| 单词 | methotrexate |
| 例句 | We ate lunch while Jeffrey was getting his methotrexate, whatever that was. Drums, Girls, and Dangerous Pie 2004-01-01T00:00:00Z The oncologist will probably come in to ask you some questions before we start the methotrexate. Drums, Girls, and Dangerous Pie 2004-01-01T00:00:00Z We went back to Dr. Kahn, who said it was time to try methotrexate, an immune suppressant that is the most commonly used treatment for juvenile idiopathic arthritis. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z In fact, he wanted to up the dose of methotrexate from 10 milligrams to 15 milligrams, because we were seeing the full effects of the initial dosage and Shepherd was still in pain. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z What if Darin was right and methotrexate was the only effective course? Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z Shane’s case makes a stronger argument, since he didn’t take methotrexate. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z It was a question I tended to visit in the middle of the night, when Dr. Kahn’s reassurances that methotrexate was completely safe gave the least amount of comfort. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z At the dose Shepherd would be getting, a minuscule fraction of that, methotrexate can still cause nausea, dizziness and drowsiness. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z But after five weeks on Walker’s regimen and the initial dose of methotrexate, Shepherd seemed to be getting worse. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z When I first gave Shepherd his methotrexate pills, he was enthusiastic about taking them. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z Dr. Imundo wanted to more than double the dose of methotrexate. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z When Shane’s rheumatologist presented methotrexate or steroid injections as the only choices, she was horrified. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z Dr. Kahn and Darin agreed to hold off on increasing the methotrexate until we gave the experiment that much time. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z But he was O.K. with the rest of Walker’s regimen as long as it was complementary to the methotrexate, not used in place of it. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z Shepherd has now been weaned off the methotrexate entirely. Motherlode Blog: The Rabbit Hole of the Rare Childhood Diagnosis 2013-02-01T19:34:26Z Published in The Lancet, the paper investigated methotrexate, a low-cost, effective treatment for inflammatory joint conditions such as rheumatoid arthritis and psoriatic arthritis. Common drug can improve hand osteoarthritis symptoms 2023-10-13T04:00:00Z The patients were given oral doses of methotrexate or ciclosporin and assessed over nine months of treatment and six months after the therapy ended. Clinical trial recommends methotrexate for children with severe atopic dermatitis 2023-09-19T04:00:00Z Isabella McDonald, then a junior at Utah Valley University, was diagnosed in April with a rare, often fatal bone cancer, whose sole treatment for young adults includes the drug methotrexate. Why There’s a Severe Shortage of Cancer Drugs 2023-06-21T04:00:00Z A good example is the use of methotrexate, which is the standard treatment for ectopic pregnancy. Doctor who sued Idaho says chaos reigns as abortion bans go into effect 2022-08-19T04:00:00Z What Hubbard knows is that a treatment regimen featuring methotrexate enabled her to resume her life after her arthritis had become so crippling she had to stop working as a nurse. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z "In our study, as with most studies of osteoarthritis, both the placebo group and methotrexate groups' pain improved in the first month or so," Professor Cicuttini said. Common drug can improve hand osteoarthritis symptoms 2023-10-13T04:00:00Z The study led by King's College London, compared the safety and efficacy of ciclosporin with methotrexate in children and young people with this debilitating skin condition. Clinical trial recommends methotrexate for children with severe atopic dermatitis 2023-09-19T04:00:00Z When Isabella’s second cycle of treatment began June 5, clinicians advised that she would be getting less than the full dose because of a methotrexate shortage, said her father, Brent. Why There’s a Severe Shortage of Cancer Drugs 2023-06-21T04:00:00Z The standard treatment is to provide the drug methotrexate, which can terminate a pregnancy. Patients and doctors trapped in a gray zone when abortion laws and emergency care mandate conflict 2022-08-08T04:00:00Z She said she fears that without methotrexate, her pain would take over her life again. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z Professor Cicuttini said in patients with hand OA and inflammation, the effects of methotrexate were present at about three months and by six months it was very clear if it worked. Common drug can improve hand osteoarthritis symptoms 2023-10-13T04:00:00Z A spokesman said Thursday that the drugstore chain recently started doing this for methotrexate and misoprostol, two drugs used in medication abortions but also to treat other conditions. CVS seeks verification on drugs with possible abortion use 2022-07-21T04:00:00Z Jacobs depends on the drug methotrexate to treat her rheumatoid arthritis. Column: As professionals flee antiabortion policies, red states face a brain drain 2022-07-19T04:00:00Z They can be terminated with an injection of the drug methotrexate, which stops the cells from growing, or through surgery. Confusion post-Roe spurs delays, denials for some lifesaving pregnancy care 2022-07-16T04:00:00Z The medicine that stopped her eyes from deteriorating further was methotrexate. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z The reminder comes after many news reports have surfaced about pharmacists refusing to fill prescriptions for medications that are used for abortion, like mifepristone, misoprostol and methotrexate. Federal government warns rebel pharmacists who refuse to fill abortion-related prescriptions 2022-07-16T04:00:00Z Missouri now bans nearly all abortions and methotrexate can be used to end a pregnancy. State abortion bans prevent women from getting essential medication 2022-07-14T04:00:00Z At issue are three drugs — mifepristone, misoprostol and methotrexate — that are often prescribed for other conditions but can also induce abortions. U.S. Tells Pharmacists Not to Withhold Pills That Can Cause Abortion 2022-07-13T04:00:00Z HHS also cited as another example of potential discrimination: a pharmacy that refuses to fill a prescription for methotrexate to halt an ectopic pregnancy, which grows outside the womb and is not viable. Pharmacies can’t discriminate on reproductive health scripts 2022-07-13T04:00:00Z “Your health can deteriorate rapidly and also permanently,” if you stop taking methotrexate, Eby said. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z For example, someone with rheumatoid arthritis may be prescribed methotrexate as a standard immunosuppressive treatment. Federal government warns rebel pharmacists who refuse to fill abortion-related prescriptions 2022-07-16T04:00:00Z In Texas, it is now a felony to dispense methotrexate to someone more than seven weeks pregnant who uses it to end a pregnancy. State abortion bans prevent women from getting essential medication 2022-07-14T04:00:00Z If an ectopic pregnancy is detected early, the embryo’s development can be arrested by the administration of the cytotoxic drug methotrexate, which inhibits the metabolism of folic acid. Anatomy and Physiology 2013-06-19T00:00:00Z “This is a notice to let you know that we are pausing all prescriptions and subsequent refills of methotrexate,” the message read. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z Doctors usually recommend against stopping methotrexate without being weaned off slowly, and some patients worry that getting cut off from the drug when they go to get a refill could be dangerous. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z Until now, UK guidance has been to continue taking methotrexate after a Covid booster - but in the US, patients have been advised to stop for a week. Covid-booster response hope for most vulnerable 2022-06-27T04:00:00Z Indiana bans medication abortion - including methotrexate - starting at 10 weeks of pregnancy. State abortion bans prevent women from getting essential medication 2022-07-14T04:00:00Z Chiancone began taking methotrexate, a powerful drug used in chemotherapy and to treat RA that has not responded to other medications. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z In one case, a pharmacist initially refused to dispense methotrexate to an 8-year-old girl in Texas. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z Some doctors also object to pharmacies requiring diagnosis codes for drugs like methotrexate, saying that a forgotten code may lead to delays filling prescriptions for patients with debilitating pain. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z Drugs such as methotrexate are good at controlling autoimmune inflammatory conditions, because they dampen down the body's immune response. Covid-booster response hope for most vulnerable 2022-06-27T04:00:00Z However, Mayo said that his reading of the law allows for the use of methotrexate to treat an ectopic pregnancy. Ripple effects of abortion restrictions confuse care for miscarriages 2022-05-13T04:00:00Z Chiancone was told to take folic acid supplements; methotrexate is known to reduce levels of folate, a vitamin essential to the formation of blood cells among other functions. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Those patients represent about 2% of the 5 million Americans who take methotrexate. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z “That requirement … is not in place for methotrexate,” Greene wrote in a text message. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z He said that for most people, pausing methotrexate for a couple of weeks was "probably a good idea" but further research was needed "to really understand if this is necessary". Covid-booster response hope for most vulnerable 2022-06-27T04:00:00Z That's because the law prohibits several medications as abortion-inducing drugs; one of those drugs, methotrexate, is used to treat ectopic pregnancies. Many states' abortion bans have life-saving "exceptions." Experts doubt they will work as intended 2022-05-12T04:00:00Z Her rheumatologist suspected that the weight loss surgery had impaired her ability to absorb methotrexate and switched her to an injectable form of the drug. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Such patients take a far lower dose of methotrexate than is used to treat ectopic pregnancy or breast cancer. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z She has gone without methotrexate injections for several weeks now, while waiting to see a gynecologist about having a tubal ligation that will prevent her from ever getting pregnant. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z It found stopping the common immune-suppressing drug methotrexate for two weeks doubled spike antibody levels for up to 12 weeks. Covid-booster response hope for most vulnerable 2022-06-27T04:00:00Z As reported by NPR, some doctors reported they received a letter from a pharmacy stating that it would no longer fill methotrexate in the case of ectopic pregnancy. Many states' abortion bans have life-saving "exceptions." Experts doubt they will work as intended 2022-05-12T04:00:00Z She was advised to immediately stop taking methotrexate and Enbrel and begin high doses of folinic acid, which counters the effects of methotrexate. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Nevertheless, some doctors have already stopped prescribing methotrexate rather than risk falling afoul of antiabortion laws. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z They say they’re troubled by accounts like Hubbard’s because they never intended to restrict drugs like methotrexate to women with chronic health conditions. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z About 1.3 million people in the UK are on methotrexate for conditions such as rheumatoid arthritis and psoriasis. Covid: Medication holiday may boost vaccine protection 2021-11-11T05:00:00Z Kim says flu and pneumococcal vaccines don’t always work as well in people on some common immune suppressants, like methotrexate, which treats cancer and autoimmune diseases. COVID-19 vaccines may protect many, but not all, people with suppressed immune systems 2021-04-27T04:00:00Z The irony, in Chiancone’s view, is that she doubts that she actually had rheumatoid arthritis, the reason she was prescribed methotrexate for nearly six years. This woman’s desperate persistence helped spark her lucky break 2022-05-14T04:00:00Z Many pharmacists have likewise refused to fill methotrexate prescriptions, or have demanded additional proof before dispensing the medication to patients they believe could get pregnant. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z But most of all, she hates the idea of going off methotrexate, an extraordinarily effective anti-inflammatory taken by nearly 60 percent of all rheumatoid arthritis patients, according to the Johns Hopkins Arthritis Center. Abortion bans complicate access to drugs for cancer, arthritis, even ulcers 2022-08-08T04:00:00Z A previous study from Korea showed that a fortnight's break from methotrexate immediately after the flu vaccine increased the patients' immune response to that jab. Covid: Medication holiday may boost vaccine protection 2021-11-11T05:00:00Z Wolfe recommended that Brenner begin taking methotrexate, a drug that suppresses the immune system and is used to treat some cancers and autoimmune diseases. Her flaming ears foretold a diagnosis that terrified her 2021-03-19T04:00:00Z The rheumatologist prescribed two drugs: methotrexate, a chemotherapy drug used to treat rheumatoid arthritis, and when that didn’t help, hydroxychloraquine, an anti-malaria drug used to treat autoimmune disorders. His anemia was followed by searing foot pain. Seventeen years later, in precarious shape, a stellar athlete learned what was wrong. 2020-06-26T04:00:00Z Without methotrexate, many of Schulert’s juvenile idiopathic arthritis patients could no longer hold a pencil or type on a computer. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z And there are signs that the bacterium might be responsible for the variation in how people respond to the rheumatoid-arthritis drug methotrexate. The complex relationship between drugs and the microbiome 2020-01-28T05:00:00Z She takes methotrexate for her psoriatic arthritis to help treat her swollen joints and dry skin. Covid: Medication holiday may boost vaccine protection 2021-11-11T05:00:00Z She finished the steroids in March, but she’ll remain on the methotrexate until Christmas. Wife recovers from bad statin reaction 2019-12-11T05:00:00Z Q: I was on weekly methotrexate for three years for rheumatic symptoms. A tip to clear effects of anesthesia with diet 2019-10-30T04:00:00Z That’s part of what makes the legal chaos around methotrexate so distressing, even to patients who still have access to the drug. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z The researchers focused on a particular chemotherapy drug, methotrexate, which is especially associated with long-term cognitive problems. How does chemo brain work? One cancer drug might interfere with brain signaling 2018-12-06T05:00:00Z That compared with improvements reported in 45 percent of patients receiving methotrexate, which is typically the first medicine prescribed for RA patients. AbbVie rheumatoid arthritis drug succeeds in late stage trial 2018-10-23T04:00:00Z There is therefore great interest in trying to reduce the side effects of methotrexate treatment. Histidine metabolism boosts cancer therapy 2018-07-10T04:00:00Z Another reader shared, “My hair thinned for a while after starting methotrexate; then it grew back undeniably curly.” A tip to clear effects of anesthesia with diet 2019-10-30T04:00:00Z “Some of our medicines don’t work as well as methotrexate. Other medications also have side effects that patients are not able to tolerate, or they interact with other medications that they have to take.” Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z Next up for the scientists was designing a mouse model of chemo brain caused by methotrexate. How does chemo brain work? One cancer drug might interfere with brain signaling 2018-12-06T05:00:00Z That compared with 46 percent of patients receiving methotrexate. AbbVie rheumatoid arthritis drug succeeds in late stage trial 2018-10-23T04:00:00Z To investigate the processes that affect the cellular response to methotrexate, Kanarek et al. used a cell line derived from a person with leukaemia. Histidine metabolism boosts cancer therapy 2018-07-10T04:00:00Z Because methotrexate, the standard drug, did not work, she was placed on an aggressive regimen involving five medicines. Born in a parking lot, the baby was fine. But something was terribly wrong with the mother. 2017-10-30T04:00:00Z In Texas, dispensing methotrexate to someone who uses it to induce a miscarriage after 49 days of gestation is a felony; that makes pharmacists hesitant to fill such prescriptions for almost anyone with a uterus. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z To answer this, her team transplanted healthy OPCs into the brains of mice previously administered methotrexate. How does chemo brain work? One cancer drug might interfere with brain signaling 2018-12-06T05:00:00Z One of the drugs FDA officials said they were concerned about was methotrexate, which treats childhood leukemia and other diseases. Nationwide drug, medical-device shortages feared as Puerto Rico struggles to recover 2017-10-04T04:00:00Z One such gene that they identified encodes a protein called SLC19A1, which transports folate and methotrexate into cells. Histidine metabolism boosts cancer therapy 2018-07-10T04:00:00Z In a statement, Mylan did not address the methotrexate shortage but said it was “working closely with F.D.A. to help address drug shortage concerns.” Hurricane Damage in Puerto Rico Leads to Fears of Drug Shortages Nationwide 2017-10-04T04:00:00Z Some lupus patients were switched to methotrexate from hydroxychloroquine in the early months of the pandemic, when the federal government briefly stockpiled the drug. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z Additional experiments on brain cells revealed methotrexate activates microglia in the brain’s white matter, causing a cascade of effects and ultimately depleting OPCs. How does chemo brain work? One cancer drug might interfere with brain signaling 2018-12-06T05:00:00Z In a statement, Mylan did not address the methotrexate shortage but said it was “working closely with FDA to help address drug shortage concerns.” Nationwide drug, medical-device shortages feared as Puerto Rico struggles to recover 2017-10-04T04:00:00Z The authors therefore proposed that greater cellular histidine degradation should deplete the THF pool and thus increase the effectiveness of methotrexate. Histidine metabolism boosts cancer therapy 2018-07-10T04:00:00Z One of the drugs F.D.A. officials said they were concerned about was methotrexate, which treats childhood leukemia and other diseases. Hurricane Damage in Puerto Rico Leads to Fears of Drug Shortages Nationwide 2017-10-04T04:00:00Z That’s what happened to Sarah Blahovec of Alexandria, Va., a Crohn’s disease patient who is waiting to see if her methotrexate prescription will be refilled in the coming weeks. Post-Roe, many autoimmune patients lose access to 'gold standard' drug 2022-07-11T04:00:00Z This one is federally funded and is testing the much cheaper but less targeted anti-inflammatory methotrexate in a similar population. Anti-inflammatory cuts risk of heart attack 2017-08-27T04:00:00Z An inquest last November found Mr Vavalidis died from liver failure and this was "most probably associated with toxicity" from methotrexate, a drug prescribed for his psoriasis. Widow shocked over husband's 'avoidable' death - BBC News 2017-08-09T04:00:00Z Doctors treated him for rheumatoid arthritis, but a cocktail of medicines — including methotrexate, a chemotherapy drug given to cancer patients — proved ineffective. Improbable Return Makes Defense of Senior Open Title Possible 2017-06-29T04:00:00Z “The magnitude of the effect,” she said, “is large — about one-third of the expected magnitude of the standard drug treatment of rheumatoid arthritis with methotrexate.” Fish as Medicine for Rheumatoid Arthritis 2017-06-21T04:00:00Z A half-point reduction is clinically significant, say the researchers; it’s about one-third the amount of improvement reported in clinical trials for methotrexate drugs, which are considered the standard of care for RA. The Surprising Benefit of Eating Fish 2017-06-21T04:00:00Z Despite her situation, she began spinal infusions of methotrexate. Perspective | I’m a doctor. When my mother was dying, I wish her doctors had told me the truth. 2017-05-05T04:00:00Z Dr Wheeler's defence states that when he took over prescribing the methotrexate, he was aware that Mr Vavalidis was established as stable on a dosage which was effective in controlling his psoriasis without side-effects. Widow shocked over husband's 'avoidable' death - BBC News 2017-08-09T04:00:00Z Supplying the two drugs required — methotrexate and misoprostol — to a pregnant woman carries the same sentence as taking them: 14 years. Abortion in Ireland: The fight for choice - BBC News 2017-03-07T05:00:00Z If self-care doesn’t help, see a doctor, who might prescribe a biologic drug for inflammation, methotrexate to slow skin-cell growth, or phototherapy. What to do about dry, itchy skin? 2016-12-30T05:00:00Z But when a different drug, methotrexate, was in short supply, pediatricians stopped giving it to all patients who required high doses, including those in research trials. Drug Shortages Forcing Hard Decisions on Rationing Treatments 2016-01-29T05:00:00Z Their first step was to alter the combination of drugs in their protocol, replacing methotrexate with a newer compound called procarbazine. How to Cure Cancer 2015-12-14T05:00:00Z Krull said that although methotrexate is linked to brain problems when given in high doses, the survivors' mental impairment appeared related to current health conditions, not that drug. Childhood Cancer Survivors May Suffer Physically, Mentally Decades Later 2015-11-19T05:00:00Z Leach began taking prescription-strength nonsteroidal anti-inflammatory drugs and prednisone to reduce her pain and swelling, followed by methotrexate, which doctors hoped would halt the progression of the disease. Biologics are revolutionizing care for some diseases, but they are very costly 2015-03-16T04:00:00Z Initially, 222 patients spent a year on weekly injections of Enbrel, along with the oral drug methotrexate. Lower Doses of Rheumatoid Arthritis Drugs May Work for Some 2014-11-05T05:00:00Z Alternative medications such as methotrexate are available, but they are not as effective and carry the same potential risk for autoimmune-related cancer, Braiteh said. Popular Crohn's, Colitis Drugs Not Linked to Short-Term Cancer Risk: Study 2014-06-18T04:00:00Z Current drugs such as methotrexate target a substance called tumor necrosis factor-alpha, which is produced in response to inflammation. Drug Shows Promise Against Arthritis Common in People with Psoriasis 2014-06-11T04:00:00Z A few women developed irregular menstrual periods, more so among those taking the herb than among women on methotrexate. Thunder god vine works as well as a Western drug for rheumatoid arthritis, a study finds 2014-04-21T19:08:18Z Ruderman says it is reasonable to require patients to try methotrexate first because it is cheaper and it may work. Biologics are revolutionizing care for some diseases, but they are very costly 2015-03-16T04:00:00Z About six months later, some remained in remission; those who'd been on lower doses of Enbrel and methotrexate fared the best -- with 44 percent still in remission. Lower Doses of Rheumatoid Arthritis Drugs May Work for Some 2014-11-05T05:00:00Z Nor may methotrexate be used for ectopic pregnancies, it said. Supreme Court lets stand Oklahoma court ruling against part of new abortion law 2013-11-04T15:30:42Z The responsiveness and tolerability to methotrexate is not the same as it is in R.A., though it can work very well in some and is worth considering. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z Participants were given doses of methotrexate that are standard for China, where the study was done, but that are lower than doses usually prescribed by U.S. doctors. Thunder god vine works as well as a Western drug for rheumatoid arthritis, a study finds 2014-04-21T19:08:18Z My fiancé was given a diagnosis of R.A. last year but after six months of taking prednisone, methotrexate and Enbrel his condition only worsened. Ask an Expert: Answers About Rheumatoid Arthritis, Part 2 2013-07-24T12:00:01Z That compared with 40 percent of those on methotrexate alone, and 23 percent of those taking neither drug. Lower Doses of Rheumatoid Arthritis Drugs May Work for Some 2014-11-05T05:00:00Z If this is the case, our experience with methotrexate over the last 30 years is that there are almost no significant long-term consequences and that benefits clearly outweigh risks. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z My rheumatologist put me on prednisone and methotrexate. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z Most children receive no radiation at all: doctors prefer to protect their young patients' brains from leukaemic invasion by injecting drugs such as methotrexate and cytarabine into their spinal fluid. Drug safety: Double jeopardy 2013-06-26T17:20:58.983Z But none of the medications — steroids, antibiotics and even big guns such as methotrexate, which is used to treat cancer, and Cellcept, a drug to prevent rejection in transplant patients — eliminated the rash. Man’s persistent rash seemed ordinary, but it was actually ominous 2012-08-27T19:14:24Z The trial will randomly assign participants to receive methotrexate given at 10 to 20 milligrams weekly for three to four years or a placebo. NHLBI Announces 7000 Patient Trial Testing Inflammation Hypothesis 2012-08-22T17:38:27Z Long-term effects of methotrexate are for the most part positive. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z After six months on methotrexate, my vision degraded threefold in one year. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z Other psoriasis treatments, such as cyclosporine, methotrexate and light therapy, also seemed to lower a patient's risk of heart disease compared to doing nothing or just using ointments, they found. Psoriasis treatment tied to fewer heart attacks 2012-08-20T20:14:30Z Data from a second Phase II trial testing the drug without methotrexate are expected in the third quarter of this year. Celgene psoriatic arthritis drug effective in trial 2012-07-12T12:51:21Z Mice treated with methotrexate or cytarabine showed deficits in novel object discrimination, suggesting that being treated with chemotherapy drugs during development resulted in cognitive deficits, similar to those seen in humans. Experimental Biology Blogging: Cancer chemotherapy and cognitive deficits 2012-04-24T19:15:17.697Z Studies also show that patients whose R.A. is being controlled on methotrexate experience less cardiovascular disease. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z Tolerating Methotrexate Q. I would ask any rheumatologist who says that methotrexate does not have difficult side effects to take it for a few years. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z The hospital couldn’t be sure that there would be enough methotrexate — the cornerstone of therapy for some childhood cancers, including leukemia and osteosarcoma — to treat Alyssa, now 9. TIME Investigates: Inside America's Drug Shortage 2012-03-19T22:05:37Z Another maker, Hospira Inc., expected today to start shipping about 31,000 vials of preservative-free methotrexate, more than enough to meet a month's demand, to hundreds of hospitals and treatment centers. FDA: New suppliers to ease 2 cancer drug shortages 2012-02-22T07:16:04Z It's also given approval to APP Pharmaceuticals to begin making a preservative-free version of methotrexate in addition to its current drug that includes preservatives. FDA: New suppliers to ease 2 cancer drug shortages 2012-02-21T15:38:09Z Your doctor should be monitoring blood tests every three or so months while on methotrexate. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z A. Caitlin highlights that some people have a great deal of difficulty tolerating methotrexate. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z The two drugs are doxorubicin and methotrexate, and in both cases supplies in the United States are being bolstered by shipments from abroad. F.D.A. Approves Imports Amid Shortage of 2 Cancer Drugs 2012-02-21T14:30:29Z The drug is methotrexate, and the cancer it treats is known as acute lymphoblastic leukemia, or A.L.L., which most often strikes children ages 2 to 5. Supply of Methotrexate, a Cancer Drug, May Run Out Soon 2012-02-11T04:15:54Z "Voraxaze is an important new treatment option for cancer patients aimed at preventing these toxicities associated with sustained high levels of methotrexate," Pazdur said in a statement. FDA approves BTG's drug for cancer toxicity 2012-01-17T23:40:05Z After a year of increasing doses of methotrexate and R.A. that would not stay managed, I switched to a vegan diet. Ask an Expert: Answers About Rheumatoid Arthritis, Part 1 2013-07-17T11:05:00Z This means that methotrexate is tolerated very well and working well in the majority. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z Standard care for ectopic pregnancies, which are life-threatening, is to inject the drug methotrexate or to remove the embryo surgically while leaving the fallopian tube intact, both procedures that are intended to preserve fertility. Religious hospitals' restrictions sparking conflicts, scrutiny 2011-01-20T03:50:01Z The cancer commonly spreads to the lining of the spine and brain, and oncologists prevent this by injecting large quantities of preservative-free methotrexate directly into the spinal fluid. Supply of Methotrexate, a Cancer Drug, May Run Out Soon 2012-02-11T04:15:54Z In a clinical trial of 22 patients, Voraxaze eliminated 95 percent of methotrexate from their blood. FDA approves BTG's drug for cancer toxicity 2012-01-17T23:40:05Z In the newest study versus methotrexate, there were three cases of cancer reported in the group that received the Abbott drug. Abbott psoriasis drug succeeds in pivotal trial 2010-10-11T16:12:00Z I have seen many patients who have remained on methotrexate for 30 years and done extremely well. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z A number of RA medications, like methotrexate and leflunomide, may be harmful to the fetus and must be stopped before a woman conceives. Rheumatoid arthritis tied to pregnancy complications 2010-03-17T19:13:00Z There are four other manufacturers of methotrexate in the United States, and they are trying to increase production, Ms. Jensen said. Supply of Methotrexate, a Cancer Drug, May Run Out Soon 2012-02-11T04:15:54Z For 10 of the patients, the methotrexate fell to a low level within 15 minutes and stayed that way for eight days, the FDA said. FDA approves BTG's drug for cancer toxicity 2012-01-17T23:40:05Z R788 is designed to help patients who do not respond to the older drug methotrexate, which is the current standard of care for rheumatoid arthritis patients. 2010-02-16T16:54:00Z There is no question that side effects like fatigue, loss of appetite, nausea, mouth sores, malaise or bowel issues are experienced by a proportion of patients who use methotrexate in the long term. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z This is very much related to the early effective use of methotrexate. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z We know that even people who need additional biologic therapies are able to stay on these longer with good effectiveness if they can stay on methotrexate. Ask an Expert: Answers About Rheumatoid Arthritis, Part 3 2013-08-01T17:53:46Z |
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