| 单词 | neutrophil |
| 例句 | “You probably don’t know this, but it’s not just granny folklore. One published study shows that the soup inhibits the movement of neutrophils, the most common type of white blood cell that defends against infection.” Sir Fig Newton and the Science of Persistence 2022-03-22T00:00:00Z It does this by directly inhibiting the ability of neutrophils, a type of white blood cell, to travel to the inflamed tissue. Does chicken soup really help when you’re sick? A nutrition specialist explains 2023-10-23T04:00:00Z My neutrophils, white blood cells that act as the body’s first line of defense against bacteria and fungi, were life-threateningly low. I wanted to publish a book before I died 2016-02-14T05:00:00Z Specific immune cells known as neutrophils play a decisive role in the initiation and maintenance of inflammatory processes in blood and tissue. Immune system: Mechanisms of alarmin release discovered 2023-11-02T04:00:00Z Reported in Cell, the study interrogates the preferential spatial niches, dynamics, gene expression patterns and functional states of neutrophils in BrMs and gliomas. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z The research published today in JCI Insight focused on studying the impact of ginger supplementation on a type of white blood cell called the neutrophil. New research adds evidence to the benefits of ginger supplements for treating autoimmune diseases 2023-09-22T04:00:00Z Then comes the depletion of cells such as neutrophils and red blood cells, meaning you can't battle germs or give your tissues oxygen effectively. Why We’ll Never Live in Space 2023-09-19T04:00:00Z The organization aims to work with at least 10 hospital systems to evaluate those cells more accurately and to research the impact of medications on people with low counts of neutrophils. Seeking to curb racial bias in medicine, Doris Duke Fund awards $10 million to health groups 2023-06-30T04:00:00Z In the course of their activation, these neutrophils already begin to release pro-inflammatory messengers into blood vessels, signaling to the body that the immune system must redouble its efforts. Immune system: Mechanisms of alarmin release discovered 2023-11-02T04:00:00Z Notably, it identifies specific cellular interactions and a pair of molecular factors in the TME that are key to converting neutrophils from potential agents of anti-tumor immunity into abettors of malignancy. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z The study found ginger consumption by healthy individuals makes their neutrophils more resistant to NETosis. New research adds evidence to the benefits of ginger supplements for treating autoimmune diseases 2023-09-22T04:00:00Z Antibodies also mark pathogens for destruction by phagocytic cells, such as macrophages or neutrophils, in a process called opsonization. Concepts of Biology 2013-04-25T00:00:00Z The HSP47 on the platelets activate neutrophils, causing them to form a “net” that traps proteins, pathogens, and cells, leading to blood clots. Now we know why hibernating bears don’t get blood clots 2023-04-12T04:00:00Z That is to say, the neutrophils can remove the formed pores again in a matter of minutes. Immune system: Mechanisms of alarmin release discovered 2023-11-02T04:00:00Z "Our identification of specific cellular and molecular factors that can turn neutrophils into immunosuppressive and pro-tumoral agents in the TME opens the door to developing therapeutic approaches to make brain cancers more susceptible to immunotherapy." Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z For example, a type of immune cell called a neutrophil migrates toward areas in the body that have a higher concentration of a protein called IL-8, which increases during infection. How cancer cells move and metastasize is influenced by the fluids surrounding them 2023-01-10T05:00:00Z For example, a neutrophil is an early arriving white blood cell that engulfs and digests pathogens. Concepts of Biology 2013-04-25T00:00:00Z When we injected a lethal dose of TNF in mice lacking the two proteins in two specific types of myeloid cells, neutrophils and macrophages, mice had reduced symptoms of sepsis and improved survival. How sepsis can lead to cell death 2023-01-01T05:00:00Z With the bacteria present, neutrophils tended to move toward the cancer cells, just as they did in the patient tumor samples. Bacteria in tumors may promote cancer 2022-11-16T05:00:00Z In all tumor types, however, their phenotypes -- or physical traits and functional states -- differ significantly from those of neutrophils in the circulation and in healthy brain tissues. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z White blood cells—including neutrophils, monocytes, lymphocytes, eosinophils, and basophils—are involved in the immune response. Biology for AP Courses 2022-06-09T00:00:00Z Figure 17.11 Cells involved in the innate immune response include mast cells, natural killer cells, and white blood cells, such as monocytes, macrophages and neutrophils. Concepts of Biology 2013-04-25T00:00:00Z This finding positions macrophages and neutrophils as major triggers for TNF-mediated death in mice. How sepsis can lead to cell death 2023-01-01T05:00:00Z The endothelium lining the local blood vessel becomes “leaky” under the influence of histamine and other inflammatory mediators allowing neutrophils, macrophages, and fluid to move from the blood into the interstitial tissue spaces. Anatomy and Physiology 2013-06-19T00:00:00Z They also become functionally suppressed, halting the production of reactive oxygen species -- the molecular bomblets neutrophils ordinarily use to destroy their cellular targets. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z A neutrophil is also a phagocytic leukocyte that engulfs and digests pathogens. Biology for AP Courses 2022-06-09T00:00:00Z Macrophages follow neutrophils and take over the phagocytosis function and are involved in the resolution of an inflamed site, cleaning up cell debris and pathogens. Concepts of Biology 2013-04-25T00:00:00Z The amazing thing is that sometimes the neutrophils survive that process, and for a time, they can fight on. Review | Most people don’t understand their immune systems. Philipp Dettmer is here to help. 2022-02-17T05:00:00Z Phagocytic cells such as macrophages and neutrophils are attracted to an infection site by chemotactic attraction to smaller complement fragments. Anatomy and Physiology 2013-06-19T00:00:00Z Both, the researchers show, are produced by neutrophils themselves as well as macrophages and microglia. Study shows how brain tumors make certain immune cells turn traitor 2023-09-28T04:00:00Z A basophil is a leukocyte that, like a neutrophil, releases chemicals to stimulate the inflammatory response as illustrated in Figure 33.5. Biology for AP Courses 2022-06-09T00:00:00Z Compared with adults, children recently infected with SARS-CoV-2 have also been found to have higher levels of activated neutrophils, cells that are on the front line in the response to unfamiliar invaders. Why Kids Beat Back COVID Better Than Adults 2021-09-15T04:00:00Z It decreases the responses of immune cells, including neutrophils, natural killer cells and macrophages—which could be one reason that men tend to have lower rates of autoimmune disease. Why Nearly 80 Percent of Autoimmune Sufferers Are Female 2021-09-15T04:00:00Z Leukotrienes attract neutrophils from the blood by chemotaxis and increase vascular permeability. Anatomy and Physiology 2013-06-19T00:00:00Z White blood cells called neutrophils and macrophages travel to the intruder and work to destroy it. Vaccine side effects don’t tell you how well your immune system will protect you from covid-19 2021-05-07T04:00:00Z Antibodies also mark pathogens for destruction by phagocytic cells, such as macrophages or neutrophils, because phagocytic cells are highly attracted to macromolecules complexed with antibodies. Biology for AP Courses 2022-06-09T00:00:00Z If white blood cells are the armed forces defending the body from outside invaders, the cells she was missing, the neutrophils, are the Marines, the fiercest first-line defenders against almost any infection. Her White Blood Count Was Dangerously Low. Was Med School Still Safe? 2021-02-18T05:00:00Z As Dr. Cloutier explained, in allergic asthma, inflammatory cells called eosinophils collect in the airways, but when a viral infection triggers the inflammation, cells called neutrophils are released, warranting a different treatment. There’s No ‘One Size Fits All’ Treatment for Asthma 2021-02-15T05:00:00Z Leukotrienes are particularly good at attracting neutrophils from the blood to the site of infection by chemotaxis. Anatomy and Physiology 2013-06-19T00:00:00Z For starters, Dr. Evans said, fever activates innate immunity — the mobilization of white blood cells: neutrophils that patrol the body for pathogens and macrophages that gobble them up. Why Are We So Afraid of Fevers? 2021-01-11T05:00:00Z The neutrophils in the recipient will identify the MHC I molecules on transplanted organ as non- self proteins, causing lysis of transplanted cells. Biology for AP Courses 2022-06-09T00:00:00Z In someone who is otherwise healthy, whose other types of blood are fine, this kind of severe drop in neutrophils — what’s known medically as neutropenia — is usually caused by a medication. Her White Blood Count Was Dangerously Low. Was Med School Still Safe? 2021-02-18T05:00:00Z A subsequent analysis of health records from about 3,300 people showed that high neutrophil counts were associated with increased COVID-19 mortality. COVID research updates: Good timing might help the immune system to control COVID-19 2020-09-21T04:00:00Z Following an early neutrophil infiltrate stimulated by macrophage cytokines, more macrophages are recruited to clean up the debris left over at the site. Anatomy and Physiology 2013-06-19T00:00:00Z A neutrophil is a type of immune cell that provides the body with one of its first lines of defence against infection. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z For example, when bacteria invade the human body, a type of white blood cell called a neutrophil will remove the invaders by this process. Biology for AP Courses 2022-06-09T00:00:00Z And she was making a healthy amount of all the white blood cells, including neutrophils. Her White Blood Count Was Dangerously Low. Was Med School Still Safe? 2021-02-18T05:00:00Z Several immune proteins that are associated with neutrophils were found at higher levels in the plasma of people who later became critically ill than in those whose illness did not become severe. COVID research updates: Good timing might help the immune system to control COVID-19 2020-09-21T04:00:00Z Figure 18.11 Granular Leukocytes A neutrophil has small granules that stain light lilac and a nucleus with two to five lobes. Anatomy and Physiology 2013-06-19T00:00:00Z Writing in Nature, Yang et al.1 shed light on how neutrophils aid this deadly process. Neutrophil ‘safety net’ causes cancer cells to metastasize and proliferate 2020-06-10T04:00:00Z Opsonin stabilizes the inward facing surface of the plasma membrane, which engulfs the antigen, whereas clathrin marks the antigen for phagocytosis by neutrophils. Biology for AP Courses 2022-06-09T00:00:00Z But when her neutrophils dropped again, she stopped — this time, she figures, for good. Her White Blood Count Was Dangerously Low. Was Med School Still Safe? 2021-02-18T05:00:00Z They found that infiltration by neutrophils and by subsets of immune cells called CD3e+ T cells was reduced, as was microglial activation, compared with the situation in untreated animals. Gut microbes tune inflammation and lifespan in a mouse model of amyotrophic lateral sclerosis 2020-05-12T04:00:00Z The most common of all the leukocytes, neutrophils will normally comprise 50–70 percent of total leukocyte count. Anatomy and Physiology 2013-06-19T00:00:00Z Ordinarily, the lungs are protected against this damage by α1-antitrypsin, which inhibits neutrophil elastase. Research round-up: COPD 2020-05-12T04:00:00Z Opsonin marks the antigen for phagocytosis by neutrophils, whereas clathrin stabilizes the inward facing surface of the plasma membrane, which engulfs the antigen. Biology for AP Courses 2022-06-09T00:00:00Z One relatively obscure accomplice when the defense system goes awry is a “Cinderella” immune cell called a neutrophil. ‘Spider-Man’ Immune Response May Promote Severe COVID-19 2020-04-28T04:00:00Z The innate immune system, composed of white blood cells such as macrophages, natural killer cells and neutrophils, was supposed to have no such memory. Can a century-old TB vaccine steel the immune system against the new coronavirus? 2020-03-23T04:00:00Z Younger and immature neutrophils begin to develop lobes and are known as “bands.” Anatomy and Physiology 2013-06-19T00:00:00Z For example, the enzyme neutrophil elastase, which neutrophils release to kill invading bacteria, also erodes the extracellular matrix, the mesh of proteins and sugars that cradles cells and provides structural support for tissue. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Consistent with previous studies4,5, the authors found that two types of myeloid cell — monocytes and neutrophils — accumulated in the lung before metastases were detectable there. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z Because a neutrophil dies when it engages in this process —or shortly thereafter—some researchers consider the webs a cellular version of suicide bombing. ‘Spider-Man’ Immune Response May Promote Severe COVID-19 2020-04-28T04:00:00Z It found that the soup inhibited the migration of neutrophils, which are the commonest white blood cells fighting infection, and those responsible for all the snot and whatnot. The best health foods? Soup, garlic and cake 2019-11-21T05:00:00Z A burn injury increases the proliferation of neutrophils in order to fight off infection that can result from the destruction of the barrier of the skin. Anatomy and Physiology 2013-06-19T00:00:00Z Researchers suspect these vagrant neutrophils release neutrophil elastase and other molecules at the wrong spots, including the lungs, causing the tissue damage seen in COPD. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z This treatment decreased the expression of CCR2 in monocytes and CXCR2 in neutrophils, and fewer of these cells reached the lung. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z He found their lungs clogged with thick mucus and overrun with neutrophils. ‘Spider-Man’ Immune Response May Promote Severe COVID-19 2020-04-28T04:00:00Z Up to 75 percent of our body’s white blood cells are neutrophils, and they play a major role in helping fight infection. When undergoing chemo or radiation, cancer patients need to avoid diseases. CDC provides vital tips. 2019-11-15T05:00:00Z Some leukocytes, such as the eosinophil and neutrophil, are characterized as granular leukocytes. Anatomy and Physiology 2013-06-19T00:00:00Z And as people age, neutrophils become less effective at combating infections and more harmful to the body. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z The impaired recruitment of tumour-promoting monocytes and neutrophils to the lungs was accompanied by a decrease in the number and size of metastases. Tweaking the DNA of myeloid cells curbs cancer spread 2020-02-25T05:00:00Z In turn, that results in the recruitment of neutrophils, which help to get rid of unwanted bacteria. Pressure regulates immune-cell function 2019-08-20T04:00:00Z When they’re needed, neutrophils are among the first cells to respond. When undergoing chemo or radiation, cancer patients need to avoid diseases. CDC provides vital tips. 2019-11-15T05:00:00Z Abnormally high counts of neutrophils indicate infection and/or inflammation, particularly triggered by bacteria, but are also found in burn patients and others experiencing unusual stress. Anatomy and Physiology 2013-06-19T00:00:00Z “We are now beginning to understand that neutrophils are linked to many diseases that blight our population,” says pulmonologist Elizabeth Sapey of the University of Birmingham in the United Kingdom. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z The reduced inflammation was accompanied by a decrease in immune cells such as neutrophils, monocytes and macrophages, which are major drivers of inflammation. Two types of fibroblast drive arthritis 2019-05-28T04:00:00Z Mature neutrophils and monocytes migrate to arterial walls, where the monocytes develop into macrophage cells. How broken sleep promotes cardiovascular disease 2019-02-12T05:00:00Z Immune cells called neutrophils seem to help breast-cancer cells to spread — or ‘metastasize’ — to the lungs. Daily briefing: How to make the most of Instagram 2019-02-07T05:00:00Z They are slightly smaller than neutrophils and eosinophils at 8–10 µm in diameter. Anatomy and Physiology 2013-06-19T00:00:00Z But researchers say there’s still hope, arguing they haven’t yet pinned down what doses to use, how best to deliver potential drugs, and which aspects of neutrophil biology to target. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Whether the neutrophils remain associated with the cancer cells until they form such a metastasis is unknown. Sticking together helps cancer to spread 2019-02-05T05:00:00Z A team of researchers from Massachusetts General Hospital and Harvard University stained a kind of immune cell called a neutrophil, and watched it use TCVs to leave the bone and travel through the body. Discovered — a previously unknown structure in the human body 2019-02-04T05:00:00Z Some controversy currently exists about whether MDSCs are a cell population that is distinct from normal neutrophils and monocytes, given that MDSCs are highly similar to those cells, yet are considered functionally different. Resistance to prostate-cancer treatment is driven by immune cells 2018-06-26T04:00:00Z Whereas macrophages act like sentries, always on guard against infection, neutrophils can be thought of as military reinforcements that are called into a battle to hasten the destruction of the enemy. Anatomy and Physiology 2013-06-19T00:00:00Z But because most neutrophils ply the bloodstream, inhaled drugs may not reach faulty cells, she says. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z These findings suggest that communication between CTCs and neutrophils promotes the metastatic potential of the cancer cells. Sticking together helps cancer to spread 2019-02-05T05:00:00Z The initial immune response involves cells of the body’s innate immune system, such as macrophages and neutrophils. How the flu hijacks your body to make you feel so wretched 2018-02-16T05:00:00Z The gene activity also pointed to a role for immune cells such as neutrophils, which launch a full-fledged inflammatory reaction, including the release of molecules that stimulate contractions of the uterus. The key to a successful pregnancy: a tamed immune reaction 2018-01-10T05:00:00Z The most abundant leukocytes are the neutrophils, which are first responders to infections, especially with bacteria. Anatomy and Physiology 2013-06-19T00:00:00Z When the team members exposed neutrophils to simvastatin in the lab, they found it boosts the cells’ migration accuracy and improves their performance in other ways. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Szczerba and colleagues add a new mechanism to the list: the possibility that neutrophils support cancer cells in their journey through the bloodstream to secondary sites. Sticking together helps cancer to spread 2019-02-05T05:00:00Z And the cells that eject them survive—NET-spewing neutrophils often die after releasing their DNA. White blood cells launch DNA ‘webs’ to warn of invaders 2018-01-03T05:00:00Z But the therapeutic benefit was marginal because, within weeks of implantation, the alginate would usually begin to attract immune cells such as macrophages and neutrophils. Diabetes: Encapsulating the problem : Nature : Nature Research 2016-12-06T05:00:00Z Macrophages, neutrophils, and dendritic cells are the major phagocytes of the immune system. Anatomy and Physiology 2013-06-19T00:00:00Z “The age-old idea was that you couldn’t touch neutrophils,” Sapey says. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Looking ahead, several key issues should be addressed before attempts are made to target CTC–neutrophil clustering in the clinic. Sticking together helps cancer to spread 2019-02-05T05:00:00Z In the 2012 trial, for example, eight people had serious side effects, such as a sharp decrease in immune cells called neutrophils, and 14 people had comparatively mild side effects like nausea. This protein is mutated in half of all cancers. New drugs aim to fix it before it’s too late 2016-10-05T04:00:00Z Hutterite children have more white blood cells involved in allergy, called eosinophils, while another cell type, called neutrophils — which specializes in repelling microbes — predominates in Amish children. Health Secrets of the Amish 2016-08-03T04:00:00Z A neutrophil is a phagocytic cell that is attracted via chemotaxis from the bloodstream to infected tissues. Anatomy and Physiology 2013-06-19T00:00:00Z More than 10 years ago, such disease links prompted some companies to begin to develop compounds that inhibit neutrophil elastase. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Another central issue is to define the window of therapeutic opportunity for interventions that target CTC clustering with neutrophils. Sticking together helps cancer to spread 2019-02-05T05:00:00Z These children’s neutrophils were newly emerged from their bone marrow, evidence of a continual low-grade reaction to microbial invaders. Barnyard Dust Offers a Clue to Stopping Asthma in Children 2016-08-03T04:00:00Z A fraction of these recruited neutrophils migrate into the lumen of the intestine — a diagnostic marker of inflammatory diarrhoea104. Interactions between the microbiota and pathogenic bacteria in the gut : Nature : Nature Publishing Group 2016-07-05T04:00:00Z A class of cells known as neutrophils, which act as the body's first responders, rush to the bite site. Mosquito spit helps viruses make us sick 2016-06-21T04:00:00Z The therapeutic possibilities are likely to broaden as researchers learn more about the biology of neutrophils. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z It is not known whether neutrophils and cancer cells cluster in the primary tumour and then enter the bloodstream together. Sticking together helps cancer to spread 2019-02-05T05:00:00Z Inflammation is a normal immune response to a pathogen threat, involving the production of various chemical signals and the activation of immune cells like neutrophils. Fighting sepsis with cancer drugs 2016-04-28T04:00:00Z Life is dynamic: cells not only crawl around, like Mullins' neutrophil, they divide, shuttle chemicals from one internal structure, or organelle, to another, and so much more. Cell imaging: Beyond the limits : Nature : Nature Publishing Group 2015-10-20T04:00:00Z An important advance in the treatment of cancer patients, Neupogen prevented infections in cancer chemotherapy patients whose immune systems were suppressed due to a dangerously low white blood cell count, particularly those cells called neutrophils. FDA Approves First US Biosimilar; Hold Your Breath On Cost Savings 2015-03-06T05:00:00Z Researchers long assumed that once neutrophils left the bloodstream and moved into infected or injured tissues, they would eventually self-destruct, allowing the inflammation at the site to clear. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z Figure 1 | Interactions between breast cancer cells and neutrophils promote the formation of lung metastases. Sticking together helps cancer to spread 2019-02-05T05:00:00Z The other professor was hospitalized with leukemia and awaited the improvement of his neutrophils, which would allow us to safely discharge him. Numbers in the Cancer Fight 2014-10-09T04:00:00Z The result: severe skin lesions and blistering due to the baby's inability to produce enough neutrophils, a key type of white blood cell needed to fight off bacterial and fungal infections. Certain Autoimmune Drugs in Pregnancy May Up Newborn Infection Risk: Study 2014-10-03T04:00:00Z There is a link between neutrophil function and the balance of stress hormones, the study authors noted. Grief Can Weigh on Immune System in Older Folks, Study Says 2014-09-18T04:00:00Z Now, Ferro and his colleagues are trying to interrupt one leg of the neutrophils’ journey. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z It is not known whether neutrophils first interact with cancer cells in the primary tumour site in breast tissue. Sticking together helps cancer to spread 2019-02-05T05:00:00Z “For every mile I walk in the hallways here, I will recover 10 neutrophils.” Numbers in the Cancer Fight 2014-10-09T04:00:00Z Of the molecules with proresolution activity, tanshinone IIA, derived from a Chinese medicinal herb, potently induced inflammation resolution in vivo both by induction of neutrophil apoptosis and by promoting reverse migration of neutrophils. [Research Articles] A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism 2014-02-26T19:25:21.240Z Pathological inflammation and autoimmune disease frequently involve elevated neutrophil activity in the absence of infectious agents. [Research Articles] The Circulating Proteinase Inhibitor {alpha}-1 Antitrypsin Regulates Neutrophil Degranulation and Autoimmunity 2014-01-01T19:25:02.977Z In animal tests, the compound deters neutrophils from entering sites of inflammation. New drugs aim to disarm the immune system’s ‘atomic bomb’ cells 2020-03-05T05:00:00Z The protein VCAM1 on the tumour-cell surface is essential for the formation of these clusters, presumably because it binds to its corresponding receptor on neutrophils. Sticking together helps cancer to spread 2019-02-05T05:00:00Z Before lesion development, we detected increased mRNA expression of chemokines in the skin associated with early infiltration of macrophages and mast cells and later infiltration of eosinophils, T cells, and neutrophils. [Research Articles] Genetic Ablation of Epidermal EGFR Reveals the Dynamic Origin of Adverse Effects of Anti-EGFR Therapy 2013-08-21T18:25:05.013Z Tanshinone IIA blocked proinflammatory signals in vivo, and its effects are conserved in human neutrophils, supporting a potential role in treating human inflammation and providing compelling evidence of the translational potential of this screening strategy. [Research Articles] A Zebrafish Compound Screen Reveals Modulation of Neutrophil Reverse Migration as an Anti-Inflammatory Mechanism 2014-02-26T19:25:21.240Z The neutrophil is at the heart of the action, a killing machine that destroys unwanted intruders. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z The selectivity of drug action is due to profound up-regulation of CD73 and adenosine AR expression in neutrophils and inflammatory monocytes as found in recovered cells from the synovial fluid of arthritic mice. [Research Articles] Selective Activation of Adenosine A2A Receptors on Immune Cells by a CD73-Dependent Prodrug Suppresses Joint Inflammation in Experimental Rheumatoid Arthritis 2012-08-08T18:55:12.537Z He was producing neutrophils and bands, white blood cells, at rates that were “very abnormal and would suggest a serious bacterial infection,” Dr. Edmond said. About New York: In Rory Staunton’s Fight for His Life, Signs That Went Unheeded 2012-07-11T18:28:53Z T cell depletion with alemtuzumab required the presence of neutrophils, a cell type frequent in blood but rare in normal skin. [Research Articles] Skin Effector Memory T Cells Do Not Recirculate and Provide Immune Protection in Alemtuzumab-Treated CTCL Patients 2012-01-18T20:25:09.533Z This protein exerts a big influence on white blood cells, spurring some of them to mature and switching on pathogen-fighters such as neutrophils. Surprising Cells Stymie Sepsis 2012-01-12T20:27:17Z The damage is limited because the neutrophils are designed to die 24-48 hours after moving into the tissue. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. [Research Articles] Neutrophil-Derived Cathelicidin Protects from Neointimal Hyperplasia 2011-10-05T18:55:12.217Z Equally worrying is another of its side effects: a sometimes fatal lowered count of white blood cells that are called neutrophils. Cocaine's Newest Risks: Dying Skin and Compromised Immunity 2011-08-23T13:15:05.460Z This hypersensitivity was associated with the infiltration of neutrophils and macrophages into the dermis, and neutralizing the effects of CXCL5 attenuated the abnormal pain-like behavior. [Research Articles] CXCL5 Mediates UVB Irradiation-Induced Pain 2011-07-06T20:25:24.577Z Swirski suggests that IRA-B cells prevent sepsis by hastening the attack by neutrophils on pathogens, consequently allowing the immune system to shut down earlier. Surprising Cells Stymie Sepsis 2012-01-12T20:27:17Z This is a reality for people on certain chemotherapy regimes which decimate neutrophil numbers. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z Short-lived but populous immune cells called neutrophils and the cellular flotsam they sometimes release might play an important role in lupus. Digging Into the Roots of Lupus 2011-03-10T20:21:00Z Circulating neutrophils from SLE patients released more NETs than those from healthy donors; this was further stimulated by the antimicrobial autoantibodies, suggesting a mechanism for the chronic release of immunogenic complexes in SLE. [Research Articles] Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus 2011-03-09T19:55:07.330Z Three recent papers in redirect focus on neutrophils, platelets, and interferon-α in the pathogenesis of SLE and reinforce the notion that researchers should seek to discover and devise combination therapies that target these processes. [Perspectives] Dissecting the Immune Cell Mayhem That Drives Lupus Pathogenesis 2011-03-09T19:55:04.693Z Blood cells called neutrophils also appeared in the new study to be important for spreading the disease. Gene Profiles May Predict TB Prognosis 2010-08-19T15:49:00Z I am a neutrophil, and several billion of me are made in your bone marrow every day. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z That study also elucidates how specific compounds—immune proteins called toll-like receptors and particularly an antimicrobial peptide called LL37—play central roles in the aberrant chain reactions involving neutrophils. Digging Into the Roots of Lupus 2011-03-10T20:21:00Z Our data establish a link between neutrophils, pDC activation, and autoimmunity in SLE, providing new potential targets for the treatment of this devastating disease. [Research Articles] Neutrophils Activate Plasmacytoid Dendritic Cells by Releasing Self-DNA-Peptide Complexes in Systemic Lupus Erythematosus 2011-03-09T19:55:07.330Z In a later stage, as is usually the case, bacteria effect an entrance into the bullæ, which now become filled with neutrophils. Histology of the Blood Normal and Pathological The nucleus as a rule is not so deeply stained as in the polynuclear neutrophil, but otherwise in its general shape is completely similar. Histology of the Blood Normal and Pathological The neutrophil releases packets of enzymes which attack the outside of the microbe. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z What’s pivotal is how the cells expire: The neutrophils’ components are extruded from the cell and form neutrophil extracellular traps, or NETs, weblike structures that comprise unwound strings of DNA, proteins and other cell components. Digging Into the Roots of Lupus 2011-03-10T20:21:00Z The size of the eosinophils frequently exceeds that of the neutrophils. Histology of the Blood Normal and Pathological He found numerous eosinophil cells in the sputum of an asthmatic patient, but only neutrophil cells in an artificially produced suppuration of the skin. Histology of the Blood Normal and Pathological A fundamental distinction from the large mononuclear cells lies in the fact that the protoplasm exhibits a more or less numerous neutrophil granulation. Histology of the Blood Normal and Pathological By understanding how neutrophils cause damage we hope to design new anti-inflammatory drugs to tone down the response and tackle these crippling conditions. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z Anderson Cancer Center in Houston finds a similar role for neutrophils in lupus. Digging Into the Roots of Lupus 2011-03-10T20:21:00Z In isolated cases the increase at this time was very considerable; and in one case amounted almost to 12% of all neutrophil cells. Histology of the Blood Normal and Pathological As a third possibility for the local origin of the eosinophil cells, their direct descent from neutrophil cells is conceivable, and is by many regarded as a kind of ripening. Histology of the Blood Normal and Pathological It is to be particularly insisted once again that the spleen has nothing at all to do with the formation of the pseudoeosinophil polynuclear cells, which are the analogues of the polynuclear neutrophils of man. Histology of the Blood Normal and Pathological However these are short term measures and what patients really need are their neutrophils. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z The reports demonstrate that the release of NETs by neutrophils and their capacity to bind to the dendritic cells “drive the chronic interferon alpha production seen in many patients with lupus.” Digging Into the Roots of Lupus 2011-03-10T20:21:00Z The leucocytosis of digestion consequently differs essentially from the other kinds, in which the neutrophil elements are chiefly increased. Histology of the Blood Normal and Pathological We begin with the discussion of the mononuclear neutrophil cells, Ehrlich's "myelocytes." Histology of the Blood Normal and Pathological Analogous observations may be made in the eosinophil cells of man and animals, and in the neutrophils of man. Histology of the Blood Normal and Pathological Yet we must not forget that we need neutrophils. Killer skills of a neutrophil 2012-09-17T13:15:00.210Z When neutrophils from healthy people were exposed to the rogue lupus antibodies, the cells didn’t release their contents in NETs. Digging Into the Roots of Lupus 2011-03-10T20:21:00Z The same differences are found more sharply marked in leukæmia even in the circulating blood, in the neutrophil as well as in the eosinophil group. Histology of the Blood Normal and Pathological The importance of these neutral staining solutions lies in the fact that they pick out definite substances, which would not be demonstrated by the individual components, and which we therefore call neutrophil. Histology of the Blood Normal and Pathological The mononuclear cells of man however are finally transformed into the neutrophil granulated cells, whilst the cells of Kurloff remain free from granules in the course of their metamorphosis. Histology of the Blood Normal and Pathological Under its influence the neutrophil elements of the bone-marrow vanish rapidly, and in many cases so completely that it needs some trouble to find a single myelocyte, as for example in a case of Ehrlich's. Histology of the Blood Normal and Pathological The extreme rarity of this condition supports our opinion that the formation of neutrophil mononuclear elements cannot be regarded as a normal function of the lymphatic glands. Histology of the Blood Normal and Pathological Polynuclear neutrophil cells are nearly always naturally present in inflamed lymph glands, as a product of the inflammation which has immigrated there. Histology of the Blood Normal and Pathological Nuclei are blue, hæmoglobin red, neutrophil granulation violet, acidophil pure red, mast cell granulation deep blue, forming one of the most beautiful microscopic pictures. Histology of the Blood Normal and Pathological In the majority of the animals observed, he found too that the polynuclear cells contained neutrophil granules; in only one animal, the white mouse, did he find them, or granulations analogous to them, completely wanting. Histology of the Blood Normal and Pathological The contrary assertions that neutrophil and eosinophil, or eosinophil and mast cell granulations occur in the same cell Ehrlich regards as unfounded, from extensive researches specially directed to this point. Histology of the Blood Normal and Pathological As will be shewn in detail in the following chapter, neutrophil and eosinophil leucocytes behave quite differently in their susceptibility to chemiotactic stimulation. Histology of the Blood Normal and Pathological Still greater is the difference between the mast cells and the other two cell groups; for so far as present investigations go, they are quite uninfluenced by substances chemiotactic for the neutrophil or eosinophil cells. Histology of the Blood Normal and Pathological The nuclei are greenish, the red blood corpuscles orange, the acidophil granulation copper red, the neutrophil violet. Histology of the Blood Normal and Pathological Afterwards these cells move away from the bacilli, and are succeeded by the polynuclear neutrophil cells, as will be mentioned later. Histology of the Blood Normal and Pathological Evidence that the substance of the granules is given off externally may sometimes be seen in the polynuclear neutrophil or their analogues. Histology of the Blood Normal and Pathological This standpoint had to be abandoned, when Ehrlich shewed that it is chiefly the emigration of the polynuclear neutrophil cells, which brings about leucocytosis. Histology of the Blood Normal and Pathological Corresponding with the increase of neutrophil blood corpuscles alone, there is always a relative decrease of lymphocytes, often to 2% and even lower. Histology of the Blood Normal and Pathological It is much to be recommended for good general preparations; it is indispensable in all cases where the study of the neutrophil granulations is concerned. Histology of the Blood Normal and Pathological A few diseases shew, besides the neutrophil leucocytosis, an increase of the eosinophils as well, as we shall describe in detail in the next section. Histology of the Blood Normal and Pathological In them the absolute number of white blood corpuscles is diminished, and chiefly at the expense of the polynuclear neutrophil cells. Histology of the Blood Normal and Pathological Of great theoretical interest is the contrast between eosinophil and neutrophil cells. Histology of the Blood Normal and Pathological Müller and Rieder should themselves have raised the obvious objection that the same holds good for the nucleus of the neutrophils. Histology of the Blood Normal and Pathological The mast cell granulations are stained pure blue, the eosinophil red, the neutrophil in mixed colour. Histology of the Blood Normal and Pathological Neusser now produced a non-specific inflammatory bulla in the skin by a vesicant, and found that the cellular elements in it were exclusively the polynuclear neutrophil concerned in all ordinary inflammations. Histology of the Blood Normal and Pathological A leucocytosis of mast cells, comparable with the eosinophil or neutrophil forms of leucocytosis, has not been demonstrated in the cases of Canon or other observers. Histology of the Blood Normal and Pathological Undeniably a valuable sign of leukæmia, they are not nearly so important as the mononuclear neutrophil cells, as follows from the numerical superiority of the latter. Histology of the Blood Normal and Pathological These two observations can only be interpreted by assuming a loss, in certain terminal stages, on the part of the organism, of its power of forming neutrophil substances. Histology of the Blood Normal and Pathological These are characterised by a coarse, round granulation, staining deeply with acid dyes, and similar in other respects to the polynuclear neutrophils. Histology of the Blood Normal and Pathological Concerning the behaviour of the forms of cell here involved, all authors are agreed that under no conditions do the lymphocytes shew the smallest spontaneous movement; whilst the polynuclear neutrophil cells always exhibit vigorous contractility. Histology of the Blood Normal and Pathological |
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