| 单词 | NGF |
| 例句 | The NGF did not return a request for comment. In Nigeria, looters target government warehouses stocked with COVID-19 relief 2020-11-09T05:00:00Z In 2005, when Tiger Woods was in his prime and the economy was humming, there were around 30 million golfers in the U.S., according to NGF. Club pros at PGA see COVID-related surge in golf back home 2020-08-05T04:00:00Z More courses remained open in rural areas than in parts of the country with concentrated populations, the NGF said. Column: No good walks spoiled as golf courses shuttered 2020-04-10T04:00:00Z Dr. Cohen determined that this early development was spurred by a substance similar to NGF, which he called epidermal growth factor, or EGF. Stanley Cohen, Nobel Prize-winning scientist who studied cellular growth, dies at 97 2020-02-06T05:00:00Z Injecting NGF into rodents and people causes their pain neurons to become sensitized. Analgesia without opioids 2019-09-10T04:00:00Z The annual NGF Golf Participation Report also showed positive numbers for golf interest beyond the traditional on-course experience. NGF report: Number of on-course golfers up, along with 10-percent jump in driving-range and non-traditional golf - Golf Digest 2019-07-01T04:00:00Z It remains to be seen whether NGF acts together with S100b to coordinate BAT innervation, or is dispensable, as in the innervation of the trachea7. Why brown fat has a lot of nerve 2019-04-30T04:00:00Z U.S. regulators early this decade placed a partial hold on NGF trials after some patients developed a fast-moving form of the degenerative joint condition osteoarthritis. The Heated Quest for Opioid Alternatives 2018-05-25T04:00:00Z That total remains the same from 2016, “contradicting claims that the sport continues to lose millennial golfers” according to the NGF. National Golf Foundation sees signs of encouragement in latest annual Golf Industry Report - Golf Digest 2018-05-15T04:00:00Z And NGF levels have been shown to spike in laboratory animals that are experiencing inflammation or peripheral nerve injury2. Analgesia without opioids 2019-09-10T04:00:00Z The NGF report also showed the number of beginning golfers at 2.6 million, “a figure near historical highs,” according to the NGF. NGF report: Number of on-course golfers up, along with 10-percent jump in driving-range and non-traditional golf - Golf Digest 2019-07-01T04:00:00Z But that trend started to shift with positive news from the NGF, a newly invigorated retailer on the scene in Golftec and now the presence of Wall Street endorsing golf. Five major takeaways from the TaylorMade sale - Golf Digest 2017-05-15T04:00:00Z The growth in driving-range activity and golf-simulator use, tracked separately in recent years, is now part of the NGF’s comprehensive participation picture. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z Obama falls into the category of the "avid golfer," which the NGF defines as golfers who play more than 25 rounds a year. We've crunched the numbers, and it's official: President Obama played A LOT of golf while in office - Golf Digest 2017-01-19T05:00:00Z NGF does this by binding to tyrosine kinase receptor A, which triggers a cascade of effects that include boosting the number of pain receptors and sensitizing nerves. Analgesia without opioids 2019-09-10T04:00:00Z That is the most since the NGF began counting in 2006. When your golf course dies - Golf Digest 2016-09-16T04:00:00Z NGF survey found that 57 percent of American kids and teens thought negatively of the game; the top response was that it was “boring.” Golf is back in the Olympics. Too bad no one plays it anymore 2016-08-05T04:00:00Z As an example, the NGF report says sports like baseball and basketball tally participation by including pick-up games or shooting baskets in the driveway. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z The NGF study is based on the organization’s database of golf retail stores, phone surveys and by consulting third-party sources. Average Golf Store A Third Larger Than in 2010 - Golf Digest 2016-07-07T04:00:00Z But the NGF report also tracked interest in the game among these latent golfers, what it calls “individuals who did not play golf during the survey year but expressed interest in playing golf now.” Number of golfers steady, more beginners coming from millennials: The Loop 2013-10-16T04:00:00Z "Those NGF statistics don't include those who have joined the game over the past decade," he told Reuters. Global game responds to cries of 'Fore' with new gimmicks 2014-05-10T19:23:09Z The authors speculated that elevated NGF levels might increase a person's feelings of euphoria or connection. What Physiological Changes Can Explain the Honeymoon Phase of a Relationship? 2013-09-09T12:45:56.050Z According to the NGF report, the average golfer is 43 years old and plays almost 20 rounds a year. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z The NGF says rounds played in the United States were up 7.4 percent through September against the same time period in 2011, with every state experiencing a gain. Golf Has Plenty Of Room For Growth 2013-01-08T05:00:00Z How does NGF control the assembly of these filamentous proteins? The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z What else does NGF do, and why would this be the trigger for ovulation in llamas and their fellow induced ovulators? Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z In the latest study, published this week in the Proceedings of the National Academy of Sciences, Adams led a team that identified the chemical as NGF. Nerve Protein In Llama Semen Could Help Human Fertility 2012-08-21T19:15:00.383Z Still, it is the lowest the NGF has reported that number in the Tiger Woods era. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z "We were looking for an unknown protein," Adams says, but in fact OIF/NGF is a molecule found throughout the bodies of many species. Semen's Secret Ingredient 2012-08-20T20:04:00Z The first real insight into the function of NGF in the living animal was provided by experiments done in our laboratory at Washington University in 1959. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z What seems to happen is that NGF activates trkA receptors in a way that eventually leads to a degradation of the follicular wall, which aids in follicular rupture from the ovary. Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z In some cases, NGF could explain why some couples find it difficult to conceive, says Adams. Nerve Protein In Llama Semen Could Help Human Fertility 2012-08-21T19:15:00.383Z “Green-grass golf participation remains an essential measure of golf’s vitality, and we will continue to measure and report on it the way we always have,” NGF president and CEO Joe Beditz said in the report. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z To Adams's surprise, the mystery substance turned out to be a protein that's crucial to the development and survival of sensory neurons: neural growth factor, or NGF. Semen's Secret Ingredient 2012-08-20T20:04:00Z NGF does not increase the number of neurons in the sympathetic ganglia by enhancing their multiplication. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z So… NGF could facilitate menstruation if timed towards the end of the cycle, or implantation, if timed during the implantation window. Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z “The beauty of this paper was that they weren’t looking for NGF,” says Ojeda. Nerve Protein In Llama Semen Could Help Human Fertility 2012-08-21T19:15:00.383Z More than three-quarters of all golfers are male, and just over 26 percent have a household income of more than $125,000, the largest segment in the NGF survey. The NGF's annual golf participation report uncovers favorable trends for the game's future - Golf Digest 2017-04-22T04:00:00Z Going forward, the team plans to study how NGF affects human fertility. Semen's Secret Ingredient 2012-08-20T20:04:00Z The effect of experimentally administered NGF is to enable the redundant neurons to survive and differentiate in spite of their failure to establish connections. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z It’s entirely possible the seminal NGF is also important to female reproductive function in some way. Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z Because NGF cannot pass through the blood–brain barrier, and because the gene must be incorporated by the specific subset of neurons most affected by the disease, precise delivery requires brain surgery. Drugs: A tangled web of targets 2011-07-13T17:20:55.130Z Like Regeneron's drug - which is being developed in partnership with Sanofi-Aventis SA - J&J's product is designed to block NGF, a protein that is associated with pain. FDA places experimental pain drugs on hold 2010-12-28T21:22:46Z Scientists have wondered whether this type of NGF, which was once thought to act in only sensory areas of the nervous system, also plays a role in reproduction. Semen's Secret Ingredient 2012-08-20T20:04:00Z In addition to apparently being essential to the survival of immature sympathetic neurons NGF seems to play a vital role in guiding nerve fibers toward their corresponding target organs. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z So I’m going to explain why this distinction is important, why this research is still really cool, and the reasons I can see that make NGF interesting in humans after all. Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z Like Regeneron's drug -- which is being developed in partnership with Sanofi-Aventis SA -- J&J's product is designed to block NGF, a protein that is associated with pain. FDA places J&J anti-NGF pain drug on clinical hold 2010-12-28T15:50:56Z Other researchers also found blood levels of nerve growth factor, or NGF, also increased. Falling in Love Is 'More Scientific Than You Think' 2010-10-26T15:00:00Z The new study, he says, indicates that NGF in male sperm actually travels through the female bloodstream to the brain, causing her hypothalamus and pituitary gland to release the hormones required for pregnancy. Semen's Secret Ingredient 2012-08-20T20:04:00Z When NGF is withdrawn from the culture medium, the cells retract their fibers, lose their other neuronal properties and resume the uncontrolled proliferation characteristic of neoplastic cells. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Breaking down the ovary’s last arguments about why the egg shouldn’t get to go out that night, NGF is like a feisty aunt that encourages troublemaking. Llama Llama Get With Mama: The Magical Semen Ingredient that Makes the Ladies Swoon (Then Ovulate) 2012-09-05T18:15:00.217Z NGF seems to be involved in transmitting the pain signal. Advances in pain relief: Agony column 2010-03-11T10:43:00Z At the Laboratory of Cell Biology in Rome, NGF was injected into the brain of newborn rodents. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Although the precise mechanisms by which NGF is acting on the pituitary gland and hypothalamus still need to be worked out in detail, Ojeda says the research itself looks solid. Semen's Secret Ingredient 2012-08-20T20:04:00Z It should be obvious to the reader that the investigation of NGF, which began more than two decades ago, is far from over. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Apparently the NGF injected into the brain diffused through the motor and sensory roots of the spinal cord and reached the sympathetic chain ganglia flanking the cord, where it induced the outgrowth of nerve fibers. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z As a consequence, blocking NGF reduces chronic pain. Advances in pain relief: Agony column 2010-03-11T10:43:00Z This finding implies that the tip of a growing sympathetic nerve fiber elongates along a diffusion gradient of NGF released by the target organ. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z The NGF gradient does not entirely determine the course of the nerve fibers but helps to orient them in the right direction. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z This finding was puzzling, since it was known that the NGF dimer by itself was biologically active. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Campenot filled one side chamber with a nutrient solution containing NGF and the other chamber with the same nutrient solution devoid of NGF. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z With the aid of purified NGF and NGF antibodies the neurobiologist is now able to increase the number of sympathetic neurons in an animal tenfold or to eliminate them altogether. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z This observation led to the hypothesis that the gene for NGF evolved from an ancestral gene for proinsulin, the large precursor polypeptide that is cleaved to yield the active molecule of insulin. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Shooter hypothesized that the alpha and gamma subunits serve to activate, store and protect the NGF molecule. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z In addition injection of NGF into either the brain or the systemic circulation enhanced the peripheral branching of the sympathetic fibers. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Shooter's hypothesis recently received support when he and Edward A. Berger isolated the proNGF molecule and demonstrated that incubation of this precursor with the gamma subunit resulted in its complete conversion into active NGF. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Small amounts of rabbit serum containing the NGF antibodies were then injected into newborn mice. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z According to his scheme the initial gene product in the manufacture of NGF is a large precursor polypeptide called proNGF, two copies of which form a dimer. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Two gamma subunits then associate with the proNGF dimer and cleave the precursor chains to generate the active NGF dimer. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Injections of the purified snake venom NGF into growing embryos resulted in the same excessive sympathetic innervation of the viscera and the blood vessels as that induced by the sarcoma-180 cells. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Unlike the typical complex of an enzyme and its product, which rapidly dissociates, the 'gamma subunits remain bound to the NGF dimer after the cleavage of the proNGF chains. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z All mammals respond to NGF the same way, although for practical reasons rodents are the experimental animals of choice. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z He observed that the growing nerve fibers migrated from the central chamber only into the side chamber containing NGF. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Since NGF is released in minute amounts from peripheral tissues receiving innervation from sympathetic ganglia, it now seems clear that a diffusion gradient of NGF directs the fibers toward their corresponding target tissues. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z The association of the gamma and alpha subunits with the NGF dimer apparently serves to protect it from further degradation by other protein-cleaving enzymes in the body fluids. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z This retrograde axonal transport of NGF is absolutely essential for the survival of the innervating neurons. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z The binding of NGF to its receptors triggers a chain of biochemical events that leads ultimately to the outgrowth of the nerve fiber. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z The discovery that two unrelated sources—mouse sarcoma and snake venom—harbor NGF suggested the possibility that still other tissues might secrete the factor. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z In the mice treated with the NGF antibodies the sympathetic ganglia were reduced to such diminutive size that they were barely visible in the dissecting microscope! The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Cohen obtained specific antibodies to NGF by injecting purified mouse NGF into rabbits. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Further evidence for a neurotropism mediated by NGF was provided by some elegant experiments done by Robert B. Campenot of the Harvard Medical School. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z Immature sympathetic neurons respond to NGF with a burst of metabolic activity that provides the material necessary for the growth of the nerve fiber and the manufacture of molecules of neurotransmitter. The Nerve-Growth Factor: A New Tool for Manipulating Neurons 2013-01-03T11:15:00.190Z |
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