| 单词 | mosaicism |
| 例句 | They use terms like “germline mosaicism,” “chromosome rearrangement,” or “delayed mutation” to explain why their science is not an exact science. Wonder 2012-02-14T00:00:00Z There are countless people under words like “germline mosaicism,” “chromosome rearrangement,” or “delayed mutation.” Wonder 2012-02-14T00:00:00Z Clonal hematopoiesis, a variety of mosaicism that affects blood-forming cells and becomes more common with age, almost doubles the likelihood of developing cardiovascular disease and boosts the risk of dying from any cause by 40%. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z This mix of cell lines is called mosaicism. An IVF Embryo Test Aims to Prevent Miscarriages. Is It Worth It? 2022-06-01T04:00:00Z A first pregnancy is questioned when test results indicate abnormal chromosomes — mosaicism — in the unborn child. Peter Ho Davies takes a candid look at fatherhood in ‘A Lie Someone Told You About Yourself’ 2021-01-02T05:00:00Z Importantly, competition was seen only when there was a mixture of genetically different cells, a phenomenon known as mosaicism. These secret battles between your body’s cells might just save your life 2019-10-14T04:00:00Z Overall, the study found fewer examples of mosaicism in some types of tissue than would be expected on the basis of previous research. The human body is a mosaic of different genomes 2019-06-05T04:00:00Z As men get older, they become more vulnerable to another type of mosaicism in which the Y chromosome vanishes from some of their cells. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z We discovered that DNA sequences vary from cell to cell, meaning that our brains are a vast mosaic of distinct genomes, a phenomenon aptly referred to as “genomic mosaicism.” A New Idea about What Triggers Alzheimer's 2019-01-09T05:00:00Z This situation is called mosaicism because the child is a mosaic of normal and edited cells. How a scientist says he made a gene-edited baby – and what health worries may ensue 2018-11-30T05:00:00Z Findings made in the past few years reveal that human skin, oesophageal and lung cells show high levels of mosaicism. These secret battles between your body’s cells might just save your life 2019-10-14T04:00:00Z But the key, says Martincorena, is that the latest analysis demonstrated that mosaicism is present across a wide array of tissues. The human body is a mosaic of different genomes 2019-06-05T04:00:00Z “Somatic mosaicism is likely playing a role” in these conditions, D’Gama says. Your cells don’t have the genome you were born with. Project aims to chart impact of new mutations 2023-08-15T04:00:00Z Taking all this into account led us to conduct studies assessing mosaicism in AD brains. A New Idea about What Triggers Alzheimer's 2019-01-09T05:00:00Z Other researchers have reported mosaicism in efforts to edit human embryos for research purposes. First CRISPR babies: 6 questions that remain 2018-11-29T05:00:00Z He said he would continue to do blood tests and analyze for mosaicism or off-target mutations. Chinese Scientist Who Says He Edited Babies’ Genes Defends His Work 2018-11-28T05:00:00Z It may be after the dust settles there’s mosaicism and off targets that affect medical outcomes. ‘I feel an obligation to be balanced.’ Noted biologist comes to defense of gene editing babies 2018-11-28T05:00:00Z The study hints at a previously unanticipated mechanism in the development of Alzheimer’s, and expands our understanding of the genesis of brain mosaicism. A newly discovered mechanism driving neuronal mutations in Alzheimer’s disease 2018-11-20T05:00:00Z Our findings showed greater mosaicism—in particular, for increased APP copy numbers. A New Idea about What Triggers Alzheimer's 2019-01-09T05:00:00Z Among women, "mosaicism"—in which a person's cells aren't all genetically identical—explains part of it. Why is a remote Colombian town a hot spot of an inherited intellectual disability? 2018-10-10T04:00:00Z To study the effect of this mosaicism, Priest and his colleagues built a computer simulation of Astrea’s heart. Every cell in your body has the same DNA — except when it doesn’t 2018-05-27T04:00:00Z But scientists are also finding that mosaicism does not automatically equal disease. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z More importantly, all sister blastomeres in all but one embryo carried identical genotypes, indicating a marked reduction in mosaicism in M-phase-injected embryos. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z We therefore closely analyzed the APP gene using nine distinct technical approaches applied to single cells or small collections of neurons to account for genomic mosaicism from normal and AD brains. A New Idea about What Triggers Alzheimer's 2019-01-09T05:00:00Z If the aim of an edit is to fix a genetic disease, such mosaicism risks nullifying the effect. Researchers get better at tweaking the genomes of human embryos 2017-08-02T04:00:00Z This time, they say, mosaicism did not occur. First Human Embryos 'Edited' in U.S.—Get the Facts 2017-08-02T04:00:00Z What we do know is that mosaicism introduces randomness into the development of our brains. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z The presence even of a single mutant blastomere within a mosaic embryo would make detection by PGD problematic; therefore, molecular mechanisms responsible for mosaicism were investigated. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z The group also managed to almost completely eliminate mosaicism—an editing failure in which only some of the desired cells are repaired. Embryo Gene-Editing Experiment Reignites Ethical Debate 2017-08-02T04:00:00Z That should reduce the mosaicism problem—with only one cell you’ll either modify all the cells or none of them, not just some of them. About that "First Gene-Edited Human Embryos" Story..... 2017-07-28T04:00:00Z Another Chinese team, from Guangzhou Medical University, in March became the first to report repairing disease-causing mutations in viable embryos, but some still contained a patchy mix of edited cells—a phenomenon called mosaicism. First U.S. team to gene-edit human embryos revealed 2017-07-27T04:00:00Z As ubiquitous as mosaicism may be, it’s still easy to overlook — and surprisingly hard to document. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z As discussed above, mosaicism in gene-corrected human embryos would be difficult to detect and would, therefore, pose serious safety issues for possible clinical applications. Correction of a pathogenic gene mutation in human embryos : Nature : Nature Research 2017-08-01T04:00:00Z But Mitalipov was able to “significantly” reduce mosaicism, according to MIT Technology Review. Human embryos reportedly edited for first time in the US using CRISPR 2017-07-27T04:00:00Z Walsh’s team is trying to understand how mosaicism in the brain — in which some cells harbour different gene variants — affects health. The trickiest family tree in biology 2017-07-04T04:00:00Z National Library of Medicine offers more information about mosaicism. Controversial Fertility Treatment Resulted in Live Births 2015-11-18T05:00:00Z Some skin diseases proved to be caused by mosaicism, too. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z For some research purposes, such as tracking cell fate, mosaicism may not matter. CRISPR: A path through the thicket 2015-11-09T05:00:00Z This kind of mosaicism is rare, affecting about 1 in 15,000 people. Sex redefined 2015-02-17T05:00:00Z Having developed this method for detecting mosaic parents, the scientists decided to conduct a larger study to see how common mosaicism is. Having More Than One Set of DNA Carries Legacy of Risk 2014-07-31T04:00:00Z Researchers from European Hospital in Rome detected chromosomal mosaicism in nearly 5 percent of about 3,800 embryos included in the study. Controversial Fertility Treatment Resulted in Live Births 2015-11-18T05:00:00Z Preliminary studies suggest that mosaicism underlies many other diseases. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z Nevertheless, it seems likely that close inspection of the genomes of all algae that evolved by eukaryote–eukaryote endosymbiosis will reveal a level of mosaicism beyond that which is typically assumed. Algal genomes reveal evolutionary mosaicism and the fate of nucleomorphs 2012-12-05T18:51:06.810Z Some people have mosaicism: they develop from a single fertilized egg but become a patchwork of cells with different genetic make-ups. Sex redefined 2015-02-17T05:00:00Z In subsequent years it became clear that the phenomenon of genetic mosaicism is not restricted to but also occurs in many organisms, including humans. Jumping Genes in the Brain Ensure That Even Identical Twins Are Different 2012-02-14T16:15:04.437Z The baby, it turned out, carried a mixture of genetically distinct cells, a condition known as mosaicism. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z But mosaicism also means that even healthy people are more different from one another than scientists had imagined. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z Dr. Walsh and his colleagues have found evidence of mosaicism in some very unexpected places. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z The effects of sex-chromosome mosaicism range from the prosaic to the extraordinary. Sex redefined 2015-02-17T05:00:00Z To study the effect of this mosaicism, Dr. Priest and his colleagues built a computer simulation of Astrea’s heart. Every Cell in Your Body Has the Same DNA. Except It Doesn’t. 2018-05-21T04:00:00Z |
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