25Z FDA tested rice that was leftover from the Illinois school lunch, and found an increased amount of niacin, or Vitamin B3, in the rice. FDA warns against eating Uncle Ben’s infused rice products served at schools, restaurants 2014-02-10T18:16:17Z Bottom line: If you are taking niacin, talk with your doctor about whether you should continue. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z "I think there's no role for adding niacin just to increase the HDL." Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z Following the news, Merck announced it would not seek approval of Tredaptive, which contained the drug niacin, in the United States and withdrew it from the European market, where it had already been approved. Merck Delays Osteoporosis Drug 2013-02-01T19:34:20Z Experts will sift the tea leaves for any clues the trial may provide about the viability of the HDL hypothesis, while some experts believe that niacin may yet prove to be found beneficial. Trials Of Niacin And Atrial Fibrillation Device Will Headline American College Of Cardiology Program 2013-01-22T18:02:04Z Just last week HPS2-THRIVE put the final nail in the niacin coffin. 2012 In Review: A Bad Year For Conventional Wisdom 2012-12-24T14:00:07Z The predicament is that the pursuit of more trials of niacin, particularly given the harms that were recently shown, is unlikely. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z Sixty-nine of them had a serious reaction to niacin, including 29 who developed the muscle fiber condition myopathy. Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z The billion dollars in health care spending on niacin might be better directed elsewhere. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z Merck had hoped to have an even bigger success with a new version that combined niacin and another drug to reduce the vitamin’s main side effect: making patients’ faces flushed and hot. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z “The failure strongly suggests that niacin simply does not improve outcomes for patients,” said Dr. Steven Nissen, chairman of cardiovascular medicine at the Cleveland Clinic. Merck Says Niacin Combination Drug Failed in Trial 2012-12-20T17:41:32Z Uncertainty about niacin may linger, accompanied by uncertainty about which patients it may benefit. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z Over the next four years, 25 percent of participants in the niacin group withdrew from the study, compared to less than 17 percent in the placebo group. Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z I am not sure why anyone would start niacin right now, pending learning more about what were the adverse events in this large study. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z There will be much less enthusiasm for prescribing niacin now.” Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z Even more troubling, the company reported that there was “a statistically significant increase in the incidence of some types of non-fatal serious adverse events in the group that received extended-release niacin/laropiprant.” HPS2-THRIVE: No Benefit, Signal Of Harm For Niacin Therapy 2012-12-20T14:58:23Z Both studies failed to show that niacin reduced the risks of heart disease, stroke and death. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z His own research on statins and niacin, without laropiprant, didn't show the same high rate of side effects. Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z In addition, the investigators noted more strokes among the individuals who took niacin. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z It could even be that niacin is effective, at least in some people, or that the unknown side effect occurred in a predictable way that would not mean the drug should never be given. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z It appears likely that the results of HPS2-THRIVE will also impact the use of existing niacin products. HPS2-THRIVE: No Benefit, Signal Of Harm For Niacin Therapy 2012-12-20T14:58:23Z It frequently causes uncomfortable flushing and itching, the reason the Merck trial tested niacin with another agent designed to block these nuisance effects. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z "I think it would be ill-advised for patients to throw the baby out with the bathwater and abandon ship with niacin," Boden said. Niacin-statin combo tied to skin, muscle side effects 2013-02-27T21:19:13Z Far too many people are taking niacin with the expectation of benefit – and without evidence to support that belief. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z The result is likely to dramatically reduce the use of niacin, already on the wane. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z HPS2-THRIVE, most agreed, would provide a more definitive test of the effect of niacin. HPS2-THRIVE: No Benefit, Signal Of Harm For Niacin Therapy 2012-12-20T14:58:23Z Third, there are still experts who say that the recent studies do not provide adequate evidence to stop recommending niacin. 3 Things to Know About Niacin and Heart Health 2014-07-16T04:00:00Z The vitamin niacin was used in a high dose as the placebo, because it produces a physiological sensation of burning or itching on the face that is harmless but produces some “drug” effect. 'Magic Mushroom' Drug Shows Promise 2012-12-07T06:20:00Z Some studies decades ago suggested that niacin might reduce the risk of heart disease. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z This is the second time that niacin, long a mainstay of therapy, has failed to benefit patients in a large clinical trial. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z We will need to decide whether to withdraw patients from niacin. HPS2-THRIVE: No Benefit, Signal Of Harm For Niacin Therapy 2012-12-20T14:58:23Z One, KY Intense, contains niacin in its base; the other, Zestra Arousal Oil, is a blend of four botanical products that produce a tingling, warming sensation. Ask an Expert: Answers About Female Sexuality, Part 1 2012-11-28T18:36:16Z She used to be a big prescriber of omega-3 fish oil, but has stopped because the failure of niacin, a drug that lowered triglycerides, to prevent heart attacks and strokes. Could A Fish Oil Backlash Wash Out Amarin Pharmaceuticals? 2012-11-19T15:11:42Z For patients and doctors, the results should add to doubts about the benefits of niacin. Lessons From Merck's Niacin Failure 2012-12-24T11:00:32Z Cardiologists say the result is likely to mean that the use of niacin will plummet. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z Other HDL drugs, such as niacin and fibrates, which do attack the underlying cause, gradually raise HDL and may prevent heart attacks years after the start of therapy. Early Look: New Methods To Enhance Cholesterol Efflux 2012-11-06T00:22:10Z Widely popular in Africa, it’s high in fiber, niacin and phosphorus. Ancient grains can help prevent cancer, heart disease and high blood pressure 2012-08-13T16:49:16Z Another downside: Gluten-free dieters often don't get enough iron, calcium, zinc, and B vitamins like folate and niacin. Is a Gluten-Free Diet Smart for Weight Loss? 2012-04-11T20:30:00Z My doctor recommended niacin since the bad LDL cholesterol is fine but the good HDL is too low. People's Pharmacy: Generic drug is matter of life or death 2012-04-04T20:59:04Z There’s already been a decline in niacin usage. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z For example, the periodic monitoring of liver enzymes was originally based on niacin experience. FDA Cautions On Memory, Diabetes Side Effects In Cholesterol-Lowering Drugs 2012-02-28T18:48:03Z One of the first crops domesticated in the Near East, its whole kernels and flour are full of fiber, iron, magnesium, niacin and zinc. Ancient grains can help prevent cancer, heart disease and high blood pressure 2012-08-13T16:49:16Z Instead, he takes niacin under his doctor's supervision. People's Pharmacy: Statins and memory loss 2012-01-11T22:13:03Z Medications such as niacin or psyllium may help. People's Pharmacy: Cutting salt questioned 2011-12-07T21:34:04Z But the Food and Drug Administration demanded a bigger study of Merck’s niacin combo, Tredaptive, before it would clear the medicine for sale. Why Merck's Niacin Failure Will Scare Drug Researchers 2012-12-20T19:11:09Z For example, the B vitamins riboflavin and niacin are critical to every chemical step in releasing the energy potential in food. The Overselling of Antioxidants 2011-12-01T10:00:04Z Barter said any decision about niacin should await the much larger HPS2-THRIVE study in a few years, as it is sufficiently powered to answer the question. Experts Clash Over Interpretation and Value of AIM-HIGH 2011-11-15T20:14:47Z To date, niacin is the most effective FDA approved means of raising HDL-cholesterol. Cholesterol and Controversy: Past, present, and future 2011-11-15T16:15:00.277Z But at a press conference at the meeting, Dr. Philip Barter of the Heart Research Institute in Sydney, Australia, said the Aim-High study was not properly designed to test the benefits of niacin. Study doubting niacin's heart effects challenged 2011-11-15T14:48:59Z In an accompanying editorial, Robert Giugliano wonders whether niacin, at 56 years of age, is ready for an early retirement. AIM-HIGH: No Benefit for Niacin on Top of Statins 2011-11-15T13:04:28Z A 2009 trial that compared adding either ezetimibe or niacin to standard statin treatment in people with heart disease found that niacin worked better than ezetimibe to reduce trial participants’ artery thickness. Cholesterol Conundrum 2011-10-25T15:15:00.250Z He agreed with Barter that the HPS2-THRIVE would provide a definitive answer about the utility of niacin. Experts Clash Over Interpretation and Value of AIM-HIGH 2011-11-15T20:14:47Z Interestingly, niacin also lowers LDL-cholesterol, as well as another type of blood lipid called triglycerides. Cholesterol and Controversy: Past, present, and future 2011-11-15T16:15:00.277Z "If that trial doesn't show a positive effect, niacin is finished," Barter said. Study doubting niacin's heart effects challenged 2011-11-15T14:48:59Z They noted that the true effect of niacin will be definitively assessed in the much larger HPS2-THRIVE study, and that additional studies are underway evaluating other HDL-related therapies. AIM-HIGH: No Benefit for Niacin on Top of Statins 2011-11-15T13:04:28Z Another option was to raise HDL levels using a drug such as niacin, which is one of the B vitamins. Cholesterol Conundrum 2011-10-25T15:15:00.250Z Boden said there is no evidence to support the continued use of niacin in the statin era, though he stopped short of saying that the drug should no longer be used. Experts Clash Over Interpretation and Value of AIM-HIGH 2011-11-15T20:14:47Z The FDA in 2009 rejected the original Acurox formulation that included niacin, a vitamin that causes redness and irritation of the face when taken in excess. Acura Surges After Winning Approval for Painkiller With Pfizer 2011-06-20T18:21:59Z Barter said any conclusions on niacin needed to wait until a much larger study involving a Merck & Co drug that includes niacin. Study doubting niacin's heart effects challenged 2011-11-15T14:48:59Z There was no benefit from adding niacin to simvastatin, and there was a slightly increased risk of stroke. People's Pharmacy: Sunscreens block vitamin D 2011-06-08T22:14:11Z The disappointing findings involve super-strength niacin, a type of B vitamin that many doctors already prescribe as potential heart protection. NIH stops study of niacin to prevent heart attacks 2011-05-26T20:22:42Z Moreover, the analysis detected a small increase in "ischemic" strokes among participants taking niacin. Study: Boosting 'good' cholesterol useless 2011-05-27T00:53:09Z But in the trial, niacin provided no benefit over simple statin therapy. Study Questions Treatment Used in Heart Disease 2011-05-27T01:39:14Z On Thursday the National Institutes of Health halted a major study of high-dose niacin, a type of B vitamin, more than a year ahead of schedule because of the lack of benefit. NIH stops study of B vitamin to prevent heart attack 2011-05-26T16:01:09Z The investigators emphasize that people taking niacin should not stop without consulting their physicians. People's Pharmacy: Sunscreens block vitamin D 2011-06-08T22:14:11Z The NIH urged people not to stop high-dose niacin without consulting a doctor. NIH stops study of niacin to prevent heart attacks 2011-05-26T20:22:42Z HDL levels rose and triglycerides dropped among those taking niacin, also known as vitamin B3. Study: Boosting 'good' cholesterol useless 2011-05-27T00:53:09Z What is remarkable about the study is that niacin seemed to be working. Study Questions Treatment Used in Heart Disease 2011-05-27T01:39:14Z But the NIH noted that several other large studies testing the HDL-raising drugs, including another international niacin study, are under way. NIH stops study of B vitamin to prevent heart attack 2011-05-26T16:01:09Z Researchers said niacin raised levels of high-density lipoproteins, or HDL, the "good" cholesterol, but that did not translate into fewer fatal and non-fatal heart problems. Taking niacin does not prevent heart problems: NIH 2011-05-26T15:18:07Z Why do doctors prefer costly statins over niacin for people with high cholesterol? People's Pharmacy: Nasal spray for 'gustatory rhinitis' 2011-04-20T18:53:03Z There were 28 strokes among those taking niacin, compared with 12 among those taking placebo. Study: Boosting 'good' cholesterol useless 2011-05-27T00:53:09Z “I’m delighted to hear that statins alone are just as good as statins and niacin,” he said. Study Questions Treatment Used in Heart Disease 2011-05-27T01:39:14Z We discuss many other ways to lower cholesterol and triglycerides, including medications such as fibrates or niacin, in our Guide to Cholesterol Control and Heart Health. People's Pharmacy: Nasal spray deadens senses of smell, taste 2011-03-03T05:11:12Z The B-vitamin niacin may raise HDL levels 15 to 35 percent. High good cholesterol linked to long life in men 2011-02-24T21:16:45Z Some were also given Niaspan, a modified form of Vitamin B, or niacin. Study questions Vytorin and Zetia in heart disease treatment 2009-11-16T05:00:00Z The National Institutes of Health urged people not to stop high-dose niacin without consulting a doctor. Study: Boosting 'good' cholesterol useless 2011-05-27T00:53:09Z This drug has five times more effect than niacin on raising HDL. Next big thing? New drug drops cholesterol 2010-11-18T04:31:00Z Notable exceptions worth exploring include niacin, plant sterols, and soluble fiber supplements. Lowering LDL Cholesterol 2010-11-17T19:00:00Z During the placebo phase, each of the 12 patients received a dose of niacin -- a vitamin that raises levels of good cholesterol -- and given the same instructions. Magic mushrooms may ease anxiety of cancer: study 2010-09-06T20:03:00Z They also had more heart attacks, strokes and other cardiovascular problems than the patients taking niacin. Study questions Vytorin and Zetia in heart disease treatment 2009-11-16T05:00:00Z Indeed, niacin appeared to increase study participants' risk for one particular type of stroke. Study: Boosting 'good' cholesterol useless 2011-05-27T00:53:09Z So, the sustained response to niacin noted above, and the response of other patients to that and other therapies, is probably not just a placebo effect. Alternative Remedies for Migraine 2010-08-16T14:17:00Z His LDL levels are down by about 60 percent thanks to diet, exercise, niacin and other supplements. Lowering LDL Cholesterol 2010-11-17T19:00:00Z While the flushing seen in some of the men could be related to niacin, McBride and his colleagues write, it's impossible to say which substances might be responsible for prolonging QT intervals. ED supplement causes 'worrisome' heartbeat changes 2010-08-10T21:18:00Z "It would have been unreasonable to continue the experiment because the trial had met its objective -- niacin is superior to ezetimibe." Study questions Vytorin and Zetia in heart disease treatment 2009-11-16T05:00:00Z Each study participant gets two drug-dose experiences, but only one of those involves psilocybin; the other is a placebo dose of niacin, which makes the face flush. Psychedelic trips aid anxiety treatments in study 2010-04-23T05:21:00Z He stopped the drug, ate a lot of oat bran, and took niacin. Statins for Prevention? Taking a Cholesterol-Lowering Drug When Cholesterol Is Normal 2010-03-01T21:22:00Z |
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